Xenobiotica, Volume 48, Issue 5 (2018)

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Xenobiotica, Volume 48, Issue 5 (2018)

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General Xenobiochemistry

Article
Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid
Svenja Heischmann & Uwe Christians
Pages: 433-441
Published online: 30 May 2017
AbstractforValidation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophenolic acid | Full Text | References | PDF (717.6 KB)
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Review
Ponesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition
Ranjeet Prasad Dash, Rana Rais & Nuggehally R. Srinivas
Pages: 442-451
Published online: 30 May 2017
AbstractforPonesimod, a selective sphingosine 1-phosphate (S1P1) receptor modulator for autoimmune diseases: review of clinical pharmacokinetics and drug disposition | Full Text | References | PDF (352.4 KB)
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Article
Everolimus-inhibited multiple isoforms of UDP-glucuronosyltransferases (UGTs)
Zuo Du, Guang Wang, Yun-Feng Cao, Cui-Min Hu, Kun Yang, Yong-Zhe Liu, Chun-Ze Zhang, Wei-Hua Zhang, Zhi-Tu Zhu, Hong-Zhi Sun, Xiao-Yu Sun, Mo Hong & Zhong-Ze Fang
Pages: 452-458
Published online: 30 Jun 2017
AbstractforEverolimus-inhibited multiple isoforms of UDP-glucuronosyltransferases (UGTs) | Full Text | References | PDF (1 MB)
  • 315 Views
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Clinical Pharmacokinetics and Metabolism

Article
Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6
Xia Chen, Ji Jiang, Nagdeep Giri & Pei Hu
Pages: 459-466
Published online: 18 Aug 2017
AbstractforPhase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6 | Full Text | References | PDF (378.1 KB)
  • 353 Views
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Animal Pharmacokinetics and Metabolism

Article
Preclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP)
Mingxiang Liao, Bei-Ching Chuang, Qing Zhu, Yuexian Li, Emily Guan, Shaoxia Yu, Johnny Yang, Shimoga Prakash & Cindy Q. Xia
Pages: 467-477
Published online: 31 May 2017
AbstractforPreclinical absorption, distribution, metabolism, excretion and pharmacokinetics of a novel selective inhibitor of breast cancer resistance protein (BCRP) | Full Text | References | PDF (449.9 KB) | Supplemental
  • 554 Views
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Article
New insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone
Silvio Aprile, Rossana Canavesi, Rosanna Matucci, Cristina Bellucci, Erika Del Grosso & Giorgio Grosa
Pages: 478-487
Published online: 06 Jul 2017
AbstractforNew insights in the metabolism of oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone | Full Text | References | PDF (1,022.7 KB) | Supplemental
  • 322 Views
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Molecular Toxicology

Article
Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Adam V. Wisnewski, Jean Kanyo, Jennifer Asher, James A. Goodrich, Grace Barnett, Lyn Patrylak, Jian Liu, Carrie A. Redlich & Ala F. Nassar
Pages: 488-497
Published online: 01 Jun 2017
AbstractforReaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy | Full Text | References | PDF (980.6 KB) | Supplemental
  • 124 Views
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Article
The effect of ethanol and N-nitrosodimethylamine on the iNOS-dependent NO production in human neutrophils. Role of NF-κB
Karolina Nowak, Wioletta Ratajczak-Wrona, Marzena Garley & Ewa Jabłońska
Pages: 498-505
Published online: 30 Jun 2017
AbstractforThe effect of ethanol and N-nitrosodimethylamine on the iNOS-dependent NO production in human neutrophils. Role of NF-κB | Full Text | References | PDF (1.2 MB)
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Topics in Xenobiochemistry

Review
Efflux proteins at the blood–brain barrier: review and bioinformatics analysis
Massoud Saidijam, Fatemeh Karimi Dermani, Sareh Sohrabi & Simon G. Patching
Pages: 506-532
Published online: 30 May 2017
AbstractforEfflux proteins at the blood–brain barrier: review and bioinformatics analysis | Full Text | References | PDF (2 MB)
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Article
Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans
Jinfang Jiang, Xiaoyan Chen & Dafang Zhong
Pages: 533-540
Published online: 07 Jun 2017
AbstractforPredominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans | Full Text | References | PDF (542.3 KB)
  • 315 Views
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