Xenobiotica, Volume 53, Issue 6-7 (2023)

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Xenobiotica, Volume 53, Issue 6-7 (2023)

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General Xenobiochemistry

Article
Cytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation
Yasuhiro Uno, Shotaro Uehara, Genki Ushirozako, Norie Murayama, Hiroshi Suemizu & Hiroshi Yamazaki
Pages: 465-473
Published online: 03 Nov 2023
AbstractforCytochrome P450 1A2 and 2C enzymes autoinduced by omeprazole in dog hepatocytes and human HepaRG and HepaSH cells are involved in omeprazole 5-hydroxylation and sulfoxidation | Full Text | References | PDF (1.6 MB) | EPUB
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Open Access
Article
Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla
Yiqing Guo, Huanhuan Lv, Jing Lv & Zenghong Jiang
Pages: 474-483
Published online: 03 Nov 2023
AbstractforMetabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from Uncaria rhynchophylla | Full Text | References | PDF (1.8 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Preclinical pharmacokinetic exploration of a novel osteoporotic quinazolinone-benzopyran-indole hybrid (S019-0385) using LC-MS/MS
Mukesh Kumar, Mridula Chauhan, Sarvesh Kumar Verma, Arpon Biswas, Alisha Ansari, Anjali Mishra, Sachin Nashik Sanap, Amol Chhatrapati Bisen, Koneni V. Sashidhara & Rabi Sankar Bhatta
Pages: 484-497
Published online: 03 Nov 2023
AbstractforPreclinical pharmacokinetic exploration of a novel osteoporotic quinazolinone-benzopyran-indole hybrid (S019-0385) using LC-MS/MS | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Evaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling
Mizuki Yamane, Kazuhisa Ozeki, Ken Okano, Toshiyuki Kudo & Kiyomi Ito
Pages: 498-506
Published online: 03 Nov 2023
AbstractforEvaluation of the non-linearity of NA808 in liver not reflected in plasma using a rat pharmacokinetic study and PBPK modelling | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Xenobiotic Transporters

Article
Comparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance
Kamil Piska, Paulina Koczurkiewicz-Adamczyk, Marek Jamrozik, Adam Bucki, Marcin Kołaczkowski & Elżbieta Pękala
Pages: 507-514
Published online: 03 Nov 2023
AbstractforComparative study on ABCB1-dependent efflux of anthracyclines and their metabolites: consequences for cancer resistance | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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