Bioengineered, Volume 12, Issue 1 (2021)

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Bioengineered, Volume 12, Issue 1 (2021)

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Research Paper

Article
Use of Spondias Mombin fruit pulp as a substrate for biosurfactant production.
Kenneth Ejike Ogbonna, Chidozie Victor Agu, Christopher Chukwudi Okonkwo, Kingsley Tochukwu Ughamba, Joseph Akor & Obioma U. Njoku
Pages: 1-12
Published online: 21 Dec 2020
AbstractforUse of Spondias Mombin fruit pulp as a substrate for biosurfactant production. | Full Text | References | PDF (792.1 KB) | EPUB
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Mini-Review

Review
Changes in global Orchidaceae disease geographical research trends: recent incidences, distributions, treatment, and challenges
Archana Jain, Surendra Sarsaiya, Jishuang Chen, Qin Wu, Yuanfu Lu & Jingshan Shi
Pages: 13-29
Published online: 21 Dec 2020
AbstractforChanges in global Orchidaceae disease geographical research trends: recent incidences, distributions, treatment, and challenges | Full Text | References | PDF (2.2 MB) | EPUB
  • 3839 Views
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Research Paper

Article
GIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma
Guifu Wang, Xuesong Bai, Guoqing Jiang, Shengjie Jin, Qian Wang, Aoqing Wang, Rui Peng, Aiwu Ke & Dousheng Bai
Pages: 30-43
Published online: 21 Dec 2020
AbstractforGIT1 overexpression promotes epithelial-mesenchymal transition and predicts poor prognosis in hepatocellular carcinoma | Full Text | References | PDF (12.9 MB) | EPUB
  • 6112 Views
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Open Access
Article
Ropivacaine inhibits the proliferation and migration of colorectal cancer cells through ITGB1
Xiao Wang & Tianzuo Li
Pages: 44-53
Published online: 21 Dec 2020
AbstractforRopivacaine inhibits the proliferation and migration of colorectal cancer cells through ITGB1 | Full Text | References | PDF (7.2 MB) | EPUB
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Open Access

Special issue on Biotechnology-Driven Innovations Towards Sustainable Development

Article
Optimization of culture conditions for gamma-aminobutyric acid production by newly identified Pediococcus pentosaceus MN12 isolated from ‘mam nem’, a fermented fish sauce
Do Thi Bich Thuy, An Tien Nguyen, Kuan Shiong Khoo, Kit Wayne Chew, Margo Cnockaert, Peter Vandamme, Yeek-Chia Ho, Nguyen Duc Huy, Heriberto Hernández Cocoletzi & Pau Loke Show
Pages: 54-62
Published online: 22 Dec 2020
AbstractforOptimization of culture conditions for gamma-aminobutyric acid production by newly identified Pediococcus pentosaceus MN12 isolated from ‘mam nem’, a fermented fish sauce | Full Text | References | PDF (1.2 MB) | EPUB
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Research Paper

Article
Glyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes
Hongna Zhang, Jingbo Liu, Lei Wang & Zhenzhen Zhai
Pages: 63-69
Published online: 21 Dec 2020
AbstractforGlyphosate escalates horizontal transfer of conjugative plasmid harboring antibiotic resistance genes | Full Text | References | PDF (2.4 MB) | EPUB
  • 3488 Views
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Review

Review
A critical review on advances in the practices and perspectives for the treatment of dye industry wastewater
Toral Shindhal, Parita Rakholiya, Sunita Varjani, Ashok Pandey, Huu Hao Ngo, Wenshan Guo, How Yong Ng & Mohammad J. Taherzadeh
Pages: 70-87
Published online: 28 Dec 2020
AbstractforA critical review on advances in the practices and perspectives for the treatment of dye industry wastewater | Full Text | References | PDF (3.1 MB) | EPUB
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Research Paper

Article
Individualized prognostic signature for pancreatic carcinoma validated by integrating immune-related gene pairs (IRGPs)
Yecheng Li, Pingan Yao, Kui Zhao, Zhenyu Ye, Haobo Zhang, Jianping Cao, Shuyu Zhang & Chungen Xing
Pages: 88-95
Published online: 04 Jan 2021
AbstractforIndividualized prognostic signature for pancreatic carcinoma validated by integrating immune-related gene pairs (IRGPs) | Full Text | References | PDF (1.9 MB) | EPUB
  • 3222 Views
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Open Access
Article
Downregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis
Jian Cheng, Yanghui Lou & Kai Jiang
Pages: 96-107
Published online: 21 Dec 2020
AbstractforDownregulation of long non-coding RNA LINC00460 inhibits the proliferation, migration and invasion, and promotes apoptosis of pancreatic cancer cells via modulation of the miR-320b/ARF1 axis | Full Text | References | PDF (3.7 MB) | EPUB
  • 2261 Views
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Open Access
Article
A genome-wide survey of interaction between rice and Magnaporthe oryzae via microarray analysis
Yanping Tan, Xiaolin Yang, Minghao Pei, Xin Xu, Chuntai Wang & Xinqiong Liu
Pages: 108-116
Published online: 28 Dec 2020
AbstractforA genome-wide survey of interaction between rice and Magnaporthe oryzae via microarray analysis | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Activating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway
Xue-Ming Wang, Xiu-Mei Liu, Yuting Wang & Zhen-Yu Chen
Pages: 117-126
Published online: 23 Dec 2020
AbstractforActivating transcription factor 3 (ATF3) regulates cell growth, apoptosis, invasion and collagen synthesis in keloid fibroblast through transforming growth factor beta (TGF-beta)/SMAD signaling pathway | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Analysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics
Shuai Chen, Yi Wei, Hanyang Liu, Yu Gong, Yan Zhou, Haojun Yang & Liming Tang
Pages: 127-137
Published online: 29 Dec 2020
AbstractforAnalysis of Collagen type X alpha 1 (COL10A1) expression and prognostic significance in gastric cancer based on bioinformatics | Full Text | References | PDF (2.8 MB) | EPUB
  • 6828 Views
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Open Access
Article
Optimization of alkali-treated poplar fiber saccharification using metal ions and surfactants
Fan Feng, Baiquan Zeng, Shilin Ouyang, Yanan zhong & Jienan Chen
Pages: 138-150
Published online: 22 Dec 2020
AbstractforOptimization of alkali-treated poplar fiber saccharification using metal ions and surfactants | Full Text | References | PDF (3.1 MB) | EPUB
  • 1370 Views
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Article
Fenretinide regulates macrophage polarization to protect against experimental colitis induced by dextran sulfate sodium
Yong Cao, Yan Lin, Yan Sun, Weiyu Liu, Yichuan Shao & Changqing Zheng
Pages: 151-161
Published online: 31 Dec 2020
AbstractforFenretinide regulates macrophage polarization to protect against experimental colitis induced by dextran sulfate sodium | Full Text | References | PDF (3.9 MB) | EPUB
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Research paper

Article
Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/β-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9)
Hanwen Zhang, Shuya Liu, Lian Tang, Jianhua Ge & Xiaobo Lu
Pages: 162-171
Published online: 28 Dec 2020
AbstractforLong non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/β-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9) | Full Text | References | PDF (3.2 MB) | EPUB
  • 2954 Views
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Article
Development of an immune-related prognostic index associated with osteosarcoma
Chao-Dong Yin, Ying-Lan Hou, Xiao-Ren Liu, Yu-Sheng He, Xin-Ping Wang, Cheng-Jie Li, Xiao-Hong Tan & Jun Liu
Pages: 172-182
Published online: 29 Dec 2020
AbstractforDevelopment of an immune-related prognostic index associated with osteosarcoma | Full Text | References | PDF (2.8 MB) | EPUB
  • 2706 Views
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Open Access
Article
Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways
Aimin Liu, Buxin Zhang, Wei Zhao, Yuanhui Tu, Qingxing Wang & Jing Li
Pages: 183-195
Published online: 31 Dec 2020
AbstractforCatalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways | Full Text | References | PDF (7.4 MB) | EPUB
  • 4317 Views
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Research Paper

Article
Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275
Junpeng Feng, Jianhang Li, Peng Qie, Zhenhua Li, Yanzhao Xu & Ziqiang Tian
Pages: 196-207
Published online: 31 Dec 2020
AbstractforLong non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275 | Full Text | References | PDF (2.2 MB) | EPUB
  • 2398 Views
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Research paper

Article
The underlying molecular mechanism and identification of transcription factor markers for laryngeal squamous cell carcinoma
Bin-Yu Mo, Guo-Sheng Li, Su-Ning Huang, Wei-Ying He, Li-Yuan Xie, Zhu-Xin Wei, Ya-Si Su, Yue Liang, Li Yang, Cheng Ye, Wen-Bin Dai & Lin Ruan
Pages: 208-224
Published online: 04 Jan 2021
AbstractforThe underlying molecular mechanism and identification of transcription factor markers for laryngeal squamous cell carcinoma | Full Text | References | PDF (5.5 MB) | EPUB
  • 2561 Views
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Research Paper

Article
Silencing of long non-coding RNA HCP5 inhibits proliferation, invasion, migration, and promotes apoptosis via regulation of miR-299-3p/SMAD5 axis in gastric cancer cells
Derong Yin & Xiaohong Lu
Pages: 225-239
Published online: 29 Dec 2020
AbstractforSilencing of long non-coding RNA HCP5 inhibits proliferation, invasion, migration, and promotes apoptosis via regulation of miR-299-3p/SMAD5 axis in gastric cancer cells | Full Text | References | PDF (9.5 MB) | EPUB
  • 2190 Views
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Article
A novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma
Huimin Shen, Hao Wu, Fengkai Sun, Jianni Qi & Qiang Zhu
Pages: 240-251
Published online: 31 Dec 2020
AbstractforA novel four-gene of iron metabolism-related and methylated for prognosis prediction of hepatocellular carcinoma | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Characteristics of immune cell infiltration and associated diagnostic biomarkers in ulcerative colitis: results from bioinformatics analysis
Guohui Xue, Lin Hua, Nanjin Zhou & Junming Li
Pages: 252-265
Published online: 11 Jan 2021
AbstractforCharacteristics of immune cell infiltration and associated diagnostic biomarkers in ulcerative colitis: results from bioinformatics analysis | Full Text | References | PDF (11 MB) | EPUB
  • 3615 Views
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Article
Increasing chitosanase production in Bacillus cereus by a novel mutagenesis and screen method
Chaozheng Zhang, Yi Li, Tianshuang Zhang & Hua Zhao
Pages: 266-277
Published online: 08 Jan 2021
AbstractforIncreasing chitosanase production in Bacillus cereus by a novel mutagenesis and screen method | Full Text | References | PDF (1.5 MB) | EPUB
  • 2171 Views
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Article
Clinical importance of serum secreted clusterin in predicting invasive breast cancer and treatment responses
Qing-Feng Chen, Lei Chang, Qun Su, Ying Zhao & Bin Kong
Pages: 278-285
Published online: 28 Jan 2021
AbstractforClinical importance of serum secreted clusterin in predicting invasive breast cancer and treatment responses | Full Text | References | PDF (945.6 KB) | EPUB
  • 1696 Views
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Article
Clinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch–Schonlein Purpura: a meta-analysis
Bowen Li, Qian Ren, Jizu Ling, Zhongbin Tao, Xuemei Yang & Yuning Li
Pages: 286-295
Published online: 08 Jan 2021
AbstractforClinical relevance of neutrophil-to-lymphocyte ratio and mean platelet volume in pediatric Henoch–Schonlein Purpura: a meta-analysis | Full Text | References | PDF (670.9 KB) | EPUB
  • 2981 Views
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Article
Identification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses
Jun Cao, Chi Zhang, Guo-Qing Jiang, Sheng-Jie Jin, Qian Wang, Ao-Qing Wang & Dou-Sheng Bai
Pages: 296-309
Published online: 18 Jan 2021
AbstractforIdentification of hepatocellular carcinoma-related genes associated with macrophage differentiation based on bioinformatics analyses | Full Text | References | PDF (10.8 MB) | EPUB
  • 7183 Views
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Open Access
Article
MicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren’s syndrome
Xiaoyan Wang, Shaojun Xin, Youqing Wang, Duo Ju, Quan Wu, Ye Qiu, Xuemin Niu, Wei Liu, Jianyou Li & Pengtian Ji
Pages: 310-324
Published online: 15 Jan 2021
AbstractforMicroRNA-146a-5p enhances T helper 17 cell differentiation via decreasing a disintegrin and metalloprotease 17 level in primary sjögren’s syndrome | Full Text | References | PDF (7.6 MB) | EPUB
  • 1864 Views
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Article
Clinical significance and potential molecular mechanism of miRNA-222-3p in metastatic prostate cancer
Yu Sun, Gang Chen, Juan He, Zhi-Guang Huang, Sheng-Hua Li, Yuan-Ping Yang, Lu-Yang Zhong, Shu-Fan Ji, Ying Huang, Xin-Hua Chen, Mao-Lin He & Hao Wu
Pages: 325-340
Published online: 12 Jan 2021
AbstractforClinical significance and potential molecular mechanism of miRNA-222-3p in metastatic prostate cancer | Full Text | References | PDF (12.6 MB) | EPUB
  • 3548 Views
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Article
The importance of cell culture parameter standardization: an assessment of the robustness of the 2102Ep reference cell line
James Willard Tonderai Kusena, Maryam Shariatzadeh, Adam James Studd, Jenna Rebekah James, Robert James Thomas & Samantha Loiuse Wilson
Pages: 341-357
Published online: 11 Jan 2021
AbstractforThe importance of cell culture parameter standardization: an assessment of the robustness of the 2102Ep reference cell line | Full Text | References | PDF (1.3 MB) | EPUB
  • 3149 Views
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Research paper

Article
Production of L-carnitine-enriched edible filamentous fungal biomass through submerged cultivation
Neda Rousta, Jorge A. Ferreira & Mohammad J. Taherzadeh
Pages: 358-368
Published online: 15 Jan 2021
AbstractforProduction of L-carnitine-enriched edible filamentous fungal biomass through submerged cultivation | Full Text | References | PDF (3.4 MB) | EPUB
  • 3355 Views
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RETRACTED ARTICLE

Article
RETRACTED ARTICLE: Long intergenic non-protein coding RNA 960 regulates cancer cell viability, migration and invasion through modulating miR-146a-5p/interleukin 1 receptor associated kinase 1 axis in pancreatic ductal adenocarcinoma
Yaoxing Huang, Qingqing Yan, Danchun Yu, Xiaojuan Sun, Shuman Jiang, Weidong Li & Lin Jia
Pages: 369-381
Published online: 11 Jan 2021
First Page PreviewforRETRACTED ARTICLE: Long intergenic non-protein coding RNA 960 regulates cancer cell viability, migration and invasion through modulating miR-146a-5p/interleukin 1 receptor associated kinase 1 axis in pancreatic ductal adenocarcinoma | PDF (14.9 MB)
  • 2047 Views
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Article
RETRACTED ARTICLE: Optimization of trypsin extraction technology of Allium cepa L. polysaccharide by response surface methodology and the antitumor effects through immunomodulation
Yu-Bin Ji & Fu-Ling Wang
Pages: 382-391
Published online: 20 Jan 2021
First Page PreviewforRETRACTED ARTICLE: Optimization of trypsin extraction technology of Allium cepa L. polysaccharide by response surface methodology and the antitumor effects through immunomodulation | PDF (7.4 MB)
  • 1608 Views
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Research Paper

Article
Microfluidics for the rapid detection of Escherichia coli O157:H7 using antibody-coated microspheres
Bo Song, Jiayuan Yu, Yan Sun, Qiao Wang, Shengnan Xu, Yichen Jia, Shuying Lin, Yueying Zhang, Chen Wang, Yingbo Zhang & Xiaojie Zhang
Pages: 392-401
Published online: 20 Jan 2021
AbstractforMicrofluidics for the rapid detection of Escherichia coli O157:H7 using antibody-coated microspheres | Full Text | References | PDF (2 MB) | EPUB
  • 2415 Views
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Open Access
Article
Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway
Jianjun Li, Chuan Xiong, Pan Xu, Qiang Luo & Ronggui Zhang
Pages: 402-413
Published online: 18 Jan 2021
AbstractforPuerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway | Full Text | References | PDF (7.4 MB) | EPUB
  • 2621 Views
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Open Access
Article
Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression
Chuan-Cui Zhang, Yuhua Li, Xian-Zhen Feng & Dian-Bo Li
Pages: 414-425
Published online: 20 Jan 2021
AbstractforCircular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression | Full Text | References | PDF (2.1 MB) | EPUB
  • 2890 Views
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Open Access
Article
Effect of fed-batch and chemostat cultivation processes of C. glutamicum CP for L-leucine production
Yufu Zhang, Haibo Xiong, Zhichao Chen, Yunpeng Fu, Qingyang Xu & Ning Chen
Pages: 426-439
Published online: 20 Jan 2021
AbstractforEffect of fed-batch and chemostat cultivation processes of C. glutamicum CP for L-leucine production | Full Text | References | PDF (1.6 MB) | EPUB
  • 2430 Views
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Open Access
Article
MicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4
Li Cai, Lu Ye, Xiaoqing Hu, Wenfeng He, Debao Zhuang, Qi Guo, Kuanyong Shu & Youkun Jie
Pages: 440-449
Published online: 25 Jan 2021
AbstractforMicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4 | Full Text | References | PDF (3.5 MB) | EPUB
  • 2003 Views
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Review

Review
Prognostic significance of microRNA miR-24 in cancers: a meta-analysis
Rongqiang Liu, Weihao Kong, Shiyang Zheng, Chenyu Yu, Yajie Yu, Yuling Xu, Linsen Ye & Yi Shao
Pages: 450-460
Published online: 08 Feb 2021
AbstractforPrognostic significance of microRNA miR-24 in cancers: a meta-analysis | Full Text | References | PDF (927.1 KB) | EPUB
  • 2317 Views
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Research Paper

Article
Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells
Hyeong-Woo Lee, Juhyun Shin, Brian S. Wilson & Jae-Wook Oh
Pages: 461-475
Published online: 28 Jan 2021
AbstractforPeripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells | Full Text | References | PDF (2 MB) | EPUB
  • 1935 Views
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Review

Review
Apple orchard waste recycling and valorization of valuable product-A review
Yumin Duan, Sanjeet Mehariya, Aman Kumar, Ekta Singh, Jianfeng Yang, Sunil Kumar, Huike Li & Mukesh Kumar Awasthi
Pages: 476-495
Published online: 20 Jan 2021
AbstractforApple orchard waste recycling and valorization of valuable product-A review | Full Text | References | PDF (1.4 MB) | EPUB
  • 8794 Views
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Research Paper

Article
Long non-coding RNA DUXAP8 promotes the cell proliferation, migration, and invasion of papillary thyroid carcinoma via miR-223-3p mediated regulation of CXCR4
Yan Liu, Hejia Zhang, Hui Wang, Jiarui Du, Peng Dong, Meihan Liu & Yuanqiang Lin
Pages: 496-506
Published online: 15 Feb 2021
AbstractforLong non-coding RNA DUXAP8 promotes the cell proliferation, migration, and invasion of papillary thyroid carcinoma via miR-223-3p mediated regulation of CXCR4 | Full Text | References | PDF (3.1 MB) | EPUB
  • 1814 Views
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Article
Ligustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway
Hong-yan Du, Rong Wang, Jian-liang Li, Huang Luo, Xiao-yan Xie, Ran Yan, Yue-ling Jian & Jin-ying Cai
Pages: 507-515
Published online: 31 Jan 2021
AbstractforLigustrazine induces viability, suppresses apoptosis and autophagy of retinal ganglion cells with ischemia/reperfusion injury through the PI3K/Akt/mTOR signaling pathway | Full Text | References | PDF (1.7 MB) | EPUB
  • 2424 Views
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Article
Bio-herbicidal potential of wheat rhizosphere bacteria on Avena fatua L. grass
Wei Li, Shuo Shen & Hongyu Chen
Pages: 516-526
Published online: 08 Feb 2021
AbstractforBio-herbicidal potential of wheat rhizosphere bacteria on Avena fatua L. grass | Full Text | References | PDF (2.3 MB) | EPUB
  • 1810 Views
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Article
Effect of polyaspartic acid and different dosages of controlled-release fertilizers on nitrogen uptake, utilization, and yield of maize cultivars
Peng-Tao Ji, Xiang-Ling Li, Yu-Juan Peng, Yue-Chen Zhang & Pei-Jun Tao
Pages: 527-539
Published online: 04 Feb 2021
AbstractforEffect of polyaspartic acid and different dosages of controlled-release fertilizers on nitrogen uptake, utilization, and yield of maize cultivars | Full Text | References | PDF (1.4 MB) | EPUB
  • 2272 Views
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Article
Immune cell infiltration landscape and immune marker molecular typing in preeclampsia
YiLin Meng, Chuang Li & Cai-Xia Liu
Pages: 540-554
Published online: 04 Feb 2021
AbstractforImmune cell infiltration landscape and immune marker molecular typing in preeclampsia | Full Text | References | PDF (5.5 MB) | EPUB
  • 3449 Views
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Article
An epithelial-mesenchymal transition-related long non-coding RNA signature to predict overall survival and immune microenvironment in kidney renal clear cell carcinoma
You-Peng Zhang MD, Yong-Biao Cheng MD, Sen Li MD, Ning Zhao MD & Zhao-Hui Zhu MD, Ph.D
Pages: 555-564
Published online: 10 Feb 2021
AbstractforAn epithelial-mesenchymal transition-related long non-coding RNA signature to predict overall survival and immune microenvironment in kidney renal clear cell carcinoma | Full Text | References | PDF (3.8 MB) | EPUB
  • 3393 Views
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Article
T-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways
Haixia Liu, Mei Song, Xiaoyan Sun, Xin Zhang, Huayan Miao & Yankui Wang
Pages: 565-577
Published online: 08 Feb 2021
AbstractforT-box transcription factor TBX1, targeted by microRNA-6727-5p, inhibits cell growth and enhances cisplatin chemosensitivity of cervical cancer cells through AKT and MAPK pathways | Full Text | References | PDF (3.5 MB) | EPUB
  • 1942 Views
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Article
Long non-coding RNA TTN antisense RNA 1 facilitates hepatocellular carcinoma progression via regulating miR-139-5p/SPOCK1 axis
Xinghao Zhu, Shiqing Jiang, Zongyao Wu, Tonghua Liu, Wei Zhang, Lili Wu, Lijun Xu & Mingliang Shao
Pages: 578-588
Published online: 08 Feb 2021
AbstractforLong non-coding RNA TTN antisense RNA 1 facilitates hepatocellular carcinoma progression via regulating miR-139-5p/SPOCK1 axis | Full Text | References | PDF (3.1 MB) | EPUB
  • 2000 Views
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Article
Withaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms
Xia Zhao, Jing Wang, Liying Tang, Pei Li, Jing Ru & Yuzhi Bai
Pages: 589-600
Published online: 10 Feb 2021
AbstractforWithaferin A protects against hyperuricemia induced kidney injury and its possible mechanisms | Full Text | References | PDF (4.9 MB) | EPUB
  • 2940 Views
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Article
The interaction of TEA domain transcription factor 4 (TEAD4) and Yes-associated protein 1 (YAP1) promoted the malignant process mediated by serum/glucocorticoid regulated kinase 1 (SGK1)
Songlin He, Hanlu Zhang, Zongwei Xiao, Sandeep Bhushan, Ke Gao & Wenping Wang
Pages: 601-614
Published online: 10 Feb 2021
AbstractforThe interaction of TEA domain transcription factor 4 (TEAD4) and Yes-associated protein 1 (YAP1) promoted the malignant process mediated by serum/glucocorticoid regulated kinase 1 (SGK1) | Full Text | References | PDF (7.1 MB) | EPUB
  • 2282 Views
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Article
Distribution characteristics of microbial community structure in atmospheric particulates of the typical industrial city in Jiangsu province, China
Xingcheng Yuan, Guangchao Li, Weihua Yang & Dan Li
Pages: 615-626
Published online: 10 Feb 2021
AbstractforDistribution characteristics of microbial community structure in atmospheric particulates of the typical industrial city in Jiangsu province, China | Full Text | References | PDF (2 MB) | EPUB
  • 1211 Views
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Article
Long non-coding RNA LINC00997 silencing inhibits the progression and metastasis of colorectal cancer by sponging miR-512-3p
Zhiliang Shi, Chenglong Shen, Cheng Yu, Xiaoling Yang, Jiazhe Shao, Jian Guo, Xinguo Zhu & Guoqiang Zhou
Pages: 627-639
Published online: 11 Feb 2021
AbstractforLong non-coding RNA LINC00997 silencing inhibits the progression and metastasis of colorectal cancer by sponging miR-512-3p | Full Text | References | PDF (3.7 MB) | EPUB
  • 1925 Views
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Article
Anti-polyphenol oxidase properties of total flavonoids from young loquat fruits: inhibitory activity and mechanism
Gui-Li Huang, Ling-Xiang Sun, Jia-Jia Ma, Si-Yao Sui & Yu-Ning Wang
Pages: 640-647
Published online: 15 Feb 2021
AbstractforAnti-polyphenol oxidase properties of total flavonoids from young loquat fruits: inhibitory activity and mechanism | Full Text | References | PDF (1.5 MB) | EPUB
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Review

Review
Anemia is associated with increased risk of contrast‑induced acute kidney injury: A Systematic Review and Meta-analysis
Wei Liang, Cheng Jie Yu, Qiong Ying Wang & Jing Yu
Pages: 648-661
Published online: 17 Feb 2021
AbstractforAnemia is associated with increased risk of contrast‑induced acute kidney injury: A Systematic Review and Meta-analysis | Full Text | References | PDF (967.8 KB) | EPUB
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Research Paper

Article
Bioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas
Dandan Zou, Yang Wang, Meng Wang, Bo Zhao, Fei Hu, Yanguo Li & Bingming Zhang
Pages: 662-672
Published online: 15 Feb 2021
AbstractforBioinformatics analysis reveals the competing endogenous RNA (ceRNA) coexpression network in the tumor microenvironment and prognostic biomarkers in soft tissue sarcomas | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Long non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma
Jie Cao, Lili Wu, Xin Lei, Keqing Shi, Liang Shi & Yifen Shi
Pages: 673-681
Published online: 23 Feb 2021
AbstractforLong non-coding RNA-based signature for predicting prognosis of hepatocellular carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Long non-coding RNA BCAR4 aggravated proliferation and migration in esophageal squamous cell carcinoma by negatively regulating p53/p21 signaling pathway
Shuo Yan, Jichong Xu, Bingyan Liu, Lin Ma, Hao Feng, Huaqiao Tan & Chun Fang
Pages: 682-696
Published online: 19 Feb 2021
AbstractforLong non-coding RNA BCAR4 aggravated proliferation and migration in esophageal squamous cell carcinoma by negatively regulating p53/p21 signaling pathway | Full Text | References | PDF (3.6 MB) | EPUB
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Article
A signature of 13 autophagy‑related gene pairs predicts prognosis in hepatocellular carcinoma
Jie Cao, Lili Wu, Xin Lei, Keqing Shi & Liang Shi
Pages: 697-707
Published online: 23 Feb 2021
AbstractforA signature of 13 autophagy‑related gene pairs predicts prognosis in hepatocellular carcinoma | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Long non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson’s disease
Ming-Yu Chen, Kai Fan, Lian-Jiang Zhao, Jie-Mei Wei, Ji-Xu Gao & Zhen-Fu Li
Pages: 708-719
Published online: 22 Feb 2021
AbstractforLong non-coding RNA nuclear enriched abundant transcript 1 (NEAT1) sponges microRNA-124-3p to up-regulate phosphodiesterase 4B (PDE4B) to accelerate the progression of Parkinson’s disease | Full Text | References | PDF (2.3 MB) | EPUB
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Review

Review
The roles of microbial products in the development of colorectal cancer: a review
Yongkun Fang, Cheng Yan, Qi Zhao, Jiaming Xu, Zhuangzhuang Liu, Jin Gao, Hanjian Zhu, Zhujiang Dai, Daorong Wang & Dong Tang
Pages: 720-735
Published online: 22 Feb 2021
AbstractforThe roles of microbial products in the development of colorectal cancer: a review | Full Text | References | PDF (1 MB) | EPUB
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Review
Association between hepatitis B virus infection and colorectal liver metastasis: a meta-analysis
Rongqiang Liu, Weihao Kong, Mingbin Deng, Guozhen Lin, Tianxing Dai & Linsen Ye
Pages: 736-744
Published online: 25 Feb 2021
AbstractforAssociation between hepatitis B virus infection and colorectal liver metastasis: a meta-analysis | Full Text | References | PDF (704.9 KB) | EPUB
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Research Paper

