Xenobiotica, Volume 51, Issue 9 (2021)

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Xenobiotica, Volume 51, Issue 9 (2021)

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General Xenobiochemistry

Article
Effects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo
Sicong Li, Xuting Li, Dingsheng Yuan, Bin Wang, Rui Yang, Min Zhang, Jinliang Li & Fuqiang Zeng
Pages: 961-967
Published online: 02 Aug 2021
AbstractforEffects of paeoniflorin on the activities and mRNA expression of rat CYP1A2, CYP2C11 and CYP3A1 enzymes in vivo | Full Text | References | PDF (855.9 KB) | EPUB
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Article
In vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice
Noriaki Ohminato, Miho Nagayasu, Kazuhisa Ozeki, Ryoichi Saitoh, Naomi Ono, Norihito Shibahara, Atsushi Suda & Kouichi Yoshinari
Pages: 968-976
Published online: 19 Aug 2021
AbstractforIn vivo-in vitro correlation of antitumor activity of heat shock protein 90 (HSP90) inhibitors with a pharmacokinetics/pharmacodynamics analysis using NCI-N87 xenograft mice | Full Text | References | PDF (1.3 MB) | EPUB
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Article
In vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes
Hui Zhao, Senyao Xue, Qingzhen Meng & Cui Zhou
Pages: 977-982
Published online: 19 Aug 2021
AbstractforIn vitro study on the effect of leonurine hydrochloride on the enzyme activity of cytochrome P450 enzymes in human liver microsomes | Full Text | References | PDF (952.8 KB) | EPUB
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Article
Empirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism
Shogo Matsumoto, Hidetaka Kamimura, Megumi Nishiwaki, Naoki Cho, Kazuhiko Kato & Taichi Yamamoto
Pages: 983-994
Published online: 15 Jul 2021
AbstractforEmpirical and theoretical approaches for the prediction of human hepatic clearance using chimeric mice with humanised liver: the use of physiologically based scaling, a novel solution for potential overprediction due to coexisting mouse metabolism | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Roles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes
Haruna Nagayoshi, Norie Murayama, Shigeo Takenaka, Vitchan Kim, Donghak Kim, Masayuki Komori, Hiroshi Yamazaki, F. Peter Guengerich & Tsutomu Shimada
Pages: 995-1009
Published online: 04 Aug 2021
AbstractforRoles of cytochrome P450 2A6 in the oxidation of flavone, 4′-hydroxyflavone, and 4′-, 3′-, and 2′-methoxyflavones by human liver microsomes | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Evaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach
Yun-Jing Zhang, Wen-Li Zhou, Fei Yu, Qian Wang, Can Peng & Jia-Yi Kan
Pages: 1010-1018
Published online: 09 Aug 2021
AbstractforEvaluation of the effect of Bovis Calculus Artifactus on eight rat liver cytochrome P450 isozymes using LC-MS/MS and cocktail approach | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
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Molecular Toxicology

Article
Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice
Li Guo, Li Zhang, Haiman Xu, Pei Yu, Zhigang Wang, Danyi Lu, Min Chen & Baojian Wu
Pages: 1019-1028
Published online: 26 Jul 2021
AbstractforDiurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR
Manar A. Helmy, Hussein Abdelaziz Abdalla, Heba Allah Abd El Rahman & Dalia Alsaied Moustafa Ahmed
Pages: 1029-1037
Published online: 09 Aug 2021
AbstractforHepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Interactions between cadmium and zinc on gene expression pattern of differentiation markers in MC3T3-E1 cell line
Sana Boughammoura, Mylène Zarka, Imed Messaoudi & Martine Cohen Solal
Pages: 1038-1046
Published online: 11 Aug 2021
AbstractforInteractions between cadmium and zinc on gene expression pattern of differentiation markers in MC3T3-E1 cell line | Full Text | References | PDF (1.8 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
Dongxue Sun, Xiaoxia Gao, Qiao Wang, Kristopher W. Krausz, Zhongze Fang, Youbo Zhang, Cen Xie & Frank J. Gonzalez
Pages: 1047-1059
Published online: 09 Aug 2021
AbstractforMetabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
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Article
Evaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase
Daigo Asano, Takahiro Shibayama, Hideyuki Shiozawa, Shin-ichi Inoue, Tsuyoshi Shinozuka, Shinji Murata, Nobuaki Watanabe & Kouichi Yoshinari
Pages: 1060-1070
Published online: 11 Aug 2021
AbstractforEvaluation of species differences in the metabolism of the selective NaV1.7 inhibitor DS-1971a, a mixed substrate of cytochrome P450 and aldehyde oxidase | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Pharmacogenetics

Article
Genetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population
Harleen Kaur Walia, Navneet Singh & Siddharth Sharma
Pages: 1071-1080
Published online: 17 Aug 2021
AbstractforGenetic polymorphism of Arg213His variant in the SULT1A1 gene is associated with reduced susceptibility to lung cancer in North Indian population | Full Text | References | PDF (976.9 KB) | EPUB | Supplemental
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Meeting Report

Meeting report of the first European biotransformation workshop
M. Walles, A. Pähler, L. Weidolf & E. M. Isin
Pages: 1081-1086
Published online: 29 Jul 2021
AbstractforMeeting report of the first European biotransformation workshop | Full Text | References | PDF (493.6 KB) | EPUB
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