Xenobiotica, Volume 51, Issue 12 (2021)

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Xenobiotica, Volume 51, Issue 12 (2021)

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General Xenobiochemistry

Article
DEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells
Xiaofei Luan, Yi Zhao, Na Bu, Yue Chen & Nan Chen
Pages: 1343-1351
Published online: 28 Nov 2021
AbstractforDEC1 negatively regulates CYP2B6 expression by binding to the CYP2B6 promoter region ascribed to IL-6-induced downregulation of CYP2B6 expression in HeLa cells | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Pirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver
Yongjie Zhang, Rei Sato, Tatsuki Fukami, Masataka Nakano & Miki Nakajima
Pages: 1352-1359
Published online: 30 Nov 2021
AbstractforPirfenidone 5-hydroxylation is mainly catalysed by CYP1A2 and partly catalysed by CYP2C19 and CYP2D6 in the human liver | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Article
Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes
Yanqing Zhou, Qian Xian, Haimin Wei, Jin Zhou, Shengjian Li, Junwei Yang, Xuedong Zhou & Yamei Li
Pages: 1360-1365
Published online: 28 Nov 2021
AbstractforAgrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes | Full Text | References | PDF (1 MB) | EPUB
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Article
In silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models
Urban Fagerholm, Sven Hellberg, Jonathan Alvarsson, Staffan Arvidsson McShane & Ola Spjuth
Pages: 1366-1371
Published online: 08 Dec 2021
AbstractforIn silico prediction of volume of distribution of drugs in man using conformal prediction performs on par with animal data-based models | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Article
Validation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide
Rania Kousovista, Georgia Karali, Katerina Vlasopoulou & Vangelis Karalis
Pages: 1372-1388
Published online: 09 Dec 2021
AbstractforValidation of population pharmacokinetic models: a comparison of internal and external validation approaches for hydrochlorothiazide | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Evaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS
Yan Qin, Haijun Dong, Jiayin Sun, Yilong Zhang, Jun Li, Tianci Zhang, Guanjun Chen, Sheng Wang, Shuai Song, Wei Wang, Yuru Fan, Jie Wang, Xiaohui Huang & Chenlin Shen
Pages: 1389-1399
Published online: 03 Jan 2022
AbstractforEvaluation of MTBH, a novel hesperetin derivative, on the activity of hepatic cytochrome P450 isoform in vitro and in vivo using a cocktail method by HPLC-MS/MS | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Species differences in oxidative metabolism of regorafenib
Ayaka Kojima, Ayuka Sogabe, Masayuki Nadai & Miki Katoh
Pages: 1400-1407
Published online: 20 Jan 2022
AbstractforSpecies differences in oxidative metabolism of regorafenib | Full Text | References | PDF (1.2 MB) | EPUB
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Clinical Pharmacokinetics and Metabolism

Article
Population pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study
Yang Zhang, Xuanling Zhang, Yue Zou, Yiqi Sun & Xingang Li
Pages: 1408-1415
Published online: 17 Jan 2022
AbstractforPopulation pharmacokinetics of sirolimus in Chinese adult liver transplant recipients: a retrospective study | Full Text | References | PDF (1 MB) | EPUB
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Article
Assessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase
Zeen Tong, Allison Gaudy, Daniel Tatosian, Francisco Ramirez-Valle, Hong Liu, Jian Chen, Matthew Hoffmann & Sekhar Surapaneni
Pages: 1416-1426
Published online: 13 Jan 2022
AbstractforAssessment of drug-drug interactions of CC-90001, a potent and selective inhibitor of c-Jun N-terminal kinase | Full Text | References | PDF (1.4 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Metabolic conversion of β-pinene to β-ionone in rats
Lujain Aloum, Mohammad H. Semreen, Taleb H. Al-Tel, Hamza Al-Hroub, Muath Mousa, Richard L. Jayaraj, Eman Alefishat, Abdu Adem & Georg A Petroianu
Pages: 1427-1435
Published online: 27 Dec 2021
AbstractforMetabolic conversion of β-pinene to β-ionone in rats | Full Text | References | PDF (1.4 MB) | EPUB
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Molecular Toxicology

Article
MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4′-methylene diphenyl diisocyanate exposed macrophages
Chen-Chung Lin, Brandon F. Law & Justin M. Hettick
Pages: 1436-1452
Published online: 02 Dec 2021
AbstractforMicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4′-methylene diphenyl diisocyanate exposed macrophages | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Xenobiotic transporters

Article
Upregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis
Xiaoli Zheng, Jian V. Zhang, Yanfeng Bai, Jiaqi Wang, Mingfeng Jiang, Su Zeng & Lvhua Wang
Pages: 1453-1462
Published online: 25 Nov 2021
AbstractforUpregulation of OATP1A2 in human oesophageal squamous cell carcinoma cells via the HDAC6-GCN5/PCAF-H3K9Ac axis | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Pharmacogenetics

Article
Association between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A
Haojing Song, Wanjun Bai, Xue Sun, Bo Qiu, Nini Guo, Caihui Guo, Yiting Hu & Zhanjun Dong
Pages: 1463-1469
Published online: 03 Jan 2022
AbstractforAssociation between pharmacokinetics of lenvatinib in healthy subjects and genetic polymorphisms of ABCB1 3435C>T and ABCB1 2677G>T/A | Full Text | References | PDF (569.1 KB) | EPUB
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Topics in Xenobiochemistry

Meeting report: 3rd workshop of the peptide ADME discussion group
Anders Sonesson, Inga Bjørnsdottir & Jesper Kammersgaard Christensen
Pages: 1470-1474
Published online: 27 Dec 2021
AbstractforMeeting report: 3rd workshop of the peptide ADME discussion group | Full Text | References | PDF (441.4 KB) | EPUB
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