Article
Complete genome sequence of the Clostridium difficile LCL126
Jianfeng Wang, Chu Yang, Chao Zhang, Xiaoyan Mao & An Lizhe
Pages: 745-754
Published online: 25 Apr 2021
AbstractforComplete genome sequence of the Clostridium difficile LCL126 | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Chrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells
Jiapeng Wang & Peng Lv
Pages: 755-762
Published online: 23 Feb 2021
AbstractforChrysophanol inhibits the osteoglycin/mTOR and activats NF2 signaling pathways to reduce viability and proliferation of malignant meningioma cells | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Interleukin-18 promotes the antitumor ability of natural killer cells in colorectal cancer via the miR-574-3p/TGF-β1 axis
Yin-Peng Li, Xian-Rong Du, Ru Zhang & Qiu Yang
Pages: 763-778
Published online: 04 Mar 2021
AbstractforInterleukin-18 promotes the antitumor ability of natural killer cells in colorectal cancer via the miR-574-3p/TGF-β1 axis | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Study on the occurrence law and green control of grape gray mold from the perspective of ecological balance
Fengying Shen, Weigang Wu, Xing Han, Jiao Wang, Yaning Li & Daqun Liu
Pages: 779-790
Published online: 28 Feb 2021
AbstractforStudy on the occurrence law and green control of grape gray mold from the perspective of ecological balance | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Targeted next-generation sequencing for cancer-associated gene mutation and copy number detection in 206 patients with non–small-cell lung cancer
Songbai Zheng, Xiaodan Wang, Ying Fu, Beibei Li, Jianhua Xu, Haifang Wang, Zhen Huang, Hui Xu, Yurong Qiu, Yaozhou Shi & Kui Li
Pages: 791-802
Published online: 25 Feb 2021
AbstractforTargeted next-generation sequencing for cancer-associated gene mutation and copy number detection in 206 patients with non–small-cell lung cancer | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Muscleblind-like 1 antisense RNA 1 inhibits cell proliferation, invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling
Xiang Ding, Xu Xu, Xue-Feng He, Ye Yuan, Chuang Chen, Xin-Yu Shen, Sai Su, Zhang Chen, Song-Tao Xu & Yu-Hua Huang
Pages: 803-814
Published online: 01 Mar 2021
AbstractforMuscleblind-like 1 antisense RNA 1 inhibits cell proliferation, invasion, and migration of prostate cancer by sponging miR-181a-5p and regulating PTEN/PI3K/AKT/mTOR signaling | Full Text | References | PDF (2.8 MB) | EPUB
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Special Issue for International conference IBCC-2020

Article
Intravesical Instillation of Kangfuxin Liquid Combined with Thrombin and Epidermal Growth Factor for Radiation-induced Hemorrhagic Cystitis in Patients with Cervical Cancer: A report of 34 cases
Qin Hu & Guihao Ke
Pages: 815-820
Published online: 28 Feb 2021
AbstractforIntravesical Instillation of Kangfuxin Liquid Combined with Thrombin and Epidermal Growth Factor for Radiation-induced Hemorrhagic Cystitis in Patients with Cervical Cancer: A report of 34 cases | Full Text | References | PDF (443.1 KB) | EPUB
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Research Paper

Article
Tumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX)
Wulong Wang, Guodai Hong, Siyuan Wang, Wenbin Gao & Ping Wang
Pages: 821-831
Published online: 25 Feb 2021
AbstractforTumor-derived exosomal miRNA-141 promote angiogenesis and malignant progression of lung cancer by targeting growth arrest-specific homeobox gene (GAX) | Full Text | References | PDF (2 MB) | EPUB
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Article
Alterations of long non-coding RNA and mRNA profiles associated with extracellular matrix homeostasis and vascular aging in rats
Qianqin Li, Zezhou Xiao, Yongsheng Wang, Ximao Liu, Hao Liu, Zhiwen Luo & Shaoyi Zheng
Pages: 832-843
Published online: 28 Feb 2021
AbstractforAlterations of long non-coding RNA and mRNA profiles associated with extracellular matrix homeostasis and vascular aging in rats | Full Text | References | PDF (1.9 MB) | EPUB
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Special Issue for International conference IBCC-2020

Article
Study on the effect of synergy effect between the mixed cultures on the power generation of microbial fuel cells
Jing Ren, Na Li, Maohua Du, Yixin Zhang, Chunxu Hao & Rui Hu
Pages: 844-854
Published online: 08 Mar 2021
AbstractforStudy on the effect of synergy effect between the mixed cultures on the power generation of microbial fuel cells | Full Text | References | PDF (1.6 MB) | EPUB
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Research Paper

Article
Identifying the Prognostic Risk Factors of Synaptojanin 2 and Its Underlying Perturbations Pathways in Hepatocellular Carcinoma
Rui Zhang, Wei-Jia Mo, Lan-Shan Huang, Ji-Tian Chen, Wei-Zi Wu, Wei-Ying He & Zhen-Bo Feng
Pages: 855-874
Published online: 01 Mar 2021
AbstractforIdentifying the Prognostic Risk Factors of Synaptojanin 2 and Its Underlying Perturbations Pathways in Hepatocellular Carcinoma | Full Text | References | PDF (8.6 MB) | EPUB
  • 1997 Views
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Review

Review
Clinical significance of long noncoding RNA MNX1-AS1 in human cancers: a meta-analysis of cohort studies and bioinformatics analysis based on TCGA datasets
Kang Chen, Jian-Xin Gan, Ze-Ping Huang, Jun Liu & Hai-Peng Liu
Pages: 875-885
Published online: 09 Mar 2021
AbstractforClinical significance of long noncoding RNA MNX1-AS1 in human cancers: a meta-analysis of cohort studies and bioinformatics analysis based on TCGA datasets | Full Text | References | PDF (1.2 MB) | EPUB
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Research Paper

Article
Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis
Lu Xie & Zhihong Pan
Pages: 886-897
Published online: 09 Mar 2021
AbstractforCircular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Identification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer
Jie Wang & Chen Zhang
Pages: 898-913
Published online: 07 Mar 2021
AbstractforIdentification and validation of potential mRNA- microRNA- long-noncoding RNA (mRNA-miRNA-lncRNA) prognostic signature for cervical cancer | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Crosstalk of low density lipoprotein and liposome as a paradigm for targeting of 5-fluorouracil into hepatic cells: cytotoxicity and liver deposition
Saleh A. Alanazi, Gamaleldin I. Harisa, Mohamed M. Badran, Fars K. Alanazi, Ehab Elzayat, Abdullah H. Alomrani, Osaid T. Al Meanazel & Ahmed T. Al Meanazel
Pages: 914-926
Published online: 08 Mar 2021
AbstractforCrosstalk of low density lipoprotein and liposome as a paradigm for targeting of 5-fluorouracil into hepatic cells: cytotoxicity and liver deposition | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression
Qiao Gu, Wenjie Hou, Lijuan Shi, Huan Liu, Zonghao Zhu & Wenfeng Ye
Pages: 927-936
Published online: 18 Mar 2021
AbstractforCircular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression | Full Text | References | PDF (2 MB) | EPUB
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Article
MicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A
Lishan Wang, Shuqing Ge & Futing Zhou
Pages: 937-947
Published online: 16 Mar 2021
AbstractforMicroRNA-487a-3p inhibits the growth and invasiveness of oral squamous cell carcinoma by targeting PPM1A | Full Text | References | PDF (3.2 MB) | EPUB
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Article
By targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice
Xindong Liu, Xin Wang, Lijuan Zhang, Yi Zhou, Le Yang & Minghao Yang
Pages: 948-959
Published online: 16 Mar 2021
AbstractforBy targeting apoptosis facilitator BCL2L13, microRNA miR-484 alleviates cerebral ischemia/reperfusion injury-induced neuronal apoptosis in mice | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Trelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (RUNX2): a therapeutic implication in osteoporosis
Haiyu Shao, Renzheng Wu, Li Cao, Haifeng Gu & Fang Chai
Pages: 960-968
Published online: 18 Mar 2021
AbstractforTrelagliptin stimulates osteoblastic differentiation by increasing runt-related transcription factor 2 (RUNX2): a therapeutic implication in osteoporosis | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Yiqi Huoxue Recipe inhibits cardiomyocyte apoptosis caused by heart failure through Keap1/Nrf2/HIF-1α signaling pathway
Ling Hu, Yanan Xu, Qian Wang, Meijie Liu, Linfeng Meng, Dongyan Yan, Huagang Hu, Minjia Xiao, Zhenzhen Yin, Ying Li & Xiaoping Kang
Pages: 969-978
Published online: 19 Mar 2021
AbstractforYiqi Huoxue Recipe inhibits cardiomyocyte apoptosis caused by heart failure through Keap1/Nrf2/HIF-1α signaling pathway | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Understanding cell culture dynamics: a tool for defining protocol parameters for improved processes and efficient manufacturing using human embryonic stem cells
J.W.T. Kusena, M. Shariatzadeh, R.J. Thomas & S.L. Wilson
Pages: 979-996
Published online: 24 Mar 2021
AbstractforUnderstanding cell culture dynamics: a tool for defining protocol parameters for improved processes and efficient manufacturing using human embryonic stem cells | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Combining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee
Xiaoyu Li, Zheting Liao, Zhonghao Deng, Nachun Chen & Liang Zhao
Pages: 997-1007
Published online: 22 Mar 2021
AbstractforCombining bulk and single-cell RNA-sequencing data to reveal gene expression pattern of chondrocytes in the osteoarthritic knee | Full Text | References | PDF (2.7 MB) | EPUB
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Correction

Correction
Correction
Pages: 1008-1011
Published online: 01 Apr 2021
First Page PreviewforCorrection | Full Text | PDF (1.8 MB) | EPUB
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Research Paper

Article
Long intergenic noncoding RNA00265 promotes proliferation of gastric cancer via the microRNA-144-3p/Chromobox 4 axis
Zengxi Yang, Xi OuYang, Liang Zheng, Lizhen Dai & Wenjuan Luo
Pages: 1012-1025
Published online: 29 Mar 2021
AbstractforLong intergenic noncoding RNA00265 promotes proliferation of gastric cancer via the microRNA-144-3p/Chromobox 4 axis | Full Text | References | PDF (7.7 MB) | EPUB
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Article
Differentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing
Zhimin Li, Yu Sun, Maolin He & Jianwei Liu
Pages: 1026-1039
Published online: 25 Mar 2021
AbstractforDifferentially-expressed mRNAs, microRNAs and long noncoding RNAs in intervertebral disc degeneration identified by RNA-sequencing | Full Text | References | PDF (3.7 MB) | EPUB
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Review

Review
Bioprospecting of gut microflora for plastic biodegradation
Sini Francis CF, Sharrel Rebello, Embalil Mathachan Aneesh, Raveendran Sindhu, Parameswaran Binod, Suren Singh & Ashok Pandey
Pages: 1040-1053
Published online: 26 Mar 2021
AbstractforBioprospecting of gut microflora for plastic biodegradation | Full Text | References | PDF (925.6 KB) | EPUB
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Research Paper

Article
Weighted gene co-expression network analysis (WGCNA) to explore genes responsive to Streptococcus oralis biofilm and immune infiltration analysis in human gingival fibroblasts cells
Xia Chen & Jianfeng Ma
Pages: 1054-1065
Published online: 29 Mar 2021
AbstractforWeighted gene co-expression network analysis (WGCNA) to explore genes responsive to Streptococcus oralis biofilm and immune infiltration analysis in human gingival fibroblasts cells | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Effect of CMNa combined with radiotherapy on the tumor immune microenvironment of mouse cervical cancer cell transplantation tumor model
Li Li, Weiqiang Shi & Juying Zhou
Pages: 1066-1077
Published online: 30 Mar 2021
AbstractforEffect of CMNa combined with radiotherapy on the tumor immune microenvironment of mouse cervical cancer cell transplantation tumor model | Full Text | References | PDF (841 KB) | EPUB
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Article
Effect of low-level ultrasound treatment on the production of L-leucine by Corynebacterium glutamicum in fed-batch culture
Yufu Zhang, Zhichao Chen, Pengjie Sun, Qingyang Xu & Ning Chen
Pages: 1078-1090
Published online: 29 Mar 2021
AbstractforEffect of low-level ultrasound treatment on the production of L-leucine by Corynebacterium glutamicum in fed-batch culture | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Novel insights into clear cell renal cell carcinoma prognosis by comprehensive characterization of aberrant alternative splicing signature: a study based on large-scale sequencing data
Dong Zhang, Wenjie Zhang, Rui Sun & Zhongxian Huang
Pages: 1091-1110
Published online: 30 Mar 2021
AbstractforNovel insights into clear cell renal cell carcinoma prognosis by comprehensive characterization of aberrant alternative splicing signature: a study based on large-scale sequencing data | Full Text | References | PDF (5.5 MB) | EPUB
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Article
Synthesis and characterization of silver substituted strontium phosphate silicate apatite using solid-state reaction for osteoregenerative applications
Dong Chen, Jingxin Zhao & Xin Jiang
Pages: 1111-1125
Published online: 05 Apr 2021
AbstractforSynthesis and characterization of silver substituted strontium phosphate silicate apatite using solid-state reaction for osteoregenerative applications | Full Text | References | PDF (3 MB) | EPUB
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Article
Down-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells
Xiaochen Wang, Yaochuan Mi, Wei He, Xiaona Hu, Shuo Yang, Lu Zhao, Yanyang Zhang & Binhong Wen
Pages: 1126-1137
Published online: 05 Apr 2021
AbstractforDown-regulation of miR-340-5p promoted osteogenic differentiation through regulation of runt-related transcription factor-2 (RUNX2) in MC3T3-E1 cells | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Integrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway
Zhuo Li, Zhiwen Lian, Jianchao Ma, Li Zhang, Xingji Lian, Shuangxin Liu, Jianteng Xie, Zhonglin Feng, Ting Lin, Hong Zhang & Xinling Liang
Pages: 1138-1149
Published online: 05 Apr 2021
AbstractforIntegrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway | Full Text | References | PDF (5.6 MB) | EPUB
  • 1966 Views
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Article
MicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3)
Jian Kang, Xu Huang, Weiguo Dong, Xueying Zhu, Ming Li & Ning Cui
Pages: 1150-1160
Published online: 05 Apr 2021
AbstractforMicroRNA-1269b inhibits gastric cancer development through regulating methyltransferase-like 3 (METTL3) | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Consensus analysis via weighted gene co-expression network analysis (WGCNA) reveals genes participating in early phase of acute respiratory distress syndrome (ARDS) induced by sepsis
Qing Fang, Qilai Wang, Zhiming Zhou & An Xie
Pages: 1161-1172
Published online: 05 Apr 2021
AbstractforConsensus analysis via weighted gene co-expression network analysis (WGCNA) reveals genes participating in early phase of acute respiratory distress syndrome (ARDS) induced by sepsis | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Transcriptomic analysis of Pinellia ternata (Thunb.) Breit T2 plus line provides insights in host responses resist Pectobacterium carotovorum infection
Fuxing Shu, Jing Han, Jean Pierre Ndayambaje, Qi Jia, Surendra Sarsaiya, Archana Jain, Minglei Huang, Minghong Liu & Jishuang Chen
Pages: 1173-1188
Published online: 08 Apr 2021
AbstractforTranscriptomic analysis of Pinellia ternata (Thunb.) Breit T2 plus line provides insights in host responses resist Pectobacterium carotovorum infection | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Long non-coding RNA SND1-IT1 accelerates cell proliferation, invasion and migration via regulating miR-132-3p/SMAD2 axis in retinoblastoma
Dong-Fang Yin, Xue-Jun Zhou, Na Li, Hui-Jie Liu & Hu Yuan
Pages: 1189-1201
Published online: 12 Apr 2021
AbstractforLong non-coding RNA SND1-IT1 accelerates cell proliferation, invasion and migration via regulating miR-132-3p/SMAD2 axis in retinoblastoma | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Prognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma
Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan & Lu Wang
Pages: 1202-1211
Published online: 08 Apr 2021
AbstractforPrognostic alternative splicing regulatory network of RBM25 in hepatocellular carcinoma | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Bushen Yijing Decoction (BSYJ) exerts an anti-systemic sclerosis effect via regulating MicroRNA-26a /FLI1 axis
Zixuan Cheng, Jialin Zhang, Wanying Deng, Shaojian Lin, Donghai Li, Ke Zhu & Qing Qi
Pages: 1212-1225
Published online: 12 Apr 2021
AbstractforBushen Yijing Decoction (BSYJ) exerts an anti-systemic sclerosis effect via regulating MicroRNA-26a /FLI1 axis | Full Text | References | PDF (3.1 MB) | EPUB
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Review

Review
Can algae contribute to the war with Covid-19?
Wen Yi Chia, Hanz Kok, Kit Wayne Chew, Sze Shin Low & Pau Loke Show
Pages: 1226-1237
Published online: 15 Apr 2021
AbstractforCan algae contribute to the war with Covid-19? | Full Text | References | PDF (953.1 KB) | EPUB
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Research Paper

Article
Identification and validation of the prognostic value of cyclic GMP-AMP synthase-stimulator of interferon (cGAS-STING) related genes in gastric cancer
Kui-Sheng Yang, Chuan-Qi Xu & Jian Lv
Pages: 1238-1250
Published online: 12 Apr 2021
AbstractforIdentification and validation of the prognostic value of cyclic GMP-AMP synthase-stimulator of interferon (cGAS-STING) related genes in gastric cancer | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Characterizing relationship between chemicals and in vitro bioactivities of teas made by six typical processing methods using a single Camellia sinensis cultivar, Meizhan
Guanhua Xie, Jingna Yan, Anxia Lu, Jirui Kun, Bei Wang, Chengda Song, Huarong Tong & Qing Meng
Pages: 1251-1263
Published online: 27 Apr 2021
AbstractforCharacterizing relationship between chemicals and in vitro bioactivities of teas made by six typical processing methods using a single Camellia sinensis cultivar, Meizhan | Full Text | References | PDF (1 MB) | EPUB
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Article
Clinical descriptive analysis of severe Pneumocystis jirovecii pneumonia in renal transplantation recipients
Dan Xie, Wen Xu, Jingya You, Xiaofeng Yuan, Mingliang Li, Xiaogang Bi, Kouxing Zhang, Heng Li & Ying Xian
Pages: 1264-1272
Published online: 25 Apr 2021
AbstractforClinical descriptive analysis of severe Pneumocystis jirovecii pneumonia in renal transplantation recipients | Full Text | References | PDF (1.1 MB) | EPUB
  • 2686 Views
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Article
The screening of immune-related biomarkers for prognosis of lung adenocarcinoma
Zhonghui Liu, Dan Sun, Qing Zhu & Xinmin Liu
Pages: 1273-1285
Published online: 17 Apr 2021
AbstractforThe screening of immune-related biomarkers for prognosis of lung adenocarcinoma | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Discovering the mechanism and involvement of the methylation of cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and its special locus region in gastric cancer
Jiye Xu, Ning Li, Wenying Deng & Suxia Luo
Pages: 1286-1298
Published online: 26 Apr 2021
AbstractforDiscovering the mechanism and involvement of the methylation of cyclin-dependent kinase inhibitor 2A (CDKN2A) gene and its special locus region in gastric cancer | Full Text | References | PDF (3.4 MB) | EPUB
  • 1920 Views
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Article
Overexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration
Qizhi Li, Jiang Liang, Shuai Zhang, Ning an, Lingfeng Xu & Changhong Ye
Pages: 1299-1310
Published online: 27 Apr 2021
AbstractforOverexpression of centromere protein K (CENPK) gene in Differentiated Thyroid Carcinoma promote cell Proliferation and Migration | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Neuronal pentraxin II (NPTX2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway
Guofeng Xu, Linfeng Fan, Shufeng Zhao & Canhui OuYang
Pages: 1311-1323
Published online: 25 Apr 2021
AbstractforNeuronal pentraxin II (NPTX2) hypermethylation promotes cell proliferation but inhibits cell cycle arrest and apoptosis in gastric cancer cells by suppressing the p53 signaling pathway | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Protective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms
Junping Guo, Wei Chen, Beibei Bao, Dayong Zhang, Jianping Pan & Mao Zhang
Pages: 1324-1337
Published online: 25 Apr 2021
AbstractforProtective effect of berberine against LPS-induced endothelial cell injury via the JNK signaling pathway and autophagic mechanisms | Full Text | References | PDF (5.8 MB) | EPUB
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Article
Screening differentially expressed proteins of coronary heart disease with congenital cold syndrome based on tandem mass tag (TMT) technology
Tingting Xie, Jiajuan Guo, Yanshu Jiang, Lijie Li, Lihong Jiang & Yan Wei
Pages: 1338-1350
Published online: 27 Apr 2021
AbstractforScreening differentially expressed proteins of coronary heart disease with congenital cold syndrome based on tandem mass tag (TMT) technology | Full Text | References | PDF (1.9 MB) | EPUB
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Research Article

Article
Effects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2)
Yan-ping Dai & Xiao-qin Gao
Pages: 1351-1359
Published online: 27 Apr 2021
AbstractforEffects of silencing epididymal vascular endothelial growth factor (VEGF) expression on hyaluronidase (HYD) activity in arsenic poisoning rats through downregulating VEGF receptor 2 (VEGFR2) | Full Text | References | PDF (1.3 MB) | EPUB
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Research Paper

Article
AGEs/RAGE blockade downregulates Endothenin-1 (ET-1), mitigating Human Umbilical Vein Endothelial Cells (HUVEC) injury in deep vein thrombosis (DVT)
Yunxin Zhang, Jianlong Liu, Wei Jia, Xuan Tian, Peng Jiang, Zhiyuan Cheng & Jinyong Li
Pages: 1360-1368
Published online: 25 Apr 2021
AbstractforAGEs/RAGE blockade downregulates Endothenin-1 (ET-1), mitigating Human Umbilical Vein Endothelial Cells (HUVEC) injury in deep vein thrombosis (DVT) | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Predicting candidate therapeutic drugs for sepsis-induced acute respiratory distress syndrome based on transcriptome profiling
Jiawei Ma, Qianqian Li, Dandan Ji, Liang Luo & Lei Hong
Pages: 1369-1380
Published online: 27 Apr 2021
AbstractforPredicting candidate therapeutic drugs for sepsis-induced acute respiratory distress syndrome based on transcriptome profiling | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis
Qin Gao, Qilin Liu & Hongfei Chen
Pages: 1381-1390
Published online: 25 Apr 2021
AbstractforCircular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Rab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide
Kai Yang & Zhi Wang
Pages: 1391-1402
Published online: 27 Apr 2021
AbstractforRab18 interacted with V-set and immunoglobulin domain-containing 4 (VSIG4) to involve in the apoptosis of glioma and the sensitivity to temozolomide | Full Text | References | PDF (4.1 MB) | EPUB
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Article
REDD1 (regulated in development and DNA damage-1)/autophagy inhibition ameliorates fine particulate matter (PM2.5) -induced inflammation and apoptosis in BEAS-2B cells
Yan Li, Xiaoxiao Xu, Liyan Wang, Xuemei Li, Running Liu, Li Zhang & Yali Xu
Pages: 1403-1414
Published online: 29 Apr 2021
AbstractforREDD1 (regulated in development and DNA damage-1)/autophagy inhibition ameliorates fine particulate matter (PM2.5) -induced inflammation and apoptosis in BEAS-2B cells | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Fus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-β1/Smad pathway
Guoqiang Wang, Hong Wu, Peng Liang, Xiaojiao He & Dong Liu
Pages: 1415-1425
Published online: 25 Apr 2021
AbstractforFus knockdown inhibits the profibrogenic effect of cardiac fibroblasts induced by angiotensin II through targeting Pax3 thereby regulating TGF-β1/Smad pathway | Full Text | References | PDF (3.2 MB) | EPUB
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Article
The interaction of miR-181a-5p and sirtuin 1 regulated human bone marrow mesenchymal stem cells differentiation and apoptosis
Haitao Zhu, Hua Chen, DeGang Ding, Shui Wang, XiaoFeng Dai & YuLong Zhu
Pages: 1426-1435
Published online: 27 Apr 2021
AbstractforThe interaction of miR-181a-5p and sirtuin 1 regulated human bone marrow mesenchymal stem cells differentiation and apoptosis | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Effect of sodium butyrate regulating IRAK1 (interleukin-1 receptor-associated kinase 1) on visceral hypersensitivity in irritable bowel syndrome and its mechanism
Yuqin He, Yan Tan, Jianru Zhu, Xiaofeng Wu, Zhiyong Huang, Hengsheng Chen, Min Yang & Dongfeng Chen
Pages: 1436-1444
Published online: 27 Apr 2021
AbstractforEffect of sodium butyrate regulating IRAK1 (interleukin-1 receptor-associated kinase 1) on visceral hypersensitivity in irritable bowel syndrome and its mechanism | Full Text | References | PDF (716 KB) | EPUB
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Article
Long non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1β-induced inflammation via regulating miR-138-5p/SIRT1
Jianming Shi, Fuyang Cao, Yingjian Chang, Chaofei Xin, Xu Jiang, Jianzhong Xu & Shitao Lu
Pages: 1445-1456
Published online: 04 May 2021
AbstractforLong non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1β-induced inflammation via regulating miR-138-5p/SIRT1 | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Analysis of mRNA‑lncRNA and mRNA‑lncRNA-pathway co‑expression networks based on WGCNA in developing pediatric sepsis
Xiaojuan Zhang, Yuqing Cui, Xianfei Ding, Shaohua Liu, Bing Han, Xiaoguang Duan, Haibo Zhang & Tongwen Sun
Pages: 1457-1470
Published online: 05 May 2021
AbstractforAnalysis of mRNA‑lncRNA and mRNA‑lncRNA-pathway co‑expression networks based on WGCNA in developing pediatric sepsis | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Functional identification of a rare vascular endothelial growth factor a (VEGFA) variant associating with the nonsyndromic cleft lip with/without cleft palate
Bohui Sun, Yangjia Liu, Wenbin Huang, Qian Zhang, Jiuxiang Lin, Weiran Li, Jieni Zhang & Feng Chen
Pages: 1471-1483
Published online: 05 May 2021
AbstractforFunctional identification of a rare vascular endothelial growth factor a (VEGFA) variant associating with the nonsyndromic cleft lip with/without cleft palate | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis
Yujuan Wang, Huafeng Zong & Haicheng Zhou
Pages: 1484-1494
Published online: 29 Apr 2021
AbstractforCircular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis | Full Text | References | PDF (2.5 MB) | EPUB
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Review

Review
The role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer
Song Wan, Xuan Liu, Wei Hua, Ming Xi, Yulin Zhou & Yueping Wan
Pages: 1495-1504
Published online: 02 May 2021
AbstractforThe role of telomerase reverse transcriptase (TERT) promoter mutations in prognosis in bladder cancer | Full Text | References | PDF (1.9 MB) | EPUB
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Research Article

Article
Cisatracurium inhibits the growth and induces apoptosis of ovarian cancer cells by promoting lincRNA-p21
Dezhang Zhu, Caifeng Shi, Yanan Jiang, Kongjuan Zhu, Xiangzhen Wang & Wei Feng
Pages: 1505-1516
Published online: 04 May 2021
AbstractforCisatracurium inhibits the growth and induces apoptosis of ovarian cancer cells by promoting lincRNA-p21 | Full Text | References | PDF (2.9 MB) | EPUB
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Research Paper

