Xenobiotica, Volume 49, Issue 10 (2019)

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Xenobiotica, Volume 49, Issue 10 (2019)

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General Xenobiochemistry

Article
In vitro inhibitory effects of sophocarpine on human liver cytochrome P450 enzymes
Jingwei Zhang, Chuansheng Li, Jingfa Zhang & Fan Zhang
Pages: 1127-1132
Published online: 11 Jun 2019
AbstractforIn vitro inhibitory effects of sophocarpine on human liver cytochrome P450 enzymes | Full Text | References | PDF (932 KB) | EPUB
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Article
Kinetics of dextromethorphan-O-demethylase activity and distribution of CYP2D in four commonly-used subcellular fractions of rat brain
Barent N. DuBois, Farideh Amirrad & Reza Mehvar
Pages: 1133-1142
Published online: 07 Jan 2019
AbstractforKinetics of dextromethorphan-O-demethylase activity and distribution of CYP2D in four commonly-used subcellular fractions of rat brain | Full Text | References | PDF (1 MB) | EPUB
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Article
The effects of para-phenylenediamine (PPD) on the skin fibroblast cells
Enayatollah Seydi, Mohsen Fatahi, Parvaneh Naserzadeh & Jalal Pourahmad
Pages: 1143-1148
Published online: 17 Jan 2019
AbstractforThe effects of para-phenylenediamine (PPD) on the skin fibroblast cells | Full Text | References | PDF (1.6 MB) | EPUB
  • 298 Views
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Article
Comparative study on the metabolism of the ergot alkaloids ergocristine, ergocryptine, ergotamine, and ergovaline in equine and human S9 fractions and equine liver preparations
Wiebke Rudolph, Daniela Remane, Dirk K. Wissenbach & Frank T. Peters
Pages: 1149-1157
Published online: 09 Jan 2019
AbstractforComparative study on the metabolism of the ergot alkaloids ergocristine, ergocryptine, ergotamine, and ergovaline in equine and human S9 fractions and equine liver preparations | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 237 Views
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Article
Comparison of the inhibition potential of parthenolide and micheliolide on various UDP-glucuronosyltransferase isoforms
Wei-Feng Gao, Yi-Xuan Li, Wei-Hua Zhang, Ran Tao, Ting-Ting Yin, Yi-Jia Wang, Li-Na Liu, Zhi-Wei Fu, Sai-Nan Li, Nai-Rong Liu, Heng Zhang, Guang Liu, Li-Zhong Zhao, Xi-Peng Zhang & Chun-Ze Zhang
Pages: 1158-1163
Published online: 25 Apr 2019
AbstractforComparison of the inhibition potential of parthenolide and micheliolide on various UDP-glucuronosyltransferase isoforms | Full Text | References | PDF (895.9 KB) | EPUB | Supplemental
  • 170 Views
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Article
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor
Poonam Giri, Lakshmikant Gupta, Sanjay Singh, Nirmal Patel, Nuggehally R. Srinivas, Brijesh Kumar Srivastva, Ranjit C. Desai & Pankaj R. Patel
Pages: 1164-1172
Published online: 08 Jan 2019
AbstractforAssessment of the in vitro cytochrome P450 (CYP) inhibition potential of ZYTP1, a novel poly (ADP-ribose) polymerase inhibitor | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 116 Views
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Animal Pharmacokinetics and Metabolism

