Xenobiotica, Volume 51, Issue 3 (2021)

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Xenobiotica, Volume 51, Issue 3 (2021)

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General Xenobiochemistry

Article
Assessment of the in vitro cytochrome P450 (CYP) inhibition potential of nafithromycin, a next generation lactone ketolide antibiotic
Rajesh Chavan, Vineet Zope, Nilesh Chavan, Kiran Patil, Ravindra Yeole, Sachin Bhagwat & Mahesh Patel
Pages: 251-261
Published online: 16 Nov 2020
AbstractforAssessment of the in vitro cytochrome P450 (CYP) inhibition potential of nafithromycin, a next generation lactone ketolide antibiotic | Full Text | References | PDF (2.8 MB) | EPUB
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Article
In vitro study on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes
Xiaofei Ji, Baodong Ding, Xiaoyou Wu, Fengyi Liu & Fengqi Yang
Pages: 262-267
Published online: 16 Nov 2020
AbstractforIn vitro study on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes | Full Text | References | PDF (1,000.1 KB) | EPUB
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Article
Tissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone
Aaro Jalkanen, Veera Lassheikki, Tommi Torsti, Elham Gharib, Marko Lehtonen & Risto O. Juvonen
Pages: 268-278
Published online: 10 Dec 2020
AbstractforTissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone | Full Text | References | PDF (1.8 MB) | EPUB
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Open Access
Article
Expression of cytochrome P450 isozyme transcripts and activities in human livers
Jie Liu, Yuan-Fu Lu, J. Christopher Corton & Curtis D. Klaassen
Pages: 279-286
Published online: 28 Dec 2020
AbstractforExpression of cytochrome P450 isozyme transcripts and activities in human livers | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Human mass balance, metabolism, and cytochrome P450 phenotyping of lusutrombopag
Tomoyuki Kawachi, Mizuki Ninomiya, Takayuki Katsube, Toshihiro Wajima & Takushi Kanazu
Pages: 287-296
Published online: 16 Nov 2020
AbstractforHuman mass balance, metabolism, and cytochrome P450 phenotyping of lusutrombopag | Full Text | References | PDF (1.6 MB) | EPUB
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Open Access
Article
Tolerability, safety, pharmacokinetics and pharmacodynamics of SHR0534, a potent G protein-coupled receptor 40 (GPR40) agonist, at single- and multiple-ascending oral doses in healthy Chinese subjects
Yuqing Zhao, Lijun Xie, Ning Ou, Jie Wu, Hongwen Zhang, Sufeng Zhou, Yun Liu, Juan Chen, Lu Wang, Libin Wang, Jingjing Wang & Feng Shao
Pages: 297-306
Published online: 28 Dec 2020
AbstractforTolerability, safety, pharmacokinetics and pharmacodynamics of SHR0534, a potent G protein-coupled receptor 40 (GPR40) agonist, at single- and multiple-ascending oral doses in healthy Chinese subjects | Full Text | References | PDF (1.6 MB) | EPUB
  • 161 Views
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Article
Pharmacokinetics, tissue distribution and excretion of a novel long-acting human insulin analogue – recombinant insulin LysArg in rats
Tao Cui, Yazhuo Li, Zihong Wei, Xingyan Zhang, Wei Li, Wei Zhou, Jiangjie Lu, Jing Li, Xiulin Yi, Yong Zeng, Changxiao Liu & Fengying Yan
Pages: 307-315
Published online: 16 Nov 2020
AbstractforPharmacokinetics, tissue distribution and excretion of a novel long-acting human insulin analogue – recombinant insulin LysArg in rats | Full Text | References | PDF (1.4 MB) | EPUB
  • 141 Views
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Article
Plasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling
Akiko Toda, Makiko Shimizu, Shotaro Uehara, Tatsuro Sasaki, Tomonori Miura, Masayuki Mogi, Masahiro Utoh, Hiroshi Suemizu & Hiroshi Yamazaki
Pages: 316-323
Published online: 19 Nov 2020
AbstractforPlasma and hepatic concentrations of acetaminophen and its primary conjugates after oral administrations determined in experimental animals and humans and extrapolated by pharmacokinetic modeling | Full Text | References | PDF (1.4 MB) | EPUB
  • 434 Views
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Article
Pharmacokinetic changes of clozapine and norclozapine in a rat model of non-alcoholic fatty liver disease induced by orotic acid
Zhengri Li, Song Hee Lee, Hee Jin Jeong & Hee Eun Kang
Pages: 324-334
Published online: 29 Nov 2020
AbstractforPharmacokinetic changes of clozapine and norclozapine in a rat model of non-alcoholic fatty liver disease induced by orotic acid | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Article
Absorption, distribution, metabolism, and excretion of three [14C]PBDE congeners in laying hens and transfer to eggs.
Heldur Hakk, Colleen Pfaff, Sara J. Lupton & Anuradha Singh
Pages: 335-344
Published online: 10 Dec 2020
AbstractforAbsorption, distribution, metabolism, and excretion of three [14C]PBDE congeners in laying hens and transfer to eggs. | Full Text | References | PDF (1.2 MB) | EPUB
  • 129 Views
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Article
Comparative HPLC-MS/MS-based pharmacokinetic studies of multiple diterpenoid alkaloids following the administration of Zhenwu Tang and Radix Aconiti Lateralis Praeparata extracts to rats
Yanhao Liu, Hua Sun, Chao Li, Zhicheng Pu, Zijing Wu, Maodi Xu, Xianghong Li, Yuanxiang Zhang, Hongjin Li, Jian Dong, Runlei Bi, Haitang Xie & Dahu Liang
Pages: 345-354
Published online: 05 Jan 2021
AbstractforComparative HPLC-MS/MS-based pharmacokinetic studies of multiple diterpenoid alkaloids following the administration of Zhenwu Tang and Radix Aconiti Lateralis Praeparata extracts to rats | Full Text | References | PDF (2.9 MB) | EPUB
  • 69 Views
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Article
Comprehensive identification, fragmentation pattern, and metabolic pathways of gefitinib metabolites via UHPLC-Q-TOF-MS/MS: in vivo study of rat plasma, urine, bile, and faeces
Xun Gao, Yue Zhang, Tiantian Feng, Lei Cao, Wenjing Wu & Kunming Qin
Pages: 355-365
Published online: 04 Jan 2021
AbstractforComprehensive identification, fragmentation pattern, and metabolic pathways of gefitinib metabolites via UHPLC-Q-TOF-MS/MS: in vivo study of rat plasma, urine, bile, and faeces | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 153 Views
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Pharmacogenetics

Article
Effects of breviscapine and C3435T MDR1 gene polymorphism on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers
Yingying Zhao, Zhimin Miao, Mingzhao Jiang, Xuan Zhou & Yong Lai
Pages: 366-372
Published online: 14 Dec 2020
AbstractforEffects of breviscapine and C3435T MDR1 gene polymorphism on the pharmacokinetics of fexofenadine, a P-glycoprotein substrate, in healthy volunteers | Full Text | References | PDF (739.5 KB) | EPUB
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Thanks to Reviewers

Thank you reviewers
Pages: I-III
Published online: 22 Feb 2021
First Page PreviewforThank you reviewers | Full Text | PDF (205.9 KB) | EPUB
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