Article
Downregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest
Keying Liu, Biyun Xue, Guiqin Bai & Wentao Zhang
Pages: 1517-1529
Published online: 29 Apr 2021
AbstractforDownregulation of Diacylglycerol kinase zeta (DGKZ) suppresses tumorigenesis and progression of cervical cancer by facilitating cell apoptosis and cell cycle arrest | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression
Xiaoyue Ren, Alex Li, Edward Ying, Jhin Fang, Mingzhu Li & Jiao Yu
Pages: 1530-1542
Published online: 03 May 2021
AbstractforUpregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression | Full Text | References | PDF (2.4 MB) | EPUB
  • 1786 Views
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Article
LncRNA AFAP-AS1 promotes anaplastic thyroid cancer progression by sponging miR-155-5p through ETS1/ERK pathway
MingLiang Ning, Shaojie Qin, Jia Tian, Yuchen Wang & Qingyuan Liu
Pages: 1543-1554
Published online: 17 May 2021
AbstractforLncRNA AFAP-AS1 promotes anaplastic thyroid cancer progression by sponging miR-155-5p through ETS1/ERK pathway | Full Text | References | PDF (5 MB) | EPUB
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Article
Identification and immunoprofiling of key prognostic genes in the tumor microenvironment of hepatocellular carcinoma
Tianbing Wang, Bang Chen, Tao Meng, Zhiqiang Liu & Wenyong Wu
Pages: 1555-1575
Published online: 06 May 2021
AbstractforIdentification and immunoprofiling of key prognostic genes in the tumor microenvironment of hepatocellular carcinoma | Full Text | References | PDF (13.4 MB) | EPUB
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Article
MIR205 host gene (MIR205HG) drives osteosarcoma metastasis via regulating the microRNA 2114-3p (miR-2114-3p)/twist family bHLH transcription factor 2 (TWIST2) axis
Xin Wang, Xiaojie Yu, Xiongwu Long & Qianqian Pu
Pages: 1576-1586
Published online: 05 May 2021
AbstractforMIR205 host gene (MIR205HG) drives osteosarcoma metastasis via regulating the microRNA 2114-3p (miR-2114-3p)/twist family bHLH transcription factor 2 (TWIST2) axis | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Long non-coding RNA XIST promotes retinoblastoma cell proliferation, migration, and invasion by modulating microRNA-191-5p/brain derived neurotrophic factor
Yifan Xu, Zheng Fu, Xuexia Gao, Ruifeng Wang & Qiuming Li
Pages: 1587-1598
Published online: 04 May 2021
AbstractforLong non-coding RNA XIST promotes retinoblastoma cell proliferation, migration, and invasion by modulating microRNA-191-5p/brain derived neurotrophic factor | Full Text | References | PDF (2.4 MB) | EPUB
  • 1647 Views
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Article
Long noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1
Weifang Song, Zhang Wenhui, Yao Ruiqiang, Xinli Hu, Ting Shi, Meijiao Wang & Haijuan Zhang
Pages: 1599-1610
Published online: 06 May 2021
AbstractforLong noncoding RNA PP7080 promotes hepatocellular carcinoma development by sponging mir-601 and targeting SIRT1 | Full Text | References | PDF (2.3 MB) | EPUB
  • 1828 Views
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Article
MicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma
Hui Liu, Zuofei Chi, Hong Jin & Wei Yang
Pages: 1611-1626
Published online: 04 May 2021
AbstractforMicroRNA miR-188-5p as a mediator of long non-coding RNA MALAT1 regulates cell proliferation and apoptosis in multiple myeloma | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Down-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinoma
He-Qing Huang, Gang Chen, Dan-Dan Xiong, Ze-Feng Lai, Li-Min Liu, Ye-Ying Fang, Jin-Hai Shen, Xiang-Yu Gan, Liu-Feng Liao & Yi-Wu Dang
Pages: 1627-1641
Published online: 05 May 2021
AbstractforDown-regulation of microRNA-125b-2-3p is a risk factor for a poor prognosis in hepatocellular carcinoma | Full Text | References | PDF (3.4 MB) | EPUB
  • 1898 Views
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Article
A genomic instability-derived risk index predicts clinical outcome and immunotherapy response for clear cell renal cell carcinoma
Sha Wu & Xiaoning Li
Pages: 1642-1662
Published online: 06 May 2021
AbstractforA genomic instability-derived risk index predicts clinical outcome and immunotherapy response for clear cell renal cell carcinoma | Full Text | References | PDF (8.3 MB) | EPUB
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Article
Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis
Yan Yang, Chun Xiao, Kang Liu, Liping Song, Yonggang Zhang & Birong Dong
Pages: 1663-1675
Published online: 12 May 2021
AbstractforSilencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis | Full Text | References | PDF (4.1 MB) | EPUB
  • 1781 Views
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Article
Identification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer
Rong Liao, Qi-Zhi Ma, Cong-Ya Zhou, Jun-Jun Li, Ning-Na Weng, Yang Yang & Qing Zhu
Pages: 1676-1688
Published online: 07 May 2021
AbstractforIdentification of biomarkers related to Tumor-Infiltrating Lymphocytes (TILs) infiltration with gene co-expression network in colorectal cancer | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Relationship between hepatocellular carcinoma and depression via online database analysis
Tiantian Han, Yingchun Zhou & Danhua Li
Pages: 1689-1697
Published online: 07 May 2021
AbstractforRelationship between hepatocellular carcinoma and depression via online database analysis | Full Text | References | PDF (1.8 MB) | EPUB
  • 2297 Views
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Retraction

Retraction
Statement of Retraction: Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression
Page: 1698
Published online: 13 May 2021
CitationforStatement of Retraction: Upregulation of oxidative stress-responsive 1(OXSR1) predicts poor prognosis and promotes hepatocellular carcinoma progression | Full Text | PDF (148.5 KB) | EPUB
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Research Paper

Article
Baicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis
Fucheng Zhao, Zhenxia Zhao, Yanru Han, Sujuan Li, Caili Liu & Kui Jia
Pages: 1699-1707
Published online: 06 May 2021
AbstractforBaicalin suppresses lung cancer growth phenotypes via miR-340-5p/NET1 axis | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Comprehensive analysis of N6-methyladenosine -related long non-coding RNAs and immune cell infiltration in hepatocellular carcinoma
Zhong Lin Yu & Zheng Ming Zhu
Pages: 1708-1724
Published online: 06 May 2021
AbstractforComprehensive analysis of N6-methyladenosine -related long non-coding RNAs and immune cell infiltration in hepatocellular carcinoma | Full Text | References | PDF (5.7 MB) | EPUB
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Article
Prediction of bladder cancer outcome by identifying and validating a mutation-derived genomic instability-associated long noncoding RNA (lncRNA) signature
Hao Wu, Zi-Yi Zhang, Ze Zhang, Xin-Ying Xiao, Sheng-Lin Gao, Chao Lu, Li Zuo & Li-Feng Zhang
Pages: 1725-1738
Published online: 06 May 2021
AbstractforPrediction of bladder cancer outcome by identifying and validating a mutation-derived genomic instability-associated long noncoding RNA (lncRNA) signature | Full Text | References | PDF (2.9 MB) | EPUB
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Article
A novel circular RNA (hsa_circ_0059930)-mediated miRNA–mRNA axis in the lipopolysaccharide-induced acute lung injury model of MRC-5 cells
Jianhua Han, Shigeng Li, Yawei Feng, Yufeng He, Weilong Hong & Zhiqiang Ye
Pages: 1739-1751
Published online: 18 May 2021
AbstractforA novel circular RNA (hsa_circ_0059930)-mediated miRNA–mRNA axis in the lipopolysaccharide-induced acute lung injury model of MRC-5 cells | Full Text | References | PDF (2.7 MB) | EPUB
  • 1765 Views
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Article
Construction and validation of nomograms for predicting the prognosis of grade 3 endometrial endometrioid adenocarcinoma cancers: a SEER-based study
Xiaofei Liu, Junbo Zhao, Zhiwei Sun & Guangwei Wang
Pages: 1752-1765
Published online: 11 May 2021
AbstractforConstruction and validation of nomograms for predicting the prognosis of grade 3 endometrial endometrioid adenocarcinoma cancers: a SEER-based study | Full Text | References | PDF (3.8 MB) | EPUB
  • 2058 Views
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Article
Meis homeobox 2 (MEIS2) inhibits the proliferation and promotes apoptosis of thyroid cancer cell and through the NF-κB signaling pathway
Xiaohui Wen, Mingyu Liu, Jingyan Du & Xun Wang
Pages: 1766-1772
Published online: 11 May 2021
AbstractforMeis homeobox 2 (MEIS2) inhibits the proliferation and promotes apoptosis of thyroid cancer cell and through the NF-κB signaling pathway | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Potential prognostic biomarkers related to immunity in clear cell renal cell carcinoma using bioinformatic strategy
Zhenfei Xiang, Erdong Shen, Mingyao Li, Danfei Hu, Zhanchun Zhang & Senquan Yu
Pages: 1773-1790
Published online: 18 May 2021
AbstractforPotential prognostic biomarkers related to immunity in clear cell renal cell carcinoma using bioinformatic strategy | Full Text | References | PDF (8.4 MB) | EPUB
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Article
Long non-coding RNA LINC00649 regulates YES-associated protein 1 (YAP1)/Hippo pathway to accelerate gastric cancer (GC) progression via sequestering miR-16-5p
Hongyan Wang, Xin Di, Yingjie Bi, Shidong Sun & Tao Wang
Pages: 1791-1802
Published online: 11 May 2021
AbstractforLong non-coding RNA LINC00649 regulates YES-associated protein 1 (YAP1)/Hippo pathway to accelerate gastric cancer (GC) progression via sequestering miR-16-5p | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Prediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature
Yu Yang, Xuan Long, Guiyun Li, Xiaohong Yu, Yu Liu, Kun Li & Xiaobin Tian
Pages: 1803-1812
Published online: 28 May 2021
AbstractforPrediction of clinical prognosis in cutaneous melanoma using an immune-related gene pair signature | Full Text | References | PDF (2.1 MB) | EPUB
  • 1869 Views
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Article
A novel ferroptosis-related gene signature for predicting outcomes in cervical cancer
Xingling Qi, Yipeng Fu, Jia Sheng, Meng Zhang, Mingxing Zhang, Yumeng Wang & Guiling Li
Pages: 1813-1825
Published online: 14 May 2021
AbstractforA novel ferroptosis-related gene signature for predicting outcomes in cervical cancer | Full Text | References | PDF (2.4 MB) | EPUB
  • 3628 Views
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Article
Ivabradine protects rats against myocardial infarction through reinforcing autophagy via inhibiting PI3K/AKT/mTOR/p70S6K pathway
Yingnan Dai, Yeping Chen, Guoqian Wei, Li Zha & Xueqi Li
Pages: 1826-1837
Published online: 11 May 2021
AbstractforIvabradine protects rats against myocardial infarction through reinforcing autophagy via inhibiting PI3K/AKT/mTOR/p70S6K pathway | Full Text | References | PDF (1.9 MB) | EPUB
  • 2286 Views
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Article
Circulating microRNA profile unveils mechanisms of action of acitretin for psoriasis vulgaris
Lin Chen, Jie Li, Ying Yao, Shanlong Wang, Shuangjin Zheng, Xinggang Ju & Bin Zhang
Pages: 1838-1850
Published online: 11 May 2021
AbstractforCirculating microRNA profile unveils mechanisms of action of acitretin for psoriasis vulgaris | Full Text | References | PDF (2.6 MB) | EPUB
  • 1840 Views
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Article
Long noncoding RNA MST1P2 promotes cervical cancer progression by sponging with microRNA miR-133b
Rongrong Xu, Xiaoyue Zhang, Yan Xu, Junqin Wang, Zhihui Li & Xiaoming Cui
Pages: 1851-1860
Published online: 25 May 2021
AbstractforLong noncoding RNA MST1P2 promotes cervical cancer progression by sponging with microRNA miR-133b | Full Text | References | PDF (2.5 MB) | EPUB
  • 1810 Views
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Article
δ-tocotrienol suppresses the migration and angiogenesis of trophoblasts in preeclampsia and promotes their apoptosis via miR-429/ ZEB1 axis
Mei Shi, Xiuyun Chen, Hui Li & Lixia Zheng
Pages: 1861-1873
Published online: 18 May 2021
Abstractforδ-tocotrienol suppresses the migration and angiogenesis of trophoblasts in preeclampsia and promotes their apoptosis via miR-429/ ZEB1 axis | Full Text | References | PDF (2.2 MB) | EPUB
  • 1657 Views
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Article
Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin
Yan Wang, Zhiqiang Cheng, Jing Xu, Meina Lai, Liming Liu, Min Zuo & Lin Dang
Pages: 1874-1889
Published online: 02 Jun 2021
AbstractforFat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin | Full Text | References | PDF (5.2 MB) | EPUB
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Article
Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA -140-3p
Chanchan Gao, Yazhou Wen, Feng Jiang, Xuyu Gu & Xinhua Zhu
Pages: 1890-1901
Published online: 18 May 2021
AbstractforCircular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA -140-3p | Full Text | References | PDF (2.2 MB) | EPUB
  • 1704 Views
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Article
Inhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1
Wenliang Song, Tiening Zhang, Ni Yang, Tao Zhang, Ri Wen & Chunfeng Liu
Pages: 1902-1915
Published online: 18 May 2021
AbstractforInhibition of micro RNA miR-122-5p prevents lipopolysaccharide-induced myocardial injury by inhibiting oxidative stress, inflammation and apoptosis via targeting GIT1 | Full Text | References | PDF (3.3 MB) | EPUB
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Article
MicroRNA miR-146a-5p inhibits the inflammatory response and injury of airway epithelial cells via targeting TNF receptor-associated factor 6
Fang Yan, Dilinuer Wufuer, Jianbing Ding & Jing Wang
Pages: 1916-1926
Published online: 18 May 2021
AbstractforMicroRNA miR-146a-5p inhibits the inflammatory response and injury of airway epithelial cells via targeting TNF receptor-associated factor 6 | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Long non-coding RNA AL139002.1 promotes gastric cancer development by sponging microRNA-490-3p to regulate Hepatitis A Virus Cellular Receptor 1 expression
Yurong Chen & Renchao Zhang
Pages: 1927-1938
Published online: 18 May 2021
AbstractforLong non-coding RNA AL139002.1 promotes gastric cancer development by sponging microRNA-490-3p to regulate Hepatitis A Virus Cellular Receptor 1 expression | Full Text | References | PDF (4 MB) | EPUB
  • 1859 Views
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Article
Toll-like receptor 2 (TLR2) is a candidate prognostic factor in testicular germ cell tumors as well as an indicator of immune function in the tumor microenvironment
Hao Wu, Ze Zhang, Xin-Ying Xiao, Zi-Yi Zhang, Sheng-Lin Gao, Chao Lu, Li Zuo & Li-Feng Zhang
Pages: 1939-1951
Published online: 18 May 2021
AbstractforToll-like receptor 2 (TLR2) is a candidate prognostic factor in testicular germ cell tumors as well as an indicator of immune function in the tumor microenvironment | Full Text | References | PDF (2.9 MB) | EPUB
  • 1957 Views
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Article
Circular RNA_0062582 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via regulation of microRNA-145/CBFB axis
Feng Li, Hao Wu, Guoyou Zou, Dingwei Cang & Yixin Shen
Pages: 1952-1963
Published online: 23 May 2021
AbstractforCircular RNA_0062582 promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via regulation of microRNA-145/CBFB axis | Full Text | References | PDF (3.2 MB) | EPUB
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Homeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression
Danyan Chen, Zhaonan Shen, Xi Cheng, Qi Wang, Junlin Zhou, Fang Ren, Yue Sun, Hongman Wang & Rongxi Huang
Pages: 1964-1975
Published online: 23 May 2021
AbstractforHomeobox A5 activates p53 pathway to inhibit proliferation and promote apoptosis of adrenocortical carcinoma cells by inducing Aldo-Keto reductase family 1 member B10 expression | Full Text | References | PDF (4.4 MB) | EPUB
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Review
The prevalence and risk factors of acute kidney injury in patients undergoing hip fracture surgery: a meta-analysis
Zi-Cai Li, Yan-Chuan Pu, Jin Wang, Hu-Lin Wang & Yan-Li Zhang
Pages: 1976-1985
Published online: 26 May 2021
AbstractforThe prevalence and risk factors of acute kidney injury in patients undergoing hip fracture surgery: a meta-analysis | Full Text | References | PDF (762.4 KB) | EPUB
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Human umbilical cord–derived mesenchymal stem cells improve chronic pancreatitis in rats via the AKT-mTOR-S6K1 signaling pathway
Lijun Kong, Xiangxiang Xu, Hewei Zhang, Yi Zhou, Hongjian Huang, Bicheng Chen & Zhenxu Zhou
Pages: 1986-1996
Published online: 28 May 2021
AbstractforHuman umbilical cord–derived mesenchymal stem cells improve chronic pancreatitis in rats via the AKT-mTOR-S6K1 signaling pathway | Full Text | References | PDF (1.9 MB) | EPUB
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Parathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase
Di Liu, Juan Du, Jing Sun & Minqi Li
Pages: 1997-2006
Published online: 23 May 2021
AbstractforParathyroid hormone-related protein inhibits nitrogen-containing bisphosphonate-induced apoptosis of human periodontal ligament fibroblasts by activating MKP1 phosphatase | Full Text | References | PDF (1.5 MB) | EPUB
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A novel classification method of lymph node metastasis in colorectal cancer
Jin Li, Peng Wang, Yang Zhou, Hong Liang, Yang Lu & Kuan Luan
Pages: 2007-2021
Published online: 23 May 2021
AbstractforA novel classification method of lymph node metastasis in colorectal cancer | Full Text | References | PDF (1.8 MB) | EPUB
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Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis
Xianliao Zhang, Zhengbo Hu, Wenhu Li, Zhongxun Liu, Jie Li, Zhaozhen Wang, Vidmi Taolam Martin, Bing Yan & Bo Yu
Pages: 2022-2032
Published online: 01 Jun 2021
AbstractforCircular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis | Full Text | References | PDF (2.6 MB) | EPUB
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MicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2)
Huang Jinghua, Zhou Qinghua, Chen Chenchen, Chen Lili, Xu Xiao, Wang Yunfei, An Zhengzhe, Lin Changxiu & Han Hui
Pages: 2033-2044
Published online: 03 Jun 2021
AbstractforMicroRNA miR-92a-3p regulates breast cancer cell proliferation and metastasis via regulating B-cell translocation gene 2 (BTG2) | Full Text | References | PDF (3.6 MB) | EPUB
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MicroRNA miR-425 promotes tumor progression by inhibiting Dickkopf-related protein-3 in gastric cancer
Yihua Pei, Zhiteng Tang, Minjing Cai, Qin Yao & Bozhen Xie
Pages: 2045-2054
Published online: 14 Jun 2021
AbstractforMicroRNA miR-425 promotes tumor progression by inhibiting Dickkopf-related protein-3 in gastric cancer | Full Text | References | PDF (2.8 MB) | EPUB
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Identification of the key genes and pathways involved in B cells in primary Sjögren’ s syndrome
Shizhen Lei & Yi Zhang
Pages: 2055-2073
Published online: 26 May 2021
AbstractforIdentification of the key genes and pathways involved in B cells in primary Sjögren’ s syndrome | Full Text | References | PDF (7.3 MB) | EPUB
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Review
Roles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis
Yuan Zhang, Xiaorong Chen, Yajuan Cao & Zongguo Yang
Pages: 2074-2086
Published online: 27 May 2021
AbstractforRoles of APOBEC3 in hepatitis B virus (HBV) infection and hepatocarcinogenesis | Full Text | References | PDF (913.5 KB) | EPUB
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Insulin reverses choriocarcinoma 5- fluorouracil resistance
Ying Shan, Yanyi Li, Hongyu Han, Cui Jiang, Hu Zhang, Jiachang Hu, Huanmei Sun & Jianglong Zhu
Pages: 2087-2094
Published online: 26 May 2021
AbstractforInsulin reverses choriocarcinoma 5- fluorouracil resistance | Full Text | References | PDF (2.1 MB) | EPUB
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Establishing functional lentiviral vector production in a stirred bioreactor for CAR-T cell therapy
Qu-Lai Tang, Li-Xing Gu, Yao Xu, Xing-Hua Liao, Yong Zhou & Tong-Cun Zhang
Pages: 2095-2105
Published online: 28 May 2021
AbstractforEstablishing functional lentiviral vector production in a stirred bioreactor for CAR-T cell therapy | Full Text | References | PDF (2.1 MB) | EPUB
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Circular RNA circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis
Dexiang Zhou, Xiaofeng Lin, Peng Wang, Yong Yang, Jiantao Zheng & Dong Zhou
Pages: 2106-2118
Published online: 30 May 2021
AbstractforCircular RNA circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis | Full Text | References | PDF (2.4 MB) | EPUB
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Long non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP)
Chengwu Tang, Wenming Feng, Ying Bao & Huimin Du
Pages: 2119-2131
Published online: 30 May 2021
AbstractforLong non-coding RNA TINCR promotes hepatocellular carcinoma proliferation and invasion via STAT3 signaling by direct interacting with T-cell protein tyrosine phosphatase (TCPTP) | Full Text | References | PDF (2.5 MB) | EPUB
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Interleukin IL-5 alleviates sepsis-induced acute lung injury by regulating the immune response in rats
Beichun Wei, Yu Chen, Wangmei Zhou, Xu Li, Lei Shi & Shengwu Liao
Pages: 2132-2139
Published online: 30 May 2021
AbstractforInterleukin IL-5 alleviates sepsis-induced acute lung injury by regulating the immune response in rats | Full Text | References | PDF (2.2 MB) | EPUB
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Identification of significant genes and therapeutic agents for breast cancer by integrated genomics
Xiao Sun, Zhenzhen Luo, Liuyun Gong, Xinyue Tan, Jie Chen, Xin Liang & Mengjiao Cai
Pages: 2140-2154
Published online: 21 Jun 2021
AbstractforIdentification of significant genes and therapeutic agents for breast cancer by integrated genomics | Full Text | References | PDF (3.7 MB) | EPUB
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Influence of different incision designs on bone increment of guided bone regeneration (Bio-Gide collagen membrane +Bio-OSS bone powder) during the same period of maxillary anterior tooth implantation
Genying Zhuang, Jianshui Mao, Guoli Yang & Huiming Wang
Pages: 2155-2163
Published online: 30 May 2021
AbstractforInfluence of different incision designs on bone increment of guided bone regeneration (Bio-Gide collagen membrane +Bio-OSS bone powder) during the same period of maxillary anterior tooth implantation | Full Text | References | PDF (464.7 KB) | EPUB
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Oral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation
Shuqi He, Wu Zhang, Xian Li, Junjie Wang, Xufeng Chen, Yu Chen & Renfa Lai
Pages: 2164-2174
Published online: 08 Jun 2021
AbstractforOral squamous cell carcinoma (OSCC)-derived exosomal MiR-221 targets and regulates phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1) to promote human umbilical vein endothelial cells migration and tube formation | Full Text | References | PDF (2.2 MB) | EPUB
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Human/eukaryotic ribosomal protein L14 (RPL14/eL14) overexpression represses proliferation, migration, invasion and EMT process in nasopharyngeal carcinoma
Zunni Zhang, Yalong Zhang, Yuling Qiu, Wuning Mo & Zheng Yang
Pages: 2175-2186
Published online: 30 May 2021
AbstractforHuman/eukaryotic ribosomal protein L14 (RPL14/eL14) overexpression represses proliferation, migration, invasion and EMT process in nasopharyngeal carcinoma | Full Text | References | PDF (2.7 MB) | EPUB
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The association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis
Chongyang Ma, Kai Yan, Zisong Wang, Qiuyun Zhang, Lianyin Gao, Tian Xu, Jiayang Sai, Fafeng Cheng & Yuqiong Du
Pages: 2187-2202
Published online: 06 Jun 2021
AbstractforThe association between hypertension and nonalcoholic fatty liver disease (NAFLD): literature evidence and systems biology analysis | Full Text | References | PDF (2.1 MB) | EPUB
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MicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway
Xinyue Zhou, Zhenyu Chen, Lipeng Pei & Jingli Sun
Pages: 2203-2213
Published online: 04 Jun 2021
AbstractforMicroRNA miR-106a-5p targets forkhead box transcription factor FOXC1 to suppress the cell proliferation, migration, and invasion of ectopic endometrial stromal cells via the PI3K/Akt/mTOR signaling pathway | Full Text | References | PDF (2.8 MB) | EPUB
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Identification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies
Jiayu Zhang, Rongguo Yu, Xiaoyu Guo, Yuanxia Zou, Sixuan Chen, Kai Zhou, Yi Chen, YongRong Li, Su Gao & Yifei Wu
Pages: 2214-2227
Published online: 09 Jun 2021
AbstractforIdentification of TYR, TYRP1, DCT and LARP7 as related biomarkers and immune infiltration characteristics of vitiligo via comprehensive strategies | Full Text | References | PDF (3.5 MB) | EPUB
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Long non-coding RNA histone deacetylase 4 antisense RNA 1 (HDAC4-AS1) inhibits HDAC4 expression in human ARPE-19 cells with hypoxic stress
Jie Pan & Luxin Zhao
Pages: 2228-2237
Published online: 30 May 2021
AbstractforLong non-coding RNA histone deacetylase 4 antisense RNA 1 (HDAC4-AS1) inhibits HDAC4 expression in human ARPE-19 cells with hypoxic stress | Full Text | References | PDF (1.6 MB) | EPUB
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Utilizing network pharmacology to explore potential mechanisms of YiSui NongJian formula in treating myelodysplastic syndrome
Lerong Qin, Haiyan Chen, Xiaoqing Ding, Ming Guo, Haiyan Lang, Junxia Liu, Ling Li, Jing Liao & Junyao Liao
Pages: 2238-2252
Published online: 08 Jun 2021
AbstractforUtilizing network pharmacology to explore potential mechanisms of YiSui NongJian formula in treating myelodysplastic syndrome | Full Text | References | PDF (13.5 MB) | EPUB
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Resveratrol acts via melanoma-associated antigen A12 (MAGEA12)/protein kinase B (Akt) signaling to inhibit the proliferation of oral squamous cell carcinoma cells
Yu Shang, Yu-Ling Jiang, Li-Jun Ye, Li-Na Chen & Yue Ke
