Xenobiotica, Volume 53, Issue 5 (2023)

Browse this journal
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Xenobiotica, Volume 53, Issue 5 (2023)

See all volumes and issues
Vol 54, 2024 Volume 53, 2023 Vol 52, 2022 Vol 51, 2021 Vol 50, 2020 Vol 49, 2019 Vol 48, 2018 Vol 47, 2017 Vol 46, 2016 Vol 45, 2015 Vol 44, 2014 Vol 43, 2013 Vol 42, 2012 Vol 41, 2011 Vol 40, 2010 Vol 39, 2009 Vol 38, 2008 Vol 37, 2007 Vol 36, 2006 Vol 35, 2005 Vol 34, 2004 Vol 33, 2003 Vol 32, 2002 Vol 31, 2001 Vol 30, 2000 Vol 29, 1999 Vol 28, 1998 Vol 27, 1997 Vol 26, 1996 Vol 25, 1995 Vol 24, 1994 Vol 23, 1993 Vol 22, 1992 Vol 21, 1991 Vol 20, 1990 Vol 19, 1989 Vol 18, 1988 Vol 17, 1987 Vol 16, 1986 Vol 15, 1985 Vol 14, 1984 Vol 13, 1983 Vol 12, 1982 Vol 11, 1981 Vol 10, 1980 Vol 9, 1979 Vol 8, 1978 Vol 7, 1977 Vol 6, 1976 Vol 5, 1975 Vol 4, 1974 Vol 3, 1973 Vol 2, 1972 Vol 1, 1971
Download citations Download PDFs Download issue

General Xenobiochemistry

Article
Physiologically based pharmacokinetic modeling (PBPK) to predict drug-drug interactions for encorafenib. Part II. Prospective predictions in hepatic and renal impaired populations with clinical inhibitors and inducers
Sivacharan Kollipara, Tausif Ahmed & Sivadasu Praveen
Pages: 339-356
Published online: 29 Aug 2023
AbstractforPhysiologically based pharmacokinetic modeling (PBPK) to predict drug-drug interactions for encorafenib. Part II. Prospective predictions in hepatic and renal impaired populations with clinical inhibitors and inducers | Full Text | References | PDF (3 MB) | EPUB | Supplemental
  • 202 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro
Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, F. Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto, Takeshi Akiyoshi & Hisakazu Ohtani
Pages: 357-365
Published online: 23 Aug 2023
AbstractforThe influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants in vitro | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 159 Views
  • 0 CrossRef citations
  • 0Altmetric
Article
Physiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and transporter inhibitors
Sivacharan Kollipara, Tausif Ahmed & Sivadasu Praveen
Pages: 366-381
Published online: 04 Sep 2023
AbstractforPhysiologically based pharmacokinetic modelling to predict drug–drug interactions for encorafenib. Part I. Model building, validation, and prospective predictions with enzyme inhibitors, inducers, and transporter inhibitors | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
  • 213 Views
  • 2 CrossRef citations
  • 0Altmetric
Article
A physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate
Richard Reiss, Anne Loccisano, Andrew Deines, Myoungwoo Kim, Gopinath Nallani, Appavu Chandrasekaran & Paul Whatling
Pages: 382-395
Published online: 14 Sep 2023
AbstractforA physiologically-based pharmacokinetic/pharmacodynamic (PBPK/PD) model for the insecticide dimethoate | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 158 Views
  • 0 CrossRef citations
  • 0Altmetric

Clinical Pharmacokinetics and Metabolism

Article
Absorption, distribution, metabolism and excretion of 14C-vatiquinone in rats, dogs, and human subjects
Jiyuan Ma, Lucy Lee, Bert Yao, Peter Giannousis, Martin Thoolen, Qing Ye, Lee Golden, Matthew Klein & Ronald Kong
Pages: 396-411
Published online: 18 Aug 2023
AbstractforAbsorption, distribution, metabolism and excretion of 14C-vatiquinone in rats, dogs, and human subjects | Full Text | References | PDF (2.5 MB) | EPUB
  • 863 Views
  • 1 CrossRef citations
  • 0Altmetric
Open Access

