Xenobiotica, Volume 54, Issue 1 (2024)

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Xenobiotica, Volume 54, Issue 1 (2024)

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General Xenobiochemistry

Article
Metabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS
Yali Yuan, Weiqiang Wang, Jing Luo, Chongzhuang Tang, Yuandong Zheng, Jinghua Yu, Honghong Xu, Mingshe Zhu, Taijun Hang, Hao Wang & Xingxing Diao
Pages: 1-9
Published online: 08 Jan 2024
AbstractforMetabolite characterisation of the peptide–drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Synthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases
Daisuke Takani, Masato Takahashi & Masakiyo Hosokawa
Pages: 10-17
Published online: 29 Dec 2023
AbstractforSynthesis and evaluation of indomethacin prodrugs with a diester structure that are metabolically activated by human carboxylesterases | Full Text | References | PDF (1 MB) | EPUB
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Animal Pharmacokinetics and Metabolism

Article
Dose proportionality and bioavailability of quinoxaline-based JNK inhibitor after single oral and intravenous administration in rats
Galina A. Frelikh, Elena A. Yanovskaya, Alexander P. Lakeev, Galina A. Chernysheva, Vera I. Smolyakova & Anastasia R. Kovrizhina
Pages: 18-25
Published online: 02 Jan 2024
AbstractforDose proportionality and bioavailability of quinoxaline-based JNK inhibitor after single oral and intravenous administration in rats | Full Text | References | PDF (1 MB) | EPUB
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Molecular Toxicology

Article
CYP-catalysed cycling of clozapine and clozapine-N-oxide promotes the generation of reactive oxygen species in vitro
Ellen Kingston, Malcolm Tingle, Brandi L. Bellissima, Nuala Helsby & Kathryn Burns
Pages: 26-37
Published online: 22 Dec 2023
AbstractforCYP-catalysed cycling of clozapine and clozapine-N-oxide promotes the generation of reactive oxygen species in vitro | Full Text | References | PDF (1.8 MB) | EPUB | Supplemental
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Pharmacogenetics

Article
Effect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers
Ying-Rong Chen, Xiang Yu, Li-Min Xu, Jue Mei, Meng-Li Tian, Min Xu, Qiu-Yue Jin, Li-Bing Ye & Shui-Xin Yang
Pages: 38-44
Published online: 18 Dec 2023
AbstractforEffect of genetic polymorphisms on the pharmacokinetics of gefitinib in healthy Chinese volunteers | Full Text | References | PDF (797.6 KB) | EPUB | Supplemental
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Thank you to reviewers

Thank you to reviewers
Pages: I-II
Published online: 18 Mar 2024
CitationforThank you to reviewers | Full Text | PDF (176.5 KB) | EPUB
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