Pages: 2253-2262
Published online: 04 Jun 2021
AbstractforResveratrol acts via melanoma-associated antigen A12 (MAGEA12)/protein kinase B (Akt) signaling to inhibit the proliferation of oral squamous cell carcinoma cells | Full Text | References | PDF (2.1 MB) | EPUB
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MicroRNA miR-509-3p inhibit metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma
Huiming Zhang, Shuang Liu, Liqiang Chen, Yanliang Sheng, Wenzhe Luo & Gang Zhao
Pages: 2263-2273
Published online: 11 Jun 2021
AbstractforMicroRNA miR-509-3p inhibit metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma | Full Text | References | PDF (2.4 MB) | EPUB
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Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular docking
Zhao Tianyu & Guan Liying
Pages: 2274-2287
Published online: 02 Jun 2021
AbstractforIdentifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network pharmacology and molecular docking | Full Text | References | PDF (2.6 MB) | EPUB
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Assessment of clinical variables as predictive markers in the development and progression of colorectal cancer
Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul Ain, Rabia Rasool, Muhammad Asif, Nisreen Anfinan, Absarul Haque, Hina Alam, Sagheer Ahmed & Mohammad Hamid Hamdard
Pages: 2288-2298
Published online: 06 Jun 2021
AbstractforAssessment of clinical variables as predictive markers in the development and progression of colorectal cancer | Full Text | References | PDF (992.3 KB) | EPUB
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SP1-induced lncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) aggravates glioma progression via the miR-515-5p/Superoxide dismutase 2 (SOD2) axis
Yaxuan Zhang, Yin Zhang, Sen Wang, Qingquan Li, Boqiang Cao, Baosheng Huang, Tianlu Wang, Ruijuan Guo & Ning Liu
Pages: 2299-2310
Published online: 02 Jun 2021
AbstractforSP1-induced lncRNA ZFPM2 antisense RNA 1 (ZFPM2-AS1) aggravates glioma progression via the miR-515-5p/Superoxide dismutase 2 (SOD2) axis | Full Text | References | PDF (2.3 MB) | EPUB
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A novel immune-related long non-coding RNA signature improves the prognosis prediction in the context of head and neck squamous cell carcinoma
Lin Chen, Zhimou Cai, Kexing Lyu, Zhiwei Cai & Wenbin Lei
Pages: 2311-2325
Published online: 24 Jun 2021
AbstractforA novel immune-related long non-coding RNA signature improves the prognosis prediction in the context of head and neck squamous cell carcinoma | Full Text | References | PDF (2.9 MB) | EPUB
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Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer
Hongjun Guan, Changpeng Sun, Yinfeng Gu, Jinjin Li, Jie Ji & Yongxian Zhu
Pages: 2326-2340
Published online: 02 Jun 2021
AbstractforCircular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer | Full Text | References | PDF (4.2 MB) | EPUB
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A new ferroptosis-related gene model for prognostic prediction of papillary thyroid carcinoma
Xiaoyu Qian, Jian Tang, Lin Li, Ziqiang Chen, Liang Chen & Yongquan Chu
Pages: 2341-2351
Published online: 02 Jun 2021
AbstractforA new ferroptosis-related gene model for prognostic prediction of papillary thyroid carcinoma | Full Text | References | PDF (2.4 MB) | EPUB
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Correlation and integration of circulating miRNA and peripheral whole blood gene expression profiles in patients with venous thromboembolism
Xiaonan Chen, Jun Cao, Zi Ge & Zhijie Xia
Pages: 2352-2363
Published online: 02 Jun 2021
AbstractforCorrelation and integration of circulating miRNA and peripheral whole blood gene expression profiles in patients with venous thromboembolism | Full Text | References | PDF (1.6 MB) | EPUB
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The functions of fluoxetine and identification of fluoxetine-mediated circular RNAs and messenger RNAs in cerebral ischemic stroke
Yitao He, Hui Zhang, Jian Deng, Zhili Cai, Mei Gu, Chenyong Zhao & Yi Guo
Pages: 2364-2376
Published online: 08 Jun 2021
AbstractforThe functions of fluoxetine and identification of fluoxetine-mediated circular RNAs and messenger RNAs in cerebral ischemic stroke | Full Text | References | PDF (2.2 MB) | EPUB
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Identification of biomarkers, pathways and potential therapeutic target for docetaxel resistant prostate cancer
Rui-ji Liu, Shu-ying- Li, Li-quan Liu, Bin Xu & Ming Chen
Pages: 2377-2388
Published online: 02 Jun 2021
AbstractforIdentification of biomarkers, pathways and potential therapeutic target for docetaxel resistant prostate cancer | Full Text | References | PDF (4.6 MB) | EPUB
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Integrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer
Zixue Xuan, Yiwen Zhang, Jinying Jiang, Xiaowei Zheng, Xiaoping Hu, Xiuli Yang, Yanfei Shao, Guobing Zhang & Ping Huang
Pages: 2389-2397
Published online: 21 Jun 2021
AbstractforIntegrative genomic analysis of N6-methyladenosine-single nucleotide polymorphisms (m6A-SNPs) associated with breast cancer | Full Text | References | PDF (2.4 MB) | EPUB
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Ginsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic
Zhongjian Pu, Fei Ge, Yajun Wang, Ziyu Jiang, Shilin Zhu, Shukui Qin, Qijun Dai, Hua Liu & Haiqing Hua
Pages: 2398-2409
Published online: 15 Jun 2021
AbstractforGinsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic | Full Text | References | PDF (2.1 MB) | EPUB
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MicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase
Cuihua Zhang & Dan Zhao
Pages: 2410-2419
Published online: 09 Jun 2021
AbstractforMicroRNA-362-5p promotes the proliferation and inhibits apoptosis of trophoblast cells via targeting glutathione-disulfide reductase | Full Text | References | PDF (3.5 MB) | EPUB
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Phloretin inhibited the pathogenicity and virulence factors against Candida albicans
Na Liu, Nan Zhang, Shengrong Zhang, Lifang Zhang & Qing Liu
Pages: 2420-2431
Published online: 24 Jun 2021
AbstractforPhloretin inhibited the pathogenicity and virulence factors against Candida albicans | Full Text | References | PDF (2.7 MB) | EPUB
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Development and validation of a novel N6-methyladenosine (m6A)-related multi- long non-coding RNA (lncRNA) prognostic signature in pancreatic adenocarcinoma
Qihang Yuan, Jie Ren, Lunxu Li, Shuang Li, Kailai Xiang & Dong Shang
Pages: 2432-2448
Published online: 07 Jul 2021
AbstractforDevelopment and validation of a novel N6-methyladenosine (m6A)-related multi- long non-coding RNA (lncRNA) prognostic signature in pancreatic adenocarcinoma | Full Text | References | PDF (14.7 MB) | EPUB
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MicroRNA-155 influences cell damage in ischemic stroke via TLR4/MYD88 signaling pathway
Wei Chen, Lingtong Wang & Zhaoping Liu
Pages: 2449-2458
Published online: 28 Jun 2021
AbstractforMicroRNA-155 influences cell damage in ischemic stroke via TLR4/MYD88 signaling pathway | Full Text | References | PDF (1.1 MB) | EPUB
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Pyrroloquinoline quinone (PQQ) alleviated sepsis-induced acute liver injury, inflammation, oxidative stress and cell apoptosis by downregulating CUL3 expression
Yanhong Wu, Meiling Zhao & Zhaoheng Lin
Pages: 2459-2468
Published online: 06 Jul 2021
AbstractforPyrroloquinoline quinone (PQQ) alleviated sepsis-induced acute liver injury, inflammation, oxidative stress and cell apoptosis by downregulating CUL3 expression | Full Text | References | PDF (1.4 MB) | EPUB
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Long non-coding RNA CRNDE regulates the growth and migration of prostate cancer cells by targeting microRNA-146a-5p
Dewang Fu, Li’e Zang, Zhaowei Li, Chenghui Fan, Huamao Jiang & Tongyi Men
Pages: 2469-2479
Published online: 07 Jul 2021
AbstractforLong non-coding RNA CRNDE regulates the growth and migration of prostate cancer cells by targeting microRNA-146a-5p | Full Text | References | PDF (2.1 MB) | EPUB
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Production of polyhydroxyalkanoates (PHAs) by Bacillus megaterium using food waste acidogenic fermentation-derived volatile fatty acids
Danh H. Vu, Steven Wainaina, Mohammad J. Taherzadeh, Dan Åkesson & Jorge A. Ferreira
Pages: 2480-2498
Published online: 11 Jun 2021
AbstractforProduction of polyhydroxyalkanoates (PHAs) by Bacillus megaterium using food waste acidogenic fermentation-derived volatile fatty acids | Full Text | References | PDF (2.2 MB) | EPUB
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Targeting the miR-6734-3p/ZEB2 axis hampers development of non-small cell lung cancer (NSCLC) and increases susceptibility of cancer cells to cisplatin treatment
Linying Wei & Jianyang Jiang
Pages: 2499-2510
Published online: 09 Jun 2021
AbstractforTargeting the miR-6734-3p/ZEB2 axis hampers development of non-small cell lung cancer (NSCLC) and increases susceptibility of cancer cells to cisplatin treatment | Full Text | References | PDF (2.5 MB) | EPUB
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Long non-coding RNA LOC366613 alleviates the cerebral ischemic injury via regulating the miR-532-5p/phosphatase and tensin homolog axis
Zhenze Lu, Ling Li, Lei Wei, Jifu Cai & Jun Wu
Pages: 2511-2522
Published online: 12 Jul 2021
AbstractforLong non-coding RNA LOC366613 alleviates the cerebral ischemic injury via regulating the miR-532-5p/phosphatase and tensin homolog axis | Full Text | References | PDF (2.9 MB) | EPUB
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A 16S rRNA gene sequencing based study of oral microbiota in migraine patients in China
Weiqing Jiang, Tingting Wang, Chen Liu, Mingzhu Deng, Xiao Ren, Fei Wang, Yaqing Zhang, Xueying Yu, Lingling Yao & Yonggang Wang
Pages: 2523-2533
Published online: 21 Jun 2021
AbstractforA 16S rRNA gene sequencing based study of oral microbiota in migraine patients in China | Full Text | References | PDF (7.6 MB) | EPUB
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Prognostic value of small mother against decapentaplegic expression in human gastric cancer
He-Wei Zhang, Ying Guo, Lin-xiao Sun, Fu-biao Ni & Ke Xu
Pages: 2534-2549
Published online: 17 Jun 2021
AbstractforPrognostic value of small mother against decapentaplegic expression in human gastric cancer | Full Text | References | PDF (3.8 MB) | EPUB
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MAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis
Mingmin Fu & Kai Zhang
Pages: 2550-2562
Published online: 11 Jun 2021
AbstractforMAPK interacting serine/threonine kinase 1 (MKNK1), one target gene of miR-223-3p, correlates with neutrophils in sepsis based on bioinformatic analysis | Full Text | References | PDF (3.8 MB) | EPUB
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Lysine Acetyltransferase 2B predicts favorable prognosis and functions as anti-oncogene in cervical carcinoma
Lei Li, Juntao Zhang & Shuping Cao
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Published online: 15 Jun 2021
AbstractforLysine Acetyltransferase 2B predicts favorable prognosis and functions as anti-oncogene in cervical carcinoma | Full Text | References | PDF (3.7 MB) | EPUB
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Screening of key biomarkers and immune infiltration in Pulmonary Arterial Hypertension via integrated bioinformatics analysis
Yu Zeng, Nanhong Li, Zhenzhen Zheng, Riken Chen, Wang Liu, Junfen Cheng, Jinru Zhu, Mingqing Zeng, Min Peng & Cheng Hong
Pages: 2576-2591
Published online: 07 Jul 2021
AbstractforScreening of key biomarkers and immune infiltration in Pulmonary Arterial Hypertension via integrated bioinformatics analysis | Full Text | References | PDF (3.9 MB) | EPUB
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Construction of lncRNA-related ceRNA regulatory network in diabetic subdermal endothelial cells
Jiangbo Wan & Bo Liu
Pages: 2592-2602
Published online: 14 Jun 2021
AbstractforConstruction of lncRNA-related ceRNA regulatory network in diabetic subdermal endothelial cells | Full Text | References | PDF (3.1 MB) | EPUB
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A computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells
Muhammad Mushtaq, Rizwan ul Haq, Waqas Anwar, Lisa Marshall, Maxim Bazhenov, Kashif Zia, Hina Alam, Lars Hertel, Abdul Aleem Awan & Thomas Martinetz
Pages: 2603-2615
Published online: 11 Jun 2021
AbstractforA computational study of suppression of sharp wave ripple complexes by controlling calcium and gap junctions in pyramidal cells | Full Text | References | PDF (1.7 MB) | EPUB
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Glycyrrhizic acid alleviates the meconium-induced acute lung injury in neonatal rats by inhibiting oxidative stress through mediating the Keap1/Nrf2/HO-1 signal pathway
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Pages: 2616-2626
Published online: 09 Sep 2021
AbstractforGlycyrrhizic acid alleviates the meconium-induced acute lung injury in neonatal rats by inhibiting oxidative stress through mediating the Keap1/Nrf2/HO-1 signal pathway | Full Text | References | PDF (3.5 MB) | EPUB
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Article
MicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma
Xijing Zhuang, Feng Gao, Lei Shi, Wei Liu, Wenjun Wang, Xuezhi He & Yang Gao
Pages: 2627-2638
Published online: 11 Jun 2021
AbstractforMicroRNA-146b-3p regulates the dysfunction of vascular smooth muscle cells via repressing phosphoinositide-3 kinase catalytic subunit gamma | Full Text | References | PDF (2.4 MB) | EPUB
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Article
MicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway
Anna Nong, Qingfeng Li, Zhijing Huang, Yunan Xu, Kebin He, Yuying Jia, Zhenyi Cen, Lianghua Liao & Yueyan Huang
Pages: 2639-2648
Published online: 11 Jun 2021
AbstractforMicroRNA miR-126 attenuates brain injury in septic rats via NF-κB signaling pathway | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Signatures and Prognostic Values of N6-methyladenosine (m6A) - related Immune Genes in Bladder Cancer
Gaoteng Lin, Jianwei Zhang, Yuqi Wu, Shimiao Zhu & Gang Li
Pages: 2649-2663
Published online: 11 Jun 2021
AbstractforSignatures and Prognostic Values of N6-methyladenosine (m6A) - related Immune Genes in Bladder Cancer | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Identification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma
Hao Xu, Chen Xiong, Yuan Chen, Chi Zhang & Dousheng Bai
Pages: 2664-2675
Published online: 11 Jun 2021
AbstractforIdentification of Rad51 as a prognostic biomarker correlated with immune infiltration in hepatocellular carcinoma | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis
Shan Mao, Shuning Tian, Xianghong Luo, Ming Zhou, Zheng Cao & Ji Li
Pages: 2676-2687
Published online: 11 Jun 2021
AbstractforOverexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Infiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer
Xiaowei Huang, Chan Chen, Yajing Xu, Lanxiao Shen, Yi Chen & Huafang Su
Pages: 2688-2701
Published online: 27 Jun 2021
AbstractforInfiltrating T-cell abundance combined with EMT-related gene expression as a prognostic factor of colon cancer | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Knockdown of long non-coding RNA NEAT1 relieves the inflammatory response of spinal cord injury through targeting miR-211-5p/MAPK1 axis
Qing An, Zipeng Lu, Yi Xie, Yu Li, Haixiang Wei & Yang Cao
Pages: 2702-2712
Published online: 21 Jun 2021
AbstractforKnockdown of long non-coding RNA NEAT1 relieves the inflammatory response of spinal cord injury through targeting miR-211-5p/MAPK1 axis | Full Text | References | PDF (2.4 MB) | EPUB
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Article
MicroRNA-17-5p inhibits thyroid cancer progression by suppressing Early growth response 2 (EGR2)
Xiang Geng, YangYang Sun, JinJin Fu, Liang Cao & Yuan Li
Pages: 2713-2722
Published online: 15 Jun 2021
AbstractforMicroRNA-17-5p inhibits thyroid cancer progression by suppressing Early growth response 2 (EGR2) | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Impact of Bupivacaine on malignant proliferation, apoptosis and autophagy of human colorectal cancer SW480 cells through regulating NF-κB signaling path
Bingwu Liu, Xinfeng Yan, Zuojia Hou, Lei Zhang & Duwen Zhang
Pages: 2723-2733
Published online: 21 Jun 2021
AbstractforImpact of Bupivacaine on malignant proliferation, apoptosis and autophagy of human colorectal cancer SW480 cells through regulating NF-κB signaling path | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Potential role of a three-gene signature in predicting diagnosis in patients with myocardial infarction
Yinhui Yao, Jingyi Zhao, Xiaohui Zhou, Junhui Hu & Ying Wang
Pages: 2734-2749
Published online: 15 Jun 2021
AbstractforPotential role of a three-gene signature in predicting diagnosis in patients with myocardial infarction | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Absent in melanoma 1-like (AIM1L) serves as a novel candidate for overall survival in hepatocellular carcinoma
Wenliang Zhou, Yuan Zhang, Shixi Zhang & Zongguo Yang
Pages: 2750-2762
Published online: 15 Jun 2021
AbstractforAbsent in melanoma 1-like (AIM1L) serves as a novel candidate for overall survival in hepatocellular carcinoma | Full Text | References | PDF (2.9 MB) | EPUB
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Article
The expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer
Lingyu Hu, Haokai Xu, Xiaoguang Wang, Bin Wu, Fei Chen, Wei Chen, Yong Gao & Zhengxiang Zhong
Pages: 2763-2778
Published online: 14 Jun 2021
AbstractforThe expression and clinical prognostic value of protein phosphatase 1 catalytic subunit beta in pancreatic cancer | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Trichosanthin inhibits cervical cancer by regulating oxidative stress-induced apoptosis
Chenglu Zhu, Cuilan Zhang, Xiaoming Cui, Jing Wu, Zhizhu Cui & Xiaojuan Shen
Pages: 2779-2790
Published online: 07 Jul 2021
AbstractforTrichosanthin inhibits cervical cancer by regulating oxidative stress-induced apoptosis | Full Text | References | PDF (4 MB) | EPUB
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Article
Role of sigma factor RpoS in Cronobacter sakazakii environmental stress tolerance
Jie Zhan, Jun Qiao & Xiaoyuan Wang
Pages: 2791-2809
Published online: 22 Jun 2021
AbstractforRole of sigma factor RpoS in Cronobacter sakazakii environmental stress tolerance | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Potential therapeutic target genes for systemic lupus erythematosus: a bioinformatics analysis
Yun Yu, Liang Liu, Long-Long Hu, Ling-Ling Yu, Jun-Pei Li, Jing-an Rao, Ling-Juan Zhu, Qian Liang, Rong-Wei Zhang, Hui-Hui Bao & Xiao-Shu Cheng
Pages: 2810-2819
Published online: 27 Jun 2021
AbstractforPotential therapeutic target genes for systemic lupus erythematosus: a bioinformatics analysis | Full Text | References | PDF (2 MB) | EPUB
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Article
Constructing a new prognostic signature of gastric cancer based on multiple data sets
Liqiang Zhou, Hao Lu, Fei Zeng, Qi Zhou, Shihao Li, You Wu, Yiwu Yuan & Lin Xin
Pages: 2820-2835
Published online: 23 Jun 2021
AbstractforConstructing a new prognostic signature of gastric cancer based on multiple data sets | Full Text | References | PDF (5.2 MB) | EPUB
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Article
Characteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection
Na Li, Wenpeng Gu, Caixia Lu, Xiaomei Sun, Pinfen Tong, Yuanyuan Han, Wenguang Wang & Jiejie Dai
Pages: 2836-2850
Published online: 06 Jul 2021
AbstractforCharacteristics of Angiotensin I-converting enzyme 2, type II transmembrane serine protease 2 and 4 in tree shrew indicate it as a potential animal model for SARS-CoV-2 infection | Full Text | References | PDF (4.4 MB) | EPUB
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Article
MicroRNA miR-497 is closely associated with poor prognosis in patients with cerebral ischemic stroke
Changyang Zhong, Congguo Yin, Guozhong Niu, Li Ning & Jinbo Pan
Pages: 2851-2862
Published online: 21 Jun 2021
AbstractforMicroRNA miR-497 is closely associated with poor prognosis in patients with cerebral ischemic stroke | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Resveratrol suppresses malignant progression of oral squamous cell carcinoma cells by inducing the ZNF750/RAC1 signaling pathway
Yue Xiao, Yanjun Duan, Yongjie Wang & Xiaojia Yin
Pages: 2863-2873
Published online: 27 Jun 2021
AbstractforResveratrol suppresses malignant progression of oral squamous cell carcinoma cells by inducing the ZNF750/RAC1 signaling pathway | Full Text | References | PDF (2.6 MB) | EPUB
  • 2002 Views
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Article
Bioinformatics-based analysis of the association between the A1-chimaerin (CHN1) gene and gastric cancer
Jie-Pin Li, Shu-Hong Zeng, Yong-Hua Zhang & Yuan-Jie Liu
Pages: 2874-2889
Published online: 21 Jun 2021
AbstractforBioinformatics-based analysis of the association between the A1-chimaerin (CHN1) gene and gastric cancer | Full Text | References | PDF (4.5 MB) | EPUB
  • 2016 Views
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Article
Identification of potential biomarkers and immune cell infiltration in acute myocardial infarction (AMI) using bioinformatics strategy
Yun Xie, Yi Wang, Linjun Zhao, Fang Wang & Jinyan Fang
Pages: 2890-2905
Published online: 06 Jul 2021
AbstractforIdentification of potential biomarkers and immune cell infiltration in acute myocardial infarction (AMI) using bioinformatics strategy | Full Text | References | PDF (4.7 MB) | EPUB
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Article
MicroRNA-9 restrains the sharp increase and boost apoptosis of human acute myeloid leukemia cells by adjusting the Hippo/YAP signaling pathway
Guoqing Wang, Xiuwen Yu, Jiajia Xia, Jie Sun, Haiyan Huang & Yeqiong Liu
Pages: 2906-2914
Published online: 24 Jun 2021
AbstractforMicroRNA-9 restrains the sharp increase and boost apoptosis of human acute myeloid leukemia cells by adjusting the Hippo/YAP signaling pathway | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Long non-coding RNA LINC00511 regulates the expression of microRNA-625-5p and activates signal transducers and activators of transcription 3 (STAT3) to accelerate the progression of gastric cancer
Ning Cui, Qinhui Sun, Hongjun Liu, Leping Li, Xiaobo Guo, Yulong Shi, Changqing Jing, Chengkun Qin & Yu Zhao
Pages: 2915-2927
Published online: 05 Jul 2021
AbstractforLong non-coding RNA LINC00511 regulates the expression of microRNA-625-5p and activates signal transducers and activators of transcription 3 (STAT3) to accelerate the progression of gastric cancer | Full Text | References | PDF (3 MB) | EPUB
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Article
Identification of hub genes in thyroid carcinoma to predict prognosis by integrated bioinformatics analysis
Yangwang Pan, Linjing Wu, Shuai He, Jun Wu, Tong Wang & Hongrui Zang
Pages: 2928-2940
Published online: 24 Jun 2021
AbstractforIdentification of hub genes in thyroid carcinoma to predict prognosis by integrated bioinformatics analysis | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Upregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study
Lin-Jie Yang, Li Gao, Yi-Nan Guo, Zi-Qian Liang, Dong-Ming Li, Yu-Lu Tang, Yi-Hong Liu, Wan-Jing Gao, Jing-Jing Zeng, Lin Shi, Kang-Lai Wei & Gang Chen
Pages: 2941-2956
Published online: 28 Jun 2021
AbstractforUpregulation of microRNA miR-141-3p and its prospective targets in endometrial carcinoma: a comprehensive study | Full Text | References | PDF (3.3 MB) | EPUB
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Silencing of the chemokine CXC receptor 4 (CXCR4) hampers cancer progression and increases cisplatin (DDP)-sensitivity in clear cell renal cell carcinoma (ccRCC)
Wenguang Wang, Zhilu Gan, Qiang Liu, Shenshen Yan, Rexiti Mulati & Yujie Wang
Pages: 2957-2969
Published online: 28 Jun 2021
AbstractforSilencing of the chemokine CXC receptor 4 (CXCR4) hampers cancer progression and increases cisplatin (DDP)-sensitivity in clear cell renal cell carcinoma (ccRCC) | Full Text | References | PDF (4.9 MB) | EPUB
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Novel natural inhibitors targeting B-RAF(V600E) by computational study
Bo Wu, Zhiyun Zhang, Gaojing Dou, Xiaye Lv, Junliang Ge, Hongyu Wang, Haoqun Xie & Dong Zhu
Pages: 2970-2983
Published online: 12 Jul 2021
AbstractforNovel natural inhibitors targeting B-RAF(V600E) by computational study | Full Text | References | PDF (1.9 MB) | EPUB
  • 2785 Views
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Article
Icariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling
Yanghua Tang, Yongfu Li, Dawei Xin, Lin Chen, Zhenfei Xiong & Xuezi Yu
Pages: 2984-2999
Published online: 24 Jun 2021
AbstractforIcariin alleviates osteoarthritis by regulating autophagy of chondrocytes by mediating PI3K/AKT/mTOR signaling | Full Text | References | PDF (4.6 MB) | EPUB
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Article
Ultrasound-Stimulated Microbubbles Inhibit Aggressive Phenotypes and Promotes Radiosensitivity of esophageal squamous cell carcinoma
Jinjun Shi, Chenchun Fu, Xiangyu Su, Shicheng Feng & Sheng Wang
Pages: 3000-3013
Published online: 27 Jun 2021
AbstractforUltrasound-Stimulated Microbubbles Inhibit Aggressive Phenotypes and Promotes Radiosensitivity of esophageal squamous cell carcinoma | Full Text | References | PDF (3.6 MB) | EPUB
  • 1783 Views
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Article
CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis
Wei Zhong, Lei Bao, Yangyi Yuan & Yanzhi Meng
Pages: 3014-3028
Published online: 28 Jun 2021
AbstractforCircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Self-assembled chitosan nanoparticles for intranasal delivery of recombinant protein interleukin-17 receptor C (IL-17RC): preparation and evaluation in asthma mice
Yongli Lv, Jianhua Zhang & Chaoying Wang
Pages: 3029-3039
Published online: 28 Jun 2021
AbstractforSelf-assembled chitosan nanoparticles for intranasal delivery of recombinant protein interleukin-17 receptor C (IL-17RC): preparation and evaluation in asthma mice | Full Text | References | PDF (1.9 MB) | EPUB
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Mini-Review

