Xenobiotica, Volume 53, Issue 2 (2023)

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Xenobiotica, Volume 53, Issue 2 (2023)

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Clinical Pharmacokinetics and Metabolism

Article
Mass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans
Xinyu Ge, Sheng Ma, Shu Yan, Yali Wu, Chong Chen, Chongzhuang Tang, Yan Zhan, Yi-cong Bian, Kai Shen, Sheng Feng, Xuehu Gao, Dafang Zhong, Hua Zhang, Li-yan Miao & Xing-xing Diao
Pages: 69-83
Published online: 12 Feb 2023
AbstractforMass balance study of [14C]SHR0302, a selective and potent JAK1 inhibitor in humans | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Development and validation of an LC-MS/MS method for simultaneous determination of SH-1028, an irreversible third-generation EGFR TKI, and two of its metabolites in human plasma: application in clinical pharmacokinetics
Sufeng Zhou, Bijun Sha, Lu Wang, Yuqing Zhao, Zhiqiang Wang, Xian Zhang, Luwei Han, Feng Shao & Xijing Chen
Pages: 84-92
Published online: 08 Mar 2023
AbstractforDevelopment and validation of an LC-MS/MS method for simultaneous determination of SH-1028, an irreversible third-generation EGFR TKI, and two of its metabolites in human plasma: application in clinical pharmacokinetics | Full Text | References | PDF (1.5 MB) | EPUB
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Animal Pharmacoknetics and Metabolism

Article
Investigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration
Billy J. Molloy, Adam King, Lee A. Gethings, Robert S. Plumb, Russell J. Mortishire-Smith & Ian D. Wilson
Pages: 93-105
Published online: 21 Feb 2023
AbstractforInvestigation of the pharmacokinetics and metabolic fate of Fasiglifam (TAK-875) in male and female rats following oral and intravenous administration | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Open Access
Article
In vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS
Panhong Wei, Minghai Tang, Ziyan MA, Jiajia Zhao, Rui Wu & Li Wan
Pages: 106-113
Published online: 13 Mar 2023
AbstractforIn vitro and in vivo metabolic profiling of PD105, a PI3Kδ inhibitor, using UHPLC-Q-Exactive plus-MS | Full Text | References | PDF (1.7 MB) | EPUB
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Xenobiotic transporters

Article
Renal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats
Naotoshi Yamamura, Tomoki Imaoka, Misa Hoshi, Makiko Yamada & Ken-ichi Itokawa
Pages: 114-122
Published online: 09 Feb 2023
AbstractforRenal tubular transporter-mediated interactions between mirogabalin and cimetidine in rats | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Meeting Report

Review
Meeting report of the 3rd European Biotransformation Workshop
Markus Walles, Axel Pähler, Emre M. Isin & Marie M. Ahlqvist
Pages: 123-127
Published online: 31 Jan 2023
AbstractforMeeting report of the 3rd European Biotransformation Workshop | Full Text | References | PDF (435.4 KB) | EPUB
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