Xenobiotica, Volume 51, Issue 2 (2021)

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Xenobiotica, Volume 51, Issue 2 (2021)

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General Xenobiochemistry

Article
Optimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations
Eleni Karatza, George Ismailos, Markos Marangos & Vangelis Karalis
Pages: 127-138
Published online: 30 Sep 2020
AbstractforOptimization of hydroxychloroquine dosing scheme based on COVID-19 patients’ characteristics: a review of the literature and simulations | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Article
Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2′-, 3′-, 4′- and 6-hydroxyflavanones by human cytochrome P450 enzymes
Tsutomu Shimada, Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Jun Katahira, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki & F. Peter Guengerich
Pages: 139-154
Published online: 23 Oct 2020
AbstractforLiquid chromatography-tandem mass spectrometry analysis of oxidation of 2′-, 3′-, 4′- and 6-hydroxyflavanones by human cytochrome P450 enzymes | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Article
Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer–Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro
Kaori Matsumoto, Tetsuya Hasegawa, Kosuke Ohara, Tomoyo Kamei, Junichi Koyanagi & Masayuki Akimoto
Pages: 155-166
Published online: 16 Nov 2020
AbstractforRole of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer–Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro | Full Text | References | PDF (1.6 MB) | EPUB
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Clinical Pharmacokinetics and Metabolism

Article
Population pharmacokinetics of mycophenolic acid in pediatric patients with juvenile dermatomyositis and optimization of limited sampling strategy
Guangfei Wang, Qiaofeng Ye, Yidie Huang, Jinmiao Lu, Hong Xu & Zhiping Li
Pages: 167-176
Published online: 16 Sep 2020
AbstractforPopulation pharmacokinetics of mycophenolic acid in pediatric patients with juvenile dermatomyositis and optimization of limited sampling strategy | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Article
Metabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor
Ellen Scheers, Carine Borgmans, Chi Keung, Hilde Bohets, Inneke Wynant, Italo Poggesi, Filip Cuyckens, Laurent Leclercq & Rao N. V. S. Mamidi
Pages: 177-193
Published online: 20 Sep 2020
AbstractforMetabolism and disposition in rats, dogs, and humans of erdafitinib, an orally administered potent pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor | Full Text | References | PDF (2.3 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetic interaction between dronedarone and ticagrelor following oral administration in rats
Dong Kyun Kim, Soo Yong Chung, Jae-Hwan Kwak, Min-Soo Kim, Christine E. Staatz, Hye Suk Lee & In-Hwan Baek
Pages: 194-201
Published online: 22 Sep 2020
AbstractforPharmacokinetic interaction between dronedarone and ticagrelor following oral administration in rats | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Enantioselective in vitro ADME, absolute oral bioavailability, and pharmacokinetics of (−)-lumefantrine and (+)-lumefantrine in mice
Bhavesh Babulal Gabani, Abhishek Dixit, Vinay Kiran, Ram Murthi Bestha, Balaji Narayanan, Nuggehally R. Srinivas & Ramesh Mullangi
Pages: 202-209
Published online: 23 Sep 2020
AbstractforEnantioselective in vitro ADME, absolute oral bioavailability, and pharmacokinetics of (−)-lumefantrine and (+)-lumefantrine in mice | Full Text | References | PDF (936.2 KB) | EPUB
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Article
Comparative toxicokinetics of bisphenol S and bisphenol AF in male rats and mice following repeated exposure via feed
Suramya Waidyanatha, Sherry R. Black, Claire R. Croutch, Bradley J. Collins, Melanie A. R. Silinski, Season Kerns, Vicki Sutherland, Veronica G. Robinson, Kristin Aillon, Reshan A. Fernando, Esra Mutlu & Timothy R. Fennell
Pages: 210-221
Published online: 06 Oct 2020
AbstractforComparative toxicokinetics of bisphenol S and bisphenol AF in male rats and mice following repeated exposure via feed | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Article
Preclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy
Mark P. Grillo, Svetlana Markova, Marc Evanchik, Marc Trellu, Patricia Moliner, Priscilla Brun, Anne Perreard-Dumaine, Pascale Vicat, Chun Yang, James P. Driscoll & Tim J. Carlson
Pages: 222-238
Published online: 16 Nov 2020
AbstractforPreclinical in vitro and in vivo pharmacokinetic properties of danicamtiv, a new targeted myosin activator for the treatment of dilated cardiomyopathy | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Xenobiotic Transporters

Article
The permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model
Ruonan Chen, Chenlin Shen, Qingqing Xu, Yaru Liu, Bo Li, Cheng Huang, Taotao Ma, Xiaoming Meng, Maomao Wu & Jun Li
Pages: 239-248
Published online: 02 Dec 2020
AbstractforThe permeability characteristics and interaction of main components from Si-Ni-San in a MDCK epithelial cell monolayer model | Full Text | References | PDF (1.5 MB) | EPUB
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Correction

Correction
Correction
Page: 249
Published online: 28 Sep 2020
CitationforCorrection | Full Text | PDF (92.4 KB) | EPUB
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