Xenobiotica, Volume 48, Issue 10 (2018)

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Xenobiotica, Volume 48, Issue 10 (2018)

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General Xenobiochemistry

Article
Metabolism of megestrol acetate in vitro and the role of oxidative metabolites
Larry House, Michael J. Seminerio, Snezana Mirkov, Jacqueline Ramirez, Maxwell Skor, Joseph R. Sachleben, Masis Isikbay, Hari Singhal, Geoffrey L. Greene, Donald Vander Griend, Suzanne D. Conzen & Mark J. Ratain
Pages: 973-983
Published online: 10 Nov 2017
AbstractforMetabolism of megestrol acetate in vitro and the role of oxidative metabolites | Full Text | References | PDF (695.1 KB) | Supplemental
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Article
Changes in CYP2D enzyme activity following induction of type 2 diabetes, and administration of cinnamon and metformin: an experimental animal study
Ali Taheri, Hoda Lavasani, Sara Kasirzadeh, Behjat Sheikholeslami, Yalda H. Ardakani & Mohammad-Reza Rouini
Pages: 984-989
Published online: 02 Nov 2017
AbstractforChanges in CYP2D enzyme activity following induction of type 2 diabetes, and administration of cinnamon and metformin: an experimental animal study | Full Text | References | PDF (544.3 KB)
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Article
Stereoselective in vitro metabolism of rhynchophylline and isorhynchophylline epimers of Uncaria rhynchophylla in rat liver microsomes
Xin Wang, Zhou Qiao, Jia Liu, Mei Zheng, Wenyuan Liu & Chunyong Wu
Pages: 990-998
Published online: 10 Nov 2017
AbstractforStereoselective in vitro metabolism of rhynchophylline and isorhynchophylline epimers of Uncaria rhynchophylla in rat liver microsomes | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation
Xiu-Xian Lin, Guang-Hui Lian, Ying Xu, Qing Zhao, Jian Xiao, Shi-Fang Peng, Mei-Fang Xiao, Dong-Sheng Ouyang, Zhi-Rong Tan, Yi-Cheng Wang, Jing-Bo Peng, Wei Zhang & Yao Chen
Pages: 999-1005
Published online: 10 Nov 2017
AbstractforThe potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation | Full Text | References | PDF (786.6 KB)
  • 228 Views
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Clinical Pharmacokinetics and Metabolism

Article
Mass balance and metabolism of Z-215, a novel proton pump inhibitor, in healthy volunteers
Ryoko Toda, Tomoharu Miyagawa, Yuka Masuda, Yusuke Hoshino, Kazuyoshi Yoshii, Masamichi Hirayama, Minaka Shibuya & Yoshihiro Kawabata
Pages: 1006-1020
Published online: 02 Nov 2017
AbstractforMass balance and metabolism of Z-215, a novel proton pump inhibitor, in healthy volunteers | Full Text | References | PDF (998.6 KB)
  • 192 Views
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Animal Pharmacokinetics and Metabolism

Article
Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole
Molly Lin, Justin Ly, Ryan Takahashi, John Chen, Alan Deese, Sarah J. Robinson, Aleksandr Kolesnikov, Susan Wong, Xiaojing Wang & Jae H. Chang
Pages: 1021-1027
Published online: 29 Sep 2017
AbstractforCharacterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole | Full Text | References | PDF (356.2 KB) | Supplemental
  • 266 Views
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Article
Quercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats
Suresh Palle & Prasad Neerati
Pages: 1028-1036
Published online: 10 Nov 2017
AbstractforQuercetin nanoparticles alter pharmacokinetics of bromocriptine, reflecting its enhanced inhibitory action on liver and intestinal CYP 3A enzymes in rats | Full Text | References | PDF (817 KB)
  • 156 Views
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Xenobiotic Transporters

Article
In vitro studies with two human organic anion transporters: OAT2 and OAT7
Sumathy Mathialagan, Chester Costales, Laurie Tylaska, Emi Kimoto, Anna Vildhede, Jillian Johnson, Nathaniel Johnson, Takami Sarashina, Kenta Hashizume, Caleb D. Isringhausen, Lydia M. M. Vermeer, Andrea R. Wolff & A. David Rodrigues
Pages: 1037-1049
Published online: 13 Oct 2017
AbstractforIn vitro studies with two human organic anion transporters: OAT2 and OAT7 | Full Text | References | PDF (513 KB) | Supplemental
  • 793 Views
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Article
MicroRNA-655-3p regulates Echinacea purpurea mediated activation of ABCG2
Charles Awortwe, Meike Kaehler, Bernd Rosenkranz, Ingolf Cascorbi & Henrike Bruckmueller
Pages: 1050-1058
Published online: 02 Nov 2017
AbstractforMicroRNA-655-3p regulates Echinacea purpurea mediated activation of ABCG2 | Full Text | References | PDF (772.6 KB) | Supplemental
  • 196 Views
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Article
Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1
Hiroyoshi Koide, Masayuki Tsujimoto, Ai Takeuchi, Miyu Tanaka, Yoko Ikegami, Mayu Tagami, Syoko Abe, Miki Hashimoto, Tetsuya Minegaki & Kohshi Nishiguchi
Pages: 1059-1071
Published online: 10 Nov 2017
AbstractforSubstrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1 | Full Text | References | PDF (1.1 MB)
  • 601 Views
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Pharmacogenetics

Article
Association with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models
Takashi Kusama, Akiko Toda, Makiko Shimizu, Shotaro Uehara, Takashi Inoue, Yasuhiro Uno, Masahiro Utoh, Erika Sasaki & Hiroshi Yamazaki
Pages: 1072-1077
Published online: 10 Nov 2017
AbstractforAssociation with polymorphic marmoset cytochrome P450 2C19 of in vivo hepatic clearances of chirally separated R-omeprazole and S-warfarin using individual marmoset physiologically based pharmacokinetic models | Full Text | References | PDF (981.6 KB)
  • 216 Views
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Corrigendum

Correction
Correction to: Koide et al., Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1
Page: x
Published online: 05 Feb 2018
CitationforCorrection to: Koide et al., Substrate-dependent effects of molecular-targeted anticancer agents on activity of organic anion transporting polypeptide 1B1 | Full Text | PDF (90.9 KB)
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