Xenobiotica, Volume 49, Issue 2 (2019)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 49, Issue 2 (2019)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Volume 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone
Kensaku Kakimoto, Norie Murayama, Shigeo Takenaka, Haruna Nagayoshi, Young-Ran Lim, Vitchan Kim, Donghak Kim, Hiroshi Yamazaki, Masayuki Komori, F. Peter Guengerich & Tsutomu Shimada
Pages: 131-142
Published online: 29 Jan 2018
AbstractforCytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 270 Views
  • 15 CrossRef citations
  • 0Altmetric
Article
Predicting the dopamine D2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic–pharmacodynamic modeling
Chenrong Huang, Ziteng Wang, Linsheng Liu, Xiaoxue Liu, Ji Dong, Qingqing Xu, Bin Zhang & Liyan Miao
Pages: 143-151
Published online: 14 Mar 2018
AbstractforPredicting the dopamine D2 receptor occupancy of ropinirole in rats using positron emission tomography and pharmacokinetic–pharmacodynamic modeling | Full Text | References | PDF (643.6 KB) | EPUB
  • 196 Views
  • 3 CrossRef citations
  • 0Altmetric
Article
Metabolic characteristics of Tanshinone I in human liver microsomes and S9 subcellular fractions
Yue Li, Yujuan Fan, Huizong Su, Qian Wang, Guo-Fu Li, Yiyang Hu, Jian Jiang, Bo Tan & Furong Qiu
Pages: 152-160
Published online: 05 Feb 2018
AbstractforMetabolic characteristics of Tanshinone I in human liver microsomes and S9 subcellular fractions | Full Text | References | PDF (1.4 MB) | EPUB
  • 246 Views
  • 9 CrossRef citations
  • 0Altmetric
Article
Predicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes
Shuting Wang, Xiange Tang, Tingting Yang, Jiong Xu, Jiaxin Zhang, Xiaodong Liu & Li Liu
Pages: 161-168
Published online: 08 Feb 2018
AbstractforPredicted contributions of cytochrome P450s to drug metabolism in human liver microsomes using relative activity factor were dependent on probes | Full Text | References | PDF (848.8 KB) | EPUB
  • 359 Views
  • 8 CrossRef citations
  • 0Altmetric
Article
Methoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole
Raghava Choudary Palacharla, Parusharamulu Molgara, Hanumanth Rao Panthangi, Rajesh Kumar Boggavarapu, Arun Kumar Manoharan, Ranjith Kumar Ponnamaneni, Devender Reddy Ajjala & Ramakrishna Nirogi
Pages: 169-176
Published online: 15 Feb 2018
AbstractforMethoxsalen as an in vitro phenotyping tool in comparison with 1-aminobenzotriazole | Full Text | References | PDF (790.6 KB) | EPUB
  • 307 Views
  • 9 CrossRef citations
  • 0Altmetric
Article
Comparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes
Marike Visser, Matthew J. Zaya, Charles W. Locuson, Dawn M. Boothe & Dawn A. Merritt
Pages: 177-186
Published online: 06 Mar 2018
AbstractforComparison of predicted intrinsic hepatic clearance of 30 pharmaceuticals in canine and feline liver microsomes | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 367 Views
  • 4 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and metabolism

Article
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes
Jade Huguet, Fleur Gaudette, Veronique Michaud & Jacques Turgeon
Pages: 187-199
Published online: 08 Mar 2018
AbstractforDevelopment and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 230 Views
  • 6 CrossRef citations
  • 0Altmetric
Article
Absorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans
Zeen Tong, Christian Atsriku, Usha Yerramilli, Xiaomin Wang, Yan Li, Josephine Reyes, Bin Fan, Hua Yang, Matthew Hoffmann & Sekhar Surapaneni
Pages: 200-210
Published online: 22 Jan 2018
AbstractforAbsorption, distribution, metabolism and excretion of an isocitrate dehydrogenase-2 inhibitor enasidenib in rats and humans | Full Text | References | PDF (614 KB) | EPUB | Supplemental
  • 445 Views
  • 12 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and metabolism

Article
Effects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism
Tonghui Li, Jijun Liu, Yingying Zheng, Shengchang Yang, Xun Liu & Xuejing Li
Pages: 211-215
Published online: 06 Mar 2018
AbstractforEffects of triptolide on pharmacokinetics of fenofibrate in rats and its potential mechanism | Full Text | References | PDF (583.3 KB) | EPUB
  • 153 Views
  • 5 CrossRef citations
  • 0Altmetric

Molecular Toxicology

Article
Investigation of the mechanisms of Genkwa Flos hepatotoxicity by a cell metabolomics strategy combined with serum pharmacology in HL-7702 liver cells
Zhipeng Wang, Yuanyuan Zhang, Quanli Liu, Linjia Sun, Mingming Lv, Peipei Yu & Xiaohui Chen
Pages: 216-226
Published online: 31 Jan 2018
AbstractforInvestigation of the mechanisms of Genkwa Flos hepatotoxicity by a cell metabolomics strategy combined with serum pharmacology in HL-7702 liver cells | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 143 Views
  • 6 CrossRef citations
  • 0Altmetric
Article
Comparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats
Corinne Haines, Lynsey R. Chatham, Audrey Vardy, Clifford R. Elcombe, John R. Foster & Brian G. Lake
Pages: 227-238
Published online: 26 Mar 2018
AbstractforComparison of the hepatic and thyroid gland effects of sodium phenobarbital and pregnenolone-16α-carbonitrile in wild-type and constitutive androstane receptor (CAR)/pregnane X receptor (PXR) knockout rats | Full Text | References | PDF (1.6 MB) | EPUB
  • 286 Views
  • 15 CrossRef citations
  • 0Altmetric

Xenobiotic transporters

Article
Interaction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3
Yanli Lu, Qingqing Hu, Lin Chen, Hong Zhang, Shibo Huang, Yuqing Xiong & Chunhua Xia
Pages: 239-246
Published online: 18 Feb 2018
AbstractforInteraction of deoxyschizandrin and schizandrin B with liver uptake transporters OATP1B1 and OATP1B3 | Full Text | References | PDF (1.6 MB) | EPUB
  • 226 Views
  • 6 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver
Yasuhiro Uno, Yoshiyuki Igawa, Maori Tanaka, Kayoko Ohura, Masakiyo Hosokawa & Teruko Imai
Pages: 247-255
Published online: 27 Apr 2018
AbstractforAnalysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 219 Views
  • 6 CrossRef citations
  • 0Altmetric

Explore articles

Explore the most recently published articles

Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Michael Z. Liao et al.
Review Article | Published online: 13 May 2024
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers
Meghan E. Gray et al.
Article | Published online: 13 May 2024
Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs
Qihong Huang et al.
Review Article | Published online: 11 May 2024
Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?
Maria Luisa Sardu et al.
Review Article | Published online: 30 Apr 2024
View all latest articles