Xenobiotica, Volume 49, Issue 4 (2019)

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Xenobiotica, Volume 49, Issue 4 (2019)

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General Xenobiochemistry

Article
Determination of low intrinsic clearance in vitro: the benefit of a novel internal standard in human hepatocyte incubations
Ugo Zanelli, Thomas Michna & Carl Petersson
Pages: 381-387
Published online: 26 Mar 2018
AbstractforDetermination of low intrinsic clearance in vitro: the benefit of a novel internal standard in human hepatocyte incubations | Full Text | References | PDF (697.7 KB) | EPUB
  • 481 Views
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Article
Metabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations
Laura Hedges, Susan Brown, Audrey Vardy, Edward Doyle, Miyoung Yoon, Thomas G. Osimitz & Brian G. Lake
Pages: 388-396
Published online: 19 Apr 2018
AbstractforMetabolism of deltamethrin and cis- and trans-permethrin by rat and human liver microsomes, liver cytosol and plasma preparations | Full Text | References | PDF (993.9 KB) | EPUB
  • 329 Views
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Article
Regioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin
So-Young Kim, Drew R. Jones, Ji-Yeon Kang, Chul-Ho Yun & Grover P. Miller
Pages: 397-403
Published online: 28 Mar 2018
AbstractforRegioselectivity significantly impacts microsomal glucuronidation efficiency of R/S-6, 7-, and 8-hydroxywarfarin | Full Text | References | PDF (763.7 KB) | EPUB
  • 159 Views
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Article
Prediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver
Keigo Nakayama, Soichiro Ito, Masahiro Suzuki, Hiroaki Takubo, Hiroshi Yamazaki & Yukihiro Nomura
Pages: 404-414
Published online: 19 Apr 2018
AbstractforPrediction of human pharmacokinetics of typical compounds by a physiologically based method using chimeric mice with humanized liver | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 677 Views
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Article
Rats and rabbits as pharmacokinetic screening tools for long acting intramuscular depots: case study with paliperidone palmitate suspension
Harilal Patel, Prakash Patel, Nirav Modi, Pinakin Patel, Yogesh Wagh, Alex George, Nirmal Desai & Nuggehally R. Srinivas
Pages: 415-421
Published online: 08 May 2018
AbstractforRats and rabbits as pharmacokinetic screening tools for long acting intramuscular depots: case study with paliperidone palmitate suspension | Full Text | References | PDF (754.2 KB) | EPUB
  • 383 Views
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Clinical Pharmacokinetics and Metabolism

Article
Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans
Rosa I. Sanchez, Kerry L. Fillgrove, Ka Lai Yee, Yuexia Liang, Bing Lu, Aditya Tatavarti, Rachael Liu, Matt S. Anderson, Martin O. Behm, Li Fan, Yun Li, Joan R. Butterton, Marian Iwamoto & Sauzanne G. Khalilieh
Pages: 422-432
Published online: 28 Mar 2018
AbstractforCharacterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans | Full Text | References | PDF (994.8 KB) | EPUB
  • 829 Views
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Article
Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans
Akifumi Kogame, Ronald Lee, Liping Pan, Miyako Sudo, Masami Nonaka, Yuu Moriya, Tomoaki Higuchi & Yoshihiko Tagawa
Pages: 433-445
Published online: 05 Apr 2018
AbstractforDisposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 474 Views
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Article
On the population pharmacokinetics and the enterohepatic recirculation of total ezetimibe
Konstantina Soulele & Vangelis Karalis
Pages: 446-456
Published online: 27 Apr 2018
AbstractforOn the population pharmacokinetics and the enterohepatic recirculation of total ezetimibe | Full Text | References | PDF (1.9 MB) | EPUB
  • 511 Views
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Article
Pharmacokinetics and bioequivalence of two strontium ranelate formulations after single oral administration in healthy Chinese subjects
Dan Zhang, Aihua Du, Xiaolin Wang, Lina Zhang, Man Yang, Jingyi Ma, Ming Deng & Huichen Liu
Pages: 457-462
Published online: 08 May 2018
AbstractforPharmacokinetics and bioequivalence of two strontium ranelate formulations after single oral administration in healthy Chinese subjects | Full Text | References | PDF (604.6 KB) | EPUB
  • 96 Views
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Animal Pharmacokinetics and Metabolism

Article
Absorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats
Hitoshi Ohno, Yasunari Kojima, Hiroshi Harada, Yoshikazu Abe, Takuro Endo & Mamoru Kobayashi
Pages: 463-473
Published online: 28 Mar 2018
AbstractforAbsorption, disposition, metabolism and excretion of [14C]mizagliflozin, a novel selective SGLT1 inhibitor, in rats | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 357 Views
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Article
Evaluation of interconversion pharmacokinetics of 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide – a novel HMG-CoA reductase inhibitor and its acid metabolite using multi-compartmental pharmacokinetic model in mice
Tulsankar Sachin Laxman, Santosh Kumar Puttervu, Anjali Mishra, Sarvesh Verma, S. P. Singh, K. V. Sashidhara, C. M. Marandi, Shivani Saxena, Manoj K. Yadav & Rabi S. Bhatta
Pages: 474-483
Published online: 11 Apr 2018
AbstractforEvaluation of interconversion pharmacokinetics of 16α-hydroxycleroda-3,13(14)Z-dien-15,16-olide – a novel HMG-CoA reductase inhibitor and its acid metabolite using multi-compartmental pharmacokinetic model in mice | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 117 Views
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Article
Disposition of tris(4-chlorophenyl)methanol and tris(4-chlorophenyl)methane in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration
Natasha R. Catlin, Suramya Waidyanatha, Sherry R. Black, James M. Mathews, Rodney W. Snyder, Purvi R. Patel, Scott L. Watson & Timothy R. Fennell
Pages: 484-494
Published online: 03 May 2018
AbstractforDisposition of tris(4-chlorophenyl)methanol and tris(4-chlorophenyl)methane in male and female Harlan Sprague Dawley rats and B6C3F1/N mice following oral and intravenous administration | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 218 Views
  • 1 CrossRef citations
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Pharmacogenetics

Article
The S-oxidation of S-carboxymethyl-L-cysteine in hepatic cytosolic fractions from BTBR and phenylketonuria enu1 and enu2 mice
Glyn B. Steventon & Stephen C. Mitchell
Pages: 495-502
Published online: 27 Apr 2018
AbstractforThe S-oxidation of S-carboxymethyl-L-cysteine in hepatic cytosolic fractions from BTBR and phenylketonuria enu1 and enu2 mice | Full Text | References | PDF (745.8 KB) | EPUB
  • 144 Views
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