Review
In-vitro digestion models: a critical review for human and fish and a protocol for in-vitro digestion in fish
Ricky Wang, Mahtab Mohammadi, Amir Mahboubi & Mohammad J. Taherzadeh
Pages: 3040-3064
Published online: 30 Jun 2021
AbstractforIn-vitro digestion models: a critical review for human and fish and a protocol for in-vitro digestion in fish | Full Text | References | PDF (1.6 MB) | EPUB
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Research Paper

Article
Rosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3β axis
Lin Huang, Jiangyan Chen, Jin Quan & Debing Xiang
Pages: 3065-3076
Published online: 05 Jul 2021
AbstractforRosmarinic acid inhibits proliferation and migration, promotes apoptosis and enhances cisplatin sensitivity of melanoma cells through inhibiting ADAM17/EGFR/AKT/GSK3β axis | Full Text | References | PDF (4.8 MB) | EPUB
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Article
Kinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p)
Haiwang Liu, Ran Liu, Meiling Hao, Xing Zhao & Chunhui Li
Pages: 3077-3088
Published online: 30 Jun 2021
AbstractforKinesin family member 3C (KIF3C) is a novel non-small cell lung cancer (NSCLC) oncogene whose expression is modulated by microRNA-150-5p (miR-150-5p) and microRNA-186-3p (miR-186-3p) | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Cullin3 aggravates the inflammatory response of periodontal ligament stem cells via regulation of SHH signaling and Nrf2
Wanhong Chen, Jiangling Su, Shixiong Cai & Chun Shi
Pages: 3089-3100
Published online: 30 Jun 2021
AbstractforCullin3 aggravates the inflammatory response of periodontal ligament stem cells via regulation of SHH signaling and Nrf2 | Full Text | References | PDF (2.6 MB) | EPUB
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Article
LncRNA MYLK-AS1 acts as an oncogene by epigenetically silencing large tumor suppressor 2 (LATS2) in gastric cancer
Juan Luo & Huifei Xiang
Pages: 3101-3112
Published online: 28 Jun 2021
AbstractforLncRNA MYLK-AS1 acts as an oncogene by epigenetically silencing large tumor suppressor 2 (LATS2) in gastric cancer | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Danshensu alleviates bleomycin-induced pulmonary fibrosis by inhibiting lung fibroblast-to-myofibroblast transition via the MEK/ERK signaling pathway
Huaman Liu, Xinyue Zhang, Yumeng Shao, Xuehong Lin, Feng Dong & Xue Liu
Pages: 3113-3124
Published online: 30 Jun 2021
AbstractforDanshensu alleviates bleomycin-induced pulmonary fibrosis by inhibiting lung fibroblast-to-myofibroblast transition via the MEK/ERK signaling pathway | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Platelet-rich plasma regulating the repair of ultraviolet B–induced acute tissue inflammation: adjusting macrophage polarization through the activin receptor–follistatin system
Gajin Park, Wen Qian, Mei-Jie Zhang, Yi-He Chen, Li-Wen Ma, Ni Zeng, Qian Lu, Yue-Yue Li, Wei-Wei Ma, Xu-Feng Yin, Bing-Rong Zhou & Dan Luo
Pages: 3125-3136
Published online: 30 Jun 2021
AbstractforPlatelet-rich plasma regulating the repair of ultraviolet B–induced acute tissue inflammation: adjusting macrophage polarization through the activin receptor–follistatin system | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Bioinformatic exploration of the immune related molecular mechanism underlying pulmonary arterial hypertension
Ruina Huang, Xifeng Zheng & Junxian Wang
Pages: 3137-3147
Published online: 12 Jul 2021
AbstractforBioinformatic exploration of the immune related molecular mechanism underlying pulmonary arterial hypertension | Full Text | References | PDF (2.6 MB) | EPUB
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Article
LncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway
Hui Long, Qin Li, Zhenping Xiao & Bo Yang
Pages: 3148-3158
Published online: 30 Jun 2021
AbstractforLncRNA MIR22HG promotes osteoarthritis progression via regulating miR-9-3p/ADAMTS5 pathway | Full Text | References | PDF (2.2 MB) | EPUB
  • 1995 Views
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Article
m6A RNA methylation regulators were associated with the malignancy and prognosis of ovarian cancer
Cheng Zhang, JinHui Liu, Hongyu Guo, Dandan Hong, Jing Ji, Qin Zhang, Qun Guan & Qingling Ren
Pages: 3159-3176
Published online: 30 Jun 2021
Abstractform6A RNA methylation regulators were associated with the malignancy and prognosis of ovarian cancer | Full Text | References | PDF (4 MB) | EPUB
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Article
MicroRNA-183-5p protects human derived cell line SH-SY5Y cells from mepivacaine-induced injury
Qian Zhou & Ling Zhang
Pages: 3177-3187
Published online: 28 Jun 2021
AbstractforMicroRNA-183-5p protects human derived cell line SH-SY5Y cells from mepivacaine-induced injury | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Identification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis
Peng Ren, JingYa Wang, Lei Li, XiaoWan Lin, GuangHan Wu, JiaYi Chen, ZhiRui Zeng & HongMei Zhang
Pages: 3188-3200
Published online: 08 Jul 2021
AbstractforIdentification of key genes involved in the recurrence of glioblastoma multiforme using weighted gene co-expression network analysis and differential expression analysis | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Identification of the correlations between interleukin-27 (IL-27) and immune-inflammatory imbalance in preterm birth
Yuxin Ran, Dongni Huang, Youwen Mei, Zheng Liu, Yunqian Zhou, Jie He, Hanwen Zhang, Nanlin Yin & Hongbo Qi
Pages: 3201-3218
Published online: 05 Jul 2021
AbstractforIdentification of the correlations between interleukin-27 (IL-27) and immune-inflammatory imbalance in preterm birth | Full Text | References | PDF (4 MB) | EPUB
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Article
MicroRNA-25-3p promotes cisplatin resistance in Non-small-cell lung carcinoma (NSCLC) through adjusting PTEN/PI3K/AKT route
Butong Sun, Nanjun Hu, Dan Cong, Kang Chen & Jun Li
Pages: 3219-3228
Published online: 16 Jul 2021
AbstractforMicroRNA-25-3p promotes cisplatin resistance in Non-small-cell lung carcinoma (NSCLC) through adjusting PTEN/PI3K/AKT route | Full Text | References | PDF (3.5 MB) | EPUB
  • 1554 Views
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Article
Pharmacological mechanism of mylabris in the treatment of leukemia based on bioinformatics and systematic pharmacology
Huali Zhan, Yujiao Bai, Yu Lv, Xianqin Zhang, Lin Zhang & Shanshan Deng
Pages: 3229-3239
Published online: 05 Jul 2021
AbstractforPharmacological mechanism of mylabris in the treatment of leukemia based on bioinformatics and systematic pharmacology | Full Text | References | PDF (1.6 MB) | EPUB
  • 1927 Views
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Article
MicroRNA miR-145-5p inhibits Phospholipase D 5 (PLD5) to downregulate cell proliferation and metastasis to mitigate prostate cancer
Juanni liu, Junhai Li, Yongtu Ma, Changbao Xu, Yigang Wang & Yanfeng He
Pages: 3240-3251
Published online: 08 Jul 2021
AbstractforMicroRNA miR-145-5p inhibits Phospholipase D 5 (PLD5) to downregulate cell proliferation and metastasis to mitigate prostate cancer | Full Text | References | PDF (2.5 MB) | EPUB
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Article
A DNA methylation profile of long non-coding RNAs can predict OS in prostate cancer
Wei Cheng, Jie Cao, Yong xia, Xin Lei, Lili Wu & Liang Shi
Pages: 3252-3262
Published online: 08 Jul 2021
AbstractforA DNA methylation profile of long non-coding RNAs can predict OS in prostate cancer | Full Text | References | PDF (1.5 MB) | EPUB
  • 1388 Views
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Identification and validation of a five-lncRNA signature for predicting survival with targeted drug candidates in ovarian cancer
Nuan Lin, Jia-zhe Lin, Yoshiaki Tanaka, Pingnan Sun & Xiaoling Zhou
Pages: 3263-3274
Published online: 05 Jul 2021
AbstractforIdentification and validation of a five-lncRNA signature for predicting survival with targeted drug candidates in ovarian cancer | Full Text | References | PDF (2.4 MB) | EPUB
  • 2398 Views
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Identification of potential micro-messenger RNAs (miRNA–mRNA) interaction network of osteosarcoma
Keteng Xu, Pei Zhang, Jiale Zhang, Huahong Quan, Jingcheng Wang & Yuan Liang
Pages: 3275-3293
Published online: 12 Jul 2021
AbstractforIdentification of potential micro-messenger RNAs (miRNA–mRNA) interaction network of osteosarcoma | Full Text | References | PDF (7.1 MB) | EPUB
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Article
Multi-omics landscape of circadian rhythm pathway alterations in Glioma
Chang Zhang, Jiahui Xu, Lijun Chen & Xiaojie Lin
Pages: 3294-3308
Published online: 05 Jul 2021
AbstractforMulti-omics landscape of circadian rhythm pathway alterations in Glioma | Full Text | References | PDF (3.9 MB) | EPUB
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Article
The integration of differentially expressed genes based on multiple microarray datasets for prediction of the prognosis in oral squamous cell carcinoma
Yinuan Zhao, Jiacheng Huang & Jianzhi Chen
Pages: 3309-3321
Published online: 05 Jul 2021
AbstractforThe integration of differentially expressed genes based on multiple microarray datasets for prediction of the prognosis in oral squamous cell carcinoma | Full Text | References | PDF (5 MB) | EPUB
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Article
The promotion of cervical cancer progression by signal transducer and activator of transcription 1-induced up-regulation of lncRNA MEOX2-AS1 as a competing endogenous RNA through miR-143-3p/VDAC1 pathway
Xiao-xing Liu, Qi-xiu Bao, Yan-mei Li & Yan-hua Zhang
Pages: 3322-3335
Published online: 05 Jul 2021
AbstractforThe promotion of cervical cancer progression by signal transducer and activator of transcription 1-induced up-regulation of lncRNA MEOX2-AS1 as a competing endogenous RNA through miR-143-3p/VDAC1 pathway | Full Text | References | PDF (3.7 MB) | EPUB
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Article
MicroRNA miR-502-5p inhibits ovarian cancer genesis by downregulation of GINS complex subunit 2
Lili Zhan, Jing Yang, Yang Liu, Yanxiang Cheng & Hua Liu
Pages: 3336-3347
Published online: 21 Jul 2021
AbstractforMicroRNA miR-502-5p inhibits ovarian cancer genesis by downregulation of GINS complex subunit 2 | Full Text | References | PDF (2.3 MB) | EPUB
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Analysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats
Zhenxing Yan, Yiting Deng, Yang Zou, Siqin Liu, Kaifeng Li, Juan Yang, Xihua Guo, Rongni He, Wenxia Zheng & Huifang Xie
Pages: 3348-3357
Published online: 05 Jul 2021
AbstractforAnalysis of regulatory effect of miR-149-5p on Sphingosine-1-phosphate receptor 2 of pericytes and its neuroprotective molecular mechanism after acute cerebral ischemia reperfusion in rats | Full Text | References | PDF (1.6 MB) | EPUB
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Cloning and expression analyses of a Pyrabactin Resistance 1 (PYR1) gene from Magnolia sieboldii K. Koch
Wan-Qi Zeng, Hong-Tao Sun, Lei Wang, Xiu-jun Lu & Xiao-lin Zhang
Pages: 3358-3366
Published online: 05 Jul 2021
AbstractforCloning and expression analyses of a Pyrabactin Resistance 1 (PYR1) gene from Magnolia sieboldii K. Koch | Full Text | References | PDF (3.1 MB) | EPUB
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Lihong Zhu, Bowen Tang, Ze Zhang, Shuzhang Wei, Zhiwei Lv, Yujuan Zhang & Minlie Yang
Pages: 3367-3384
Published online: 08 Jul 2021
AbstractforEffect of interleukin-8 receptor B (IL8RB) rs1126579 C>T variation on the risk to cancer | Full Text | References | PDF (3.9 MB) | EPUB
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CircRAB3IP upregulates twist family BHLH transcription factor (TWIST1) to promote osteosarcoma progression by sponging miR-580-3p
Guojun Tang, Linghua Liu, Zhihong Xiao, Shuo Wen, Liangyuan Chen & Peng Yang
Pages: 3385-3397
Published online: 05 Jul 2021
AbstractforCircRAB3IP upregulates twist family BHLH transcription factor (TWIST1) to promote osteosarcoma progression by sponging miR-580-3p | Full Text | References | PDF (3.3 MB) | EPUB
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Overexpression of Notch2 enhances radiosensitivity via inhibition of the AKT/mTOR signaling pathway in nasopharyngeal carcinoma
Li-Zhi Wu, Mao-Ling Huang, Cheng-Lin Qi, Li-Jun Shen, You Zou, Rui Yang, Jian-Fei Sheng & Shi-Ming Chen
Pages: 3398-3409
Published online: 05 Jul 2021
AbstractforOverexpression of Notch2 enhances radiosensitivity via inhibition of the AKT/mTOR signaling pathway in nasopharyngeal carcinoma | Full Text | References | PDF (2.3 MB) | EPUB
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Comprehensive analysis of lncRNA-miRNA-mRNA regulatory networks for microbiota-mediated colorectal cancer associated with immune cell infiltration
Xiangzhou Tan, Linfeng Mao, Changhao Huang, Weimin Yang, Jianping Guo, Zhikang Chen & Zihua Chen
Pages: 3410-3425
Published online: 06 Jul 2021
AbstractforComprehensive analysis of lncRNA-miRNA-mRNA regulatory networks for microbiota-mediated colorectal cancer associated with immune cell infiltration | Full Text | References | PDF (3.8 MB) | EPUB
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High expression of Stabilin-2 predicts poor prognosis in non-small-cell lung cancer
Juanjuan Yong, Liyun Huang, Gengbiao Chen, Xiaoya Luo, Hui Chen & Lin Wang
Pages: 3426-3433
Published online: 06 Jul 2021
AbstractforHigh expression of Stabilin-2 predicts poor prognosis in non-small-cell lung cancer | Full Text | References | PDF (566.1 KB) | EPUB
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Development and validation of a survival model for esophageal adenocarcinoma based on autophagy-associated genes
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Pages: 3434-3454
Published online: 12 Jul 2021
AbstractforDevelopment and validation of a survival model for esophageal adenocarcinoma based on autophagy-associated genes | Full Text | References | PDF (5.3 MB) | EPUB
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Circular RNA _NLRP1 targets mouse microRNA-199b-3p to regulate apoptosis and pyroptosis of hippocampal neuron under oxygen-glucose deprivation exposure
Bin Sun, Xiaoxian Liu, Han Peng, Xin Xiang & Hua Yang
Pages: 3455-3466
Published online: 06 Jul 2021
AbstractforCircular RNA _NLRP1 targets mouse microRNA-199b-3p to regulate apoptosis and pyroptosis of hippocampal neuron under oxygen-glucose deprivation exposure | Full Text | References | PDF (4.3 MB) | EPUB
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The role of CCR2 in prognosis of patients with endometrial cancer and tumor microenvironment remodeling
Lin Xu, Qin Fang, Youqing Miao, Mengting Xu, Yichun Wang, Lizhou Sun & Xuemei Jia
Pages: 3467-3484
Published online: 12 Jul 2021
AbstractforThe role of CCR2 in prognosis of patients with endometrial cancer and tumor microenvironment remodeling | Full Text | References | PDF (4.4 MB) | EPUB
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Declined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging
Jingbao Kan, Yifang Hu, Yaoqi Ge, WenSong Zhang, Shan Lu, Cuiping Zhao, Rihua Zhang & Yun Liu
Pages: 3485-3502
Published online: 06 Jul 2021
AbstractforDeclined expressions of vast mitochondria-related genes represented by CYCS and transcription factor ESRRA in skeletal muscle aging | Full Text | References | PDF (8.4 MB) | EPUB
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Identification and validation of the miRNA–mRNA regulatory network in fetoplacental arterial endothelial cells of gestational diabetes mellitus
Longkai He, Xiaotong Wang, Ya Jin, Weipeng Xu, Yi Guan, Jingchao Wu, Shasha Han & Guosheng Liu
Pages: 3503-3515
Published online: 07 Jul 2021
AbstractforIdentification and validation of the miRNA–mRNA regulatory network in fetoplacental arterial endothelial cells of gestational diabetes mellitus | Full Text | References | PDF (3.9 MB) | EPUB
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Angelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway
Chunfeng Li, Shumin Liu, Jian Zheng & Yingwei Xue
Pages: 3516-3524
Published online: 06 Jul 2021
AbstractforAngelica sinensis polysaccharide (ASP) attenuates diosbulbin-B (DB)-induced hepatotoxicity through activating the MEK/ERK pathway | Full Text | References | PDF (2.1 MB) | EPUB
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Long non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p
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Pages: 3525-3538
Published online: 04 Aug 2021
AbstractforLong non-coding RNA MCM3AP antisense RNA 1 promotes non-small cell lung cancer progression through targeting microRNA-195-5p | Full Text | References | PDF (2.7 MB) | EPUB
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Qiang Wang, Leqi Qian, Mengyuan Tao, Jiaqi Liu & Fa-zhi Qi
Pages: 3539-3549
Published online: 07 Jul 2021
AbstractforKnockdown of DEAD-box RNA helicase 52 (DDX52) suppresses the proliferation of melanoma cells in vitro and of nude mouse xenografts by targeting c-Myc | Full Text | References | PDF (3 MB) | EPUB
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Mei-feng Yang, Xing-Xing Long, Hong-sai Hu, Yu-ling Bin, Xuan-ming Chen, Ben-hua Wu, Quan-zhou Peng, Li-sheng Wang, Jun Yao & De-feng Li
Pages: 3550-3565
Published online: 07 Jul 2021
AbstractforComprehensive analysis on the expression profile and prognostic values of Synaptotagmins (SYTs) family members and their methylation levels in gastric cancer | Full Text | References | PDF (4.9 MB) | EPUB
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Transcription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial–mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-β1 /Smad2/3 pathway
Jing Wang, Zhenyu Fan, Jia Li, Jingmao Yang, Xiaofei Liu & Jilin Cheng
Pages: 3566-3577
Published online: 19 Jul 2021
AbstractforTranscription factor specificity protein 1-mediated Serine/threonine kinase 39 upregulation promotes the proliferation, migration, invasion and epithelial–mesenchymal transition of hepatocellular carcinoma cells by activating the transforming growth factor-β1 /Smad2/3 pathway | Full Text | References | PDF (3.9 MB) | EPUB
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Immune implication of FAM83D gene in hepatocellular carcinoma
Tao Meng, Zhong Tong, Ming-Ya Yang, Yan Zhang, Yu Liu, Zhen-Zhen Wang, Li-Xin Zhu & Jin Wu
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Published online: 24 Jul 2021
AbstractforImmune implication of FAM83D gene in hepatocellular carcinoma | Full Text | References | PDF (3.8 MB) | EPUB
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Yalan Lei, Rong Tang, Jin Xu, Bo Zhang, Jiang Liu, Chen Liang, Qingcai Meng, Jie Hua, Xianjun Yu, Wei Wang & Si Shi
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Published online: 09 Jul 2021
AbstractforConstruction of a novel risk model based on the random forest algorithm to distinguish pancreatic cancers with different prognoses and immune microenvironment features | Full Text | References | PDF (1.6 MB) | EPUB
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MiRNA based tumor mutation burden diagnostic and prognostic prediction models for endometrial cancer
Nan Lu, Jinhui Liu, Chengjian Ji, Yichun Wang, Zhipeng Wu, Shuning Yuan, Yan Xing & Feiyang Diao
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Published online: 12 Jul 2021
AbstractforMiRNA based tumor mutation burden diagnostic and prognostic prediction models for endometrial cancer | Full Text | References | PDF (2.6 MB) | EPUB
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Jing Han, Hua Tang, Longfei Yao, Erliang Jin, Wanxi Pan & Shaojun Chen
Pages: 3621-3633
Published online: 16 Jul 2021
AbstractforAzilsartan protects against hyperglycemia-induced hyperpermeability of the blood-brain barrier | Full Text | References | PDF (2.4 MB) | EPUB
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Pages: 3634-3646
Published online: 12 Jul 2021
AbstractforData mining-based study of collagen type III alpha 1 (COL3A1) prognostic value and immune exploration in pan-cancer | Full Text | References | PDF (4.2 MB) | EPUB
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Xi Pan & Jian-Hao Liu
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Published online: 14 Jul 2021
AbstractforIdentification of four key biomarkers and small molecule drugs in nasopharyngeal carcinoma by weighted gene co-expression network analysis | Full Text | References | PDF (3.4 MB) | EPUB
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MicroRNA-30b-5p promotes the proliferation and migration of human airway smooth muscle cells induced by platelet-derived growth factor by targeting phosphatase and tensin homolog deleted on chromosome ten
Wentao Wang, Jian Guo & Yan Wang
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Published online: 12 Jul 2021
AbstractforMicroRNA-30b-5p promotes the proliferation and migration of human airway smooth muscle cells induced by platelet-derived growth factor by targeting phosphatase and tensin homolog deleted on chromosome ten | Full Text | References | PDF (2.3 MB) | EPUB
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Jianfeng Zhao, Lijuan Lin, Yihua Luo, Qinghe Cai, Xiaojie Jiang, Changxi Liao & Huimin Wei
Pages: 3674-3683
Published online: 14 Jul 2021
AbstractforOptimization of GPC3-specific chimeric antigen receptor structure and its effect on killing hepatocellular carcinoma cells | Full Text | References | PDF (1.7 MB) | EPUB
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Effects of different patterns of maize-straw application on soil microorganisms, enzyme activities, and grain yield
Xilin Ning, Xiaohui Wang, Zheyun Guan, Yan Gu, Chunsheng Wu & Wenhe Hu
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Published online: 13 Jul 2021
AbstractforEffects of different patterns of maize-straw application on soil microorganisms, enzyme activities, and grain yield | Full Text | References | PDF (718.4 KB) | EPUB
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Dynamic changes of plasma extracellular vesicle long RNAs during perioperative period of colorectal cancer
Qing Hua, Wenhao Xu, Xuefang Shen, Xi Tian, Hailiang Zhang, Yan Li & Pingbo Xu
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AbstractforDynamic changes of plasma extracellular vesicle long RNAs during perioperative period of colorectal cancer | Full Text | References | PDF (2.8 MB) | EPUB
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Published online: 16 Jul 2021
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Metabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients
Jian-ying Ma, Shao-hua Liu, Jie Chen & Qin Liu
Pages: 3726-3736
Published online: 13 Jul 2021
AbstractforMetabolism-related long non-coding RNAs (lncRNAs) as potential biomarkers for predicting risk of recurrence in breast cancer patients | Full Text | References | PDF (1.3 MB) | EPUB
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Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor
Xingjian Zhang, Peng Du, Kaifeng Luo, Yong Li, Zhongzhong Liu, Wei Wang, Cheng Zeng, Qifa Ye & Qi Xiao
Pages: 3737-3752
Published online: 21 Jul 2021
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Transcriptome-based stemness indices analysis reveals platinum-based chemo-theraputic response indicators in advanced-stage serous ovarian cancer
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Published online: 16 Jul 2021
AbstractforTranscriptome-based stemness indices analysis reveals platinum-based chemo-theraputic response indicators in advanced-stage serous ovarian cancer | Full Text | References | PDF (5.1 MB) | EPUB
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Long non-coding RNA DDX11-AS1 promotes esophageal carcinoma cell proliferation and migration through regulating the miR-514b-3p/RBX1 axis
Chao Wu, Zhibin Wang, Xuetao Tian, Jianqiang Wang, Yuesong Zhang & Biao Wu
Pages: 3772-3786
Published online: 19 Jul 2021
AbstractforLong non-coding RNA DDX11-AS1 promotes esophageal carcinoma cell proliferation and migration through regulating the miR-514b-3p/RBX1 axis | Full Text | References | PDF (3.1 MB) | EPUB
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Review

