Xenobiotica, Volume 51, Issue 8 (2021)

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Xenobiotica, Volume 51, Issue 8 (2021)

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General Xenobiochemistry

S-Carboxymethyl-l-cysteine: a multiple dosing study using pharmacokinetic modelling
Glyn B. Steventon & Stephen C. Mitchell
Pages: 865-870
Published online: 04 Jun 2021
AbstractforS-Carboxymethyl-l-cysteine: a multiple dosing study using pharmacokinetic modelling | Full Text | References | PDF (768.8 KB) | EPUB
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Article
4-O-galloylalbiflorin inhibits the activity of CYP3A, 2C9, and 2D in human liver microsomes
Yu Sun, Mengya He, Yanling Sun & Jianhong Wei
Pages: 871-876
Published online: 08 Jun 2021
Abstractfor4-O-galloylalbiflorin inhibits the activity of CYP3A, 2C9, and 2D in human liver microsomes | Full Text | References | PDF (1 MB) | EPUB
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Article
Drug–drug interaction comparison between tacrolimus and phenobarbital in different formulations for paediatrics and adults
Xianmei Zhao, Xiaoqing Lu, Meiling Zuo, Nan Wang, Yuan Zhang, Jingtao Chen, Liqin Zhu & Wei Liu
Pages: 877-884
Published online: 02 Jul 2021
AbstractforDrug–drug interaction comparison between tacrolimus and phenobarbital in different formulations for paediatrics and adults | Full Text | References | PDF (983 KB) | EPUB
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Article
Employing in vitro metabolism to guide design of F-labelled PET probes of novel α-synuclein binding bifunctional compounds
Chukwunonso K. Nwabufo, Omozojie P. Aigbogun, Kevin J.H Allen, Madeline N. Owens, Jeremy S. Lee, Christopher P. Phenix & Ed S. Krol
Pages: 885-900
Published online: 30 Jun 2021
AbstractforEmploying in vitro metabolism to guide design of F-labelled PET probes of novel α-synuclein binding bifunctional compounds | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Pharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition
John P. Kowalski, Robert D. Pelletier, Matthew G. McDonald, Edward J. Kelly & Allan E. Rettie
Pages: 901-915
Published online: 11 Jun 2021
AbstractforPharmacokinetics, metabolism and off-target effects in the rat of 8-[(1H- benzotriazol-1-yl)amino]octanoic acid, a selective inhibitor of human cytochrome P450 4Z1: β-oxidation as a potential augmenting pathway for inhibition | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Pharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale
Di Zhao, Su-Xiang Feng, Hao-Jie Zhang, Na Zhang, Xue-Fang Liu, Yan Wan, Yu-Xiao Zhou & Jian-Sheng Li
Pages: 916-925
Published online: 28 Jun 2021
AbstractforPharmacokinetics, tissue distribution and excretion of five rhubarb anthraquinones in rats after oral administration of effective fraction of anthraquinones from rheum officinale | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
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Article
Effect of naringenin on the pharmacokinetics of metoprolol succinate in rats
Ravindra Babu Pingili, Sridhar Vemulapalli, Vijaya R. Dirisala, Surya Sandeep Mullapudi, Yamini Gullapalli & Naveen Babu Kilaru
Pages: 926-932
Published online: 28 Jun 2021
AbstractforEffect of naringenin on the pharmacokinetics of metoprolol succinate in rats | Full Text | References | PDF (672.9 KB) | EPUB
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Article
Preclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor
Silvi A. Chacko, Wu Yang, Yufeng Wang, Yuan Tian, Yang Hong, Michael Wallace, Bonnie Wang, William R. Ewing, Joseph M. Luettgen, Yue-Zhong Shu & Lisa J. Christopher
Pages: 933-948
Published online: 05 Jul 2021
AbstractforPreclinical metabolism and disposition of an orally bioavailable macrocyclic FXIa inhibitor | Full Text | References | PDF (1.7 MB) | EPUB
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Pharmacogenetics

Article
Prevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa
Rene de Beer, Kim Outhoff, Alisa Phulukdaree & Prashilla Soma
Pages: 949-959
Published online: 30 Jun 2021
AbstractforPrevalence of SLCO1B1 single nucleotide variations and their association with hypercholesterolaemia in hypercholesterolemic patients in Gauteng, South Africa | Full Text | References | PDF (1,010.8 KB) | EPUB
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