Xenobiotica, Volume 48, Issue 4 (2018)

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Xenobiotica, Volume 48, Issue 4 (2018)

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General Xenobiochemistry

Article
Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa
Anne Tammimäki, Anu Aonurm-Helm & Pekka T. Männistö
Pages: 325-331
Published online: 21 Apr 2017
AbstractforDelayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa | Full Text | References | PDF (662 KB)
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Article
Metabolism studies on hydroxygenkwanin and genkwanin in human liver microsomes by UHPLC-Q-TOF-MS
Lin Yuan, Caijuan Liang, Xinpeng Diao, Xiaoye Cheng, Man Liao & Lantong Zhang
Pages: 332-341
Published online: 05 May 2017
AbstractforMetabolism studies on hydroxygenkwanin and genkwanin in human liver microsomes by UHPLC-Q-TOF-MS | Full Text | References | PDF (896.4 KB) | Supplemental
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Article
Terfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines
Shotaro Uehara, Yukako Yuki, Yasuhiro Uno, Takashi Inoue, Erika Sasaki & Hiroshi Yamazaki
Pages: 342-347
Published online: 15 May 2017
AbstractforTerfenadine t-butyl hydroxylation catalyzed by human and marmoset cytochrome P450 3A and 4F enzymes in livers and small intestines | Full Text | References | PDF (485 KB)
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Article
A strategy for early-risk predictions of clinical drug–drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors
Anna-Karin Sohlenius-Sternbeck, Gabrielle Meyerson, Ann-Louise Hagbjörk, Sanja Juric & Ylva Terelius
Pages: 348-356
Published online: 15 May 2017
AbstractforA strategy for early-risk predictions of clinical drug–drug interactions involving the GastroPlusTM DDI module for time-dependent CYP inhibitors | Full Text | References | PDF (736.9 KB)
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Article
Glucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes
Li Wang, Xiaodan Hong, Zhihong Yao, Yi Dai, Guoping Zhao, Zifei Qin, Baojian Wu, Frank J. Gonzalez & Xinsheng Yao
Pages: 357-367
Published online: 15 May 2017
AbstractforGlucuronidation of icaritin by human liver microsomes, human intestine microsomes and expressed UDP-glucuronosyltransferase enzymes: identification of UGT1A3, 1A9 and 2B7 as the main contributing enzymes | Full Text | References | PDF (1.5 MB)
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Article
Establishment and assessment of a novel in vitro bio-PK/PD system in predicting the in vivo pharmacokinetics and pharmacodynamics of cyclophosphamide
Shanshan Tong, Hong Sun, Caifu Xue, Hanmei Chen, Jing Liu, Huiying Yang, Ning Zhou, Xiaoqiang Xiang & Weimin Cai
Pages: 368-375
Published online: 06 Jun 2017
AbstractforEstablishment and assessment of a novel in vitro bio-PK/PD system in predicting the in vivo pharmacokinetics and pharmacodynamics of cyclophosphamide | Full Text | References | PDF (804.1 KB)
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Clinical Pharmacokinetics and Metabolism

Article
Pharmacodynamic properties and bioequivalence of dalteparin sodium subcutaneous injection in healthy Chinese male subjects
Lijin Yu, Xin Guo, Sujie Jia, Yuanyuan Xiang, Zhigang Ding & Ren Guo
Pages: 376-381
Published online: 21 Apr 2017
AbstractforPharmacodynamic properties and bioequivalence of dalteparin sodium subcutaneous injection in healthy Chinese male subjects | Full Text | References | PDF (344.5 KB)
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Article
Disposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics
Kenneth C. Cassidy, Ivelina Gueorguieva, Colin Miles, Jessica Rehmel, Ping Yi & William J. Ehlhardt
Pages: 382-399
Published online: 16 May 2017
AbstractforDisposition and metabolism of [14C]-galunisertib, a TGF-βRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics | Full Text | References | PDF (1 MB) | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
The effect of fenofibric acid on the pharmacokinetics and pharmacodynamics of warfarin in rats
Chaorui Guo, Siqi Xue, Xiufen Zheng, Yang Lu, Di Zhao, Xijing Chen & Ning Li
Pages: 400-406
Published online: 31 Mar 2017
AbstractforThe effect of fenofibric acid on the pharmacokinetics and pharmacodynamics of warfarin in rats | Full Text | References | PDF (392.4 KB)
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Article
Influence of grapefruit juice on pharmacokinetics of triptolide in rats grapefruit juice on the effects of triptolide
Yuzhen Jia, Jie Liu & Jisen Xu
Pages: 407-411
Published online: 16 Apr 2017
AbstractforInfluence of grapefruit juice on pharmacokinetics of triptolide in rats grapefruit juice on the effects of triptolide | Full Text | References | PDF (349.5 KB)
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Article
Study on the pharmacokinetics of deoxyschizandrin and schizandrin in combination with epigallocatechin gallate, a component of green tea, in rats
Yan Liu, Dong Zhang, Yingli Wang, Wenjuan Zhang & Xiaohong Liu
Pages: 412-421
Published online: 30 May 2017
AbstractforStudy on the pharmacokinetics of deoxyschizandrin and schizandrin in combination with epigallocatechin gallate, a component of green tea, in rats | Full Text | References | PDF (509.1 KB)
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Topics in Xenobiochemistry

Review
Stereoselective and nonstereoselective pharmacokinetics of rabeprazole – an overview
Ranjeet Prasad Dash, Rana Rais & Nuggehally R. Srinivas
Pages: 422-432
Published online: 06 Apr 2017
AbstractforStereoselective and nonstereoselective pharmacokinetics of rabeprazole – an overview | Full Text | References | PDF (311 KB)
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Corrigendum

Correction
Correction to: Cassidy et al., Disposition and metabolism of [14C]-galunisertib, a TGF-bRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics
Pages: x-xi
Published online: 06 Feb 2018
CitationforCorrection to: Cassidy et al., Disposition and metabolism of [14C]-galunisertib, a TGF-bRI kinase/ALK5 inhibitor, following oral administration in healthy subjects and mechanistic prediction of the effect of itraconazole on galunisertib pharmacokinetics | Full Text | PDF (342.5 KB)
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