Autophagy, Volume 12, Issue 12 (2016)

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Autophagy, Volume 12, Issue 12 (2016)

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Basic Brief Report

Brief Report
Mice deficient in the Vici syndrome gene Epg5 exhibit features of retinitis pigmentosa
Guangyan Miao, Yan G. Zhao, Hongyu Zhao, Cuicui Ji, Huayu Sun, Yingyu Chen & Hong Zhang
Pages: 2263-2270
Published online: 01 Nov 2016
AbstractforMice deficient in the Vici syndrome gene Epg5 exhibit features of retinitis pigmentosa | Full Text | References | PDF (1.2 MB) | Supplemental
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Basic Research Paper

Article
Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy
Hsiang-Cheng Chi, Shen-Liang Chen, Chung-Ying Tsai, Wen-Yu Chuang, Ya-Hui Huang, Ming-Ming Tsai, Sheng-Ming Wu, Cheng-Pu Sun, Chau-Ting Yeh & Kwang-Huei Lin
Pages: 2271-2285
Published online: 14 Oct 2016
AbstractforThyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy | Full Text | References | PDF (2.1 MB) | Supplemental
  • 2244 Views
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Article
Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury
Yue Hu, Jian Lou, Yuan-Yuan Mao, Tian-Wen Lai, Li-Yao Liu, Chen Zhu, Chao Zhang, Juan Liu, Yu-Yan Li, Fan Zhang, Wen Li, Song-Min Ying, Zhi-Hua Chen & Hua-Hao Shen
Pages: 2286-2299
Published online: 01 Nov 2016
AbstractforActivation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury | Full Text | References | PDF (1.5 MB) | Supplemental
  • 6049 Views
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Article
Progress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo
Franziska Wild, Muzamil Majid Khan, Tatjana Straka & Rüdiger Rudolf
Pages: 2300-2310
Published online: 01 Nov 2016
AbstractforProgress of endocytic CHRN to autophagic degradation is regulated by RAB5-GTPase and T145 phosphorylation of SH3GLB1 at mouse neuromuscular junctions in vivo | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1354 Views
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Article
KSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression
R. Santarelli, M. Granato, G. Pentassuglia, V. Lacconi, M. S. Gilardini Montani, R. Gonnella, M. Tafani, M. R. Torrisi, A. Faggioni & M. Cirone
Pages: 2311-2325
Published online: 01 Nov 2016
AbstractforKSHV reduces autophagy in THP-1 cells and in differentiating monocytes by decreasing CAST/calpastatin and ATG5 expression | Full Text | References | PDF (1.2 MB)
  • 1936 Views
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Article
Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice
Jihye Han, Joonbeom Bae, Chang-Yong Choi, Sang-Pil Choi, Hyung-Sik Kang, Eun-Kyeong Jo, Jongsun Park, Young Sik Lee, Hyun-Seuk Moon, Chung-Gyu Park, Myung-Shik Lee & Taehoon Chun
Pages: 2326-2343
Published online: 26 Oct 2016
AbstractforAutophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice | Full Text | References | PDF (1.7 MB) | Supplemental
  • 5661 Views
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Article
Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis
Pierre-Michaël Coly, Nicolas Perzo, Vadim Le Joncour, Céline Lecointre, Marie-Thérèse Schouft, Laurence Desrues, Marie-Christine Tonon, Olivier Wurtz, Pierrick Gandolfo, Hélène Castel & Fabrice Morin
Pages: 2344-2362
Published online: 01 Nov 2016
AbstractforChemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis | Full Text | References | PDF (1.9 MB) | Supplemental
  • 2385 Views
  • 24 CrossRef citations
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Article
Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy
Yao Kuang, Kaili Ma, Changqian Zhou, Pengfei Ding, Yushan Zhu, Quan Chen & Bin Xia
Pages: 2363-2373
Published online: 01 Nov 2016
AbstractforStructural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2890 Views
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Article
A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis