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Algae-derived hydrocolloids in foods: applications and health-related issues
Yu-Chen Liao, Chia-Che Chang, Dillirani Nagarajan, Chun-Yen Chen & Jo-Shu Chang
Pages: 3787-3801
Published online: 19 Jul 2021
AbstractforAlgae-derived hydrocolloids in foods: applications and health-related issues | Full Text | References | PDF (1,007 KB) | EPUB
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A hypoxia related long non-coding RNA signature could accurately predict survival outcomes in patients with bladder cancer
Facai Zhang, Xiaoming Wang, Huan Hu, Yubo Yang, Jiahao Wang, Yin Tang, Dengxiong Li, Yunjin Bai & Ping Han
Pages: 3802-3823
Published online: 19 Jul 2021
AbstractforA hypoxia related long non-coding RNA signature could accurately predict survival outcomes in patients with bladder cancer | Full Text | References | PDF (5.1 MB) | EPUB
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Circular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate Bone Morphogenetic Protein BMP2
Rongkui Zhou, Shichang Miao, Jun Xu, Liping Sun & Yaofei Chen
Pages: 3824-3836
Published online: 16 Jul 2021
AbstractforCircular RNA circ_0000020 promotes osteogenic differentiation to reduce osteoporosis via sponging microRNA miR-142-5p to up-regulate Bone Morphogenetic Protein BMP2 | Full Text | References | PDF (3.1 MB) | EPUB
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Delphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells
Qionghua Long, Hongyan Chen, Wenhui Yang, Li Yang & Lijuan Zhang
Pages: 3837-3849
Published online: 20 Jul 2021
AbstractforDelphinidin-3-sambubioside from Hibiscus sabdariffa. L attenuates hyperlipidemia in high fat diet-induced obese rats and oleic acid-induced steatosis in HepG2 cells | Full Text | References | PDF (2.8 MB) | EPUB
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Comprehensive Analysis of Monocarboxylate Transporter 4 (MCT4) expression in breast cancer prognosis and immune infiltration via integrated bioinformatics analysis
Chen Yuan, Jie Zhang, Jianjuan Lou, Siqi Wang, Yanni Jiang, Feiyun Wu & Shouju Wang
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Published online: 16 Jul 2021
AbstractforComprehensive Analysis of Monocarboxylate Transporter 4 (MCT4) expression in breast cancer prognosis and immune infiltration via integrated bioinformatics analysis | Full Text | References | PDF (3 MB) | EPUB
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MicroRNA expression profile and identification of novel microRNA biomarkers for metabolic syndrome
Guanzhi Liu, Yutian Lei, Sen Luo, Zhuo Huang, Chen Chen, Kunzheng Wang, Pei Yang & Xin Huang
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Published online: 16 Jul 2021
AbstractforMicroRNA expression profile and identification of novel microRNA biomarkers for metabolic syndrome | Full Text | References | PDF (1.7 MB) | EPUB
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ETS like-1 protein ELK1-induced lncRNA LINC01638 accelerates the progression of papillary thyroid cancer by regulating Axin2 through Wnt/β-catenin signaling pathway
Pin Lv & Yuan Xue
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Published online: 19 Jul 2021
AbstractforETS like-1 protein ELK1-induced lncRNA LINC01638 accelerates the progression of papillary thyroid cancer by regulating Axin2 through Wnt/β-catenin signaling pathway | Full Text | References | PDF (3.3 MB) | EPUB
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PAX6 upstream antisense RNA (PAUPAR) inhibits colorectal cancer progression through modulation of the microRNA (miR)-17-5p / zinc finger protein 750 (ZNF750) axis
Ruhui Wen, Chao Chen, Xiaohua Zhong & Chen Hu
Pages: 3886-3899
Published online: 21 Jul 2021
AbstractforPAX6 upstream antisense RNA (PAUPAR) inhibits colorectal cancer progression through modulation of the microRNA (miR)-17-5p / zinc finger protein 750 (ZNF750) axis | Full Text | References | PDF (3.4 MB) | EPUB
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All-trans-retinoic acid suppresses rat embryo hindlimb bud mesenchymal chondrogenesis by modulating HoxD9 expression
Quan Hong, Xue-Dong Li, Peng Xie & Shi-Xin Du
Pages: 3900-3911
Published online: 21 Jul 2021
AbstractforAll-trans-retinoic acid suppresses rat embryo hindlimb bud mesenchymal chondrogenesis by modulating HoxD9 expression | Full Text | References | PDF (1.7 MB) | EPUB
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Telmisartan mitigates lipopolysaccharide (LPS)-induced production of mucin 5AC (MUC5AC) through increasing suppressor of cytokine signaling 1 (SOCS1)
Ling Chen, Jiajia Xu, Meiyu Deng, Yanling Liang, Jinfu Ma, Linghui Zhang, Yijie Wang & Jinping Zhang
Pages: 3912-3923
Published online: 19 Jul 2021
AbstractforTelmisartan mitigates lipopolysaccharide (LPS)-induced production of mucin 5AC (MUC5AC) through increasing suppressor of cytokine signaling 1 (SOCS1) | Full Text | References | PDF (2.1 MB) | EPUB
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Knockdown of DNA polymerase ζ relieved the chemoresistance of glioma via inhibiting the PI3K/AKT signaling pathway
Junbao Yang, Weilong Ding, Xiangyu Wang & Yongsheng Xiang
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Published online: 19 Jul 2021
AbstractforKnockdown of DNA polymerase ζ relieved the chemoresistance of glioma via inhibiting the PI3K/AKT signaling pathway | Full Text | References | PDF (2.9 MB) | EPUB
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Knockdown of carbohydrate sulfotransferase 12 decreases the proliferation and mobility of glioblastoma cells via the WNT/β-catenin pathway
Juan Wang, Xiaoning Xia, Xiuqin Tao, Pingping Zhao & Chuanyu Deng
Pages: 3934-3946
Published online: 21 Jul 2021
AbstractforKnockdown of carbohydrate sulfotransferase 12 decreases the proliferation and mobility of glioblastoma cells via the WNT/β-catenin pathway | Full Text | References | PDF (2.9 MB) | EPUB
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Investigation on the expression regulation of RIPK1/RIPK3 in the retinal ganglion cells (RGCs) cultured in high glucose
Sheng Gao, Xi Huang, Yi Zhang, Li Bao, Xiaoyue Wang & Meixia Zhang
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Published online: 19 Jul 2021
AbstractforInvestigation on the expression regulation of RIPK1/RIPK3 in the retinal ganglion cells (RGCs) cultured in high glucose | Full Text | References | PDF (1.9 MB) | EPUB
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Zhenxing Yan, Yang Zou, Yiting Deng, Siqin Liu, Kaifeng Li, Juan Yang, Xihua Guo, Rongni He, Wenxia Zheng & Huifang Xie
Pages: 3957-3967
Published online: 21 Jul 2021
AbstractforAnalysis of role of rat cerebral pericytes in cerebral vasospasm after subarachnoid hemorrhage and molecular mechanism of neurovascular injury | Full Text | References | PDF (1 MB) | EPUB
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Anagliptin prevented interleukin 1β (IL-1β)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1)
Juan Zhao, Xinrong He, Mei Zuo, Xinguo Li & Zhiming Sun
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Published online: 21 Jul 2021
AbstractforAnagliptin prevented interleukin 1β (IL-1β)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1) | Full Text | References | PDF (1.5 MB) | EPUB
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Yu-jia Zhao, Lin-Yong Wu, Jin-shu Pang, Wei Liao, Yu-ji Chen, Yun He & Hong Yang
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Published online: 21 Jul 2021
AbstractforIntegrated multi-omics analysis of the clinical relevance and potential regulatory mechanisms of splicing factors in hepatocellular carcinoma | Full Text | References | PDF (5.6 MB) | EPUB
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Long noncoding RNA SNHG20 regulates cell migration, invasion, and proliferation via the microRNA-19b-3p/RAB14 axis in oral squamous cell carcinoma
Xiaomi Zhu, Hanzhong Zhang & Juan Xu
Pages: 3993-4003
Published online: 20 Jul 2021
AbstractforLong noncoding RNA SNHG20 regulates cell migration, invasion, and proliferation via the microRNA-19b-3p/RAB14 axis in oral squamous cell carcinoma | Full Text | References | PDF (3.2 MB) | EPUB
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Bing Chen, Haoran Wang, Chenglin Lv, Chongdan Mao & Yuguang Cui
Pages: 4004-4015
Published online: 21 Jul 2021
AbstractforLong non-coding RNA H19 protects against intracerebral hemorrhage injuries via regulating microRNA-106b-5p/acyl-CoA synthetase long chain family member 4 axis | Full Text | References | PDF (3.5 MB) | EPUB
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Chuming Tao, Haitao Luo, Luyue Chen, Jingying Li, Xingen Zhu & Kai Huang
Pages: 4016-4031
Published online: 21 Jul 2021
AbstractforIdentification of an epithelial-mesenchymal transition related long non-coding RNA (LncRNA) signature in Glioma | Full Text | References | PDF (6 MB) | EPUB
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Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway
Ye Yao, Xiaoqin Li, Lihua Cheng, Xiuhua Wu & Bobo Wu
Pages: 4032-4043
Published online: 21 Jul 2021
AbstractforCircular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway | Full Text | References | PDF (2.3 MB) | EPUB
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Article
MicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2
Liang Ai, Xiaojun Luo, Xiong Yan & Shan Jiang
Pages: 4044-4053
Published online: 21 Jul 2021
AbstractforMicroRNA-506-3p inhibits colorectal cancer cell proliferation through targeting enhancer of zeste homologue 2 | Full Text | References | PDF (3.2 MB) | EPUB
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Clinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissues
Wei-Jian Huang, Wei-Ying He, Jian-Di Li, Rong-Quan He, Zhi-Guang Huang, Xian-Guo Zhou, Jian-Jun Li, Da-Tong Zeng, Ji-Tian Chen, Wei-Zi Wu, Yi-Wu Dang & Gang Chen
Pages: 4054-4069
Published online: 08 Aug 2021
AbstractforClinical significance and molecular mechanism of angiotensin-converting enzyme 2 in hepatocellular carcinoma tissues | Full Text | References | PDF (5.1 MB) | EPUB
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G protein-coupled receptor 39 activation alleviates oxidized low-density lipoprotein-induced macrophage inflammatory response, lipid accumulation and apoptosis by inducing A20 expression
Lu Chen, Zhengdong Fang, Xiaotian Wang, Xiaojie Sun, Xinbao Ge, Can Cheng & Hejie Hu
Pages: 4070-4080
Published online: 21 Jul 2021
AbstractforG protein-coupled receptor 39 activation alleviates oxidized low-density lipoprotein-induced macrophage inflammatory response, lipid accumulation and apoptosis by inducing A20 expression | Full Text | References | PDF (2.5 MB) | EPUB
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N6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis
Naijun Hu & Hong Ji
Pages: 4081-4091
Published online: 21 Jul 2021
AbstractforN6-methyladenosine (m6A)-mediated up-regulation of long noncoding RNA LINC01320 promotes the proliferation, migration, and invasion of gastric cancer via miR495-5p/RAB19 axis | Full Text | References | PDF (3 MB) | EPUB
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MicroRNA-488 serves as a diagnostic marker for atherosclerosis and regulates the biological behavior of vascular smooth muscle cells
Zhen Li, Congjian Xu & Di Sun
Pages: 4092-4099
Published online: 21 Jul 2021
AbstractforMicroRNA-488 serves as a diagnostic marker for atherosclerosis and regulates the biological behavior of vascular smooth muscle cells | Full Text | References | PDF (667.6 KB) | EPUB
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lncRNA PROX1-AS1 mediates the migration and invasion of placental trophoblast cells via the miR-211-5p/caspase-9 axis
Dan Tang, Li Geng & Jing Ma
Pages: 4100-4110
Published online: 21 Jul 2021
AbstractforlncRNA PROX1-AS1 mediates the migration and invasion of placental trophoblast cells via the miR-211-5p/caspase-9 axis | Full Text | References | PDF (2.2 MB) | EPUB
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Circular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis
Wei Zeng, Mengmeng Guo, Lin Yao & Zhang Deng
Pages: 4111-4122
Published online: 21 Jul 2021
AbstractforCircular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Construction of an immune-related lncRNA pairs model to predict prognosis and immune landscape of lung adenocarcinoma patients
Junhui Liu, Hao Wu, Zhaojia Gao, Ming Lou & Kai Yuan
Pages: 4123-4135
Published online: 21 Jul 2021
AbstractforConstruction of an immune-related lncRNA pairs model to predict prognosis and immune landscape of lung adenocarcinoma patients | Full Text | References | PDF (2.1 MB) | EPUB
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Ephedrine alleviates middle cerebral artery occlusion-induced neurological deficits and hippocampal neuronal damage in rats by activating PI3K/AKT signaling pathway
Lixian Huang, Bo Zhao, Qunxian Li, Jing Wu, Hui Jiang & Qingbin Li
Pages: 4136-4149
Published online: 21 Jul 2021
AbstractforEphedrine alleviates middle cerebral artery occlusion-induced neurological deficits and hippocampal neuronal damage in rats by activating PI3K/AKT signaling pathway | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Long non-coding RNA SNHG5 regulates ulcerative colitis via microRNA-375 / Janus kinase-2 axis
Hui Li, Ji Xuan, Wei Zhang, Zhentao An, Xinyu Fan, Min Lu & Yaozhou Tian
Pages: 4150-4158
Published online: 02 Aug 2021
AbstractforLong non-coding RNA SNHG5 regulates ulcerative colitis via microRNA-375 / Janus kinase-2 axis | Full Text | References | PDF (2.1 MB) | EPUB
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Circular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429
Yute Sun, Zuoqiong Hou, Binlin Luo, Chujun Li, Jinfang Liu, Jianlan Liu, Jian Tang & Gang Yao
Pages: 4159-4173
Published online: 21 Jul 2021
AbstractforCircular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429 | Full Text | References | PDF (4.5 MB) | EPUB
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Clinical significance of the serum miR-455-5p expression in patients with neonatal sepsis
Yue-Yan Mao, Chang Su, Cheng-Chao Fang, Xiao-Ping Fan, Li-Ping Wang, Shan-Shan Zhu & Hai-Ming Yao
Pages: 4174-4182
Published online: 21 Jul 2021
AbstractforClinical significance of the serum miR-455-5p expression in patients with neonatal sepsis | Full Text | References | PDF (872.8 KB) | EPUB
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Article
Laboratory characteristics analysis of the efficacy of levothyroxine on subclinical hypothyroidism during pregnancy: a single-center retrospective study
Luyang Han, Yan Ma, Zhaoxia Liang & Danqing Chen
Pages: 4183-4190
Published online: 21 Jul 2021
AbstractforLaboratory characteristics analysis of the efficacy of levothyroxine on subclinical hypothyroidism during pregnancy: a single-center retrospective study | Full Text | References | PDF (534.1 KB) | EPUB
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Article
Etomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes
Xiaohua Sun, Jizheng Zhang, Yi Li, Wanlu Ren & Lijun Wang
Pages: 4191-4200
Published online: 24 Jul 2021
AbstractforEtomidate ameliorated advanced glycation end-products (AGEs)-induced reduction of extracellular matrix genes expression in chondrocytes | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Identification of an eleven-miRNA signature to predict the prognosis of endometrial cancer
Jing Lu, Jianqiang Liang, Mengting Xu, Zhipeng Wu, Wenjun Cheng & Jie Wu
Pages: 4201-4216
Published online: 01 Aug 2021
AbstractforIdentification of an eleven-miRNA signature to predict the prognosis of endometrial cancer | Full Text | References | PDF (2.9 MB) | EPUB
  • 2175 Views
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Article
A ferroptosis-related gene signature for graft loss prediction following renal allograft
Zhenlei Fan, Tao Liu, Hanfei Huang, Jie Lin & Zhong Zeng
Pages: 4217-4232
Published online: 01 Aug 2021
AbstractforA ferroptosis-related gene signature for graft loss prediction following renal allograft | Full Text | References | PDF (3.4 MB) | EPUB
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Pan-cancer analysis of clinical significance and associated molecular features of glycolysis
Yi-chen Liu, Peng Lin, Yu-jia Zhao, Lin-Yong Wu, Yu-quan Wu, Jin-bo Peng, Yun He & Hong Yang
Pages: 4233-4246
Published online: 24 Jul 2021
AbstractforPan-cancer analysis of clinical significance and associated molecular features of glycolysis | Full Text | References | PDF (5.7 MB) | EPUB
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Article
Prognostic and immunological significance of metastasis associated lung adenocarcinoma transcript 1 among different kinds of cancers
Lili Guo, Xiuwen Zhang, Hongli Pan, Yang Li, Jing Wang, Lin Li, Yafang Dong, Xinxin Du, Jun Chen & Fengjie Guo
Pages: 4247-4258
Published online: 24 Jul 2021
AbstractforPrognostic and immunological significance of metastasis associated lung adenocarcinoma transcript 1 among different kinds of cancers | Full Text | References | PDF (3.2 MB) | EPUB
  • 1933 Views
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A united risk model of 11 immune‑related gene pairs and clinical stage for prediction of overall survival in clear cell renal cell carcinoma patients
Zijia Tao, Enchong Zhang, Lei Li, Jianyi Zheng, Yiqiao Zhao & Xiaonan Chen
Pages: 4259-4277
Published online: 24 Jul 2021
AbstractforA united risk model of 11 immune‑related gene pairs and clinical stage for prediction of overall survival in clear cell renal cell carcinoma patients | Full Text | References | PDF (3.7 MB) | EPUB
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Anti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis
Qijin Pan, Ka Wu, Jiachang Tan, Yu Li, Xiao Liang & Min Su
Pages: 4278-4288
Published online: 26 Jul 2021
AbstractforAnti-neoplastic characteristics and potential targets of calycosin against bisphenol A-related osteosarcoma: bioinformatics analysis | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Incomplete thermal ablation-induced up-regulation of transcription factor nuclear receptor subfamily 2, group F, member 6 (NR2F6) contributes to the rapid progression of residual liver tumor in hepatoblastoma
Jin-shu Pang, Dong-yue Wen, Rong-quan He, Gang Chen, Peng Lin, Jin-hong Li, Yu-jia Zhao, Lin-Yong Wu, Jun-Hong Chen, Yun He, Li-Ting Qin, Jia-bo Chen, Yong Li & Hong Yang
Pages: 4289-4303
Published online: 24 Jul 2021
AbstractforIncomplete thermal ablation-induced up-regulation of transcription factor nuclear receptor subfamily 2, group F, member 6 (NR2F6) contributes to the rapid progression of residual liver tumor in hepatoblastoma | Full Text | References | PDF (2.6 MB) | EPUB
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Identification of potential targets of triptolide in regulating the tumor microenvironment of stomach adenocarcinoma patients using bioinformatics
Hairong Qiu, Xiaobo Zhang, Han Yu, Rui Gao, Jianglong Shi & Tao Shen
Pages: 4304-4319
Published online: 04 Aug 2021
AbstractforIdentification of potential targets of triptolide in regulating the tumor microenvironment of stomach adenocarcinoma patients using bioinformatics | Full Text | References | PDF (4.8 MB) | EPUB
  • 2020 Views
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Article
An in vivo study of the effect of c-Jun on intervertebral disc degeneration in rats
Ming Lei, Kangcheng Zhao, Wenbin Hua, Kun Wang, Shuai Li, Xinghuo Wu & Cao Yang
Pages: 4320-4330
Published online: 24 Jul 2021
AbstractforAn in vivo study of the effect of c-Jun on intervertebral disc degeneration in rats | Full Text | References | PDF (2.9 MB) | EPUB
  • 1744 Views
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Article
Identification and validation of a novel redox-related lncRNA prognostic signature in lung adenocarcinoma
Jie Ren, Aman Wang, Jiwei Liu & Qihang Yuan
Pages: 4331-4348
Published online: 01 Aug 2021
AbstractforIdentification and validation of a novel redox-related lncRNA prognostic signature in lung adenocarcinoma | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Sulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1ɑ pathway
Yu-jie Zhang & Qian Wu
Pages: 4349-4360
Published online: 24 Jul 2021
AbstractforSulforaphane protects intestinal epithelial cells against lipopolysaccharide-induced injury by activating the AMPK/SIRT1/PGC-1ɑ pathway | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Identification of the RP11-21C4.1/SVEP1 gene pair associated with FAT2 mutations as a potential biomarker in gastric cancer
Lingshan Zhou, Yuan Yang, Min Liu, Yuling Gan, Rong Liu, Man Ren, Ya Zheng, Yuping Wang & Yongning Zhou
Pages: 4361-4373
Published online: 24 Jul 2021
AbstractforIdentification of the RP11-21C4.1/SVEP1 gene pair associated with FAT2 mutations as a potential biomarker in gastric cancer | Full Text | References | PDF (9.1 MB) | EPUB
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Article
Krüppel-like factor 1 (KLF1) promoted the proliferation, migration and invasion of human lens epithelial cells by enhancing the expression of Zinc Finger and BTB Domain Containing 7A (ZBTB7A) and activating Wnt/β-catenin pathway
Guangming Shi & Feng Yang
Pages: 4374-4384
Published online: 24 Jul 2021
AbstractforKrüppel-like factor 1 (KLF1) promoted the proliferation, migration and invasion of human lens epithelial cells by enhancing the expression of Zinc Finger and BTB Domain Containing 7A (ZBTB7A) and activating Wnt/β-catenin pathway | Full Text | References | PDF (3.6 MB) | EPUB
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Article
PTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway
Lina Bai, Junhua Yang, Hong Zhang, Wei Liao & Yunguang Cen
Pages: 4385-4396
Published online: 24 Jul 2021
AbstractforPTB domain and leucine zipper motif 1 (APPL1) inhibits myocardial ischemia/hypoxia-reperfusion injury via inactivation of apoptotic protease activating factor-1 (APAF-1)/Caspase9 signaling pathway | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Circular RNA circ_0000228 promotes the malignancy of cervical cancer via microRNA-195-5p/ lysyl oxidase-like protein 2 axis
Shimei Liu, Bingqing Li, Ying Li & Huaihua Song
Pages: 4397-4406
Published online: 24 Jul 2021
AbstractforCircular RNA circ_0000228 promotes the malignancy of cervical cancer via microRNA-195-5p/ lysyl oxidase-like protein 2 axis | Full Text | References | PDF (1.6 MB) | EPUB
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Article
An easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facility
Abhishek Das, Satarupa Dutta, Dewanshu Sharma, Amit Pal, Nirmalya Ganguli & Subeer S. Majumdar
Pages: 4407-4419
Published online: 26 Aug 2021
AbstractforAn easy method for developing fusion enabled SARS-CoV2 virus fusion mimic (SCFM), bypassing the need of Bio Safety Level (BSL) facility | Full Text | References | PDF (3.5 MB) | EPUB
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Article
Online analysis of D-glucose and D-mannose aqueous mixtures using Raman spectroscopy: an in silico and experimental approach
Vincent Dumouilla & Claude Gilles Dussap
Pages: 4420-4431
Published online: 24 Jul 2021
AbstractforOnline analysis of D-glucose and D-mannose aqueous mixtures using Raman spectroscopy: an in silico and experimental approach | Full Text | References | PDF (2 MB) | EPUB
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Human circular RNA hsa_circRNA_101705 (circTXNDC11) regulates renal cancer progression by regulating MAPK/ERK pathway
Chong-Yi Yang, Jie Wang, Jian-Qiu Zhang & Hong-miao Cai
Pages: 4432-4441
Published online: 24 Jul 2021
AbstractforHuman circular RNA hsa_circRNA_101705 (circTXNDC11) regulates renal cancer progression by regulating MAPK/ERK pathway | Full Text | References | PDF (2.2 MB) | EPUB
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Estimation of polymorphisms in the drug-metabolizing enzyme, cytochrome P450 2C19 gene in six major ethnicities of Pakistan
Sagheer Ahmed, Saima Gul, Muhammad Akhlaq, Abrar Hussain, Sidrah Tariq Khan, Halimur Rehman, Muhammad Hanif Bangash, Fadwa Al Mughairbi & Muhammad Hamid Hamdard
Pages: 4442-4451
Published online: 24 Jul 2021
AbstractforEstimation of polymorphisms in the drug-metabolizing enzyme, cytochrome P450 2C19 gene in six major ethnicities of Pakistan | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Dendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4
Jing Meng, Xiaoying Song, Guoliang Yan, Haihui Wang, Haitao Li & Danfei Lou
Pages: 4452-4463
Published online: 24 Jul 2021
AbstractforDendrobine suppresses endoplasmic reticulum stress-induced apoptosis through upregulating microRNA miR-381-3p to decrease caspase-4 | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Inhibitory effect of Astragalus Membranaceus on osteoporosis in SAMP6 mice by regulating vitaminD/FGF23/Klotho signaling pathway
Yihui Chai, Xiang Pu, Yongzhen Wu, Xingzhong Tian, Qian Li, Fanyong Zeng, Jing Wang, Jie Gao, Huaqian Gong & Yunzhi Chen
Pages: 4464-4474
Published online: 24 Jul 2021
AbstractforInhibitory effect of Astragalus Membranaceus on osteoporosis in SAMP6 mice by regulating vitaminD/FGF23/Klotho signaling pathway | Full Text | References | PDF (2 MB) | EPUB
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Article
Plumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways
Wei Shi, Yuanyuan Fang, Yueming Jiang, Siyang Jiang, Yu Li, Wentao Li, Mingpeng Xu, Michael Aschner & Guangnan Liu
Pages: 4475-4488
Published online: 24 Jul 2021
AbstractforPlumbagin attenuates traumatic tracheal stenosis in rats and inhibits lung fibroblast proliferation and differentiation via TGF-β1/Smad and Akt/mTOR pathways | Full Text | References | PDF (2.7 MB) | EPUB
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Profile of gut microbiota in patients with traumatic thoracic spinal cord injury and its clinical implications: a case-control study in a rehabilitation setting
Binbin Yu, Huaide Qiu, Shupeng Cheng, Feng Ye, Jiahui Li, Sijing Chen, Li Zhou, Yumei Yang, Caiyun Zhong & Jianan Li
Pages: 4489-4499
Published online: 26 Jul 2021
AbstractforProfile of gut microbiota in patients with traumatic thoracic spinal cord injury and its clinical implications: a case-control study in a rehabilitation setting | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Mesenchymal stem cells (MSC) delays the occurrence of graft-versus-host disease(GVHD) in the inhibition of hematopoietic stem cells in major histocompatibility complex semi-consistent mice by regulating the expression of IFN-γ/IL-6
Ying Wang
Pages: 4500-4507
Published online: 24 Jul 2021
AbstractforMesenchymal stem cells (MSC) delays the occurrence of graft-versus-host disease(GVHD) in the inhibition of hematopoietic stem cells in major histocompatibility complex semi-consistent mice by regulating the expression of IFN-γ/IL-6 | Full Text | References | PDF (850 KB) | EPUB
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Article
miR-148a-3p suppresses the progression of acute myeloid leukemia via targeting cyclin-dependent kinase 6 (CDK6)
Hong Zhou, Xiaofeng Jia, Fan Yang & Pengfei Shi
Pages: 4508-4519
Published online: 24 Jul 2021
AbstractformiR-148a-3p suppresses the progression of acute myeloid leukemia via targeting cyclin-dependent kinase 6 (CDK6) | Full Text | References | PDF (2.6 MB) | EPUB
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Lysophosphatidylcholine promotes intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells via an orphan G protein receptor 2-mediated signaling pathway
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai & Fuhou Chang
Pages: 4520-4535
Published online: 04 Aug 2021
AbstractforLysophosphatidylcholine promotes intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression in human umbilical vein endothelial cells via an orphan G protein receptor 2-mediated signaling pathway | Full Text | References | PDF (2.3 MB) | EPUB
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Long non-coding RNA PTAR inhibits apoptosis but promotes proliferation, invasion and migration of cervical cancer cells by binding miR-101
Xuehe Wang, Huaqin Sun & Simin Zhu
Pages: 4536-4545
Published online: 29 Jul 2021
AbstractforLong non-coding RNA PTAR inhibits apoptosis but promotes proliferation, invasion and migration of cervical cancer cells by binding miR-101 | Full Text | References | PDF (2.8 MB) | EPUB
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Long non-coding RNA LUCAT1 inhibits myocardial oxidative stress and apoptosis after myocardial infarction via targeting microRNA-181a-5p
Shi-Hui Xiao, Ying Wang, Xuecai Cao & Zhe Su
Pages: 4546-4555
Published online: 20 Aug 2021
AbstractforLong non-coding RNA LUCAT1 inhibits myocardial oxidative stress and apoptosis after myocardial infarction via targeting microRNA-181a-5p | Full Text | References | PDF (1.5 MB) | EPUB
  • 1992 Views
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Article
Development of a gene signature associated with iron metabolism in lung adenocarcinoma
Junqi Qin, Zhanyu Xu, Kun Deng, Fanglu Qin, Jiangbo Wei, Liqiang Yuan, Yu Sun, Tiaozhan Zheng & Shikang Li
Pages: 4556-4568
Published online: 29 Jul 2021
AbstractforDevelopment of a gene signature associated with iron metabolism in lung adenocarcinoma | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Crocin exerts anti-proliferative and apoptotic effects on cutaneous squamous cell carcinoma via miR-320a/ATG2B
Xiaoqing Bi, Zhenjuan Jiang, Zhaohui Luan & Daoqing Qiu
Pages: 4569-4580
Published online: 29 Jul 2021
AbstractforCrocin exerts anti-proliferative and apoptotic effects on cutaneous squamous cell carcinoma via miR-320a/ATG2B | Full Text | References | PDF (1.7 MB) | EPUB
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Article
The effect of propofol on the proliferation and apoptosis of hepatocellular carcinoma cells through TGF-Β1/Smad2 signaling pathway
Zongchao Li, Honglei Liu, Yunxiao Zhang & Hongyu Tan
Pages: 4581-4592
Published online: 29 Jul 2021
AbstractforThe effect of propofol on the proliferation and apoptosis of hepatocellular carcinoma cells through TGF-Β1/Smad2 signaling pathway | Full Text | References | PDF (1.2 MB) | EPUB
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Phytochemical analysis and protective effects of Vaccinium macrocarpon (cranberry) in rats (Rattus norvegicus) following ethylene oxide-induced oxidative insult
Mahmood Rasool, Arif Malik, Muhammad Abdul Basit Ashraf, Rabia Mubbin, Ujala Ayyaz, Sulayman Waquar, Muhammad Asif, Muhammad Umar, Gan Siew Hua, Zafar Iqbal, Hina Alam & Niaz M. Achakzai
Pages: 4593-4604
Published online: 04 Aug 2021
AbstractforPhytochemical analysis and protective effects of Vaccinium macrocarpon (cranberry) in rats (Rattus norvegicus) following ethylene oxide-induced oxidative insult | Full Text | References | PDF (3.2 MB) | EPUB
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Article
In vitro antimicrobial effect and mechanism of action of plasma-activated liquid on planktonic Neisseria gonorrhoeae
Jia Liu, Chunjun Yang, Cheng Cheng, Chenchen Zhang, Jun Zhao & Chuyu Fu
Pages: 4605-4619
Published online: 29 Jul 2021
AbstractforIn vitro antimicrobial effect and mechanism of action of plasma-activated liquid on planktonic Neisseria gonorrhoeae | Full Text | References | PDF (2.3 MB) | EPUB
  • 1113 Views
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Article
Elevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma
Jianjia Xiao, Qingqing Liu, Weijie Wu, Ying Yuan, Jie Zhou, Jieyu Shi & Shaorong Zhou
Pages: 4620-4632
Published online: 29 Jul 2021
AbstractforElevated Ras related GTP binding B (RRAGB) expression predicts poor overall survival and constructs a prognostic nomogram for colon adenocarcinoma | Full Text | References | PDF (5.4 MB) | EPUB
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The clinical significance of microRNA-409 in pancreatic carcinoma and associated tumor cellular functions
Kui Long, Qingbin Zeng & Wenzhi Dong
Pages: 4633-4642
Published online: 02 Aug 2021
AbstractforThe clinical significance of microRNA-409 in pancreatic carcinoma and associated tumor cellular functions | Full Text | References | PDF (2 MB) | EPUB
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Regulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer
Xinyu Tang, YiHe Wu, Jie Yang & Wenyu Zhu
Pages: 4643-4653
Published online: 29 Jul 2021
AbstractforRegulating COX10-AS1 / miR-142-5p / PAICS axis inhibits the proliferation of non-small cell lung cancer | Full Text | References | PDF (1.9 MB) | EPUB
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Fermitin family homolog 2 (Kindlin-2) affects vascularization during the wound healing process by regulating the Wnt/β-catenin signaling pathway in vascular endothelial cells
Jianghui Ying, Qiang Wang, Lu Lu, Jiaqi Liu, Rong Guo, Hao Hu, Hua Jiang & Fazhi Qi
Pages: 4654-4665
Published online: 02 Aug 2021
AbstractforFermitin family homolog 2 (Kindlin-2) affects vascularization during the wound healing process by regulating the Wnt/β-catenin signaling pathway in vascular endothelial cells | Full Text | References | PDF (3.2 MB) | EPUB
  • 2022 Views
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Prognostic marker identification based on weighted gene co-expression network analysis and associated in vitro confirmation in gastric cancer
Haonan Guo, Jun Yang, Shanshan Liu, Tao Qin, Qianwen Zhao, Xianliang Hou & Lei Ren
Pages: 4666-4680
Published online: 02 Aug 2021
AbstractforPrognostic marker identification based on weighted gene co-expression network analysis and associated in vitro confirmation in gastric cancer | Full Text | References | PDF (12.5 MB) | EPUB
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Article
Inhibin β-A (INHBA) induces epithelial–mesenchymal transition and accelerates the motility of breast cancer cells by activating the TGF-β signaling pathway
Yingying Yu, Weiwei Wang, Wenying Lu, Wei Chen & Anquan Shang
Pages: 4681-4696
Published online: 04 Aug 2021
AbstractforInhibin β-A (INHBA) induces epithelial–mesenchymal transition and accelerates the motility of breast cancer cells by activating the TGF-β signaling pathway | Full Text | References | PDF (4.3 MB) | EPUB
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Review

Review
Recovery of resources from industrial wastewater employing electrochemical technologies: status, advancements and perspectives
Viralkunvar Devda, Kashika Chaudhary, Sunita Varjani, Bhawana Pathak, Anil Kumar Patel, Reeta Rani Singhania, Mohammad J. Taherzadeh, Huu Hao Ngo, Jonathan W. C. Wong, Wenshan Guo & Preeti Chaturvedi
Pages: 4697-4718
Published online: 01 Aug 2021
AbstractforRecovery of resources from industrial wastewater employing electrochemical technologies: status, advancements and perspectives | Full Text | References | PDF (723.3 KB) | EPUB
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Research Paper

