Xenobiotica, Volume 51, Issue 5 (2021)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 51, Issue 5 (2021)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Vol 52, 2022 Volume 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Preliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist
Eva Ayet, Sandra Yeste, Raquel F. Reinoso, María José Pretel, Ariadna Balada & Maria Teresa Serafini
Pages: 501-512
Published online: 23 Feb 2021
AbstractforPreliminary in vitro approach to evaluate the drug-drug interaction potential of EST73502, a dual µ-opioid receptor partial agonist and σ1 receptor antagonist | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 248 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
The characterisation of the in vitro metabolism and transport of 6-hydroxykynurenic acid, an important constituent of Ginkgo biloba extracts
Jadera Talap, Zhuowei Shen, Jing Nie, Jie Pan, Mingcheng Xu, Kui Zeng, Kaifeng He, Fengting Ou, Houhong He, Jianbiao Yao, Ruwei Wang, Lushan Yu & Su Zeng
Pages: 513-521
Published online: 08 Feb 2021
AbstractforThe characterisation of the in vitro metabolism and transport of 6-hydroxykynurenic acid, an important constituent of Ginkgo biloba extracts | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 254 Views
  • 1 CrossRef citations
  • 0Altmetric
Article
In vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole
Hiroyuki Sasabe, Toshihisa Koga, Masayuki Furukawa, Masayuki Matsunaga, Katsunori Sasahara, Kenta Hashizume, Yoshihiro Oozone, Immaculate Amunom, Mikako Torii, Ken Umehara, Eiji Kashiyama & Kenji Takeuchi
Pages: 522-535
Published online: 11 Mar 2021
AbstractforIn vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 360 Views
  • 8 CrossRef citations
  • 0Altmetric
Article
In vitro metabolism assessment of thiacloprid in rainbow trout and rat by LC-UV and high resolution-mass spectrometry
Jose Serrano, Richard C. Kolanczyk, Brett R. Blackwell, Barbara R. Sheedy & Mark A. Tapper
Pages: 536-548
Published online: 15 Mar 2021
AbstractforIn vitro metabolism assessment of thiacloprid in rainbow trout and rat by LC-UV and high resolution-mass spectrometry | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 209 Views
  • 1 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
Metabolism, excretion, and pharmacokinetics of [14C]mirogabalin, a novel α2δ ligand, in healthy volunteers following oral administration
Naotoshi Yamamura, Jeanne Mendel-Harary, Karen Brown, Minoru Uchiyama, Yoko Urasaki, Makoto Takahashi, Vance Warren & Vijay Vashi
Pages: 549-563
Published online: 03 Feb 2021
AbstractforMetabolism, excretion, and pharmacokinetics of [14C]mirogabalin, a novel α2δ ligand, in healthy volunteers following oral administration | Full Text | References | PDF (2 MB) | EPUB
  • 212 Views
  • 6 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
A comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap–orbitrap mass spectrometer
Shan Jiang, Shaoping Wang, Pingping Dong, Lei Shi, Qiyan Li, Xia Wei, Peng Gao & Jiayu Zhang
Pages: 564-581
Published online: 04 Jan 2021
AbstractforA comprehensive profiling and identification of liquiritin metabolites in rats using ultra-high-performance liquid chromatography coupled with linear ion trap–orbitrap mass spectrometer | Full Text | References | PDF (4.5 MB) | EPUB
  • 500 Views
  • 7 CrossRef citations
  • 0Altmetric
Article
Methyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes
Shotaro Uehara, Nao Yoneda, Yuichiro Higuchi, Hiroshi Yamazaki & Hiroshi Suemizu
Pages: 582-589
Published online: 18 Feb 2021
AbstractforMethyl-hydroxylation and subsequent oxidation to produce carboxylic acid is the major metabolic pathway of tolbutamide in chimeric TK-NOG mice transplanted with human hepatocytes | Full Text | References | PDF (1.1 MB) | EPUB
  • 532 Views
  • 12 CrossRef citations
  • 0Altmetric
Article
Pharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human
Hiroyuki Sasabe, Toshihisa Koga, Masayuki Furukawa, Masayuki Matsunaga, Yosuke Kaneko, Noriyuki Koyama, Yukihiro Hirao, Hitomi Akazawa, Mitsuhiko Kawabata, Eiji Kashiyama & Kenji Takeuchi
Pages: 590-604
Published online: 09 Mar 2021
AbstractforPharmacokinetics and metabolism of brexpiprazole, a novel serotonin-dopamine activity modulator and its main metabolite in rat, monkey and human | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 480 Views
  • 9 CrossRef citations
  • 0Altmetric

Molecular Toxicology

Article
Activation of Nrf2 decreases bile acid concentrations in livers of female mice
Jing Liu, Andrew J. Lickteig, Youcai Zhang, Iván L. Csanaky & Curtis D. Klaassen
Pages: 605-615
Published online: 31 Jan 2021
AbstractforActivation of Nrf2 decreases bile acid concentrations in livers of female mice | Full Text | References | PDF (2.9 MB) | EPUB
  • 211 Views
  • 3 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Effect of CYP2C9 genetic polymorphism and breviscapine on losartan pharmacokinetics in healthy subjects
Hang-Xing Huang, He Wu, Yingying Zhao, Tao Zhou, Xin Ai, Yu Dong, Yan Zhang & Yong Lai
Pages: 616-623
Published online: 03 Feb 2021
AbstractforEffect of CYP2C9 genetic polymorphism and breviscapine on losartan pharmacokinetics in healthy subjects | Full Text | References | PDF (1.1 MB) | EPUB
  • 171 Views
  • 4 CrossRef citations
  • 0Altmetric

Explore articles