Xenobiotica, Volume 48, Issue 6 (2018)

Browse this journal
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

Xenobiotica, Volume 48, Issue 6 (2018)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Volume 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Utility of in vitro and in vivo systems for studying the permeability of capsaicin and nonivamide through different intestinal regions
Lian Duan, Huaidong Peng, Guangcan Li, Ruolun Wang & Yanfang Chen
Pages: 541-545
Published online: 06 Jul 2017
AbstractforUtility of in vitro and in vivo systems for studying the permeability of capsaicin and nonivamide through different intestinal regions | Full Text | References | PDF (269.3 KB)
  • 146 Views
  • 0 CrossRef citations
  • 0Altmetric
Article
In vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes
Toshito Nakagawa, Stephen Fowler, Kenji Takanashi, Kuresh Youdim, Tsuyoshi Yamauchi, Kosuke Kawashima, Mika Sato-Nakai, Li Yu & Masaki Ishigai
Pages: 546-554
Published online: 21 Jul 2017
AbstractforIn vitro metabolism of alectinib, a novel potent ALK inhibitor, in human: contribution of CYP3A enzymes | Full Text | References | PDF (662.7 KB)
  • 594 Views
  • 14 CrossRef citations
  • 0Altmetric
Article
In vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450
Alex McCormick, Helen Swaisland, Venkatesh Pilla Reddy, Maria Learoyd & Graeme Scarfe
Pages: 555-564
Published online: 25 Jul 2017
AbstractforIn vitro evaluation of the inhibition and induction potential of olaparib, a potent poly(ADP-ribose) polymerase inhibitor, on cytochrome P450 | Full Text | References | PDF (308.2 KB) | Supplemental
  • 575 Views
  • 22 CrossRef citations
  • 0Altmetric
Article
Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants
Tsutomu Shimada, Norie Murayama, Kensaku Kakimoto, Shigeo Takenaka, Young-Ran Lim, Sora Yeom, Donghak Kim, Hiroshi Yamazaki, F. Peter Guengerich & Masayuki Komori
Pages: 565-575
Published online: 21 Jul 2017
AbstractforOxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants | Full Text | References | PDF (2.9 MB) | Supplemental
  • 175 Views
  • 13 CrossRef citations
  • 0Altmetric
Article
Altered hepatic drug-metabolizing activity in rats suffering from hypoxemia with experimentally induced acute lung impairment
Yuki Hori, Yasumasa Shimizu & Tetsuya Aiba
Pages: 576-583
Published online: 25 Jul 2017
AbstractforAltered hepatic drug-metabolizing activity in rats suffering from hypoxemia with experimentally induced acute lung impairment | Full Text | References | PDF (436.4 KB)
  • 101 Views
  • 5 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
Absorption, metabolism and excretion of [14C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans
Shiyao Xu, Dan Tatosian, Ian Mcintosh, Maria Caceres, Catherine Matthews, Koppara Samuel, Diana Selverian, Sanjeev Kumar & Eunkyung Kauh
Pages: 584-591
Published online: 25 Jul 2017
AbstractforAbsorption, metabolism and excretion of [14C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans | Full Text | References | PDF (467.9 KB) | Supplemental
  • 413 Views
  • 17 CrossRef citations
  • 0Altmetric
Article
Disposition, profiling and identification of emixustat and its metabolites in humans
Michael E. Fitzsimmons, Gang Sun, Vladimir Kuksa & Michael J. Reid
Pages: 592-604
Published online: 28 Jul 2017
AbstractforDisposition, profiling and identification of emixustat and its metabolites in humans | Full Text | References | PDF (1.5 MB)
  • 364 Views
  • 7 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Profiling and identification of chlorogenic acid metabolites in rats by ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer
Fei Wang, Zhanpeng Shang, Lulu Xu, Zhibin Wang, Wenjing Zhao, XiaoDan Mei, Jianqiu Lu & Jia Yu Zhang
Pages: 605-617
Published online: 04 Aug 2017
AbstractforProfiling and identification of chlorogenic acid metabolites in rats by ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer | Full Text | References | PDF (1.1 MB) | Supplemental
  • 202 Views
  • 13 CrossRef citations
  • 0Altmetric
Article
Identification of three new phase II metabolites of a designer drug methylone formed in rats by N-demethylation followed by conjugation with dicarboxylic acids
Monika Židková, Igor Linhart, Marie Balíková, Michal Himl, Veronika Dvořáčková, Eva Lhotková & Tomáš Páleníček
Pages: 618-625
Published online: 25 Jul 2017
AbstractforIdentification of three new phase II metabolites of a designer drug methylone formed in rats by N-demethylation followed by conjugation with dicarboxylic acids | Full Text | References | PDF (395.9 KB)
  • 197 Views
  • 5 CrossRef citations
  • 0Altmetric

Molecular Toxicology

Article
Mass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol
Justin M. Hettick, Brandon F. Law, Chen-Chung Lin, Adam V. Wisnewski & Paul D. Siegel
Pages: 626-636
Published online: 21 Jul 2017
AbstractforMass spectrometry-based analysis of murine bronchoalveolar lavage fluid following respiratory exposure to 4,4'-methylene diphenyl diisocyanate aerosol | Full Text | References | PDF (914 KB) | Supplemental
  • 273 Views
  • 7 CrossRef citations
  • 0Altmetric

Xenobiotic Transporters

Article
In vitro drug–drug interactions of budesonide: inhibition and induction of transporters and cytochrome P450 enzymes
Nancy Chen, Donghui Cui, Qing Wang, Zhiming Wen, Richard D. Finkelman & Devin Welty
Pages: 637-646
Published online: 21 Jul 2017
AbstractforIn vitro drug–drug interactions of budesonide: inhibition and induction of transporters and cytochrome P450 enzymes | Full Text | References | PDF (403.3 KB) | Supplemental
  • 4450 Views
  • 13 CrossRef citations
  • 0Altmetric
Open Access

Explore articles