Animal Pharmacokinetics and Metabolism

Article
Toxicokinetic and mass balance of morpholine in rats
Aleksandra Piotrowski, Saïd Kinani, Fabrice Nesslany, Nicolas Aubert, Sylvaine Ronga, Magali Boize, Salma Achawi & Pierre-André Cabanes
Pages: 412-420
Published online: 17 Aug 2023
AbstractforToxicokinetic and mass balance of morpholine in rats | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 66 Views
  • 0 CrossRef citations
  • 0Altmetric
Article
Danazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats
Shuhei Fukuno, Katsuhito Nagai, Akemi Kurotobi, Yuki Sahori, Ryo Nakagawa, Rena Nomura, Takuya Ito & Hiroki Konishi
Pages: 421-428
Published online: 05 Sep 2023
AbstractforDanazol increases the oral bioavailability of midazolam by inactivation of hepatic and intestinal CYP3A in rats | Full Text | References | PDF (863.8 KB) | EPUB
  • 111 Views
  • 0 CrossRef citations
  • 0Altmetric
Article
Impact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats
Min Zhang, Bin Wang, Xu-ting Li, Qin Yin, Ge Liang & Si-cong Li
Pages: 429-437
Published online: 05 Oct 2023
AbstractforImpact of tectoridin on the pharmacokinetics of florfenicol via targeting cytochrome P450 and P-glycoprotein of rats | Full Text | References | PDF (1.2 MB) | EPUB
  • 70 Views
  • 0 CrossRef citations
  • 0Altmetric
Article
Pharmacokinetics of the novel 5-HT4 receptor agonist, DA-6886, in dogs
Dae Young Lee & Hee Eun Kang
Pages: 438-444
Published online: 05 Oct 2023
AbstractforPharmacokinetics of the novel 5-HT4 receptor agonist, DA-6886, in dogs | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 76 Views
  • 0 CrossRef citations
  • 0Altmetric

Molecular Toxicology

Article
Metabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death
Mohammad A. Alfhili & Jawaher Alsughayyir
Pages: 445-453
Published online: 21 Aug 2023
AbstractforMetabolic exhaustion and casein kinase 1α drive deguelin-induced premature red blood cell death | Full Text | References | PDF (1.6 MB) | EPUB
  • 88 Views
  • 6 CrossRef citations
  • 0Altmetric

Xenobiotic transporters

Article
Two curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies
Chung-Ping Yu, Yi-Ru Wang, Yu-Chi Hou, Min-Tsang Hsieh, Pei-Ying Li, Sheng-Chu Kuo & Shiuan-Pey Lin
Pages: 454-464
Published online: 05 Oct 2023
AbstractforTwo curcumin analogs inhibited the function and protein expression of breast cancer resistance protein: in vitro and in vivo studies | Full Text | References | PDF (1.3 MB) | EPUB
  • 59 Views
  • 0 CrossRef citations
  • 0Altmetric

Explore articles

Explore the most recently published articles

Translational PK/PD framework for antibody-drug conjugates to inform drug discovery and development
Michael Z. Liao et al.
Review Article | Published online: 13 May 2024
A comparison of the activity, lysosomal stability, and efficacy of legumain-cleavable and cathepsin cleavable ADC linkers
Meghan E. Gray et al.
Article | Published online: 13 May 2024
Approaches to Improve the Translation of Safety, Pharmacokinetics and Therapeutic Index of ADCs
Qihong Huang et al.
Review Article | Published online: 11 May 2024
Pharmacokinetics of Intranasal Drugs, Still a Missed Opportunity?
Maria Luisa Sardu et al.
Review Article | Published online: 30 Apr 2024
View all latest articles