Xenobiotica, Volume 50, Issue 6 (2020)

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Xenobiotica, Volume 50, Issue 6 (2020)

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General Xenobiochemistry

Article
Hepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans
Silvi A. Chacko, Van T. Ly, Lisa J. Christopher & Jinping Gan
Pages: 621-629
Published online: 10 Oct 2019
AbstractforHepatocyte spheroids as a viable in vitro model for recapitulation of complex in vivo metabolism pathways of loratadine in humans | Full Text | References | PDF (1.5 MB) | EPUB
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General Xenobochemistry

Article
Structure–activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids
Supattra Boonruang, Khanistha Prakobsri, Phisit Pouyfung, Aruna Prasopthum, Pornpimol Rongnoparut & Songklod Sarapusit
Pages: 630-639
Published online: 14 Oct 2019
AbstractforStructure–activity relationship and in vitro inhibition of human cytochrome CYP2A6 and CYP2A13 by flavonoids | Full Text | References | PDF (2.7 MB) | EPUB
  • 219 Views
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General Xenobiochemistry

Article
Temsirolimus metabolic pathways revisited
Touraj Shokati, Marcel Hartmann, Baharak Davari, Jost Klawitter, Jelena Klawitter & Uwe Christians
Pages: 640-653
Published online: 23 Oct 2019
AbstractforTemsirolimus metabolic pathways revisited | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 351 Views
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Article
Evaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system
Mariko Taniguchi, Hirotaka Miyamoto, Ayako Tokunaga, Shintaro Fumoto, Takashi Tanaka & Koyo Nishida
Pages: 654-662
Published online: 05 Nov 2019
AbstractforEvaluation of mRNA expression of drug-metabolizing enzymes in acetaminophen-induced hepatotoxicity using a three-dimensional hepatocyte culture system | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 274 Views
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Article
Capillary microsampling in mice: effective way to move from sparse sampling to serial sampling in pharmacokinetics profiling
Amol A. Raje, Vallabh Mahajan, Vishal V. Pathade, Kaushal Joshi, Ashutosh Gavali, Ashwani Gaur & Vishwottam Kandikere
Pages: 663-669
Published online: 30 Oct 2019
AbstractforCapillary microsampling in mice: effective way to move from sparse sampling to serial sampling in pharmacokinetics profiling | Full Text | References | PDF (855 KB) | EPUB
  • 574 Views
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Article
Liver metabolomic characterization of Sophora flavescens alcohol extract-induced hepatotoxicity in rats through UPLC/LTQ-Orbitrap mass spectrometry
Peng Jiang, Yancai Sun & Nengneng Cheng
Pages: 670-676
Published online: 20 Nov 2019
AbstractforLiver metabolomic characterization of Sophora flavescens alcohol extract-induced hepatotoxicity in rats through UPLC/LTQ-Orbitrap mass spectrometry | Full Text | References | PDF (1.4 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Comparison of pharmacokinetics of phytoecdysones and triterpenoid saponins of monomer, crude and processed Radix Achyranthis Bidentatae by UHPLC-MS/MS
Liu Yang, Hai Jiang, Meiling Yan, Xudong Xing, Xinyue Guo, Wenjing Man, Ajiao Hou, Bingyou Yang, Qiuhong Wang & Haixue Kuang
Pages: 677-684
Published online: 25 Mar 2019
AbstractforComparison of pharmacokinetics of phytoecdysones and triterpenoid saponins of monomer, crude and processed Radix Achyranthis Bidentatae by UHPLC-MS/MS | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 110 Views
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Article
Effects of atorvastatin on pharmacokinetics of amlodipine in rats and its potential mechanism
Jianling Yang, Yuanyuan Li, Yang Li, Xueqi Rui, Meiqing Du & Zengfu Wang
Pages: 685-688
Published online: 09 Oct 2019
AbstractforEffects of atorvastatin on pharmacokinetics of amlodipine in rats and its potential mechanism | Full Text | References | PDF (469.4 KB) | EPUB
  • 237 Views
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Article
Metabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison
Esra Mutlu, C. Edwin Garner, Christopher J. Wegerski, Jacob D. McDonald, Barry S. McIntyre, Melanie Doyle-Eisele & Suramya Waidyanatha
Pages: 689-704
Published online: 31 Oct 2019
AbstractforMetabolism and disposition of 2-hydroxy-4-methoxybenzophenone, a sunscreen ingredient, in Harlan Sprague Dawley rats and B6C3F1/N mice; a species and route comparison | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 381 Views
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Article
Effects of sulfotanshinone sodium injection on the pharmacokinetics and pharmacodynamics of warfarin in rats in vivo
Yuan Shi, Wenlong Zhang, Meiting Jiang, Lijun Huang, Yangxu Zhou, Jiayu Chen, Duo Liu, Gaofeng Liu & Mei Dong
Pages: 705-712
Published online: 28 Oct 2019
AbstractforEffects of sulfotanshinone sodium injection on the pharmacokinetics and pharmacodynamics of warfarin in rats in vivo | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Comparative pharmacokinetics of verapamil and norverapamil in normal and ulcerative colitis rats after oral administration of low and high dose verapamil by UPLC-MS/MS
Hongping Yao, Changhe Wang, Wen Lu, Wen Li, Wanghui Jing, Jiye Zhang, Guangde Yang & Aiguo Zeng
Pages: 713-721
Published online: 31 Oct 2019
AbstractforComparative pharmacokinetics of verapamil and norverapamil in normal and ulcerative colitis rats after oral administration of low and high dose verapamil by UPLC-MS/MS | Full Text | References | PDF (1 MB) | EPUB
  • 160 Views
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Animal Phermacokinetics and Metabolism

Article
Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration
Anika L. Dzierlenga, Veronica G. Robinson, Suramya Waidyanatha, Michael J. DeVito, Max A. Eifrid, Seth T. Gibbs, Courtney A. Granville & Chad R. Blystone
Pages: 722-732
Published online: 07 Nov 2019
AbstractforToxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 979 Views
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Animal Pharmacokinetics and Metabolism

Article
Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu
Pages: 733-740
Published online: 12 Nov 2019
AbstractforMetabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes | Full Text | References | PDF (1 MB) | EPUB
  • 257 Views
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Referee Acknowledgements

Referee acknowledgements
Pages: 741-745
Published online: 17 Apr 2020
First Page PreviewforReferee acknowledgements | Full Text | PDF (318.7 KB) | EPUB
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