Xenobiotica, Volume 49, Issue 9 (2019)

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Xenobiotica, Volume 49, Issue 9 (2019)

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General Xenobiochemistry

Article
Pharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital
Miho Yamazaki-Nishioka, Minoru Kogiku, Masayuki Noda, Sumio Endo, Mitsuru Takekawa, Hirohisa Kishi, Miki Ota, Yuki Notsu, Makiko Shimizu & Hiroshi Yamazaki
Pages: 1001-1006
Published online: 11 Dec 2018
AbstractforPharmacokinetics of anticoagulants apixaban, dabigatran, edoxaban and rivaroxaban in elderly Japanese patients with atrial fibrillation treated in one general hospital | Full Text | References | PDF (895.6 KB) | EPUB
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Article
QSPR modelling of in vitro degradation half-life of acyl glucuronides
Gulcin Tugcu & Hande Sipahi
Pages: 1007-1014
Published online: 29 Oct 2018
AbstractforQSPR modelling of in vitro degradation half-life of acyl glucuronides | Full Text | References | PDF (906.7 KB) | EPUB | Supplemental
  • 278 Views
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Article
Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes
Risto O. Juvonen, Mira Ahinko, Juhani Huuskonen, Hannu Raunio & Olli T. Pentikäinen
Pages: 1015-1024
Published online: 29 Nov 2018
AbstractforDevelopment of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 360 Views
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Article
Biotransformation of anthocyanins from Vitis amurensis Rupr of “Beibinghong” extract by human intestinal microbiota
Fei Zheng, Mingxin Han, Yang He, Yan Zhang, Shuying Liu, Hao Yue & Liankui Wen
Pages: 1025-1032
Published online: 04 Jan 2019
AbstractforBiotransformation of anthocyanins from Vitis amurensis Rupr of “Beibinghong” extract by human intestinal microbiota | Full Text | References | PDF (1.1 MB) | EPUB
  • 132 Views
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Clinical Pharmacokinetics and Metabolism

Article
Absorption, disposition and metabolic pathway of amiselimod (MT-1303) in healthy volunteers in a mass balance study
Takayuki Kifuji, Shinsuke Inoue, Megumi Furukawa, Begonya Perez Madera, Takahiro Goto, Hiroshi Kumagai, Stuart J Mair & Atsuhiro Kawaguchi
Pages: 1033-1043
Published online: 21 Dec 2018
AbstractforAbsorption, disposition and metabolic pathway of amiselimod (MT-1303) in healthy volunteers in a mass balance study | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 321 Views
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Article
Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects
Shuichi Ohnishi, Kazuya Fukumura, Ryuji Kubota & Toshihiro Wajima
Pages: 1044-1053
Published online: 04 Jan 2019
AbstractforAbsorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 300 Views
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Animal Pharmacokinetics and Metabolism

Article
Comparative toxicity and toxicokinetic studies of oxiracetam and (S)-oxiracetam in dogs
Tian-tian Liu, Xin-miao Guo, Zu-yuan Rong, Xiang-feng Ye, Jin-feng Wei, Ai-ping Wang & Hong-tao Jin
Pages: 1054-1062
Published online: 04 Jan 2019
AbstractforComparative toxicity and toxicokinetic studies of oxiracetam and (S)-oxiracetam in dogs | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 129 Views
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Article
Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor
Bianca M. Liederer, Jonathan Cheong, Kang-Jye Chou, Peter S. Dragovich, Hoa Le, Xiaorong Liang, Justin Ly, Sophie Mukadam, Jason Oeh, Deepak Sampath, Leslie Wang & Susan Wong
Pages: 1063-1077
Published online: 17 Jan 2019
AbstractforPreclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 483 Views
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Article
Disposition of fullerene C60 in rats following intratracheal or intravenous administration
K. A. Shipkowski, J. M. Sanders, J. D. McDonald, N. J. Walker & S. Waidyanatha
Pages: 1078-1085
Published online: 12 Apr 2019
AbstractforDisposition of fullerene C60 in rats following intratracheal or intravenous administration | Full Text | References | PDF (1.4 MB) | EPUB
  • 185 Views
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Article
Comprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys
Yoko Nagai, Masataka Oitate, Hideyuki Shiozawa & Osamu Ando
Pages: 1086-1096
Published online: 04 Jan 2019
AbstractforComprehensive preclinical pharmacokinetic evaluations of trastuzumab deruxtecan (DS-8201a), a HER2-targeting antibody-drug conjugate, in cynomolgus monkeys | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3055 Views
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Article
Preclinical pharmacokinetics of a novel anti-c-Met antibody–drug conjugate, SHR-A1403, in rodents and non-human primates
Changyong Yang, Xiaoping Zhao, Xing Sun, Jinlong Li, Weiqiang Wang, Lianshan Zhang & Shaohua Gou
Pages: 1097-1105
Published online: 04 Jan 2019
AbstractforPreclinical pharmacokinetics of a novel anti-c-Met antibody–drug conjugate, SHR-A1403, in rodents and non-human primates | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 566 Views
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Molecular Toxicology

Article
Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways
Joshua L. Kennedy, Richard C. Kurten, Sandra McCullough, Reynold A. Panettieri, Cynthia Koziol-White, Stacie M. Jones, Katherine Caid, Pritmohinder S. Gill, Dean Roberts, Hartmut Jaeschke, Mitchell R. McGill & Laura James
Pages: 1106-1115
Published online: 30 Jan 2019
AbstractforAcetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 230 Views
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Xenobiotic transporters

Article
Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney
Xiaoyu Qu, Jinghui Zhai, Tingting Hu, Huan Gao, Lina Tao, Yueming Zhang, Yanqing Song & Sixi Zhang
Pages: 1116-1125
Published online: 15 May 2019
AbstractforDioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney | Full Text | References | PDF (3.5 MB) | EPUB
  • 185 Views
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