Xenobiotica, Volume 52, Issue 3 (2022)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 52, Issue 3 (2022)

See all volumes and issues
Vol 54, 2024 Vol 53, 2023 Volume 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Elucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats
Chenghong Zhang, Sungjoon Cho, José G. Napolitano, David Russell, Christine Gu, Alan Deese, Chong Han, Yuan Chen & Shuguang Ma
Pages: 219-228
Published online: 21 Apr 2022
AbstractforElucidating the structure and cytochrome P450-mediated mechanism for novel metabolites of GDC-0575 in rats | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 210 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
Comparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes
Shotaro Uehara, Norie Murayama, Yuichiro Higuchi, Nao Yoneda, Hiroshi Yamazaki & Hiroshi Suemizu
Pages: 229-239
Published online: 26 Apr 2022
AbstractforComparison of mouse and human cytochrome P450 mediated-drug metabolising activities in hepatic and extrahepatic microsomes | Full Text | References | PDF (2.5 MB) | EPUB
  • 394 Views
  • 4 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans
Tim F. Ryder, Arthur Bergman, Amanda King-Ahmad, Neeta B. Amin, Manjinder S. Lall, T. Eric Ballard & Amit S. Kalgutkar
Pages: 240-253
Published online: 13 Apr 2022
AbstractforPharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 312 Views
  • 1 CrossRef citations
  • 0Altmetric
Article
Absorption, metabolism, and excretion of [14C]YY-20394, a highly selective PI3K-Delta inhibitor in humans
Jinghua Yu, Hua Zhang, Yifan Zhang, Yan Zhan, Sheng Ma, Tao Hu, Ning Zhang, Yangtong Lou, Hanying Bao, Zusheng Xu, Dafang Zhong, Liyan Miao & Xingxing Diao
Pages: 254-264
Published online: 11 Apr 2022
AbstractforAbsorption, metabolism, and excretion of [14C]YY-20394, a highly selective PI3K-Delta inhibitor in humans | Full Text | References | PDF (1.7 MB) | EPUB
  • 208 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Population pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma
Min Zhan, Yiqi Sun, Fang Zhou, Honghong Wang, Zebin Chen, Lianzhen Yan & Xingang Li
Pages: 265-273
Published online: 28 Apr 2022
AbstractforPopulation pharmacokinetics of methotrexate in paediatric patients with acute lymphoblastic leukaemia and malignant lymphoma | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 196 Views
  • 5 CrossRef citations
  • 0Altmetric
Article
Population pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients
Yao Du, Wei Song, Xiaofu Xiong, Weihong Ge & Huaijun Zhu
Pages: 274-283
Published online: 16 May 2022
AbstractforPopulation pharmacokinetics and dosage optimisation of tacrolimus coadministration with Wuzhi capsule in adult liver transplant patients | Full Text | References | PDF (2 MB) | EPUB
  • 182 Views
  • 2 CrossRef citations
  • 0Altmetric

Animal Pharmacokinetics and Metabolism

Article
Identification of in vivo metabolites of a potential anti-rheumatoid arthritis compound, the quinazolinone derivative PD110, using ultra-high performance liquid chromatography coupled with Q-Exactive plus mass spectrometrys
Huan Wang, Minghai Tang, Xiang Qiu, Yan Tan, Yong Guo, Kongjun Liu, Xiandeng Li, Wenshuang Wu & Li Wan
Pages: 284-294
Published online: 13 Apr 2022
AbstractforIdentification of in vivo metabolites of a potential anti-rheumatoid arthritis compound, the quinazolinone derivative PD110, using ultra-high performance liquid chromatography coupled with Q-Exactive plus mass spectrometrys | Full Text | References | PDF (2.2 MB) | EPUB
  • 102 Views
  • 1 CrossRef citations
  • 0Altmetric
Article
Role of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model
Rabiha Salam, Syeda Nayyab Batool Rizvi, Naqi Hussain, Shama Firdous, Muhammad Zaheer & Muhammad Naeem
Pages: 295-300
Published online: 26 Apr 2022
AbstractforRole of hesperidin and fresh orange juice in altering the bioavailability of beta-blocker, metoprolol tartrate. An in vivo model | Full Text | References | PDF (1.4 MB) | EPUB
  • 143 Views
  • 1 CrossRef citations
  • 0Altmetric

Molecular Toxicology

Article
The common indoor air pollutant α-pinene is metabolised to a genotoxic metabolite α-pinene oxide
Suramya Waidyanatha, Sherry R. Black, Kristine L. Witt, Timothy R. Fennell, Carol Swartz, Leslie Recio, Scott L. Watson, Purvi Patel, Reshan A. Fernando & Cynthia V. Rider
Pages: 301-311
Published online: 04 May 2022
AbstractforThe common indoor air pollutant α-pinene is metabolised to a genotoxic metabolite α-pinene oxide | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 251 Views
  • 3 CrossRef citations
  • 0Altmetric

Pharmacogenetics

Article
Effect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes
Shu-Fang Zhang, Bo-Hao Tang, An-hua Wei, Yue Du, Zi-Wan Guan & Yan Li
Pages: 312-321
Published online: 20 Apr 2022
AbstractforEffect of drug combination on tacrolimus target dose in renal transplant patients with different CYP3A5 genotypes | Full Text | References | PDF (1.5 MB) | EPUB
  • 288 Views
  • 1 CrossRef citations
  • 0Altmetric
Article
Predictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy
Harleen Walia, Parul Sharma, Navneet Singh & Siddharth Sharma
Pages: 322-331
Published online: 10 May 2022
AbstractforPredictive role of polymorphic variants of phase II drug metabolising enzyme in modulating toxicity in North Indian lung cancer patients undergoing chemotherapy | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 113 Views
  • 0 CrossRef citations
  • 0Altmetric

Commentary

Article
Commentary concerning the publication by Zheng X et al.: Metabolic activation of deferiprone mediated by CYP2A6 (Xenobiotica, published online 18 May 2021)
Fernando Tricta
Pages: 332-333
Published online: 06 Oct 2021
CitationforCommentary concerning the publication by Zheng X et al.: Metabolic activation of deferiprone mediated by CYP2A6 (Xenobiotica, published online 18 May 2021) | Full Text | References | PDF (284.8 KB) | EPUB
  • 891 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access

Response to Commentary

Article
Response to the comments raised by Fernando Tricta
Jiang Zheng
Page: 334
Published online: 21 Apr 2022
CitationforResponse to the comments raised by Fernando Tricta | Full Text | References | PDF (217.5 KB) | EPUB
  • 56 Views
  • 1 CrossRef citations
  • 0Altmetric

Explore articles