Xenobiotica, Volume 52, Issue 8 (2022)

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Xenobiotica, Volume 52, Issue 8 (2022)

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50th year of the DMDG

Research Article

Article
The 50th anniversary of the DMDG
Simon Taylor, Jamie Henshall, Kevin Beaumont, Steve Hood, Barry Jones, Ian Wilson & Dennis Smith
Pages: 767-769
Published online: 20 Dec 2022
First Page PreviewforThe 50th anniversary of the DMDG | Full Text | References | PDF (623 KB) | EPUB
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Reviews

Review
ADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs)
Kevin Beaumont, Andy Pike, Michael Davies, Adriana Savoca, Christina Vasalou, Steffi Harlfinger, Diane Ramsden, Douglas Ferguson, Niresh Hariparsad, Owen Jones & Dermot McGinnity
Pages: 770-785
Published online: 20 Dec 2022
AbstractforADME and DMPK considerations for the discovery and development of antibody drug conjugates (ADCs) | Full Text | References | PDF (1.5 MB) | EPUB
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Review
A commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies
Vanessa Martins, Lynsey Fazal, Aram Oganesian, Alpesh Shah, Jessie Stow, Hugh Walton & Nicola Wilsher
Pages: 786-796
Published online: 20 Dec 2022
AbstractforA commentary on the use of pharmacoenhancers in the pharmaceutical industry and the implication for DMPK drug discovery strategies | Full Text | References | PDF (1.4 MB) | EPUB
  • 1667 Views
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Open Access
Review
One small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development
John S. Kendrick & Colin Webber
Pages: 797-810
Published online: 20 Dec 2022
AbstractforOne small step in time, one giant leap for DMPK kind – a CRO perspective of the evolving core discipline of drug development | Full Text | References | PDF (1.7 MB) | EPUB
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Review
Potential application of mass spectrometry imaging in pharmacokinetic studies
Chukwunonso K. Nwabufo & Omozojie P. Aigbogun
Pages: 811-827
Published online: 20 Dec 2022
AbstractforPotential application of mass spectrometry imaging in pharmacokinetic studies | Full Text | References | PDF (2.4 MB) | EPUB
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Review
Subcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations
Simone Esposito, Laura Orsatti & Vincenzo Pucci
Pages: 828-839
Published online: 20 Dec 2022
AbstractforSubcutaneous catabolism of peptide therapeutics: bioanalytical approaches and ADME considerations | Full Text | References | PDF (1.6 MB) | EPUB
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Review
Application of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities
Rachel H. Rose, Armin Sepp, Felix Stader, Katherine L. Gill, Cong Liu & Iain Gardner
Pages: 840-854
Published online: 20 Dec 2022
AbstractforApplication of physiologically based pharmacokinetic models for therapeutic proteins and other novel modalities | Full Text | References | PDF (1.4 MB) | EPUB
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Research Articles

Article
A translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist
Caroline Rynn, Kenichi Umehara, Tianyi Jiang, Malika Ait-Goughoulte & Neil Parrott
Pages: 855-867
Published online: 20 Dec 2022
AbstractforA translational strategy employing physiologically based modelling to predict the pharmacological active dose of RO7119929, an oral prodrug of a targeted cancer immunotherapy TLR7 agonist | Full Text | References | PDF (2 MB) | EPUB | Supplemental
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Article
Use of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development
Melanie Golding, Oliver Light, Beth Williamson & Karelle Ménochet
Pages: 868-877
Published online: 20 Dec 2022
AbstractforUse of selective substrates and inhibitors to rapidly characterise batches of cryopreserved primary human hepatocytes for assessment of active uptake liability in drug discovery and development | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 311 Views
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Article
Time matters – in vitro cellular disposition kinetics help rationalizing cellular potency disconnects
Birk Poller, Sophie Werner, Norbert Domange, Lina Mettler, Richard R. Stein, Jacqueline Loretan, Markus Wartmann, Bernard Faller & Felix Huth
Pages: 878-889
Published online: 20 Dec 2022
AbstractforTime matters – in vitro cellular disposition kinetics help rationalizing cellular potency disconnects | Full Text | References | PDF (1.5 MB) | EPUB
  • 347 Views
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Article
Drug clearance by aldehyde oxidase: can we avoid clinical failure?
Francesca Toselli, Melanie Golding, Johan Nicolaï, Eric Gillent & Hugues Chanteux
Pages: 890-903
Published online: 20 Dec 2022
AbstractforDrug clearance by aldehyde oxidase: can we avoid clinical failure? | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
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Article
The in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652
Anna Kerins, Marta Koszyczarek, Caroline Smith, Phil Butler, Rob Riley, Vamsi Madgula, Nilkanth Naik, Matthew R. Redinbo & Ian D. Wilson
Pages: 904-915
Published online: 20 Dec 2022
AbstractforThe in vitro metabolism and in vivo pharmacokinetics of the bacterial β-glucuronidase inhibitor UNC10201652 | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 1274 Views
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Open Access
Article
An HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds
Omozojie P. Aigbogun, Chukwunonso K. Nwabufo, Madeline N. Owens, Kevin J. H. Allen, Jeremy S. Lee, Christopher P. Phenix & Ed S. Krol
Pages: 916-927
Published online: 20 Dec 2022
AbstractforAn HPLC-UV validated bioanalytical method for measurement of in vitro phase 1 kinetics of α-synuclein binding bifunctional compounds | Full Text | References | PDF (1.7 MB) | EPUB
  • 964 Views
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Article
A discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism
Daniel J. Weston, Mehul Dave, Kevin Colizza, Steve Thomas, Laura Tomlinson, Richard Gregory, Claire Beaumont, Jill Pirhalla & Gordon J. Dear
Pages: 928-942
Published online: 01 Nov 2022
AbstractforA discovery biotransformation strategy: combining in silico tools with high-resolution mass spectrometry and software-assisted data analysis for high-throughput metabolism | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 814 Views
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Article
Non-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models
Iain Gardner, Mandy Xu, Chunyan Han, Yi Wang, Xingjin Jiao, Masoud Jamei, Hiba Khalidi, Peter Kilford, Sibylle Neuhoff, Roz Southall, David B. Turner, Helen Musther, Barry Jones & Simon Taylor
Pages: 943-956
Published online: 20 Dec 2022
AbstractforNon-specific binding of compounds in in vitro metabolism assays: a comparison of microsomal and hepatocyte binding in different species and an assessment of the accuracy of prediction models | Full Text | References | PDF (2.3 MB) | EPUB | Supplemental
  • 3829 Views
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Open Access

Review

Review
Meeting report: oligonucleotide ADME workshop
Steve Hood, David Kenworthy & Jesper Kammersgaard Christensen
Pages: 957-961
Published online: 12 Sep 2022
AbstractforMeeting report: oligonucleotide ADME workshop | Full Text | References | PDF (591.2 KB) | EPUB
  • 2255 Views
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Open Access

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