Xenobiotica, Volume 48, Issue 11 (2018)

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Xenobiotica, Volume 48, Issue 11 (2018)

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General Xenobiochemistry

Article
Metabonomics analysis of serum from rats given long-term and low-level cadmium by ultra-performance liquid chromatography–mass spectrometry
Liyan Hu, Lu Bo, Meiyan Zhang, Siqi Li, Xiujuan Zhao & Changhao Sun
Pages: 1079-1088
Published online: 16 Nov 2017
AbstractforMetabonomics analysis of serum from rats given long-term and low-level cadmium by ultra-performance liquid chromatography–mass spectrometry | Full Text | References | PDF (808.4 KB)
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Article
The impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo
Kateřina Lněničková, Hana Svobodová, Lenka Skálová, Martin Ambrož, Filip Novák & Petra Matoušková
Pages: 1089-1097
Published online: 10 Nov 2017
AbstractforThe impact of sesquiterpenes β-caryophyllene oxide and trans-nerolidol on xenobiotic-metabolizing enzymes in mice in vivo | Full Text | References | PDF (344 KB)
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Article
Indirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice
Yuki Yamasaki, Kaoru Kobayashi, Asumi Inaba, Daisuke Uehara, Hiroki Tojima, Satoru Kakizaki & Kan Chiba
Pages: 1098-1105
Published online: 23 Nov 2017
AbstractforIndirect activation of pregnane X receptor in the induction of hepatic CYP3A11 by high-dose rifampicin in mice | Full Text | References | PDF (427.1 KB) | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Changes in gefitinib, erlotinib and osimertinib pharmacokinetics under various gastric pH levels following oral administration of omeprazole and vonoprazan in rats
Osamu Yasumuro, Shinya Uchida, Yasuharu Kashiwagura, Ayae Suzuki, Shimako Tanaka, Naoki Inui, Hiroshi Watanabe & Noriyuki Namiki
Pages: 1106-1112
Published online: 17 Nov 2017
AbstractforChanges in gefitinib, erlotinib and osimertinib pharmacokinetics under various gastric pH levels following oral administration of omeprazole and vonoprazan in rats | Full Text | References | PDF (304.5 KB)
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Article
Metabolism of metofluthrin in rats: II. Excretion, distribution and amount of metabolites
Jun Abe, Yoshitaka Tomigahara, Hirokazu Tarui, Hirohisa Nagahori, Motohiro Kurosawa, Kenji Sugimoto & Naohiko Isobe
Pages: 1113-1127
Published online: 20 Nov 2017
AbstractforMetabolism of metofluthrin in rats: II. Excretion, distribution and amount of metabolites | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Disposition of [14C]hydroquinone in Harlan Sprague-Dawley rats and B6C3F1/N mice: species and route comparison
Sherry R. Black, Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Purvi R. Patel, Scott L. Watson, Vicki Sutherland & Suramya Waidyanatha
Pages: 1128-1141
Published online: 22 Nov 2017
AbstractforDisposition of [14C]hydroquinone in Harlan Sprague-Dawley rats and B6C3F1/N mice: species and route comparison | Full Text | References | PDF (865 KB) | Supplemental
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Article
Metabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro
Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre & Suramya Waidyanatha
Pages: 1142-1156
Published online: 23 Nov 2017
AbstractforMetabolism and disposition of 2-ethylhexyl-p-methoxycinnamate following oral gavage and dermal exposure in Harlan Sprague Dawley rats and B6C3F1/N mice and in hepatocytes in vitro | Full Text | References | PDF (573.7 KB)
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Article
Effects of glycyrrhizin on the pharmacokinetics of puerarin in rats
Qun Zhao, Yingli Wang, Hongqin Wang & Lichun Feng
Pages: 1157-1163
Published online: 21 Nov 2017
AbstractforEffects of glycyrrhizin on the pharmacokinetics of puerarin in rats | Full Text | References | PDF (390.7 KB)
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Molecular Toxicology

Article
Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole
Ai-Hong Yang, Lei Zhang, De-Xian Zhi, Wen-Li Liu, Xue Gao & Xin He
Pages: 1164-1172
Published online: 22 Nov 2017
AbstractforIdentification and analysis of the reactive metabolites related to the hepatotoxicity of safrole | Full Text | References | PDF (896 KB) | Supplemental
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Xenobiotic transporters

Article
Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug–drug interaction profiles
Pu Shi, Mingxiang Liao, Bei-Ching Chuang, Robert Griffin, Judy Shi, Marc Hyer, John K. Fallon, Philip C. Smith, Chao Li & Cindy Q. Xia
Pages: 1173-1183
Published online: 16 Nov 2017
AbstractforEfflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug–drug interaction profiles | Full Text | References | PDF (523.1 KB)
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