Xenobiotica, Volume 49, Issue 11 (2019)

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Xenobiotica, Volume 49, Issue 11 (2019)

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General Xenobiochemistry

Article
Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach
Shinji Iwasaki, Yohei Kosugi, Andy Z.X. Zhu, Sayaka Nakagawa, Noriyasu Sano, Miyuki Funami, Mai Kosaka, Atsutoshi Furuta, Hideki Hirabayashi & Nobuyuki Amano
Pages: 1251-1259
Published online: 03 Feb 2019
AbstractforApplication of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach | Full Text | References | PDF (870.1 KB) | EPUB | Supplemental
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Article
Evaluation of the inhibition of human carboxylesterases (CESs) by the active ingredients from Schisandra chinensis
Qiang Fu, Kai Yang, Rui-Xia Hu, Zuo Du, Cui-Min Hu & Xibo Zhang
Pages: 1260-1268
Published online: 04 Jan 2019
AbstractforEvaluation of the inhibition of human carboxylesterases (CESs) by the active ingredients from Schisandra chinensis | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 227 Views
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Article
Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers
Yan Chen, Jing Yu, Xu Wang, Hui Li, Xu Mao, Ying Peng & Jiang Zheng
Pages: 1269-1278
Published online: 07 Jan 2019
AbstractforCharacterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers | Full Text | References | PDF (1.7 MB) | EPUB
  • 201 Views
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Article
Metabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom)
Shyam H. Kamble, Abhisheak Sharma, Tamara I. King, Francisco León, Christopher R. McCurdy & Bonnie A. Avery
Pages: 1279-1288
Published online: 07 Jan 2019
AbstractforMetabolite profiling and identification of enzymes responsible for the metabolism of mitragynine, the major alkaloid of Mitragyna speciosa (kratom) | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1458 Views
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Article
Effects of catalpol on the activity of human liver cytochrome P450 enzymes
Lu Liu, Xiangang Cao, Tingxin Li & Xiaohua Li
Pages: 1289-1295
Published online: 21 Jun 2019
AbstractforEffects of catalpol on the activity of human liver cytochrome P450 enzymes | Full Text | References | PDF (1.1 MB) | EPUB
  • 170 Views
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Article
Gut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome
Lenka Jourova, Pavel Anzenbacher, Zuzana Matuskova, Rostislav Vecera, Jan Strojil, Milan Kolar, Milan Nobilis, Petra Hermanova, Tomas Hudcovic, Hana Kozakova, Miloslav Kverka & Eva Anzenbacherova
Pages: 1296-1302
Published online: 22 Feb 2019
AbstractforGut microbiota metabolizes nabumetone in vitro: Consequences for its bioavailability in vivo in the rodents with altered gut microbiome | Full Text | References | PDF (1.3 MB) | EPUB
  • 369 Views
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Article
Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo
Genki Minegishi, Yasuhiro Kazuki, Yuki Yamasaki, Fuka Okuya, Hidetaka Akita, Mitsuo Oshimura & Kaoru Kobayashi
Pages: 1303-1310
Published online: 14 Jun 2019
AbstractforComparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo | Full Text | References | PDF (922.8 KB) | EPUB | Supplemental
  • 365 Views
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Article
Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver
Hiroshi Iwata, Masatomo Goto, Norifumi Sakai, Hiroshi Suemizu & Hiroshi Yamazaki
Pages: 1311-1322
Published online: 21 Jun 2019
AbstractforPredictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver | Full Text | References | PDF (1.8 MB) | EPUB
  • 241 Views
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Article
Regioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6
Shotaro Uehara, Norie Murayama, Hiroshi Yamazaki & Hiroshi Suemizu
Pages: 1323-1331
Published online: 14 Jun 2019
AbstractforRegioselective hydroxylation of an antiarrhythmic drug, propafenone, mediated by rat liver cytochrome P450 2D2 differs from that catalyzed by human P450 2D6 | Full Text | References | PDF (1.7 MB) | EPUB
  • 178 Views
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Clinical Pharmacokinetics and Metabolism

Article
Ascending single dose pharmacokinetics of cytisine in healthy adult smokers
Soo Hee Jeong, Janie Sheridan, Chris Bullen, David Newcombe, Natalie Walker & Malcolm Tingle
Pages: 1332-1337
Published online: 19 Jun 2019
AbstractforAscending single dose pharmacokinetics of cytisine in healthy adult smokers | Full Text | References | PDF (871.9 KB) | EPUB
  • 334 Views
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics of S-EPA, and its inhibition on indoleamine 2,3-dioxgenase: a case of sulfur-substitution affecting distributions in blood cells
Wenyan Wang, Xuhui Zhuang, Heyuan Sun, Lina Dong, Zongliang Liu, Guangying Du, Liang Ye & Jingwei Tian
Pages: 1338-1343
Published online: 17 Dec 2018
AbstractforPharmacokinetics of S-EPA, and its inhibition on indoleamine 2,3-dioxgenase: a case of sulfur-substitution affecting distributions in blood cells | Full Text | References | PDF (942.5 KB) | EPUB
  • 140 Views
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Article
Pharmacokinetic interaction between shuanghuanglian and azithromycin injection: a nonlinear mixed-effects model analysis in rats
Jingchen Tian, Shusen Sun, Zhigang Zhao & Xingang Li
Pages: 1344-1351
Published online: 18 Jan 2019
AbstractforPharmacokinetic interaction between shuanghuanglian and azithromycin injection: a nonlinear mixed-effects model analysis in rats | Full Text | References | PDF (1.1 MB) | EPUB
  • 224 Views
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Article
The metabolic fate and effects of 2-Bromophenol in male Sprague–Dawley rats
Kyrillos N. Adesina-Georgiadis, Nicola Gray, Robert S. Plumb, David F. Thompson, Elaine Holmes, Jeremy K. Nicholson & Ian D. Wilson
Pages: 1352-1359
Published online: 22 Feb 2019
AbstractforThe metabolic fate and effects of 2-Bromophenol in male Sprague–Dawley rats | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 145 Views
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Article
An in vivo evaluation of the ontogeny of stereoselective fluoxetine metabolism and disposition in lambs from birth to one year of age
Timothy W. Chow, Tuan-Anh Nguyen, K. Wayne Riggs & Dan W. Rurak
Pages: 1360-1372
Published online: 19 Jun 2019
AbstractforAn in vivo evaluation of the ontogeny of stereoselective fluoxetine metabolism and disposition in lambs from birth to one year of age | Full Text | References | PDF (1.6 MB) | EPUB
  • 86 Views
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Pharmacogenetics

Article
Effects of MDR1 1236C > T-2677G > T-3435C > T polymorphisms on the intracellular accumulation of tacrolimus, cyclosporine A, sirolimus and everolimus
Rong Wang, Xuan Sun, Yong-Shu Deng & Xu-Wen Qiu
Pages: 1373-1378
Published online: 14 Jun 2019
AbstractforEffects of MDR1 1236C > T-2677G > T-3435C > T polymorphisms on the intracellular accumulation of tacrolimus, cyclosporine A, sirolimus and everolimus | Full Text | References | PDF (816.4 KB) | EPUB
  • 209 Views
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