Rui Kang, Ling Zeng, Yangchun Xie, Zhengwen Yan, Borong Zhou, Lizhi Cao, Daniel J. Klionsky, Kevin J. Tracey, Jianhua Li, Haichao Wang, Timothy R. Billiar, Jianxin Jiang & Daolin Tang
Pages: 2374-2385
Published online: 07 Nov 2016
AbstractforA novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis | Full Text | References | PDF (1.9 MB) | Supplemental
  • 4101 Views
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Article
Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP
Zuriñe Antón, Ane Landajuela, Javier H. Hervás, L. Ruth Montes, Sonia Hernández-Tiedra, Guillermo Velasco, Felix M. Goñi & Alicia Alonso
Pages: 2386-2403
Published online: 07 Nov 2016
AbstractforHuman Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP | Full Text | References | PDF (1.7 MB) | Supplemental
  • 3206 Views
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Article
BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation
Gayathri Swaminathan, Wan Zhu & Edward D. Plowey
Pages: 2404-2419
Published online: 01 Nov 2016
AbstractforBECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation | Full Text | References | PDF (1.9 MB) | Supplemental
  • 2516 Views
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Article
Enhanced autophagy in pulmonary endothelial cells on exposure to HIV-Tat and morphine: Role in HIV-related pulmonary arterial hypertension
Pranjali Dalvi, Himanshu Sharma, Mahendran Chinnappan, Miles Sanderson, Julie Allen, Ruoxi Zeng, Augustine Choi, Amy O'Brien-Ladner & Navneet K. Dhillon
Pages: 2420-2438
Published online: 01 Nov 2016
AbstractforEnhanced autophagy in pulmonary endothelial cells on exposure to HIV-Tat and morphine: Role in HIV-related pulmonary arterial hypertension | Full Text | References | PDF (2.1 MB) | Supplemental
  • 1659 Views
  • 35 CrossRef citations
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Article
Autophagy-mediated catabolism of visual transduction proteins prevents retinal degeneration
Jingyu Yao, Lin Jia, Kecia Feathers, Chengmao Lin, Naheed W. Khan, Daniel J. Klionsky, Thomas A. Ferguson & David N. Zacks
Pages: 2439-2450
Published online: 01 Nov 2016
AbstractforAutophagy-mediated catabolism of visual transduction proteins prevents retinal degeneration | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2122 Views
  • 30 CrossRef citations
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Article
Hepatitis B virus–triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response
Gu-Choul Shin, Hong Seok Kang, Ah Ram Lee & Kyun-Hwan Kim
Pages: 2451-2466
Published online: 01 Nov 2016
AbstractforHepatitis B virus–triggered autophagy targets TNFRSF10B/death receptor 5 for degradation to limit TNFSF10/TRAIL response | Full Text | References | PDF (1.8 MB) | Supplemental
  • 2527 Views
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Article
Autophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy
Matteo Bordi, Martin J. Berg, Panaiyur S. Mohan, Corrinne M. Peterhoff, Melissa J. Alldred, Shaoli Che, Stephen D. Ginsberg & Ralph A. Nixon
Pages: 2467-2483
Published online: 04 Nov 2016
AbstractforAutophagy flux in CA1 neurons of Alzheimer hippocampus: Increased induction overburdens failing lysosomes to propel neuritic dystrophy | Full Text | References | PDF (1.3 MB)
  • 6329 Views
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Clinical Research Paper

Article
Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial
Silvia Castagnaro, Camilla Pellegrini, Massimo Pellegrini, Martina Chrisam, Patrizia Sabatelli, Silvia Toni, Paolo Grumati, Claudio Ripamonti, Loredana Pratelli, Nadir M. Maraldi, Daniela Cocchi, Valeria Righi, Cesare Faldini, Marco Sandri, Paolo Bonaldo & Luciano Merlini
Pages: 2484-2495
Published online: 01 Nov 2016
AbstractforAutophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial | Full Text | References | PDF (876.9 KB) | Supplemental
  • 2843 Views
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Autophagic Punctum