Article
Inhibition of MicroRNA miR-101-3p on prostate cancer progression by regulating Cullin 4B (CUL4B) and PI3K/AKT/mTOR signaling pathways
Zhenhua Gu, Zhixin You, Yucheng Yang, Rui Ding, Meili Wang, Jianming Pu & Jian Chen
Pages: 4719-4735
Published online: 01 Aug 2021
AbstractforInhibition of MicroRNA miR-101-3p on prostate cancer progression by regulating Cullin 4B (CUL4B) and PI3K/AKT/mTOR signaling pathways | Full Text | References | PDF (5.9 MB) | EPUB
  • 1336 Views
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Article
MicroRNA 200a inhibits liver fibrosis of schistosoma
Ailei Xu, Guanzhen Zhong, Jiwen Wang, Chong Liu, Yaqian Liu & Wei Wang
Pages: 4736-4746
Published online: 02 Aug 2021
AbstractforMicroRNA 200a inhibits liver fibrosis of schistosoma | Full Text | References | PDF (2.1 MB) | EPUB
  • 2066 Views
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Article
Diagnostic and prognostic value of microRNA-2355-3p and contribution to the progression in lung adenocarcinoma
Yanan Zhao, Wenlong Zhang, Yang Yang, Enyong Dai & Yuansong Bai
Pages: 4747-4756
Published online: 01 Aug 2021
AbstractforDiagnostic and prognostic value of microRNA-2355-3p and contribution to the progression in lung adenocarcinoma | Full Text | References | PDF (1.1 MB) | EPUB
  • 1105 Views
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Article
Uncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication
Lu Yang, Jianxin Yang, Xiao Liang, Wenjun Huang, Xiaoxi Zhang & Rong Li
Pages: 4757-4767
Published online: 02 Aug 2021
AbstractforUncovering antiobesity-related hypertension targets and mechanisms of metformin, an antidiabetic medication | Full Text | References | PDF (2.7 MB) | EPUB
  • 2472 Views
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Article
Activation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury
WenJuan Liu, GuangMing Zhang, Bo Sun, ShuYan Wang, YinZhong Lu & Hong Xie
Pages: 4768-4779
Published online: 04 Aug 2021
AbstractforActivation of NLR family, domain of pyrin containing 3 inflammasome by nitrous oxide through thioredoxin-interacting protein to induce nerve cell injury | Full Text | References | PDF (2.4 MB) | EPUB
  • 1273 Views
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Article
Identification of four gastric cancer subtypes based on genetic analysis of cholesterogenic and glycolytic pathways
Zhou Zhu, Jian Qin, Chencheng Dong, Jin Yang, Maughan Yang, Jana Tian & Xiaogang Zhong
Pages: 4780-4793
Published online: 04 Aug 2021
AbstractforIdentification of four gastric cancer subtypes based on genetic analysis of cholesterogenic and glycolytic pathways | Full Text | References | PDF (4.2 MB) | EPUB
  • 3141 Views
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Article
Dexmedetomidine improves oxygen-glucose deprivation/reoxygenation (OGD/R) -induced neurological injury through regulating SNHG11/miR-324-3p/VEGFA axis
Yujie Chen, Zhiying Fan & Qingwei Wu
Pages: 4794-4804
Published online: 02 Aug 2021
AbstractforDexmedetomidine improves oxygen-glucose deprivation/reoxygenation (OGD/R) -induced neurological injury through regulating SNHG11/miR-324-3p/VEGFA axis | Full Text | References | PDF (3.4 MB) | EPUB
  • 1830 Views
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Article
Omarigliptin ameliorated high glucose-induced nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation through activating adenosine monophosphate-activated protein kinase α (AMPKα) in renal glomerular endothelial cells
Ling Li, Kelei Qian, Yuli Sun, Yong Zhao, Yun Zhou, Ying Xue & Xinyu Hong
Pages: 4805-4815
Published online: 02 Aug 2021
AbstractforOmarigliptin ameliorated high glucose-induced nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome activation through activating adenosine monophosphate-activated protein kinase α (AMPKα) in renal glomerular endothelial cells | Full Text | References | PDF (1.6 MB) | EPUB
  • 1351 Views
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Article
A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells
Yuan Tan, Zhenglan Huang, Xin Wang, Hongdan Dai, Guoyun Jiang & Wenli Feng
Pages: 4816-4827
Published online: 04 Aug 2021
AbstractforA novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells | Full Text | References | PDF (3 MB) | EPUB
  • 1562 Views
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Article
Prognostic and immunological role of Ras-related protein Rap1b in pan-cancer
Guoliang Cui, Can Wang, Zhenyan Lin, Xiaoke Feng, Muxin Wei, Zhengyue Miao, Zhiguang Sun & Fei Wei
Pages: 4828-4840
Published online: 04 Aug 2021
AbstractforPrognostic and immunological role of Ras-related protein Rap1b in pan-cancer | Full Text | References | PDF (4 MB) | EPUB
  • 3467 Views
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Article
Nucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma
Gang Wang, Fangfang Qu, Shouyong Liu, Jincai Zhou & Yi Wang
Pages: 4841-4855
Published online: 01 Aug 2021
AbstractforNucleolar protein NOP2 could serve as a potential prognostic predictor for clear cell renal cell carcinoma | Full Text | References | PDF (5.3 MB) | EPUB
  • 2729 Views
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Article
Transmembrane protein TMEM119 facilitates the stemness of breast cancer cells by activating Wnt/β-catenin pathway
Ben Yang, Fengling Wang & Gang Zheng
Pages: 4856-4867
Published online: 01 Aug 2021
AbstractforTransmembrane protein TMEM119 facilitates the stemness of breast cancer cells by activating Wnt/β-catenin pathway | Full Text | References | PDF (3.4 MB) | EPUB
  • 2090 Views
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Article
Ramelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway
Chuo Li, Yusheng Zhang, Rongrong Liu & Yuzhen Mai
Pages: 4868-4877
Published online: 04 Aug 2021
AbstractforRamelteon ameliorated 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in neuronal cells in a mitochondrial-dependent pathway | Full Text | References | PDF (1.3 MB) | EPUB
  • 1440 Views
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Article
Resveratrol acts via the mitogen-activated protein kinase (MAPK) pathway to protect retinal ganglion cells from apoptosis induced by hydrogen peroxide
Ming-jing Ye & Ni Meng
Pages: 4878-4886
Published online: 10 Aug 2021
AbstractforResveratrol acts via the mitogen-activated protein kinase (MAPK) pathway to protect retinal ganglion cells from apoptosis induced by hydrogen peroxide | Full Text | References | PDF (1.1 MB) | EPUB
  • 1701 Views
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Article
Formononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation
Baohua Zhang, Zhongwei Hao, Wenli Zhou, Shan Zhang, Mingyan Sun, Honglei Li, Naijing Hou, Cui Jing & Mingxing Zhao
Pages: 4887-4898
Published online: 08 Aug 2021
AbstractforFormononetin protects against ox-LDL-induced endothelial dysfunction by activating PPAR-γ signaling based on network pharmacology and experimental validation | Full Text | References | PDF (3.1 MB) | EPUB
  • 4326 Views
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Article
miR-152-3p aggravates vascular endothelial cell dysfunction by targeting DEAD-box helicase 6 (DDX6) under hypoxia
Zhongyan Zhao, Chanji Wu, Xiangying He, Eryi Zhao, Shijun Hu, Yeguang Han, Ting Wang, Yanquan Chen, Tao Liu & Shixiong Huang
Pages: 4899-4910
Published online: 10 Aug 2021
AbstractformiR-152-3p aggravates vascular endothelial cell dysfunction by targeting DEAD-box helicase 6 (DDX6) under hypoxia | Full Text | References | PDF (1.7 MB) | EPUB
  • 1529 Views
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Article
Circular RNA Circ_0005564 promotes osteogenic differentiation of bone marrow mesenchymal cells in osteoporosis
Zitao Liu, Qiyu Liu, Shanchuang Chen, Haitao Su & Tao Jiang
Pages: 4911-4923
Published online: 10 Aug 2021
AbstractforCircular RNA Circ_0005564 promotes osteogenic differentiation of bone marrow mesenchymal cells in osteoporosis | Full Text | References | PDF (3.8 MB) | EPUB
  • 1749 Views
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Article
Identification of prognostic markers by weighted gene co‐expression network analysis in non-small cell lung cancer
Binglin Chen, Xiaowei Xie, Feifeng Lan & Wenqi Liu
Pages: 4924-4935
Published online: 08 Aug 2021
AbstractforIdentification of prognostic markers by weighted gene co‐expression network analysis in non-small cell lung cancer | Full Text | References | PDF (2.6 MB) | EPUB
  • 2758 Views
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Article
Upregulated circRNA_102231 promotes gastric cancer progression and its clinical significance
Gaofeng Yuan, Wenwen Ding, Bingjie Sun, Lin Zhu, Yuewen Gao & Lulu Chen
Pages: 4936-4945
Published online: 10 Aug 2021
AbstractforUpregulated circRNA_102231 promotes gastric cancer progression and its clinical significance | Full Text | References | PDF (2.3 MB) | EPUB
  • 4134 Views
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Article
Solute carrier family 12 member 8 (SLC12A8) is a potential biomarker and related to tumor immune cell infiltration in bladder cancer
Qian Zhang, Yunen Liu, Peng Chen, Xiuyun Shi, Ying Liu, Lin Shi, Peifang Cong, Shun Mao, Cangci Tong, Cheng Du & Mingxiao Hou
Pages: 4946-4961
Published online: 09 Aug 2021
AbstractforSolute carrier family 12 member 8 (SLC12A8) is a potential biomarker and related to tumor immune cell infiltration in bladder cancer | Full Text | References | PDF (5.5 MB) | EPUB
  • 2389 Views
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Article
Effects of fluid shear stress on expression of focal adhesion kinase in MG-63 human osteoblast-like cells on different surface modification of titanium
Xin Lei, Qiong Liu, Shiyi Li, Zhaoqiang Zhang & Xiaoyu Yang
Pages: 4962-4971
Published online: 10 Aug 2021
AbstractforEffects of fluid shear stress on expression of focal adhesion kinase in MG-63 human osteoblast-like cells on different surface modification of titanium | Full Text | References | PDF (1.3 MB) | EPUB
  • 1140 Views
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Article
Long non-coding RNA AK006774 inhibits cardiac ischemia-reperfusion injury via sponging miR-448
Shen Nie, Xiaoya Cui, Jinping Guo, Xiaohua Ma, Haijun Zhi, Shilei Li & Yong Li
Pages: 4972-4982
Published online: 08 Aug 2021
AbstractforLong non-coding RNA AK006774 inhibits cardiac ischemia-reperfusion injury via sponging miR-448 | Full Text | References | PDF (2 MB) | EPUB
  • 1736 Views
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Article
Transferrin receptor-mediated reactive oxygen species promotes ferroptosis of KGN cells via regulating NADPH oxidase 1/PTEN induced kinase 1/acyl-CoA synthetase long chain family member 4 signaling
Lingzhi Zhang, Fang Wang, Dongmei Li, Yufeng Yan & Hongyan Wang
Pages: 4983-4994
Published online: 08 Aug 2021
AbstractforTransferrin receptor-mediated reactive oxygen species promotes ferroptosis of KGN cells via regulating NADPH oxidase 1/PTEN induced kinase 1/acyl-CoA synthetase long chain family member 4 signaling | Full Text | References | PDF (3.7 MB) | EPUB
  • 7803 Views
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Article
Inhibition of HMGB1/RAGE axis suppressed the lipopolysaccharide (LPS)-induced vicious transformation of cervical epithelial cells
Lifang You, Hongyin Cui, Fen Zhao, Huier Sun, Huanxin Zhong, Guoli Zhou & Xuejun Chen
Pages: 4995-5003
Published online: 08 Aug 2021
AbstractforInhibition of HMGB1/RAGE axis suppressed the lipopolysaccharide (LPS)-induced vicious transformation of cervical epithelial cells | Full Text | References | PDF (2.2 MB) | EPUB
  • 2097 Views
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Article
Two types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma
Ziyou Tao, Chao Lu, Shuai Gao, Peng Zhang, Yuan Chen, Yuanguo Wang, Zhaoyu Yang, Kai Xiong, Yuxin Liu & Peng Zhang
Pages: 5004-5016
Published online: 08 Oct 2021
AbstractforTwo types of immune infiltrating cells and six hub genes can predict the occurrence of myasthenia gravis in patients with thymoma | Full Text | References | PDF (3.8 MB) | EPUB
  • 1975 Views
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Article
Curcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression
Xuelian Gong, Ling Jiang, Wei Li, Qingbin Liang & Zhen Li
Pages: 5017-5027
Published online: 17 Aug 2021
AbstractforCurcumin induces apoptosis and autophagy inhuman renal cell carcinoma cells via Akt/mTOR suppression | Full Text | References | PDF (2.7 MB) | EPUB
  • 3136 Views
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Article
Long non-coding RNA VCAN-AS1 promotes the malignant behaviors of breast cancer by regulating the miR-106a-5p-mediated STAT3/HIF-1α pathway
Peng Du, Kaifeng Luo, Guoyong Li, Jisheng Zhu, Qi Xiao, Yong Li & Xingjian Zhang
Pages: 5028-5044
Published online: 09 Aug 2021
AbstractforLong non-coding RNA VCAN-AS1 promotes the malignant behaviors of breast cancer by regulating the miR-106a-5p-mediated STAT3/HIF-1α pathway | Full Text | References | PDF (4.6 MB) | EPUB
  • 2343 Views
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Article
Pseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals
Min Pan, Xiaohui Yin & Yi-chuan Huang
Pages: 5045-5055
Published online: 09 Aug 2021
AbstractforPseudopodium enriched atypical kinase 1(PEAK1) promotes invasion and of melanoma cells by activating JAK/STAT3 signals | Full Text | References | PDF (4.7 MB) | EPUB
  • 1462 Views
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Article
Single-cell RNA-seq reveals invasive trajectory and determines cancer stem cell-related prognostic genes in pancreatic cancer
Xuechen Ren, Chengliang Zhou, Yu Lu, Fulin Ma, Yong Fan & Chen Wang
Pages: 5056-5068
Published online: 02 Sep 2021
AbstractforSingle-cell RNA-seq reveals invasive trajectory and determines cancer stem cell-related prognostic genes in pancreatic cancer | Full Text | References | PDF (3.5 MB) | EPUB
  • 6403 Views
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Article
Systematic analysis of Long non-coding RNAs reveals diagnostic biomarkers and potential therapeutic drugs for intervertebral disc degeneration
Jiawen Zhan, Shangquan Wang, Xu Wei, Minshan Feng, Xunlu Yin, Jie Yu, Tao Han, Guangwei Liu, Wangwen Xuan, Xiaobo Wang, Rui Xie, Kai Sun & Liguo Zhu
Pages: 5069-5084
Published online: 17 Aug 2021
AbstractforSystematic analysis of Long non-coding RNAs reveals diagnostic biomarkers and potential therapeutic drugs for intervertebral disc degeneration | Full Text | References | PDF (2.7 MB) | EPUB
  • 1995 Views
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Article
The regulation of long non-coding RNA 00958 (LINC00958) for oral squamous cell carcinoma (OSCC) cells death through absent in melanoma 2 (AIM2) depending on microRNA-4306 and Sirtuin1 (SIRT1) in vitro
Lei Jiang, Wenyu Ge, Yifei Cui & Xiaofeng Wang
Pages: 5085-5098
Published online: 12 Aug 2021
AbstractforThe regulation of long non-coding RNA 00958 (LINC00958) for oral squamous cell carcinoma (OSCC) cells death through absent in melanoma 2 (AIM2) depending on microRNA-4306 and Sirtuin1 (SIRT1) in vitro | Full Text | References | PDF (3.4 MB) | EPUB
  • 2905 Views
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Article
Discovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients
Mahmood Rasool, Angel Carracedo, Abdulrahman Sibiany, Faten Al-Sayes, Sajjad Karim, Absarul Haque, Peter Natesan Pushparaj, Muhammad Asif & Niaz M. Achakzai
Pages: 5099-5109
Published online: 08 Aug 2021
AbstractforDiscovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients | Full Text | References | PDF (1.8 MB) | EPUB
  • 1497 Views
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Article
Interplays of enzyme, substrate, and surfactant on hydrolysis of native lignocellulosic biomass
Sengthong Lee, Saengchai Akeprathumchai, Damkerng Bundidamorn, Lakha Salaipeth, Kanokwan Poomputsa, Khanok Ratanakhanokchai, Ken-Lin Chang & Paripok Phitsuwan
Pages: 5110-5124
Published online: 08 Aug 2021
AbstractforInterplays of enzyme, substrate, and surfactant on hydrolysis of native lignocellulosic biomass | Full Text | References | PDF (2 MB) | EPUB
  • 1706 Views
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Article
Knockdown of long non-coding RNA CDKN2B-AS1 suppresses the progression of breast cancer by miR-122-5p/STK39 axis
Shaojie Qin, Mingliang Ning, Qingyuan Liu, Xiaoyun Ding, Yanbai Wang & Qilun Liu
Pages: 5125-5137
Published online: 10 Aug 2021
AbstractforKnockdown of long non-coding RNA CDKN2B-AS1 suppresses the progression of breast cancer by miR-122-5p/STK39 axis | Full Text | References | PDF (2.4 MB) | EPUB
  • 1805 Views
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Article
Prognostic role and clinical significance of C-reactive protein-lymphocyte ratio in colorectal cancer
Yongsheng Meng, Chenyan Long, Xiaoliang Huang, Lihaoyun Huang, Lixian Liao, Weizhong Tang & Jungang Liu
Pages: 5138-5148
Published online: 26 Aug 2021
AbstractforPrognostic role and clinical significance of C-reactive protein-lymphocyte ratio in colorectal cancer | Full Text | References | PDF (1.9 MB) | EPUB
  • 2230 Views
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Article
Identification of candidate biomarkers correlated with poor prognosis of breast cancer based on bioinformatics analysis
Gang Chen, Mingwei Yu, Jianqiao Cao, Huishan Zhao, Yuanping Dai, Yizi Cong & Guangdong Qiao
Pages: 5149-5161
Published online: 12 Aug 2021
AbstractforIdentification of candidate biomarkers correlated with poor prognosis of breast cancer based on bioinformatics analysis | Full Text | References | PDF (4.2 MB) | EPUB
  • 4917 Views
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Article
Short- and long-term follow-up outcomes of patients with Brucella endocarditis: a systematic review of 207 Brucella endocarditis Cases
Xiufeng Li, Tan Wang, Yuanzhi Wang, Songsong Xie, Wenbo Tan & Ping Li
Pages: 5162-5172
Published online: 18 Aug 2021
AbstractforShort- and long-term follow-up outcomes of patients with Brucella endocarditis: a systematic review of 207 Brucella endocarditis Cases | Full Text | References | PDF (831.6 KB) | EPUB
  • 1729 Views
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Article
Changes in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension
Wei Hong, Qiudi Mo, Luyao Wang, Fang Peng, Yuming Zhou, Weifeng Zou, Ruiting Sun, Chunxiao Liang, Mengning Zheng, Haiqing Li, Dongxing Zhao, Mi Gao, Jinding Pu, Bing Li, Pixin Ran & Gongyong Peng
Pages: 5173-5183
Published online: 18 Aug 2021
AbstractforChanges in the gut microbiome and metabolome in a rat model of pulmonary arterial hypertension | Full Text | References | PDF (2.6 MB) | EPUB
  • 4858 Views
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Article
Tamsulosin attenuates high glucose- induced injury in glomerular endothelial cells
Lin Sun, Chengmin Sun, Shibo Zhou, Lan Zhang & Wenping Hu
Pages: 5184-5194
Published online: 17 Aug 2021
AbstractforTamsulosin attenuates high glucose- induced injury in glomerular endothelial cells | Full Text | References | PDF (1.4 MB) | EPUB
  • 2083 Views
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Article
Glucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa
Dongyue Li, Youlin Yang, Xunhai Yin, Yang Liu, Hongyu Xu, Yu Ni, Ping Hang, Sijia Niu, Huichao Zhang, Wenbo Ding & Hongyu Kuang
Pages: 5195-5209
Published online: 17 Aug 2021
AbstractforGlucagon-like peptide (GLP) -2 improved colonizing bacteria and reduced severity of ulcerative colitis by enhancing the diversity and abundance of intestinal mucosa | Full Text | References | PDF (4.8 MB) | EPUB
  • 2047 Views
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Article
Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts
Qinghua Wu, Junjie Chen, Ziming Tan, Dehuai Wang, Jianwen Zhou, Dan Li & Ying Cen
Pages: 5210-5219
Published online: 20 Aug 2021
AbstractforLong non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) regulates fibroblast growth factor receptor substrate 2 (FRS2) by targeting microRNA (miR)-29-3p in hypertrophic scar fibroblasts | Full Text | References | PDF (2 MB) | EPUB
  • 1325 Views
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Article
A novel circular RNA circPPFIA1 promotes laryngeal squamous cell carcinoma progression through sponging miR-340-3p and regulating ELK1 expression
Yu Shuang, Jing Liu, Juntao Niu, Wenyu Guo & Chao Li
Pages: 5220-5230
Published online: 30 Aug 2021
AbstractforA novel circular RNA circPPFIA1 promotes laryngeal squamous cell carcinoma progression through sponging miR-340-3p and regulating ELK1 expression | Full Text | References | PDF (4.5 MB) | EPUB
  • 1239 Views
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Article
Long non-coding RNA ZFAS1 alleviates bupivacaine-induced neurotoxicity by regulating the miR-421/zinc finger protein564 (ZNF564) axis
Liuqing Yuan, Houren Xu, Rui Guo, Ting Lu & Xiaoling Li
Pages: 5231-5240
Published online: 20 Aug 2021
AbstractforLong non-coding RNA ZFAS1 alleviates bupivacaine-induced neurotoxicity by regulating the miR-421/zinc finger protein564 (ZNF564) axis | Full Text | References | PDF (2.1 MB) | EPUB
  • 985 Views
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Article
Notum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma
Hua Gong, Qiang Niu, Yi Zhou, YUN-Xia Wang, Xuan-Fu Xu & Ke-Zhu Hou
Pages: 5241-5252
Published online: 17 Aug 2021
AbstractforNotum palmitoleoyl-protein carboxylesterase regulates Fas cell surface death receptor-mediated apoptosis via the Wnt signaling pathway in colon adenocarcinoma | Full Text | References | PDF (2 MB) | EPUB
  • 1683 Views
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Article
Immune-associated molecular occurrence and prognosis predictor of hepatocellular carcinoma: an integrated analysis of GEO datasets
Guanjun Liu, Dongmei Wu, Yiyang Wen & Shundong Cang
Pages: 5253-5265
Published online: 23 Aug 2021
AbstractforImmune-associated molecular occurrence and prognosis predictor of hepatocellular carcinoma: an integrated analysis of GEO datasets | Full Text | References | PDF (1.6 MB) | EPUB
  • 1974 Views
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Article
Long non-coding RNA FOXD3 antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363/ trefoil factor 1/ phosphatidylinositol 3-kinase/protein kinase B axis
Lili Ren, Huanhuan Zhou, Lei Lei, Yongjun Zhang, Hu Cai & Xiaojia Wang
Pages: 5266-5278
Published online: 23 Aug 2021
AbstractforLong non-coding RNA FOXD3 antisense RNA 1 augments anti-estrogen resistance in breast cancer cells through the microRNA-363/ trefoil factor 1/ phosphatidylinositol 3-kinase/protein kinase B axis | Full Text | References | PDF (2.6 MB) | EPUB
  • 1651 Views
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Article
Interleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis
Fei Han, Shijie Li, Yankun Yang & Zhonghu Bai
Pages: 5279-5288
Published online: 17 Aug 2021
AbstractforInterleukin-6 promotes ferroptosis in bronchial epithelial cells by inducing reactive oxygen species-dependent lipid peroxidation and disrupting iron homeostasis | Full Text | References | PDF (1.5 MB) | EPUB
  • 5798 Views
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Article
Identification of prognostic and bone metastatic alternative splicing signatures in bladder cancer
Runzhi Huang, Zixuan Zheng, Shuyuan Xian, Jiayao Zhang, Jingyi Jia, Dianwen Song, Penghui Yan, Huabin Yin, Peng Hu, Xiaolong Zhu, Zongqiang Huang, Tong Meng & Jie Zhang
Pages: 5289-5304
Published online: 17 Aug 2021
AbstractforIdentification of prognostic and bone metastatic alternative splicing signatures in bladder cancer | Full Text | References | PDF (3.4 MB) | EPUB
  • 2468 Views
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Article
Oncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway
Lingling Zhang, Ran Ren, Xue Yang, Yiman Ge, Xiajun Zhang & Hongping Yuan
Pages: 5305-5322
Published online: 19 Aug 2021
AbstractforOncogenic role of early growth response-1 in liver cancer through the regulation of the microRNA-675/sestrin 3 and the Wnt/β-catenin signaling pathway | Full Text | References | PDF (6.1 MB) | EPUB
  • 1812 Views
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Article
The tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients
Wenfa Yi, Yong Yu, Yafei Li, Juan Yang, Shuying Gao & Lingfen Xu
Pages: 5323-5333
Published online: 09 Sep 2021
AbstractforThe tumor-suppressive effects of alpha-ketoglutarate-dependent dioxygenase FTO via N6-methyladenosine RNA methylation on bladder cancer patients | Full Text | References | PDF (2 MB) | EPUB
  • 2280 Views
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Retraction

Article
RETRACTED ARTICLE: MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel
Jie Yan, Litong Shi, Shan Lin & Yi Li
Pages: 5334-5347
Published online: 20 Aug 2021
AbstractforRETRACTED ARTICLE: MicroRNA-624-mediated ARRDC3/YAP/HIF1α axis enhances esophageal squamous cell carcinoma cell resistance to cisplatin and paclitaxel | PDF (5.5 MB)
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Article
Cullin-5 (CUL5) as a potential prognostic marker in a pan-cancer analysis of human tumors
Zian Li, Nan Hu, Lirui Dai, Xuelei Hou, Weihua Hu, Wulong Liang & Xinjun Wang
Pages: 5348-5360
Published online: 20 Aug 2021
AbstractforCullin-5 (CUL5) as a potential prognostic marker in a pan-cancer analysis of human tumors | Full Text | References | PDF (4.3 MB) | EPUB
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Article
The protective effects of naproxen against interleukin-1β (IL-1β)- induced damage in human umbilical vein endothelial cells (HUVECs)
Yuliang Wu, Ruina Hao, Beidi Lan, Yiping Mu, Fuping Dang & Ruitao Wang
Pages: 5361-5372
Published online: 24 Aug 2021
AbstractforThe protective effects of naproxen against interleukin-1β (IL-1β)- induced damage in human umbilical vein endothelial cells (HUVECs) | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Circ_nuclear factor I X (circNfix) attenuates pressure overload-induced cardiac hypertrophy via regulating miR-145-5p/ATF3 axis
Jun Pan, Zhenjun Xu, Guanjun Guo, Can Xu, Zhizhao Song, Kunsheng Li, Kai Zhong & Dongjin Wang
Pages: 5373-5385
Published online: 01 Sep 2021
AbstractforCirc_nuclear factor I X (circNfix) attenuates pressure overload-induced cardiac hypertrophy via regulating miR-145-5p/ATF3 axis | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Identification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated bioinformatic analysis
Yuejun Wang, Mingming Zhao & Yu Zhang
Pages: 5386-5401
Published online: 23 Aug 2021
AbstractforIdentification of fibronectin 1 (FN1) and complement component 3 (C3) as immune infiltration-related biomarkers for diabetic nephropathy using integrated bioinformatic analysis | Full Text | References | PDF (2 MB) | EPUB
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Article
The up-regulation of miR-21 by gastrodin to promote the angiogenesis ability of human umbilical vein endothelial cells by activating the signaling pathway of PI3K/Akt
Jianli Wang & Minghua Wu
Pages: 5402-5410
Published online: 23 Aug 2021
AbstractforThe up-regulation of miR-21 by gastrodin to promote the angiogenesis ability of human umbilical vein endothelial cells by activating the signaling pathway of PI3K/Akt | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p
Cheng Cheng, Haoping Zhang, Zhipeng Dai & Jia Zheng
Pages: 5411-5427
Published online: 23 Aug 2021
AbstractforCircular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p | Full Text | References | PDF (4.2 MB) | EPUB
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Article
C–X–C motif chemokine ligand 12: a potential therapeutic target in Duchenne muscular dystrophy
Jie Chen & Xinsheng Lai
Pages: 5428-5439
Published online: 23 Aug 2021
AbstractforC–X–C motif chemokine ligand 12: a potential therapeutic target in Duchenne muscular dystrophy | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Carnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ25-35
Yiyun Ding, Hongxia Zhang, Zhaojun Liu, Qiuping Li, Yujiao Guo, Ye Chen, Yue Chang & Hongyan Cui
Pages: 5440-5449
Published online: 23 Aug 2021
AbstractforCarnitine palmitoyltransferase 1 (CPT1) alleviates oxidative stress and apoptosis of hippocampal neuron in response to beta-Amyloid peptide fragment Aβ25-35 | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Ursolic acid treats renal tubular epithelial cell damage induced by calcium oxalate monohydrate via inhibiting oxidative stress and inflammation
Zhaohui Jia, Wensheng Li, Pan Bian, Liuyang Yang, Hui Liu, Dong Pan & Zhongling Dou
Pages: 5450-5461
Published online: 10 Sep 2021
AbstractforUrsolic acid treats renal tubular epithelial cell damage induced by calcium oxalate monohydrate via inhibiting oxidative stress and inflammation | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Long non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM
Fuji Lai, Huiqin Zhang, Binbin Xu, Yangyang Xie & Hua Yu
Pages: 5462-5475
Published online: 10 Sep 2021
AbstractforLong non-coding RNA NBR2 suppresses the progress of colorectal cancer in vitro and in vivo by regulating the polarization of TAM | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Upregulated lncRNA Cyclin‐dependent kinase inhibitor 2B antisense RNA 1 induces the proliferation and migration of colorectal cancer by miR-378b/CAPRIN2 axis
Yu Zheng, Jintao Zeng, Haoyun Xia, Xiangyu Wang, Hongyuan Chen, Liangxiang Huang & Changqing Zeng
Pages: 5476-5490
Published online: 13 Sep 2021
AbstractforUpregulated lncRNA Cyclin‐dependent kinase inhibitor 2B antisense RNA 1 induces the proliferation and migration of colorectal cancer by miR-378b/CAPRIN2 axis | Full Text | References | PDF (3.4 MB) | EPUB
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Article
The protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction
Xiaopan Chen, Chuan Yun, Hailong Zheng, Xu Chen, Qianfei Han, Hua Pan, Yang Wang & Jianghua Zhong
Pages: 5491-5503
Published online: 10 Sep 2021
AbstractforThe protective effects of S14G-humanin (HNG) against streptozotocin (STZ)-induced cardiac dysfunction | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data
Hang Huang, Haokai Xu, Ping Li, Xueting Ye, Wei Chen, Wei Chen & Xixi Huang
Pages: 5504-5515
Published online: 13 Sep 2021
AbstractforZinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Overexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy
Lijin Zhu, Yuanyuan Zhao, Li Yu, Xinjia He, Yingju Wang, Peng Jiang, Rong Yu, Wei Li, Bin Dong, Xiang Wang & Yinying Dong
Pages: 5516-5528
Published online: 16 Sep 2021
AbstractforOverexpression of ADAM9 decreases radiosensitivity of hepatocellular carcinoma cell by activating autophagy | Full Text | References | PDF (3.4 MB) | EPUB
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Article
Argon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury
Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan & Chunqing Meng
Pages: 5529-5539
Published online: 10 Sep 2021
AbstractforArgon inhibits reactive oxygen species oxidative stress via the miR-21-mediated PDCD4/PTEN pathway to prevent myocardial ischemia/reperfusion injury | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Circular RNA SMEK1 promotes neuropathic pain in rats through targeting microRNA-216a-5p to mediate Thioredoxin Interacting Protein (TXNIP) expression
Yufu Xin, Xinrong Song & Qingye Ge
Pages: 5540-5551
Published online: 14 Sep 2021
AbstractforCircular RNA SMEK1 promotes neuropathic pain in rats through targeting microRNA-216a-5p to mediate Thioredoxin Interacting Protein (TXNIP) expression | Full Text | References | PDF (2.2 MB) | EPUB
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Article
MicroRNA -148 alleviates cardiac dysfunction, immune disorders and myocardial apoptosis in myocardial ischemia-reperfusion (MI/R) injury by targeting pyruvate dehydrogenase kinase (PDK4)
Myocardial protection of miR-148/PDK4 in immature rats.
Qi Yin, Ping Wang & Xiaohua Wu
Pages: 5552-5565
Published online: 14 Sep 2021
AbstractforMicroRNA -148 alleviates cardiac dysfunction, immune disorders and myocardial apoptosis in myocardial ischemia-reperfusion (MI/R) injury by targeting pyruvate dehydrogenase kinase (PDK4) | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Long non-coding RNA TUG1 knockdown prevents neurons from death to alleviate acute spinal cord injury via the microRNA-338/BIK axis
Hongbo Wu, Yi Li, Xiaofeng Wang, Zhiwen Zhang & Yuliang Huang
Pages: 5566-5582
Published online: 14 Sep 2021
AbstractforLong non-coding RNA TUG1 knockdown prevents neurons from death to alleviate acute spinal cord injury via the microRNA-338/BIK axis | Full Text | References | PDF (4 MB) | EPUB
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Article
Lycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis
Ji Wu, Yang Fu, Ying-xing Wu, Zu-xiang Wu, Zhen-hua Wang & Ping Li
Pages: 5583-5594
Published online: 13 Sep 2021
AbstractforLycorine ameliorates isoproterenol-induced cardiac dysfunction mainly via inhibiting inflammation, fibrosis, oxidative stress and apoptosis | Full Text | References | PDF (4.1 MB) | EPUB
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Article
Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer
Xiao Xie, Huajiang Lin, Xiaolei Zhang, Pengtao Song, Xiangyi He, Jing Zhong & Jiemin Shi
Pages: 5595-5606
Published online: 13 Sep 2021
AbstractforOverexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Long non-coding RNA LINC01296 acts as a migration and invasion promoter in head and neck squamous cell carcinoma and predicts poor prognosis
Jing Wu, Hua Chen, Jingjing Li, Xiaoyu Li, Jun Cao & Min Qi
Pages: 5607-5619
Published online: 13 Sep 2021
AbstractforLong non-coding RNA LINC01296 acts as a migration and invasion promoter in head and neck squamous cell carcinoma and predicts poor prognosis | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells
Yuefu Han, Xingqiao Wen, Xiaojuan Li, Dong Chen, Lian Peng, Bin Lai & Hongcai Huang
Pages: 5620-5631
Published online: 13 Sep 2021
AbstractforCircular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells | Full Text | References | PDF (3.6 MB) | EPUB
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Article
microRNA-3646 serves as a diagnostic marker and mediates the inflammatory response induced by acute coronary syndrome
Jinming Yu, Yongmei Li, Deguo Leng, Cheng Cao, Yongzhi Yu & Yijuan Wang
Pages: 5632-5640
Published online: 14 Sep 2021
AbstractformicroRNA-3646 serves as a diagnostic marker and mediates the inflammatory response induced by acute coronary syndrome | Full Text | References | PDF (687.3 KB) | EPUB
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Article
Glucoside xylosyltransferase 2 as a diagnostic and prognostic marker in gastric cancer via comprehensive analysis
Yunxia Zhao, Shangshang Hu, Jinyan Zhang, Zhaogen Cai, Shuanhu Wang, Mulin Liu, Jing Dai & Yu Gao
Pages: 5641-5654
Published online: 10 Sep 2021
AbstractforGlucoside xylosyltransferase 2 as a diagnostic and prognostic marker in gastric cancer via comprehensive analysis | Full Text | References | PDF (3.2 MB) | EPUB
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Article
MiR-212-3p promotes proliferation and migration of trophoblast in fetal growth restriction by targeting placental growth factor
Limin Yu, Yan Sun & Zanjun Chu
Pages: 5655-5663
Published online: 02 Sep 2021
AbstractforMiR-212-3p promotes proliferation and migration of trophoblast in fetal growth restriction by targeting placental growth factor | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis
Guan Fang, Tingting Chen, Ruibo Mao, Xiaming Huang & Ling Ji
Pages: 5664-5678
Published online: 13 Sep 2021
AbstractforCircular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis | Full Text | References | PDF (2.4 MB) | EPUB
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Circular RNA Hsa_circ_0006766 targets microRNA miR-4739 to regulate osteogenic differentiation of human bone marrow mesenchymal stem cells
Zhaodi Guo, Manlin Xie, Yanfang Zou, Qianxin Liang, Fubin Liu, Jing Su, Zhiliang He, Xiuping Cai, Zhixiang Chen, Qing Zhao & Kewei Zhao
Pages: 5679-5687
Published online: 15 Sep 2021
AbstractforCircular RNA Hsa_circ_0006766 targets microRNA miR-4739 to regulate osteogenic differentiation of human bone marrow mesenchymal stem cells | Full Text | References | PDF (2.2 MB) | EPUB
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Article
α-Actinin1 promotes tumorigenesis and epithelial-mesenchymal transition of gastric cancer via the AKT/GSK3β/β-Catenin pathway
Siwen Zhang, Junfu Wang, Ting Chen, Jiancheng Wang, Ye Wang, Zhu Yu, Kun Zhao, Kaitian Zheng, Yeyang Chen, Zhen Wang, Bopei Li, Congjun Wang, Weijia Huang, Zhao Fu & Junqiang Chen
Pages: 5688-5704
Published online: 21 Sep 2021
Abstractforα-Actinin1 promotes tumorigenesis and epithelial-mesenchymal transition of gastric cancer via the AKT/GSK3β/β-Catenin pathway | Full Text | References | PDF (3.9 MB) | EPUB
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Article
MicroRNA-221-3p alleviates cell apoptosis and inflammatory response by targeting cyclin dependent kinase inhibitor 1B in chronic obstructive pulmonary disease
Hua Yang, Lijuan Zhang & Quandong Wang
Pages: 5705-5715
Published online: 13 Sep 2021
AbstractforMicroRNA-221-3p alleviates cell apoptosis and inflammatory response by targeting cyclin dependent kinase inhibitor 1B in chronic obstructive pulmonary disease | Full Text | References | PDF (2.1 MB) | EPUB
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Article
CTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt)
Zhiwen Liu & Bin Yang
Pages: 5716-5726
Published online: 13 Sep 2021
AbstractforCTRP6(C1q/Tumor Necrosis Factor (TNF)-related protein-6) alleviated the sevoflurane induced injury of mice central nervous system by promoting the expression of p-Akt (phosphorylated Akt) | Full Text | References | PDF (1.8 MB) | EPUB
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Article
A nine-hub-gene signature of metabolic syndrome identified using machine learning algorithms and integrated bioinformatics
Guanzhi Liu, Sen Luo, Yutian Lei, Jianhua Wu, Zhuo Huang, Kunzheng Wang, Pei Yang & Xin Huang
Pages: 5727-5738
Published online: 13 Sep 2021
AbstractforA nine-hub-gene signature of metabolic syndrome identified using machine learning algorithms and integrated bioinformatics | Full Text | References | PDF (2.2 MB) | EPUB
  • 2004 Views
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Article
Protein tyrosine phosphatase, receptor type B is a potential biomarker and facilitates cervical cancer metastasis via epithelial-mesenchymal transition
Zhuo-Ya Huang, Peng-Juan Liao, Ying-xia Liu, Ming Zhong, Ai-hua Sun, Xiao-cong Jiang, Xiu-Ping Wang & Min Zhang
Pages: 5739-5748
Published online: 13 Sep 2021
AbstractforProtein tyrosine phosphatase, receptor type B is a potential biomarker and facilitates cervical cancer metastasis via epithelial-mesenchymal transition | Full Text | References | PDF (5.2 MB) | EPUB
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Article
High expression of ladinin-1 (LAD1) predicts adverse outcomes: a new candidate docetaxel resistance gene for prostatic cancer (PCa)
Jianping Li, Ziming Wang & Chong Tie
Pages: 5749-5759
Published online: 13 Sep 2021
AbstractforHigh expression of ladinin-1 (LAD1) predicts adverse outcomes: a new candidate docetaxel resistance gene for prostatic cancer (PCa) | Full Text | References | PDF (1.7 MB) | EPUB
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Article
TTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer
Na Lu & Lixin Ren
Pages: 5759-5768
Published online: 13 Sep 2021
AbstractforTTK (threonine tyrosine kinase) regulates the malignant behaviors of cancer cells and is regulated by microRNA-582-5p in ovarian cancer | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Design and characterization of small-diameter tissue-engineered blood vessels constructed by electrospun polyurethane-core and gelatin-shell coaxial fiber
Yuanguo Zhang, Yuhao Jiao, Cong Wang, Chengchao Zhang, Han Wang, Zengguo Feng, Yongquan Gu & Zhonggao Wang
Pages: 5769-5788
Published online: 14 Sep 2021
AbstractforDesign and characterization of small-diameter tissue-engineered blood vessels constructed by electrospun polyurethane-core and gelatin-shell coaxial fiber | Full Text | References | PDF (5.3 MB) | EPUB
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Article
MicroRNA-21 regulate the cell apoptosis and cell proliferation of polycystic ovary syndrome (PCOS) granulosa cells through target toll like receptor TLR8
Yingying Yu, Guojing Li, Xiaoying He, Yu Lin, Zheng Chen, Xianhua Lin & Hong Xu
Pages: 5789-5796
Published online: 13 Sep 2021
AbstractforMicroRNA-21 regulate the cell apoptosis and cell proliferation of polycystic ovary syndrome (PCOS) granulosa cells through target toll like receptor TLR8 | Full Text | References | PDF (929.5 KB) | EPUB
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Article
The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro
The protective mechanism of rhein in preventing obesity
Li Ji & Huan Gu
Pages: 5797-5813
Published online: 13 Sep 2021
AbstractforThe anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro | Full Text | References | PDF (5.9 MB) | EPUB
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Review
CRISPR–Cas9-based genetic engineering for crop improvement under drought stress
Abdul Sami, Zhao Xue, Saheera Tazein, Ayesha Arshad, Zong He Zhu, Ya Ping Chen, Yue Hong, Xiao Tian Zhu & Ke Jin Zhou
Pages: 5814-5829
Published online: 10 Sep 2021
AbstractforCRISPR–Cas9-based genetic engineering for crop improvement under drought stress | Full Text | References | PDF (855.7 KB) | EPUB
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Article
MicroRNA-26b-5p suppresses the proliferation of tongue squamous cell carcinoma via targeting proline rich 11 (PRR11)
Liang Yi, Ying Liu, Anji Xu, Sha Li, Hailin Zhang, Mingjing Peng, Zan Li, Huayi Ren, Jie Dai, Chenhui Luo, Yazhou Xiao, Xiao Zhou & Ying Long
Pages: 5830-5838
Published online: 07 Sep 2021
AbstractforMicroRNA-26b-5p suppresses the proliferation of tongue squamous cell carcinoma via targeting proline rich 11 (PRR11) | Full Text | References | PDF (1.4 MB) | EPUB
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Article
MicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1
Jianyong Xiong, Lijuan Zhang, Ren Tang & Zhengming Zhu
Pages: 5839-5849
Published online: 07 Sep 2021
AbstractforMicroRNA-301b-3p facilitates cell proliferation and migration in colorectal cancer by targeting HOXB1 | Full Text | References | PDF (3.5 MB) | EPUB
  • 1327 Views
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Article
Mex-3 RNA binding MEX3A promotes the proliferation and migration of breast cancer cells via regulating RhoA/ROCK1/LIMK1 signaling pathway
Li Yan, Hongjing Li, Wenbo an, Wei Wei, Xiaolei Zhang & Linlin Wang
Pages: 5850-5858
Published online: 05 Sep 2021
AbstractforMex-3 RNA binding MEX3A promotes the proliferation and migration of breast cancer cells via regulating RhoA/ROCK1/LIMK1 signaling pathway | Full Text | References | PDF (1.8 MB) | EPUB
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Article
RecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway
Fei Zhou, Leiming Wang, Kangpeng Jin & Yang Wu
Pages: 5859-5869
Published online: 03 Sep 2021
AbstractforRecQ-like helicase 4 (RECQL4) exacerbates resistance to oxaliplatin in colon adenocarcinoma via activation of the PI3K/AKT signaling pathway | Full Text | References | PDF (5.2 MB) | EPUB
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Article
Tetrandrine suppresses the growth of human osteosarcoma cells by regulating multiple signaling pathways
Nan Wang, Shengdong Yang, Tao Tan, Yanran Huang, Yangmei Chen, Chaoqun Dong, Jin Chen & Xiaoji Luo
Pages: 5870-5882
Published online: 03 Sep 2021
AbstractforTetrandrine suppresses the growth of human osteosarcoma cells by regulating multiple signaling pathways | Full Text | References | PDF (5.7 MB) | EPUB
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Review

