Xenobiotica, Volume 48, Issue 2 (2018)

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Xenobiotica, Volume 48, Issue 2 (2018)

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General Xenobiochemistry

Article
Identification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation
Guiyuan He, Johanna Troberg, Xia Lv, Yang-Liu Xia, Liang-Liang Zhu, Jing Ning, Guang-Bo Ge, Moshe Finel & Ling Yang
Pages: 109-116
Published online: 25 Jul 2017
AbstractforIdentification and characterization of human UDP-glucuronosyltransferases responsible for xanthotoxol glucuronidation | Full Text | References | PDF (432 KB)
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Article
Human plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice
Miho Yamazaki-Nishioka, Makiko Shimizu, Hiroshi Suemizu, Megumi Nishiwaki, Marina Mitsui & Hiroshi Yamazaki
Pages: 117-123
Published online: 21 Feb 2017
AbstractforHuman plasma metabolic profiles of benzydamine, a flavin-containing monooxygenase probe substrate, simulated with pharmacokinetic data from control and humanized-liver mice | Full Text | References | PDF (423 KB)
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Article
Dimethylarsinic acid modulates the aryl hydrocarbon receptor-regulated genes in C57BL/6 mice: in vivo study
Osama H. Elshenawy, Ghada Abdelhamid, Hassan N. Althurwi & Ayman O. S. El-Kadi
Pages: 124-134
Published online: 21 Feb 2017
AbstractforDimethylarsinic acid modulates the aryl hydrocarbon receptor-regulated genes in C57BL/6 mice: in vivo study | Full Text | References | PDF (873.3 KB)
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Article
Predictions of bisphenol A hepatic clearance in the isolated perfused rat liver (IPRL): impact of albumin binding and of co-administration with naproxen
Sara Bounakta, Michel Bteich, Marc Mantha, Patrick Poulin & Sami Haddad
Pages: 135-147
Published online: 03 Mar 2017
AbstractforPredictions of bisphenol A hepatic clearance in the isolated perfused rat liver (IPRL): impact of albumin binding and of co-administration with naproxen | Full Text | References | PDF (426.9 KB)
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Article
Area under the curve predictions of dalbavancin, a new lipoglycopeptide agent, using the end of intravenous infusion concentration data point by regression analyses such as linear, log-linear and power models
Ravi Kanth Bhamidipati, Muzeeb Syed, Ramesh Mullangi & Nuggehally Srinivas
Pages: 148-156
Published online: 14 Mar 2017
AbstractforArea under the curve predictions of dalbavancin, a new lipoglycopeptide agent, using the end of intravenous infusion concentration data point by regression analyses such as linear, log-linear and power models | Full Text | References | PDF (301.7 KB)
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Animal Pharmacokinetics and Metabolism

Article
Metabolism of metofluthrin in rats: I. Identification of metabolites
Jun Abe, Hirohisa Nagahori, Hirokazu Tarui, Yoshitaka Tomigahara & Naohiko Isobe
Pages: 157-169
Published online: 05 Feb 2017
AbstractforMetabolism of metofluthrin in rats: I. Identification of metabolites | Full Text | References | PDF (1 MB) | Supplemental
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Article
Aldehyde oxidase-dependent species difference in hepatic metabolism of fasudil to hydroxyfasudil
Zhengsheng Mao, Yali Wu, Qiuying Li, Xin Wang, Youping Liu & Xin Di
Pages: 170-177
Published online: 02 Mar 2017
AbstractforAldehyde oxidase-dependent species difference in hepatic metabolism of fasudil to hydroxyfasudil | Full Text | References | PDF (648.9 KB) | Supplemental
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Article
Effect of piperine on the bioavailability and pharmacokinetics of rosmarinic acid in rat plasma using UPLC-MS/MS
Jun-Hui Yang, Kun-Jun Mao, Ping Huang, Yin-Jun Ye, Hua-Shan Guo & Bao-Chang Cai
Pages: 178-185
Published online: 03 Jul 2017
AbstractforEffect of piperine on the bioavailability and pharmacokinetics of rosmarinic acid in rat plasma using UPLC-MS/MS | Full Text | References | PDF (910 KB)
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Article
Pharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs and monkeys
Tomohiko Ichikawa, Tetsuhiro Yamada, Alexander Treiber, Carmela Gnerre & Kiyoko Nonaka
Pages: 186-196
Published online: 02 Mar 2017
AbstractforPharmacokinetics of the selective prostacyclin receptor agonist selexipag in rats, dogs and monkeys | Full Text | References | PDF (812.7 KB)
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Xenobiotic Transporters

Article
The inhibitory effects of five alkaloids on the substrate transport mediated through human organic anion and cation transporters
Tahiatul Shams, Xiaoxi Lu, Ling Zhu & Fanfan Zhou
Pages: 197-205
Published online: 01 Feb 2017
AbstractforThe inhibitory effects of five alkaloids on the substrate transport mediated through human organic anion and cation transporters | Full Text | References | PDF (860.8 KB)
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Pharmacogenetics

Article
R-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys
Masahiro Utoh, Takashi Kusama, Tomonori Miura, Marina Mitsui, Mirai Kawano, Takahiro Hirano, Makiko Shimizu, Yasuhiro Uno & Hiroshi Yamazaki
Pages: 206-210
Published online: 20 Feb 2017
AbstractforR-warfarin clearances from plasma associated with polymorphic cytochrome P450 2C19 and simulated by individual physiologically based pharmacokinetic models for 11 cynomolgus monkeys | Full Text | References | PDF (176.1 KB)
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Topics in Xenobiochemistry

Review
Xenobiotic C-sulfonate derivatives; metabolites or metabonates?
Stephen C. Mitchell
Pages: 211-218
Published online: 28 Feb 2017
AbstractforXenobiotic C-sulfonate derivatives; metabolites or metabonates? | Full Text | References | PDF (504.3 KB)
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