Article
Effects of astragaloside IV on the pharmacokinetics of puerarin in rats
Lu Liu, Pihong Li, Lujun Qiao & Xiaohua Li
Pages: 1173-1177
Published online: 14 Jun 2019
AbstractforEffects of astragaloside IV on the pharmacokinetics of puerarin in rats | Full Text | References | PDF (585.8 KB) | EPUB
  • 149 Views
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Article
Effects of verapamil on the pharmacokinetics of puerarin in rats
Yun Zhou, Xiaoli Song & Gang Dong
Pages: 1178-1182
Published online: 11 Jun 2019
AbstractforEffects of verapamil on the pharmacokinetics of puerarin in rats | Full Text | References | PDF (514 KB) | EPUB
  • 169 Views
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Article
Pharmacokinetics behaviors of l-menthol after inhalation and intravenous injection in rats and its inhibition effects on CYP450 enzymes in rat liver microsomes
Xiuli Feng, Yan Liu, Xiao Sun, Ang Li, Xiaoyan Jiang, Xiaosong Zhu & Zhongxi Zhao
Pages: 1183-1191
Published online: 11 Jun 2019
AbstractforPharmacokinetics behaviors of l-menthol after inhalation and intravenous injection in rats and its inhibition effects on CYP450 enzymes in rat liver microsomes | Full Text | References | PDF (1,016.6 KB) | EPUB
  • 245 Views
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Article
Antiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species
Nithya Srinivas, Elias P. Rosen, William M. Gilliland Jr, Martina Kovarova, Leila Remling-Mulder, Gabriela De La Cruz, Nicole White, Lourdes Adamson, Amanda P. Schauer, Craig Sykes, Paul Luciw, J. Victor Garcia, Ramesh Akkina & Angela D. M. Kashuba
Pages: 1192-1201
Published online: 17 Dec 2018
AbstractforAntiretroviral concentrations and surrogate measures of efficacy in the brain tissue and CSF of preclinical species | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 448 Views
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Article
Differential pharmacokinetic drug-drug interaction potential of eletriptan between oral and subcutaneous routes
Harilal Patel, Nirmal Desai, Prakash Patel, Nirav Modi, Krunal Soni, Nitin Dobaria & Nuggehally R. Srinivas
Pages: 1202-1208
Published online: 27 Dec 2018
AbstractforDifferential pharmacokinetic drug-drug interaction potential of eletriptan between oral and subcutaneous routes | Full Text | References | PDF (834.7 KB) | EPUB | Supplemental
  • 179 Views
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Article
Influence of inflammatory disorders on pharmacokinetics of lisofylline in rats: implications for studies in humans
Artur Świerczek, Elżbieta Wyska, Krzysztof Pociecha, Sebastian Baś & Jacek Mlynarski
Pages: 1209-1220
Published online: 11 Dec 2018
AbstractforInfluence of inflammatory disorders on pharmacokinetics of lisofylline in rats: implications for studies in humans | Full Text | References | PDF (1.8 MB) | EPUB
  • 121 Views
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Xenobiotic transporters

Article
Modulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis
Lin Chen, Linlin Liu, Yu Chen, Mingyi Liu, Yuqing Xiong, Hong Zhang, Shibo Huang & Chunhua Xia
Pages: 1221-1228
Published online: 11 Jun 2019
AbstractforModulation of transporter activity of OATP1B1 and OATP1B3 by the major active components of Radix Ophiopogonis | Full Text | References | PDF (1.3 MB) | EPUB
  • 222 Views
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Article
In vitro inhibition of human nucleoside transporters and uptake of azacitidine by an isocitrate dehydrogenase-2 inhibitor enasidenib and its metabolite AGI-16903
Zeen Tong, Usha Yerramilli, Sylvia Yao, James D. Young, Matthew Hoffmann & Sekhar Surapaneni
Pages: 1229-1236
Published online: 29 Nov 2018
AbstractforIn vitro inhibition of human nucleoside transporters and uptake of azacitidine by an isocitrate dehydrogenase-2 inhibitor enasidenib and its metabolite AGI-16903 | Full Text | References | PDF (920.8 KB) | EPUB
  • 267 Views
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Article
Jatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice
Siyuan Sun, Sisi Zhou, Shaowei Lei, Shujie Zhu, Kai Wang, Huidi Jiang & Hui Zhou
Pages: 1237-1243
Published online: 09 Jan 2019
AbstractforJatrorrhizine reduces 5-HT and NE uptake via inhibition of uptake-2 transporters and produces antidepressant-like action in mice | Full Text | References | PDF (899.5 KB) | EPUB | Supplemental
  • 333 Views
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Pharmacogenetics

Article
Novel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria
Makiko Shimizu, Hiromi Yoda, Narumi Igarashi, Miki Makino, Emi Tokuyama & Hiroshi Yamazaki
Pages: 1244-1250
Published online: 29 Nov 2018
AbstractforNovel variants and haplotypes of human flavin-containing monooxygenase 3 gene associated with Japanese subjects suffering from trimethylaminuria | Full Text | References | PDF (894.2 KB) | EPUB
  • 156 Views
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