Article Commentary
Autophagy inhibition and mitochondrial remodeling join forces to amplify apoptosis in activation-induced cell death
Mauro Corrado & Silvia Campello
Pages: 2496-2497
Published online: 01 Nov 2016
AbstractforAutophagy inhibition and mitochondrial remodeling join forces to amplify apoptosis in activation-induced cell death | Full Text | PDF (413.3 KB)
  • 1302 Views
  • 7 CrossRef citations
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Article Commentary
Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer
Kui Wang, Wei Gao, Qianhui Dou, Haining Chen, Qifu Li, Edouard C. Nice & Canhua Huang
Pages: 2498-2499
Published online: 01 Nov 2016
AbstractforIvermectin induces PAK1-mediated cytostatic autophagy in breast cancer | Full Text | PDF (351.3 KB)
  • 5011 Views
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Article Commentary
Regulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome–lysosome fusion
Shuhei Nakamura, Junya Hasegawa & Tamotsu Yoshimori
Pages: 2500-2501
Published online: 01 Nov 2016
AbstractforRegulation of lysosomal phosphoinositide balance by INPP5E is essential for autophagosome–lysosome fusion | Full Text | PDF (355.2 KB)
  • 1980 Views
  • 14 CrossRef citations
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Article Commentary
ATG proteins: Are we always looking at autophagy?
Mario Mauthe & Fulvio Reggiori
Pages: 2502-2503
Published online: 01 Nov 2016
AbstractforATG proteins: Are we always looking at autophagy? | Full Text | PDF (307.3 KB)
  • 2900 Views
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Article Commentary
Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B
Si Ming Man & Thirumala-Devi Kanneganti
Pages: 2504-2505
Published online: 07 Nov 2016
AbstractforRegulation of lysosomal dynamics and autophagy by CTSB/cathepsin B | Full Text | PDF (334.3 KB)
  • 6734 Views
  • 107 CrossRef citations
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Article Commentary
Life in lights: Tracking mitochondrial delivery to lysosomes in vivo
Thomas G. McWilliams & Ian G. Ganley
Pages: 2506-2507
Published online: 01 Nov 2016
AbstractforLife in lights: Tracking mitochondrial delivery to lysosomes in vivo | Full Text | PDF (275.1 KB)
  • 3099 Views
  • 15 CrossRef citations
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Article Commentary
TBK1 directs WIPI2 against Salmonella
Keith B. Boyle, Teresa L. M. Thurston & Felix Randow
Pages: 2508-2509
Published online: 03 Nov 2016
AbstractforTBK1 directs WIPI2 against Salmonella | Full Text | PDF (345 KB)
  • 2010 Views
  • 2 CrossRef citations
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Article Commentary
The ART and science of sperm mitophagy
Won-Hee Song, Young-Joo Yi, Miriam Sutovsky, Stuart Meyers & Peter Sutovsky
Pages: 2510-2511
Published online: 03 Nov 2016
AbstractforThe ART and science of sperm mitophagy | Full Text | PDF (242.7 KB)
  • 1653 Views
  • 12 CrossRef citations
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Views and Commentaries

Article Commentary
Role of actin in shaping autophagosomes
Katarzyna Zientara-Rytter & Suresh Subramani
Pages: 2512-2515
Published online: 01 Nov 2016
AbstractforRole of actin in shaping autophagosomes | Full Text | References | PDF (416.9 KB)
  • 1929 Views
  • 15 CrossRef citations
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Article Commentary
Targeting neuronal MAPK14/p38α activity to modulate autophagy in the Alzheimer disease brain
John Alam & Wiep Scheper
Pages: 2516-2520
Published online: 01 Nov 2016
AbstractforTargeting neuronal MAPK14/p38α activity to modulate autophagy in the Alzheimer disease brain | Full Text | References | PDF (396.9 KB)
  • 2662 Views
  • 28 CrossRef citations
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