Xenobiotica, Volume 51, Issue 7 (2021)

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Xenobiotica, Volume 51, Issue 7 (2021)

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General Xenobiochemistry

Article
In vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone
Linling Li, Xi Luo & Zeneng Cheng
Pages: 745-751
Published online: 18 May 2021
AbstractforIn vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone | Full Text | References | PDF (1 MB) | EPUB
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Article
A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction
Han Li, Yu-Guang Wang, Zeng-Chun Ma, Gao Yun-Hang, Song Ling, Chen Teng-Fei, Zhang Guang-Ping & Yue Gao
Pages: 752-763
Published online: 03 May 2021
AbstractforA high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction | Full Text | References | PDF (2.2 MB) | EPUB
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Article
In vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice
Genki Minegishi, Yasuhiro Kazuki, Shin-Ichiro Nitta, Atsushi Miyajima, Hidetaka Akita & Kaoru Kobayashi
Pages: 764-770
Published online: 20 May 2021
AbstractforIn vivo evaluation of intestinal human CYP3A inhibition by macrolide antibiotics in CYP3A-humanised mice | Full Text | References | PDF (731.3 KB) | EPUB | Supplemental
  • 231 Views
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Article
Evaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines
Toshiya Ueno, Saori Takahashi, Tomoya Nakamura, Yasuhiro Tanaka, Hisako Hori, Kenta Mizoi & Takuo Ogihara
Pages: 771-777
Published online: 17 May 2021
AbstractforEvaluation system for cell-permeable CYP3A4 inhibitory activity using 1α,25-dihydroxy-vitamin D3-induced intestinal cell lines | Full Text | References | PDF (948.8 KB) | EPUB | Supplemental
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Hypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia
Soghra Bagheri & Ali A. Saboury
Pages: 778-785
Published online: 25 May 2021
AbstractforHypothesis of using albumin to improve drug efficacy in cancers accompanied by hypoalbuminemia | Full Text | References | PDF (1.1 MB) | EPUB
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Pharmacokinetics and Metabolism

Article
Drug–drug interaction potential and clinical pharmacokinetics of enerisant, a novel potent and selective histamine H3 receptor antagonist
Shuichi Terasaka, Kenji Hachiuma, Yoko Mano, Koichi Onishi, Iwao Kitajima, Izumi Nishino & Hiromi Endo
Pages: 786-795
Published online: 28 Apr 2021
AbstractforDrug–drug interaction potential and clinical pharmacokinetics of enerisant, a novel potent and selective histamine H3 receptor antagonist | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Open Access
Article
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans
Qin Yue, S. Cyrus Khojasteh, Sungjoon Cho, Shuguang Ma, Teresa Mulder, John Chen, Jodie Pang, Xiao Ding, Alan Deese, Jackson D. Pellet, Nicholas Siebers, Lori Joas, Laurent Salphati & Joseph A. Ware
Pages: 796-810
Published online: 24 May 2021
AbstractforAbsorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-Kinase (PI3K) inhibitor, in rats, dogs, and humans | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats
Jae-Hwan Kwak, Younghwa Kim, Christine E. Staatz & In-hwan Baek
Pages: 811-817
Published online: 17 May 2021
AbstractforOral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats | Full Text | References | PDF (1.2 MB) | EPUB
  • 191 Views
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Article
Rutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats
Xian-Mei Song, Bing-Jie Li, Yan-Yan Zhang, Wen-Jing Ge, She-Feng Zhang, Wei-Feng Cui, Geng-Sheng Li & Rui-Feng Liang
Pages: 818-830
Published online: 17 May 2021
AbstractforRutaecarpine enhances the anti-diabetic activity and hepatic distribution of metformin via up-regulation of Oct1 in diabetic rats | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Phenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats
Suramya Waidyanatha, Esra Mutlu, Seth Gibbs, Jessica Pierfelice, Jeremy P. Smith, Brian Burback & Chad T. Blystone
Pages: 831-841
Published online: 24 May 2021
AbstractforPhenolic benzotriazoles: a class comparison of toxicokinetics of ultraviolet-light absorbers in male rats | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Molecular Toxicology

Metal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster
Xiaoyu Yu, Xianhan Tian, Yiwen Wang & Chunfeng Zhu
Pages: 842-851
Published online: 13 May 2021
AbstractforMetal-metal interaction and metal toxicity: a comparison between mammalian and D. melanogaster | Full Text | References | PDF (1.1 MB) | EPUB
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Pharmacogenetics

Article
Association of polymorphism of CYP3A4, ABCB1, ABCC2, ABCG2, NFKB1, POR, and PXR with the concentration of cyclosporin A in allogeneic haematopoietic stem cell transplantation recipients
Linlin Wang, Guangting Zeng, Jianqiang Li, Jia Luo, Huilan Li & Zanling Zhang
Pages: 852-858
Published online: 24 May 2021
AbstractforAssociation of polymorphism of CYP3A4, ABCB1, ABCC2, ABCG2, NFKB1, POR, and PXR with the concentration of cyclosporin A in allogeneic haematopoietic stem cell transplantation recipients | Full Text | References | PDF (835.3 KB) | EPUB | Supplemental
  • 115 Views
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Article
Influence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children
Zhaosong Du, Hua Xu, Peiwei Zhao, Jing Wang, Qiong Xu & Maochang Liu
Pages: 859-864
Published online: 26 May 2021
AbstractforInfluence of UGT2B7 and UGT1A6 polymorphisms on plasma concentration to dose ratio of valproic acid in Chinese epileptic children | Full Text | References | PDF (562.8 KB) | EPUB | Supplemental
  • 141 Views
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