Xenobiotica, Volume 53, Issue 8-9 (2023)

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Xenobiotica, Volume 53, Issue 8-9 (2023)

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General Xenobiochemistry

Article
N, N-dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation
Emma Eckernäs, Alicia Macan-Schönleben, Moa Andresen-Bergström, Sofia Birgersson, Kurt-Jürgen Hoffmann & Michael Ashton
Pages: 515-522
Published online: 26 Nov 2023
AbstractforN, N-dimethyltryptamine forms oxygenated metabolites via CYP2D6 - an in vitro investigation | Full Text | References | PDF (972.1 KB) | EPUB | Supplemental
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Article
Empirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers
Hidetaka Kamimura, Shotaro Uehara, Nao Yoneda & Hiroshi Suemizu
Pages: 523-535
Published online: 26 Nov 2023
AbstractforEmpirical scaling factor for predicting human pharmacokinetic profiles of disproportionate metabolites using the Css–MRTpo method and chimeric mice with humanised livers | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
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Clinical Pharmacokinetics and Metabolism

Article
The metabolite profiling of YR-1702 injection in human plasma, urine and feces by HPLC-Q-TOF-MS/MS
Yuxuan Fan, Yufeng Ni, Minlu Cheng, Wenjing Guo, Huaye Gao, WenHui Hu, Chang Shu & Li Ding
Pages: 536-546
Published online: 26 Nov 2023
AbstractforThe metabolite profiling of YR-1702 injection in human plasma, urine and feces by HPLC-Q-TOF-MS/MS | Full Text | References | PDF (1.8 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Evobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective
Holger Scheible, Hanno Schieferstein, Ralf Schmidt, Klaus Pusecker, Ulrike Gradhand, Sathej Gopalakrishnan, Khalid Iqbal, Jennifer Dong, Reinaldo Jones, Claudia Meli, Jayaprakasam Bolleddula, Martin Dyroff & Katrin Georgi
Pages: 547-558
Published online: 26 Nov 2023
AbstractforEvobrutinib pathway to its major metabolite M463-2 and insights from a biotransformation and DDI perspective | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Xenobiotic transporters

Article
Hyperoside ameliorates cisplatin-induced acute kidney injury by regulating the expression and function of Oat1
Wenjing Yuan, Shanshan Kou, Ying Ma, Yusi Qian, Xinyu Li, Yuanyuan Chai, Zhenzhou Jiang, Luyong Zhang, Lixin Sun & Xin Huang
Pages: 559-571
Published online: 26 Nov 2023
AbstractforHyperoside ameliorates cisplatin-induced acute kidney injury by regulating the expression and function of Oat1 | Full Text | References | PDF (2.7 MB) | EPUB
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