Xenobiotica, Volume 52, Issue 12 (2022)

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Xenobiotica, Volume 52, Issue 12 (2022)

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General Xenobiochemistry

Article
Characterisation of UDP-glucuronosyltransferase activity in sea turtle Chelonia mydas
Vera Helena V. Dias, Jacó J. Mattos, Camila L. V. Bastolla, Karim H. Lüchmann & Afonso C. D. Bainy
Pages: 1011-1019
Published online: 16 Jan 2023
AbstractforCharacterisation of UDP-glucuronosyltransferase activity in sea turtle Chelonia mydas | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
Human pharmacokinetics prediction with an in vitro–in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy® for the treatment of HIV-1 infection
Raju Subramanian, Jianhong Wang, Bernard Murray, Joseph Custodio, Jia Hao, Scott Lazerwith, Kelly MacLennan Staiger, Judy Mwangi, Hailing Sun, Jennifer Tang, Kelly Wang, Gerry Rhodes, Samantha Wijaya, Heather Zhang & Bill J. Smith
Pages: 1020-1030
Published online: 26 Jan 2023
AbstractforHuman pharmacokinetics prediction with an in vitro–in vivo correction factor approach and in vitro drug-drug interaction profile of bictegravir, a potent integrase-strand transfer inhibitor component in approved biktarvy® for the treatment of HIV-1 infection | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Animal Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs
Jiyuan Ma, Qing Ye, Valerie Northcutt, John Babiak & Ronald Kong
Pages: 1031-1040
Published online: 03 Feb 2023
AbstractforAbsorption, distribution, metabolism and excretion of 14C-Emvododstat following a single oral dose in rats and dogs | Full Text | References | PDF (1.6 MB) | EPUB
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Molecular Toxicology

Article
The effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells
Avril Kirsten Moses, Terisha Ghazi, Savania Nagiah & Anil Chuturgoon
Pages: 1041-1051
Published online: 20 Jan 2023
AbstractforThe effect of ARVs on the MEKKK1 gene promoter, inflammatory cytokine expression and signalling in acute treated Jurkat T cells | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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