Xenobiotica, Volume 49, Issue 1 (2019)

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Xenobiotica, Volume 49, Issue 1 (2019)

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General Xenobiochemistry

Article
Metabolic profile elucidation of Zhi–Zi–Da–Huang decoction in rat intestinal bacteria using high-resolution mass spectrometry combined with multiple analytical perspectives
Miao Wang, Qing Hu, Qingshui Shi, Gongjun Yang & Fang Feng
Pages: 1-12
Published online: 22 Dec 2017
AbstractforMetabolic profile elucidation of Zhi–Zi–Da–Huang decoction in rat intestinal bacteria using high-resolution mass spectrometry combined with multiple analytical perspectives | Full Text | References | PDF (758.5 KB) | EPUB | Supplemental
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Article
Utility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice
Rowan Stringer, Valerie Cordier, Catherine Afatsawo, Philip Arabin, Sandrine Desrayaud, Laurent Hoffmann, Daniel Lehmann, Philip John Lowe, Francis Risser, Julia Thiel, Toni Widmer, Peter Wipfli & Marc Bigaud
Pages: 13-21
Published online: 29 Jan 2018
AbstractforUtility of food pellets containing 1-aminobenzotriazole for longer term in vivo inhibition of cytochrome P450 in mice | Full Text | References | PDF (365.7 KB) | EPUB | Supplemental
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Article
Direct and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model
Yannick Parmentier, Corinne Pothier, Nicola Hewitt, Ludwig Vincent, Fabrice Caradec, Jia Liu, Feifei Lin, Marie-Michèle Trancart, Fabrice Guillet, Belkacem Bouaita, Christophe Chesne & Bernard Walther
Pages: 22-35
Published online: 10 Jan 2018
AbstractforDirect and quantitative evaluation of the major human CYP contribution (fmCYP) to drug clearance using the in vitro Silensomes™ model | Full Text | References | PDF (349.3 KB) | EPUB
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Open Access
Article
In vitro analysis of itraconazole cis-diastereoisomers inhibition of nine cytochrome P450 enzymes: stereoselective inhibition of CYP3A
Kristyna Krasulova, Zdenek Dvorak & Pavel Anzenbacher
Pages: 36-42
Published online: 22 Jan 2018
AbstractforIn vitro analysis of itraconazole cis-diastereoisomers inhibition of nine cytochrome P450 enzymes: stereoselective inhibition of CYP3A | Full Text | References | PDF (457.2 KB) | EPUB
  • 230 Views
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Clinical Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism, and excretion of mTOR kinase inhibitor CC-223 in rats, dogs, and humans
Zeen Tong, Christian Atsriku, Usha Yerramilli, Xiaomin Wang, Jim Nissel, Yan Li & Sekhar Surapaneni
Pages: 43-53
Published online: 19 Dec 2017
AbstractforAbsorption, distribution, metabolism, and excretion of mTOR kinase inhibitor CC-223 in rats, dogs, and humans | Full Text | References | PDF (408.7 KB) | EPUB | Supplemental
  • 197 Views
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Article
Assessment of drug–drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase
Zeen Tong, Rangaraj Narayanan, Christian Atsriku, Jim Nissel, Yan Li, Hong Liu, Xiaomin Wang & Sekhar Surapaneni
Pages: 54-70
Published online: 17 Jan 2018
AbstractforAssessment of drug–drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase | Full Text | References | PDF (635.9 KB) | EPUB
  • 353 Views
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Animal Pharmacokinetics and Metabolism

Article
The in vivo pharmacokinetics, tissue distribution and excretion investigation of mesaconine in rats and its in vitro intestinal absorption study using UPLC-MS/MS
Xiuxiu Liu, Minghai Tang, Taohong Liu, Chunyan Wang, Qiaoxin Tang, Yaxin Xiao, Ruixin Yang & Ruobing Chao
Pages: 71-79
Published online: 27 Dec 2017
AbstractforThe in vivo pharmacokinetics, tissue distribution and excretion investigation of mesaconine in rats and its in vitro intestinal absorption study using UPLC-MS/MS | Full Text | References | PDF (465.1 KB) | EPUB | Supplemental
  • 159 Views
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Article
Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry
Liwei Chai, Paul Owusu Donkor, Kun Wang, Yingjie Sun, Mahmood Brobbey Oppong, Kai Wang, Liqin Ding & Feng Qiu
Pages: 80-89
Published online: 27 Dec 2017
AbstractforMetabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 157 Views
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Article
Metabolism and pharmacokinetics studies of allyl methyl disulfide in rats
Yan Liu, Ang Li, Xiaoyan Jiang, Xiaosong Zhu, Xiuli Feng, Xiao Sun & Zhongxi Zhao
Pages: 90-97
Published online: 08 Jan 2018
AbstractforMetabolism and pharmacokinetics studies of allyl methyl disulfide in rats | Full Text | References | PDF (397.3 KB) | EPUB
  • 189 Views
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Article
Pregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit
Francesca M. Russo, Paola Mian, Elke H. Krekels, Kristel Van Calsteren, Dick Tibboel, Jan Deprest & Karel Allegaert
Pages: 98-105
Published online: 10 Jan 2018
AbstractforPregnancy affects the pharmacokinetics of sildenafil and its metabolite in the rabbit | Full Text | References | PDF (815.6 KB) | EPUB
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Article
Non-clinical pharmacokinetic profiles of rovatirelin, an orally available thyrotropin-releasing hormone analogue
Kaoru Kobayashi, Yoshikazu Abe, Hiroshi Harada, Emiko Oota, Takuro Endo & Hiroo Takeda
Pages: 106-119
Published online: 31 Jan 2018
AbstractforNon-clinical pharmacokinetic profiles of rovatirelin, an orally available thyrotropin-releasing hormone analogue | Full Text | References | PDF (625.5 KB) | EPUB | Supplemental
  • 518 Views
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Pharmacogenetics

Article
Functional characterization of 21 CYP3A4 variants on amiodarone metabolism in vitro
Cheng-Cheng Yang, Xiang Zheng, Teng-Hui Liu, Chen-Chen Wang, Peng-Fei Tang, Zhe Chen, Bo-Wen Zhang, Ping Fang, Guo-Xin Hu & Jian-Ping Cai
Pages: 120-126
Published online: 14 Mar 2018
AbstractforFunctional characterization of 21 CYP3A4 variants on amiodarone metabolism in vitro | Full Text | References | PDF (264.4 KB) | EPUB
  • 229 Views
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Thanks to Reviewers

Thanks to reviewers
Pages: 127-130
Published online: 28 Jan 2019
First Page PreviewforThanks to reviewers | Full Text | PDF (120.6 KB) | EPUB
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