Xenobiotica, Volume 50, Issue 2 (2020)

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Xenobiotica, Volume 50, Issue 2 (2020)

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General Xenobiochemistry

Article
Metabolism of cyclic phenones in rainbow trout in vitro assays
Jose Serrano, Mark A. Tapper, Richard C. Kolanczyk, Barbara R. Sheedy, Tylor Lahren, Dean E. Hammermeister, Jeffrey S. Denny, Michael W. Hornung, Alena Kubátová, Patricia A. Kosian, Jessica Voelker & Patricia K. Schmieder
Pages: 115-131
Published online: 15 Apr 2019
AbstractforMetabolism of cyclic phenones in rainbow trout in vitro assays | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
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Article
Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine
Jessica L. Murray, Susan L. Mercer & Klarissa D. Jackson
Pages: 132-145
Published online: 24 Apr 2019
AbstractforImpact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 227 Views
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Article
Mechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats
Shinji Kobuchi, Yosuke Katsuyama & Yukako Ito
Pages: 146-153
Published online: 25 Apr 2019
AbstractforMechanism-based pharmacokinetic–pharmacodynamic (PK–PD) modeling and simulation of oxaliplatin for hematological toxicity in rats | Full Text | References | PDF (1.4 MB) | EPUB
  • 342 Views
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Article
In vitro inhibitory effects of phellodendrine on human liver cytochrome P450 enzymes
Jinxiu Li, Haibin Wen & Zhiqiang Gao
Pages: 154-159
Published online: 15 May 2019
AbstractforIn vitro inhibitory effects of phellodendrine on human liver cytochrome P450 enzymes | Full Text | References | PDF (1 MB) | EPUB
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Clinical Pharmacokinetics and Metabolism

Article
Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects
Phi Tran, Imad Hanna, Fabian Kurt Eggimann, Joseph Schoepfer, Tapan Ray, Bing Zhu, Lai Wang, Petra Priess, Xianbin Tian, Florence Hourcade-Potelleret & Heidi J. Einolf
Pages: 160-179
Published online: 06 May 2019
AbstractforDisposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1125 Views
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Article
Population pharmacokinetic modeling and simulation of HPPH in Chinese patients with esophageal carcinoma
Lin Chen, Xuxiao Ye, Kuan Hu, Yu Zhai, Wenping Li, Xin Wang & Jin Yang
Pages: 180-187
Published online: 24 Apr 2019
AbstractforPopulation pharmacokinetic modeling and simulation of HPPH in Chinese patients with esophageal carcinoma | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 102 Views
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Article
Population pharmacokinetics and dosing regimen optimization of tacrolimus in Chinese pediatric hematopoietic stem cell transplantation patients
Dongdong Wang, Xiao Chen, Hong Xu & Zhiping Li
Pages: 188-195
Published online: 25 Apr 2019
AbstractforPopulation pharmacokinetics and dosing regimen optimization of tacrolimus in Chinese pediatric hematopoietic stem cell transplantation patients | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 366 Views
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Article
Impact of body composition on pharmacokinetics of tacrolimus in liver transplantation recipients
Lu Chen, Xiaoqing Lu, Guijun Tan, Liqin Zhu, Yihe Liu & Mengxue Li
Pages: 196-201
Published online: 22 Jul 2019
AbstractforImpact of body composition on pharmacokinetics of tacrolimus in liver transplantation recipients | Full Text | References | PDF (756 KB) | EPUB
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Animal pharmacokinetics and metabolism

Article
The tissue distribution and excretion study of mosapride and its active des-p-fluorobenzyl and 4′-N-oxide metabolites in rats by ultra-high performance liquid chromatography-tandem mass spectrometry method
Kunjie Li, Xu Jiang, Zhili Xiong, Feng Qin & Longshan Zhao
Pages: 202-211
Published online: 20 Mar 2019
AbstractforThe tissue distribution and excretion study of mosapride and its active des-p-fluorobenzyl and 4′-N-oxide metabolites in rats by ultra-high performance liquid chromatography-tandem mass spectrometry method | Full Text | References | PDF (1.6 MB) | EPUB
  • 77 Views
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Article
Metabolic profile of lung-targeted docetaxel liposomes in rabbits, rats and mice
Mengya Li, Lijuan Wang, Rui Li, Li Zhang, Jie Wang & Yu Yu
Pages: 212-221
Published online: 10 Apr 2019
AbstractforMetabolic profile of lung-targeted docetaxel liposomes in rabbits, rats and mice | Full Text | References | PDF (2 MB) | EPUB
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Article
Stereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the rac-dropropizine to Sprague–Dawley rats
Bhavesh Babulal Gabani, Umesh Todmal, Neeraj Kumar Saini, Vinod A. Balakrishna, Suresh P. Sulochana, Ashok Timmapuram, Mohd Zainuddin, Narayanan Balaji, Praharaj Shuvranshu, Nuggehally R. Srinivas & Ramesh Mullangi
Pages: 222-231
Published online: 10 May 2019
AbstractforStereoselective pharmacokinetics and tissue distribution of levodropropizine after administration of pure levodropropizine and the rac-dropropizine to Sprague–Dawley rats | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 136 Views
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Article
Food effect on meal administration time of pharmacokinetic profile of cilostazol, a BCS class II drug
Masateru Miyake, Yoshikazu Oka & Tadashi Mukai
Pages: 232-236
Published online: 02 May 2019
AbstractforFood effect on meal administration time of pharmacokinetic profile of cilostazol, a BCS class II drug | Full Text | References | PDF (538.5 KB) | EPUB
  • 221 Views
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Pharmacogenetics

Article
Effects of the ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of afatinib in healthy Chinese volunteers
Yanan Tan, Kangna Cao, Guanghui Ren, Zhiying Qin, Di Zhao, Ning Li, Xijing Chen, Yufeng Xia & Yang Lu
Pages: 237-243
Published online: 20 Aug 2019
AbstractforEffects of the ABCB1 and ABCG2 polymorphisms on the pharmacokinetics of afatinib in healthy Chinese volunteers | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 361 Views
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