Xenobiotica, Volume 48, Issue 12 (2018)

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Xenobiotica, Volume 48, Issue 12 (2018)

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General Xenobiochemistry

Article
In vitro inhibitory effects of pristimerin on human liver cytochrome P450 enzymes
Xiaoyi Hao, Jianlei Yuan, Yansen Xu, Zhao Wang, Jianzhang Hou & Tao Hu
Pages: 1185-1191
Published online: 27 Apr 2018
AbstractforIn vitro inhibitory effects of pristimerin on human liver cytochrome P450 enzymes | Full Text | References | PDF (568.5 KB)
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Article
Qualitative and quantitative prediction of human in vivo metabolic pathways in a human hepatocyte-murine stromal cell co-culture model
Kenneth C. Cassidy & Ping Yi
Pages: 1192-1205
Published online: 16 Nov 2017
AbstractforQualitative and quantitative prediction of human in vivo metabolic pathways in a human hepatocyte-murine stromal cell co-culture model | Full Text | References | PDF (962.8 KB)
  • 227 Views
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Article
Evaluation of separate role of intestine and liver in first pass metabolism of budesonide in rat
Amol A. Raje, Radni D. Deshpande, Vishal V. Pathade, Vallabh Mahajan, Kaushal Joshi, Ashwini Tambe, Ramana Jinugu, Vamsi L. M. Madgula, Ashwani Gaur, Vishwottam Kandikere, Chandragouda R. Patil & Kasim A. Mookhtiar
Pages: 1206-1214
Published online: 28 Nov 2017
AbstractforEvaluation of separate role of intestine and liver in first pass metabolism of budesonide in rat | Full Text | References | PDF (349.5 KB)
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Article
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors
Xiaoliang Zhuo, Ying-Zi Wang, Kap-Sun Yeung, Juliang Zhu, Xiaohua Stella Huang, Kyle E. Parcella, Kyle J. Eastman, John F. Kadow, Nicholas A. Meanwell, Yue-Zhong Shu & Benjamin M. Johnson
Pages: 1215-1226
Published online: 12 Dec 2017
AbstractforBioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors | Full Text | References | PDF (924.3 KB)
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Article
Allosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding
Tomohiko Ichikawa, Hirofumi Tsujino, Takahiro Miki, Masaya Kobayashi, Chiaki Matsubara, Sara Miyata, Taku Yamashita, Kohei Takeshita, Yasushige Yonezawa & Tadayuki Uno
Pages: 1227-1236
Published online: 18 Dec 2017
AbstractforAllosteric activation of cytochrome P450 3A4 by efavirenz facilitates midazolam binding | Full Text | References | PDF (705.4 KB)
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Article
The effects of aging on hepatic microsomal scaling factor and hepatocellularity number in the horse
Khaled A. Shibany, Sabine Tötemeyer, Stefanie L. Pratt & Stuart W. Paine
Pages: 1237-1244
Published online: 19 Dec 2017
AbstractforThe effects of aging on hepatic microsomal scaling factor and hepatocellularity number in the horse | Full Text | References | PDF (429.6 KB) | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Plasma concentrations of cytisine, a commercially available plant-based alkaloid, in healthy adult smokers taking recommended doses for smoking cessation
Soo Hee Jeong, Janie Sheridan, David Newcombe & Malcolm Tingle
Pages: 1245-1248
Published online: 12 Dec 2017
AbstractforPlasma concentrations of cytisine, a commercially available plant-based alkaloid, in healthy adult smokers taking recommended doses for smoking cessation | Full Text | References | PDF (188.8 KB)
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Animal Pharmacokinetics and Metabolism

Article
Efficient brain uptake of piperine and its pharmacokinetics characterization after oral administration
Tianjing Ren, Qianwen Wang, Chenrui Li, Mengbi Yang & Zhong Zuo
Pages: 1249-1257
Published online: 28 Nov 2017
AbstractforEfficient brain uptake of piperine and its pharmacokinetics characterization after oral administration | Full Text | References | PDF (545.3 KB)
  • 387 Views
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Article
Leishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution
Barbra Sanches Moraes, Francine Johansson Azeredo, Jessica Cristina Izoton, Marina Amaral, Eliezer de Jesus Barreiro, Rodrigo José Freddo, Teresa Dalla Costa, Lídia Moreira Lima & Sandra Elisa Haas
Pages: 1258-1267
Published online: 27 Dec 2017
AbstractforLeishmanicidal candidate LASSBio-1736, a cysteine protease inhibitor with favorable pharmacokinetics: low clearance and good distribution | Full Text | References | PDF (1.2 MB)
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Article
Preclinical evaluation of saroglitazar magnesium, a dual PPAR-α/γ agonist for treatment of dyslipidemia and metabolic disorders
Harilal Patel, Poonam Giri, Prakash Patel, Sanjay Singh, Laxmikant Gupta, Urvesh Patel, Nirav Modi, Kalpesh Shah, Mukul R. Jain, Nuggehally R. Srinivas & Pankaj Patel
Pages: 1268-1277
Published online: 22 Dec 2017
AbstractforPreclinical evaluation of saroglitazar magnesium, a dual PPAR-α/γ agonist for treatment of dyslipidemia and metabolic disorders | Full Text | References | PDF (445.3 KB)
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Molecular Toxicology

Article
Toxicity of new synthetic amphetamine drug mephedrone On Rat Heart mitochondria: a warning for its abuse
Parvaneh Naserzadeh, Farzaneh Jokar, Farzaneh Vafaei, Enayatollah Seydi & Jalal Pourahmad
Pages: 1278-1284
Published online: 28 Nov 2017
AbstractforToxicity of new synthetic amphetamine drug mephedrone On Rat Heart mitochondria: a warning for its abuse | Full Text | References | PDF (983 KB)
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