Xenobiotica, Volume 50, Issue 4 (2020)

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Xenobiotica, Volume 50, Issue 4 (2020)

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General Xenobiochemistry

Article
Model extrapolation to a real-world dataset: evaluation of tacrolimus population pharmacokinetics and drug interaction in pediatric liver transplantation patients
Dong-Dong Wang, Xiao Chen, Meng Fu, Qing-Shan Zheng, Hong Xu & Zhi-Ping Li
Pages: 371-379
Published online: 03 Jul 2019
AbstractforModel extrapolation to a real-world dataset: evaluation of tacrolimus population pharmacokinetics and drug interaction in pediatric liver transplantation patients | Full Text | References | PDF (1.7 MB) | EPUB
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Article
In vitro characterization of glycyrol metabolites in human liver microsomes using HR-resolution MS spectrometer coupled with tandem mass spectrometry
Younah Kim, Riya Shrestha, Sunjoo Kim, Jeong Ah Kim, Jaeick Lee, Tae Cheon Jeong, Ju-Hyun Kim & Sangkyu Lee
Pages: 380-388
Published online: 05 Jul 2019
AbstractforIn vitro characterization of glycyrol metabolites in human liver microsomes using HR-resolution MS spectrometer coupled with tandem mass spectrometry | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Reduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment
Jiajia Zhao, Tianjing Ren, Mengbi Yang, Yufeng Zhang, Qianwen Wang & Zhong Zuo
Pages: 389-400
Published online: 01 Aug 2019
AbstractforReduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Bergamottin can be used to assess CYP3A-mediated intestinal first-pass metabolism without affecting P-glycoprotein-mediated efflux in rats
Kei Suzuki, Kazuhiro Taniyama, Takao Aoyama & Yoshiaki Watanabe
Pages: 401-407
Published online: 01 Aug 2019
AbstractforBergamottin can be used to assess CYP3A-mediated intestinal first-pass metabolism without affecting P-glycoprotein-mediated efflux in rats | Full Text | References | PDF (865.1 KB) | EPUB
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Article
In vitro inhibition of the hepatic S-oxygenation of the anthelmintic albendazole by the natural monoterpene thymol in sheep
Victoria Miró, Adrian Lifschitz, Paula Viviani, Carolina Rocha, Carlos Lanusse, Livio Costa Jr & Guillermo Virkel
Pages: 408-414
Published online: 01 Aug 2019
AbstractforIn vitro inhibition of the hepatic S-oxygenation of the anthelmintic albendazole by the natural monoterpene thymol in sheep | Full Text | References | PDF (1.2 MB) | EPUB
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Article
A mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method
Simon J. Carter, Alex S. Ferecskó, Lloyd King, Karelle Ménochet, Ted Parton & Michael J. Chappell
Pages: 415-426
Published online: 19 Aug 2019
AbstractforA mechanistic modelling approach for the determination of the mechanisms of inhibition by cyclosporine on the uptake and metabolism of atorvastatin in rat hepatocytes using a high throughput uptake method | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Open Access

Clinical Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects
Mike Ufer, Christine Huynh, Jan Jaap van Lier, Eva Caroff, Hartmut Fischer & Jasper Dingemanse
Pages: 427-434
Published online: 07 Aug 2019
AbstractforAbsorption, distribution, metabolism and excretion of the P2Y12 receptor antagonist selatogrel after subcutaneous administration in healthy subjects | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Population pharmacokinetics and initial dosing regimen optimization of cyclosporin in pediatric hemophagocytic lymphohistiocytosis patients
Dong-Dong Wang, Qiao-Feng Ye, Xiao Chen, Hong Xu & Zhi-Ping Li
Pages: 435-441
Published online: 14 Aug 2019
AbstractforPopulation pharmacokinetics and initial dosing regimen optimization of cyclosporin in pediatric hemophagocytic lymphohistiocytosis patients | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 276 Views
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Animal Pharmacokinetics and Metabolism

Article
Disposition and metabolism of sulfolane in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans
Suramya Waidyanatha, Sherry R. Black, Chad R. Blystone, Purvi R. Patel, Scott L. Watson, Rodney W. Snyder & Timothy R. Fennell
Pages: 442-453
Published online: 05 Jul 2019
AbstractforDisposition and metabolism of sulfolane in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Accumulation of plasma levels of anthocyanins following multiple saskatoon berry supplements
Jim Fang & Jiannan Huang
Pages: 454-457
Published online: 10 Jul 2019
AbstractforAccumulation of plasma levels of anthocyanins following multiple saskatoon berry supplements | Full Text | References | PDF (421.5 KB) | EPUB
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Article
Correlation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study
F. Colombo, S. Smith, G. W. Lai, D. Nix, P. G. Smith, J. Schindler & N. Rioux
Pages: 458-467
Published online: 02 Aug 2019
AbstractforCorrelation of the in vitro biotransformation of H3B-6527 in dog and human hepatocytes with the in vivo metabolic profile of 14C-H3B-6527 in a dog mass balance study | Full Text | References | PDF (1.3 MB) | EPUB
  • 252 Views
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Article
In vitro metabolism and in vivo pharmacokinetics of bentysrepinine (Y101), an investigational new drug for anti-HBV-infected hepatitis: focus on interspecies comparison
Huirong Fan, Aijie Zhang, Cuiping Liao, Yuanhui Yang, Lihua Zhang, Jianfeng Liu, Yuanyuan Xia, Duanyun Si, Shiqi Dong & Changxiao Liu
Pages: 468-478
Published online: 24 Sep 2019
AbstractforIn vitro metabolism and in vivo pharmacokinetics of bentysrepinine (Y101), an investigational new drug for anti-HBV-infected hepatitis: focus on interspecies comparison | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 261 Views
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Xenobiotic transporters

Article
Involvement of organic anion-transporting polypeptides and organic cation transporter in the hepatic uptake of jatrorrhizine
Rui-Feng Liang, Wen-Jing Ge, Xian-Mei Song, Jun-Ping Zhang, Wei-Feng Cui, She-Feng Zhang & Geng-Sheng Li
Pages: 479-487
Published online: 15 Aug 2019
AbstractforInvolvement of organic anion-transporting polypeptides and organic cation transporter in the hepatic uptake of jatrorrhizine | Full Text | References | PDF (1.5 MB) | EPUB
  • 232 Views
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Pharmacogenetics

Article
Pharmacogenomics analysis in Chinese pediatric liver transplantation patients with renal toxicity induced by tacrolimus
Dongdong Wang, Xiao Chen, Meng Fu, Hong Xu & Zhiping Li
Pages: 488-493
Published online: 14 Aug 2019
AbstractforPharmacogenomics analysis in Chinese pediatric liver transplantation patients with renal toxicity induced by tacrolimus | Full Text | References | PDF (882.8 KB) | EPUB
  • 270 Views
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