Xenobiotica, Volume 49, Issue 5 (2019)

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Xenobiotica, Volume 49, Issue 5 (2019)

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General Xenobiochemistry

Article
Functional assessment of rat pulmonary flavin-containing monooxygenase activity
Yildiz Yilmaz, Gareth Williams, Nenad Manevski, Markus Walles, Stephan Krähenbühl & Gian Camenisch
Pages: 503-512
Published online: 15 May 2018
AbstractforFunctional assessment of rat pulmonary flavin-containing monooxygenase activity | Full Text | References | PDF (1,017.5 KB) | EPUB
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Article
Human urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate
Tomonori Miura, Hiroshi Suemizu, Masatomo Goto, Norifumi Sakai, Hiroshi Iwata, Makiko Shimizu & Hiroshi Yamazaki
Pages: 513-520
Published online: 18 May 2018
AbstractforHuman urinary concentrations of monoisononyl phthalate estimated using physiologically based pharmacokinetic modeling and experimental pharmacokinetics in humanized-liver mice orally administered with diisononyl phthalate | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Metabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes
Laura Hedges, Susan Brown, A. Kenneth MacLeod, Audrey Vardy, Edward Doyle, Gina Song, Marjory Moreau, Miyoung Yoon, Thomas G. Osimitz & Brian G. Lake
Pages: 521-527
Published online: 04 Jun 2018
AbstractforMetabolism of deltamethrin and cis- and trans-permethrin by human expressed cytochrome P450 and carboxylesterase enzymes | Full Text | References | PDF (795.8 KB) | EPUB
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Article
Prediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms
Prashant B. Nigade, Jayasagar Gundu, K. Sreedhara Pai, Kumar V. S. Nemmani & Rashmi Talwar
Pages: 528-539
Published online: 07 Jun 2018
AbstractforPrediction of volume of distribution in preclinical species and humans: application of simplified physiologically based algorithms | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Bisphenol S modulates concentrations of bisphenol A and oestradiol in female and male mice
Tyler Pollock, Lucas J. Greville, Rachel E. Weaver, Marija Radenovic & Denys deCatanzaro
Pages: 540-548
Published online: 08 Jun 2018
AbstractforBisphenol S modulates concentrations of bisphenol A and oestradiol in female and male mice | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Article
Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies
Senem Ozcan-Sezer, Elif Ince, Atilla Akdemir, Özlem Öztürk Ceylan, Sibel Suzen & Hande Gurer-Orhan
Pages: 549-556
Published online: 12 Sep 2018
AbstractforAromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies | Full Text | References | PDF (1.4 MB) | EPUB
  • 507 Views
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Article
Suitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates
Kanami Shimura, Norie Murayama, Saki Tanaka, Shunsuke Onozeki & Hiroshi Yamazaki
Pages: 557-562
Published online: 18 Jun 2018
AbstractforSuitable albumin concentrations for enhanced drug oxidation activities mediated by human liver microsomal cytochrome P450 2C9 and other forms predicted with unbound fractions and partition/distribution coefficients of model substrates | Full Text | References | PDF (985.6 KB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Effects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats
Qingling Zhao, Jinlan Wei & Hongying Zhang
Pages: 563-568
Published online: 04 Jun 2018
AbstractforEffects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats | Full Text | References | PDF (738.7 KB) | EPUB
  • 298 Views
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Article
Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat
Ahmed Samir, Ayano Kage, Kayoko Ohura & Teruko Imai
Pages: 569-576
Published online: 05 Jul 2018
AbstractforDevelopment of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat | Full Text | References | PDF (913.9 KB) | EPUB
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Article
Characterization of in vitro and in vivo metabolism of leelamine using liquid chromatography-tandem mass spectrometry
Riya Shrestha, Jung Jae Jo, DooHyun Lee, Taeho Lee & Sangkyu Lee
Pages: 577-583
Published online: 12 Jun 2018
AbstractforCharacterization of in vitro and in vivo metabolism of leelamine using liquid chromatography-tandem mass spectrometry | Full Text | References | PDF (902.8 KB) | EPUB | Supplemental
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Article
The effect of elevated α1-acid glycoprotein on the pharmacokinetics of TAK-272 (SCO-272), an orally active renin inhibitor, in rats
Takuya Ebihara, Hisao Shimizu, Masami Yamamoto, Tomoaki Higuchi, Fumihiro Jinno & Yoshihiko Tagawa
Pages: 584-590
Published online: 25 Jun 2018
AbstractforThe effect of elevated α1-acid glycoprotein on the pharmacokinetics of TAK-272 (SCO-272), an orally active renin inhibitor, in rats | Full Text | References | PDF (696.4 KB) | EPUB
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Molecular Toxicology

Article
Lipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis
Bao-Long Wang, Chang-Wen Zhang, Liang Wang, Kun-Long Tang, Naoki Tanaka, Frank J. Gonzalez, Yong Xu & Zhong-Ze Fang
Pages: 591-601
Published online: 17 Dec 2018
AbstractforLipidomics reveal aryl hydrocarbon receptor (Ahr)-regulated lipid metabolic pathway in alpha-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 228 Views
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Xenobiotic Transporters

Article
Unremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse
Jae H. Chang, Xiaolin Zhang, Kirsten Messick, Yi-Chen Chen, Eugene Chen, Jonathan Cheong & Justin Ly
Pages: 602-610
Published online: 06 Jun 2018
AbstractforUnremarkable impact of Oatp inhibition on the liver concentration of fluvastatin, lovastatin and pitavastatin in wild-type and Oatp1a/1b knockout mouse | Full Text | References | PDF (927.2 KB) | EPUB | Supplemental
  • 447 Views
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Topics in Xenobiochemistry

Review
Pharmacokinetic alterations in poloxamer 407-induced hyperlipidemic rats
Unji Lee, Mi Hye Kwon & Hee Eun Kang
Pages: 611-625
Published online: 08 May 2018
AbstractforPharmacokinetic alterations in poloxamer 407-induced hyperlipidemic rats | Full Text | References | PDF (1.1 MB) | EPUB
  • 336 Views
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