Xenobiotica, Volume 52, Issue 7 (2022)

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Xenobiotica, Volume 52, Issue 7 (2022)

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General Xenobiochemistry

Article
Species differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats
Hiroyuki Ikuta, Hiroaki Shimada, Kenjiro Sakamoto, Rena Nakamura, Atsushi Kawase & Masahiro Iwaki
Pages: 653-660
Published online: 10 Oct 2022
AbstractforSpecies differences in liver microsomal hydrolysis of acyl glucuronide in humans and rats | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Utility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model
Eva Sherbetjian, Sheila-Annie Peters & Carl Petersson
Pages: 661-668
Published online: 11 Oct 2022
AbstractforUtility of preclinical species for uncertainty assessment and correction of prediction of human volume of distribution using the Rodgers-Lukacova model | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Article
Effects of multi-kinase inhibitors on the activity of cytochrome P450 2J2
Ayaka Kojima, Masayuki Nadai, Norie Murayama, Hiroshi Yamazaki & Miki Katoh
Pages: 669-675
Published online: 25 Oct 2022
AbstractforEffects of multi-kinase inhibitors on the activity of cytochrome P450 2J2 | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Article
Characterisation of seven medications approved for attention-deficit/hyperactivity disorder using in vitro models of hepatic metabolism
Rebecca Law, David Lewis, Daniel Hain, Rachel Daut, Melissa P. DelBello, Jean A. Frazier, Jeffrey H. Newcorn, Erika Nurmi, Elizabeth S. Cogan, Susanne Wagner, Holly Johnson & Jerry Lanchbury
Pages: 676-686
Published online: 07 Nov 2022
AbstractforCharacterisation of seven medications approved for attention-deficit/hyperactivity disorder using in vitro models of hepatic metabolism | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Open Access
Article
Newly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes
Yasuhiro Uno, Genki Ushirozako, Shotaro Uehara, Norie Murayama, Yuki Fujiki, Hiroaki Kawaguchi, Kyoko Tsukiyama-Kohara & Hiroshi Yamazaki
Pages: 687-696
Published online: 03 Nov 2022
AbstractforNewly identified tree shrew cytochrome P450 2B6 (CYP2B6) and pig CYP2B6b are functional drug-metabolising enzymes | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Predictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats
Shinji Kobuchi, Megumi Matsui & Yukako Ito
Pages: 697-706
Published online: 22 Nov 2022
AbstractforPredictive marker for exposure-driven haematological toxicity of tegafur-uracil and proposed modified-dosage regimen by pharmacometric approach in rats | Full Text | References | PDF (1.7 MB) | EPUB
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Clinical Pharmacokinetics and Metabolism

Article
Absorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants
Peter Mutch, Mohammad Bashir, Bonnie Jung, Ping Yi & Matt Iverson
Pages: 707-717
Published online: 17 Oct 2022
AbstractforAbsorption, metabolism, and excretion of [14C]-sebetralstat (KVD900) following a single oral dose in healthy male participants | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Open Access

Animal Pharmacokinetics and Metabolism

Article
Curcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment
Yao Zeng, Yalan Lv, Mengyun Hu, Feng Guo & Chunbo Zhang
Pages: 718-728
Published online: 24 Oct 2022
AbstractforCurcumin-loaded hydroxypropyl-β-cyclodextrin inclusion complex with enhanced dissolution and oral bioavailability for epilepsy treatment | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Elucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals?
Hiroki Takano, Akiko Mizuno-Yasuhira, Jun-ichi Yamaguchi & Hiromi Endo
Pages: 729-741
Published online: 17 Nov 2022
AbstractforElucidation of clearance mechanism of TP0463518, a novel hypoxia-inducible factor prolyl hydroxylase inhibitor: does a species difference in excretion routes exist between humans and animals? | Full Text | References | PDF (1.2 MB) | EPUB
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Xenobiotic transporters

Article
Comprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay
Xianmei Cai, Shivani Patel, Chunli Huang, Anthony Paiva, Yongnian Sun, Gregory Barker, Harold Weller & Wilson Shou
Pages: 742-750
Published online: 13 Oct 2022
AbstractforComprehensive characterization and optimization of Caco-2 cells enabled the development of a miniaturized 96-well permeability assay | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Do differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors?
Donna A. Volpe, Abhay Joshi & Vikram Arya
Pages: 751-757
Published online: 24 Oct 2022
AbstractforDo differences in cell lines and methods used for calculation of IC50 values influence categorisation of drugs as P-glycoprotein substrates and inhibitors? | Full Text | References | PDF (956.8 KB) | EPUB | Supplemental
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Article
Changes in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis
Chieri Fujino, Satoshi Ueshima & Toshiya Katsura
Pages: 758-766
Published online: 27 Oct 2022
AbstractforChanges in the expression of drug-metabolising enzymes and drug transporters in mice with collagen antibody-induced arthritis | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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