Xenobiotica, Volume 50, Issue 5 (2020)

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Xenobiotica, Volume 50, Issue 5 (2020)

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Topics in Xenobiochemistry

Review
Circadian clock-controlled drug metabolism and transport
Mengjing Zhao, Huijie Xing, Min Chen, Dong Dong & Baojian Wu
Pages: 495-505
Published online: 01 Oct 2019
AbstractforCircadian clock-controlled drug metabolism and transport | Full Text | References | PDF (1.4 MB) | EPUB
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General Xenobiochemistry

Article
Effects of dexamethasone to reverse decreased hepatic midazolam metabolism in rats with acute renal failure
Masami Doi, Noriko Kajikawa & Tetsuya Aiba
Pages: 506-514
Published online: 28 Aug 2019
AbstractforEffects of dexamethasone to reverse decreased hepatic midazolam metabolism in rats with acute renal failure | Full Text | References | PDF (1.3 MB) | EPUB
  • 174 Views
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Article
Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum
Le Zhang, Xiaoyi Liu, Can Tu, Chunyu Li, Di Song, Jingxiao Zhu, Yuanyuan Zhou, Xiaohui Wang, Ruisheng Li, Xiaohe Xiao, Youping Liu & Jiabo Wang
Pages: 515-525
Published online: 02 Sep 2019
AbstractforComponents synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 400 Views
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Article
Predicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver
Takeshi Sawada, Yoshiyuki Yamaura, Satonori Higuchi, Haruo Imawaka & Hiroshi Yamazaki
Pages: 526-535
Published online: 13 Sep 2019
AbstractforPredicting successful/unsuccessful extrapolation for in vivo total clearance of model compounds with a variety of hepatic intrinsic metabolism and protein bindings in humans from pharmacokinetic data using chimeric mice with humanised liver | Full Text | References | PDF (1.6 MB) | EPUB
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Article
A hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in rats
Priyanka Kulkarni, Ken Korzekwa & Swati Nagar
Pages: 536-544
Published online: 01 Oct 2019
AbstractforA hybrid model to evaluate the impact of active uptake transport on hepatic distribution of atorvastatin in rats | Full Text | References | PDF (1.1 MB) | EPUB
  • 234 Views
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Clinical Pharmacokinetics and Metabolism

Article
Plasma and cerebrospinal fluid pharmacokinetics of hydroxysafflor yellow A in patients with traumatic brain injury after intravenous administration of Xuebijing using LC-MS/MS method
Chenxia Sheng, Weijun Peng, Zian Xia & Yang Wang
Pages: 545-551
Published online: 24 Sep 2019
AbstractforPlasma and cerebrospinal fluid pharmacokinetics of hydroxysafflor yellow A in patients with traumatic brain injury after intravenous administration of Xuebijing using LC-MS/MS method | Full Text | References | PDF (1.1 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics and lung distribution of macrolide antibiotics in sepsis model rats
Shinji Kobuchi, Akihiro Fujita, Akihito Kato, Hiromu Kobayashi, Yukako Ito & Toshiyuki Sakaeda
Pages: 552-558
Published online: 29 Aug 2019
AbstractforPharmacokinetics and lung distribution of macrolide antibiotics in sepsis model rats | Full Text | References | PDF (988 KB) | EPUB
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Article
Metabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans
Wenbin Zhang, Xiaoyan Li, Haifeng Ding, Yuan Lu, Geoff E. Stilwell, Yuan-Di Halvorsen & Ajith Welihinda
Pages: 559-569
Published online: 27 Aug 2019
AbstractforMetabolism and disposition of the SGLT2 inhibitor bexagliflozin in rats, monkeys and humans | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Open Access
Article
Mass spectrometric investigations into the brain delivery of abacavir, stavudine and didanosine in a rodent model
Sipho Mdanda, Sphamandla Ntshangase, Sanil D. Singh, Tricia Naicker, Hendrik G. Kruger, Sooraj Baijnath & Thavendran Govender
Pages: 570-579
Published online: 29 Aug 2019
AbstractforMass spectrometric investigations into the brain delivery of abacavir, stavudine and didanosine in a rodent model | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 169 Views
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Article
Effect of different doses of borneol on the pharmacokinetics of vinpocetine in rat plasma and brain after intraocular administration
Qun Ma, Manman Dai, Huimin Zhang, Luyu Bai & Ning He
Pages: 580-587
Published online: 28 Aug 2019
AbstractforEffect of different doses of borneol on the pharmacokinetics of vinpocetine in rat plasma and brain after intraocular administration | Full Text | References | PDF (1.2 MB) | EPUB
  • 134 Views
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Article
Effects of antibiotics on the pharmacokinetics of indoxyl sulfate, a nephro-cardiovascular toxin
Shu-Shang Luo, Chung-Ping Yu, Yow-Wen Hsieh, Pei-Dawn Lee Chao, Douglas H. Sweet, Yu-Chi Hou & Shiuan-Pey Lin
Pages: 588-592
Published online: 04 Sep 2019
AbstractforEffects of antibiotics on the pharmacokinetics of indoxyl sulfate, a nephro-cardiovascular toxin | Full Text | References | PDF (869.9 KB) | EPUB
  • 230 Views
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Article
The characteristics and mechanism of co-administration of lovastatin solid dispersion with kaempferol to increase oral bioavailability
Jiaqi Li, Liuying Di, Xu Cheng, Weiwen Ji, Hongyu Piao, Gang Cheng & Meijuan Zou
Pages: 593-601
Published online: 11 Sep 2019
AbstractforThe characteristics and mechanism of co-administration of lovastatin solid dispersion with kaempferol to increase oral bioavailability | Full Text | References | PDF (1.3 MB) | EPUB
  • 163 Views
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Article
Influence of glycyrrhetinic acid on the pharmacokinetics of warfarin in rats
Jiaying Song, Huizhen Dai, Huan Zhang, Yanchao Liu & Wenjing Zhang
Pages: 602-605
Published online: 01 Oct 2019
AbstractforInfluence of glycyrrhetinic acid on the pharmacokinetics of warfarin in rats | Full Text | References | PDF (461.2 KB) | EPUB
  • 161 Views
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Pharmacogenetics

Article
Optimization of initial dosing scheme of tacrolimus in pediatric refractory nephrotic syndrome patients based on CYP3A5 genotype and coadministration with wuzhi-capsule
Xiao Chen, Dong-Dong Wang, Hong Xu & Zhi-Ping Li
Pages: 606-613
Published online: 25 Sep 2019
AbstractforOptimization of initial dosing scheme of tacrolimus in pediatric refractory nephrotic syndrome patients based on CYP3A5 genotype and coadministration with wuzhi-capsule | Full Text | References | PDF (1.7 MB) | EPUB
  • 183 Views
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Article
Effect of cyclosporine a and polymorphisms in CYP2C19 and ABCC2 on the concentration of voriconazole in patients undergoing allogeneic hematopoietic stem cell transplantation
Guangting Zeng, Lihong Shi, Huilan Li, Linlin Wang, Miaomiao Zhu, Jia Luo & Zanling Zhang
Pages: 614-619
Published online: 11 Oct 2019
AbstractforEffect of cyclosporine a and polymorphisms in CYP2C19 and ABCC2 on the concentration of voriconazole in patients undergoing allogeneic hematopoietic stem cell transplantation | Full Text | References | PDF (563.2 KB) | EPUB | Supplemental
  • 244 Views
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Correction

Correction
Correction
Page: 620
Published online: 30 Aug 2019
CitationforCorrection | Full Text | PDF (212.4 KB) | EPUB
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