Review
Application of three-dimensional printing technology in peripheral hip diseases
Shuai Liang, Jia Xie, Fangyuan Wang, Juehua Jing & Jun Li
Pages: 5883-5891
Published online: 03 Sep 2021
AbstractforApplication of three-dimensional printing technology in peripheral hip diseases | Full Text | References | PDF (1.3 MB) | EPUB
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Article
Genome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer
Yue Liu, Weiming Lou, Guang Chen, Bing Ding, Jin Kuang, Yize Zhang, Cong Wang, Sainan Duan, Ying Deng & Xiongbing Lu
Pages: 5892-5903
Published online: 05 Sep 2021
AbstractforGenome-wide screening for the G-protein-coupled receptor (GPCR) pathway-related therapeutic gene RGS19 (regulator of G protein signaling 19) in bladder cancer | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Coordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease
Zan Xie, Qianli Wang & Shaojuan Hu
Pages: 5904-5915
Published online: 05 Sep 2021
AbstractforCoordination of PRKCA/PRKCA-AS1 interplay facilitates DNA methyltransferase 1 recruitment on DNA methylation to affect protein kinase C alpha transcription in mitral valve of rheumatic heart disease | Full Text | References | PDF (1.9 MB) | EPUB
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Identification of a 3-gene signature based on differentially expressed invasion genes related to cancer molecular subtypes to predict the prognosis of osteosarcoma patients
Yue Wan, Ning Qu, Yang Yang, Jing Ma, Zhe Li & Zhenyu Zhang
Pages: 5916-5931
Published online: 07 Sep 2021
AbstractforIdentification of a 3-gene signature based on differentially expressed invasion genes related to cancer molecular subtypes to predict the prognosis of osteosarcoma patients | Full Text | References | PDF (4.6 MB) | EPUB
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A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma
Jiahang Song, Yuanyuan Sun, Hui Cao, Zhengcheng Liu, Lei Xi, Changqing Dong, Rusong Yang & Ye Shi
Pages: 5932-5949
Published online: 07 Sep 2021
AbstractforA novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma | Full Text | References | PDF (2.5 MB) | EPUB
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Centromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma
Ke Shi, Xinyue Zhu, Jiali Wu, Yuhong Chen, Jingfa Zhang & Xiaodong Sun
Pages: 5950-5970
Published online: 05 Sep 2021
AbstractforCentromere protein E as a novel biomarker and potential therapeutic target for retinoblastoma | Full Text | References | PDF (8.5 MB) | EPUB
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Comprehensive analysis of pivotal biomarkers, immune cell infiltration and therapeutic drugs for steroid-induced osteonecrosis of the femoral head
Bo Wang, Song Gong, Wenkai Shao, Lizhi Han, Zilin Li, Zhichao Zhang, Yang Zheng, Fang Ouyang, Yan Ma, Weihua Xu & Yong Feng
Pages: 5971-5984
Published online: 07 Sep 2021
AbstractforComprehensive analysis of pivotal biomarkers, immune cell infiltration and therapeutic drugs for steroid-induced osteonecrosis of the femoral head | Full Text | References | PDF (3.9 MB) | EPUB
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The anti-tumor effects of evodiamine on oral squamous cell carcinoma (OSCC) through regulating advanced glycation end products (AGE) / receptor for advanced glycation end products (RAGE) pathway
Liuyang Ren, Ying Lou & Mingyu Sun
Pages: 5985-5995
Published online: 03 Sep 2021
AbstractforThe anti-tumor effects of evodiamine on oral squamous cell carcinoma (OSCC) through regulating advanced glycation end products (AGE) / receptor for advanced glycation end products (RAGE) pathway | Full Text | References | PDF (3.1 MB) | EPUB
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CKS2 (CDC28 protein kinase regulatory subunit 2) is a prognostic biomarker in lower grade glioma: a study based on bioinformatic analysis and immunohistochemistry
Menglong Hu, Zongkuo Li, Jinhuan Qiu, Ruizhen Zhang, Junkai Feng, Guiming Hu & Jingli Ren
Pages: 5996-6009
Published online: 08 Sep 2021
AbstractforCKS2 (CDC28 protein kinase regulatory subunit 2) is a prognostic biomarker in lower grade glioma: a study based on bioinformatic analysis and immunohistochemistry | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Long noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690
Hao Zhang, Zhenghua Fang, Yesong Guo & Dejun Wang
Pages: 6010-6020
Published online: 03 Sep 2021
AbstractforLong noncoding RNA SNHG10 promotes colorectal cancer cells malignant progression by targeting miR-3690 | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Integrated weighted gene co-expression network analysis uncovers STAT1(signal transducer and activator of transcription 1) and IFI44L (interferon-induced protein 44-like) as key genes in pulmonary arterial hypertension
Han Yang, Yang Lu, Hongmin Yang, Yaoxi Zhu, Yaohan Tang, Lixia Li, Changhu Liu & Jing Yuan
Pages: 6021-6034
Published online: 13 Sep 2021
AbstractforIntegrated weighted gene co-expression network analysis uncovers STAT1(signal transducer and activator of transcription 1) and IFI44L (interferon-induced protein 44-like) as key genes in pulmonary arterial hypertension | Full Text | References | PDF (4 MB) | EPUB
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Article
Pinocembrin suppresses proliferation and enhances apoptosis in lung cancer cells in vitro by restraining autophagy
Hongxia Gong
Pages: 6035-6044
Published online: 04 Sep 2021
AbstractforPinocembrin suppresses proliferation and enhances apoptosis in lung cancer cells in vitro by restraining autophagy | Full Text | References | PDF (3.6 MB) | EPUB
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Article
Astragaloside IV suppresses histamine-induced inflammatory factors and mucin 5 subtype AC overproduction in nasal epithelial cells via regulation of inflammation-related genes
Jie Guo & Shuai Xu
Pages: 6045-6056
Published online: 05 Sep 2021
AbstractforAstragaloside IV suppresses histamine-induced inflammatory factors and mucin 5 subtype AC overproduction in nasal epithelial cells via regulation of inflammation-related genes | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Long non-coding RNA XIST promotes osteoporosis by inhibiting the differentiation of bone marrow mesenchymal stem cell by sponging miR-29b-3p that suppresses nicotinamide N-methyltransferase
Jiang Yu, Min Xiao & Guohai Ren
Pages: 6057-6069
Published online: 05 Sep 2021
AbstractforLong non-coding RNA XIST promotes osteoporosis by inhibiting the differentiation of bone marrow mesenchymal stem cell by sponging miR-29b-3p that suppresses nicotinamide N-methyltransferase | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Liquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo
Yingchen Ji, Weiwei Hu, Yan Jin, Huiming Yu & Jin Fang
Pages: 6070-6082
Published online: 07 Sep 2021
AbstractforLiquiritigenin exerts the anti-cancer role in oral cancer via inducing autophagy-related apoptosis through PI3K/AKT/mTOR pathway inhibition in vitro and in vivo | Full Text | References | PDF (3.9 MB) | EPUB
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Article
Long non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis
Junyu Ren, Ning Xu, Ruize Zhou, Fengchang Huang, Hongbin Zhang & Wenliang Li
Pages: 6083-6095
Published online: 13 Sep 2021
AbstractforLong non-coding RNA PCED1B antisense RNA 1 promotes gastric cancer progression via modulating microRNA-215-3p / C-X-C motif chemokine receptor 1 axis | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Genome-wide analysis and characterization of GRAS family in switchgrass
Xiaoqin Wang, Guixia Li, Yajing Sun, Zhongyu qin & Pengcheng Feng
Pages: 6096-6114
Published online: 03 Sep 2021
AbstractforGenome-wide analysis and characterization of GRAS family in switchgrass | Full Text | References | PDF (7.6 MB) | EPUB
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Article
Expression of N6-methyladenosine (m6A) regulators correlates with immune microenvironment characteristics and predicts prognosis in diffuse large cell lymphoma (DLBCL)
Zucheng Xie, Meiwei Li, Haoyuan Hong, Qingyuan Xu, Zhendong He & Zhigang Peng
Pages: 6115-6133
Published online: 04 Sep 2021
AbstractforExpression of N6-methyladenosine (m6A) regulators correlates with immune microenvironment characteristics and predicts prognosis in diffuse large cell lymphoma (DLBCL) | Full Text | References | PDF (4.2 MB) | EPUB
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Article
Exploration of differentially-expressed exosomal mRNAs, lncRNAs and circRNAs from serum samples of gallbladder cancer and xantho-granulomatous cholecystitis patients
Jiajun Ren, Sheng Chen, Feng Ye, Xiaoyong Gong, Ye Lu, Qiang Cai & Yongjun Chen
Pages: 6134-6143
Published online: 04 Sep 2021
AbstractforExploration of differentially-expressed exosomal mRNAs, lncRNAs and circRNAs from serum samples of gallbladder cancer and xantho-granulomatous cholecystitis patients | Full Text | References | PDF (2.3 MB) | EPUB
  • 1998 Views
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Article
RNA binding protein serine/arginine splicing factor 1 promotes the proliferation, migration and invasion of hepatocellular carcinoma by interacting with RecQ protein-like 4 mRNA
Ying Ye, Feng Yu, Zhao Li, Yaping Xie & Xiaohong Yu
Pages: 6144-6154
Published online: 04 Sep 2021
AbstractforRNA binding protein serine/arginine splicing factor 1 promotes the proliferation, migration and invasion of hepatocellular carcinoma by interacting with RecQ protein-like 4 mRNA | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Downregulation of Salusin-β protects renal tubular epithelial cells against high glucose-induced inflammation, oxidative stress, apoptosis and lipid accumulation via suppressing miR-155-5p
Hongmei Chen & Genjuan Jin
Pages: 6155-6165
Published online: 04 Sep 2021
AbstractforDownregulation of Salusin-β protects renal tubular epithelial cells against high glucose-induced inflammation, oxidative stress, apoptosis and lipid accumulation via suppressing miR-155-5p | Full Text | References | PDF (4.3 MB) | EPUB
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Article
A pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers
Yuxi Gu, Shouyi Tang, Zhen Wang, Luyao Cai, Haosen Lian, Yingqiang Shen & Yu Zhou
Pages: 6166-6185
Published online: 04 Sep 2021
AbstractforA pan-cancer analysis of the prognostic and immunological role of β-actin (ACTB) in human cancers | Full Text | References | PDF (6.9 MB) | EPUB
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Article
Integrated analysis of hypoxia-associated lncRNA signature to predict prognosis and immune microenvironment of lung adenocarcinoma patients
Jun Shao, Boqing Zhang, Lin Kuai & Qingguo Li
Pages: 6186-6200
Published online: 04 Sep 2021
AbstractforIntegrated analysis of hypoxia-associated lncRNA signature to predict prognosis and immune microenvironment of lung adenocarcinoma patients | Full Text | References | PDF (4.9 MB) | EPUB
  • 2572 Views
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Article
miR-195-5p regulates cell proliferation, apoptosis, and invasion of thyroid cancer by targeting telomerase reverse transcriptase
Zhiwen Liu, Li Zhang, Wen Chen, Fenqian Yuan, Zhi Yang, Sheng Liu & Fei Le
Pages: 6201-6209
Published online: 05 Sep 2021
AbstractformiR-195-5p regulates cell proliferation, apoptosis, and invasion of thyroid cancer by targeting telomerase reverse transcriptase | Full Text | References | PDF (2.4 MB) | EPUB
  • 1437 Views
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Article
Gene expression and prognosis of x-ray repair cross-complementing family members in non-small cell lung cancer
Yongfei Fan, Zhaojia Gao, Xinwei Li, Shuzhang Wei & Kai Yuan
Pages: 6210-6228
Published online: 05 Sep 2021
AbstractforGene expression and prognosis of x-ray repair cross-complementing family members in non-small cell lung cancer | Full Text | References | PDF (5.5 MB) | EPUB
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Article
Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer
Xin Hu, Ping Wang, Chen Qu, Haibo Zhang & Liang Li
Pages: 6229-6239
Published online: 14 Sep 2021
AbstractforCircular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Quercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis
Haifeng Lan, Wei Hong, Dongyang Qian, Fang Peng, Haiqing Li, Chunxiao Liang, Min Du, Jinlan Gu, Junxuan Mai, Bo Bai & Gongyong Peng
Pages: 6240-6250
Published online: 05 Sep 2021
AbstractforQuercetin modulates the gut microbiota as well as the metabolome in a rat model of osteoarthritis | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Long non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis
Zijun Yu, Yeming Wang, Jianwu Deng, Dong Liu, Lingling Zhang, Hua Shao, Zilu Wang, Wenjun Zhu, Cheng Zhao & Qungang Ke
Pages: 6251-6263
Published online: 03 Sep 2021
AbstractforLong non-coding RNA COL4A2-AS1 facilitates cell proliferation and glycolysis of colorectal cancer cells via miR-20b-5p/hypoxia inducible factor 1 alpha subunit axis | Full Text | References | PDF (2.7 MB) | EPUB
  • 1885 Views
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Article
Long coding RNA CCAT2 enhances the proliferation and epithelial-mesenchymal transition of cervical carcinoma cells via the microRNA-493-5p/CREB1 axis
Jing Wang, Yan Liu, Hongbing Cai, Hong Jiang, Wei Li & Yuying Shi
Pages: 6264-6274
Published online: 09 Sep 2021
AbstractforLong coding RNA CCAT2 enhances the proliferation and epithelial-mesenchymal transition of cervical carcinoma cells via the microRNA-493-5p/CREB1 axis | Full Text | References | PDF (3.3 MB) | EPUB
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Article
A novel long non-coding RNA-based prognostic signature for renal cell carcinoma patients with stage IV and histological grade G4
Ning Li, Haiying Zhang, Keyao Hu & Jianfeng Chu
Pages: 6275-6285
Published online: 09 Sep 2021
AbstractforA novel long non-coding RNA-based prognostic signature for renal cell carcinoma patients with stage IV and histological grade G4 | Full Text | References | PDF (1.6 MB) | EPUB
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Research Article

Article
Evaluation of tumor microenvironmental immune regulation and prognostic in lung adenocarcinoma from the perspective of purinergic receptor P2Y13
Jiangtao Wang, Weiwei Shi, Yandong Miao, Jian Gan, Quanlin Guan & Juntao Ran
Pages: 6286-6304
Published online: 08 Sep 2021
AbstractforEvaluation of tumor microenvironmental immune regulation and prognostic in lung adenocarcinoma from the perspective of purinergic receptor P2Y13 | Full Text | References | PDF (7.7 MB) | EPUB
  • 2526 Views
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Research Paper

Article
The circular RNA circ0005654 interacts with specificity protein 1 via microRNA-363 sequestration to promote gastric cancer progression
Cui Yang & Shengjin Han
Pages: 6305-6317
Published online: 09 Sep 2021
AbstractforThe circular RNA circ0005654 interacts with specificity protein 1 via microRNA-363 sequestration to promote gastric cancer progression | Full Text | References | PDF (2.2 MB) | EPUB
  • 1510 Views
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Article
Potential biomarkers: differentially expressed proteins of the extrinsic coagulation pathway in plasma samples from patients with depression
Chunyue Yu, Teli Zhang, Shanshan Shi, Taiming Wei & Qi Wang
Pages: 6318-6331
Published online: 07 Sep 2021
AbstractforPotential biomarkers: differentially expressed proteins of the extrinsic coagulation pathway in plasma samples from patients with depression | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Knock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death
Feng Shi, Luquan Zhang, Xing Liu & Yue Wang
Pages: 6332-6342
Published online: 07 Sep 2021
AbstractforKnock-down of microRNA miR-556-5p increases cisplatin-sensitivity in non-small cell lung cancer (NSCLC) via activating NLR family pyrin domain containing 3 (NLRP3)-mediated pyroptotic cell death | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Resveratrol-modified mesoporous silica nanoparticle for tumor-targeted therapy of gastric cancer
Mingzhen Lin, Wenxia Yao, Yao Xiao, Zhijie Dong, Wei Huang, Fan Zhang, Xinke Zhou & Min Liang
Pages: 6343-6353
Published online: 10 Sep 2021
AbstractforResveratrol-modified mesoporous silica nanoparticle for tumor-targeted therapy of gastric cancer | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Lactobacillus johnsonii BS15 combined with abdominal massage on intestinal permeability in rats with nonalcoholic fatty liver and cell biofilm repair
Wei Zhang, Huanan Li, Na Zhao, Xiongfei Luo, Siwen Liu, an Bao, Yingying Chen, Haiteng Wang, Junshi Wang & Jingui Wang
Pages: 6354-6363
Published online: 13 Sep 2021
AbstractforLactobacillus johnsonii BS15 combined with abdominal massage on intestinal permeability in rats with nonalcoholic fatty liver and cell biofilm repair | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Sevoflurane promotes the apoptosis of laryngeal squamous cell carcinoma in-vitro and inhibits its malignant progression via miR-26a/FOXO1 axis
Dan Liu, Lang Wan, Hao Gong, Shiming Chen, Yonggang Kong & Bokui Xiao
Pages: 6364-6376
Published online: 13 Sep 2021
AbstractforSevoflurane promotes the apoptosis of laryngeal squamous cell carcinoma in-vitro and inhibits its malignant progression via miR-26a/FOXO1 axis | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Long non-coding RNA MALAT1 enhances the protective effect of dexmedetomidine on acute lung injury by sponging miR-135a-5p to downregulate the ratio of X-box binding proteins XBP-1S/XBP-1U
Pengyi Li, Lianbing Gu, Qingming Bian, Dian Jiao, Zeping Xu & Lijun Wang
Pages: 6377-6389
Published online: 13 Sep 2021
AbstractforLong non-coding RNA MALAT1 enhances the protective effect of dexmedetomidine on acute lung injury by sponging miR-135a-5p to downregulate the ratio of X-box binding proteins XBP-1S/XBP-1U | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Nucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy
Jiayong Xie, Ying Yuan, Gang Yao, Zhi Chen, Wenjuan Yu & Qiang Zhu
Pages: 6390-6402
Published online: 17 Sep 2021
AbstractforNucleoporin 160 (NUP160) inhibition alleviates diabetic nephropathy by activating autophagy | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Long noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2’-5’-oligoadenylate synthetase 2 axis in acute myeloid leukemia
Hong Zhou, Xiaofeng Jia, Fan Yang & Pengfei Shi
Pages: 6403-6417
Published online: 13 Sep 2021
AbstractforLong noncoding RNA SATB1-AS1 contributes to the chemotherapy resistance through the microRNA-580/ 2’-5’-oligoadenylate synthetase 2 axis in acute myeloid leukemia | Full Text | References | PDF (5.3 MB) | EPUB
  • 1995 Views
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Review

Review
Bioengineered bioreactors: a review on enhancing biomethane and biohydrogen production by CFD modeling
Anand Kumar Saini, Tanja Radu, Kunwar Paritosh, Vinod Kumar, Nidhi Pareek, Dharmendra Tripathi & Vivekanand Vivekanand
Pages: 6418-6433
Published online: 17 Sep 2021
AbstractforBioengineered bioreactors: a review on enhancing biomethane and biohydrogen production by CFD modeling | Full Text | References | PDF (1.1 MB) | EPUB
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Research Paper

Article
Mesenchymal stem cell conditioned medium attenuates oxidative stress injury in hepatocytes partly by regulating the miR-486-5p/PIM1 axis and the TGF-β/Smad pathway
Ning Ma, Shuo Li, Chao Lin, Xianbin Cheng & Zihui Meng
Pages: 6434-6447
Published online: 14 Sep 2021
AbstractforMesenchymal stem cell conditioned medium attenuates oxidative stress injury in hepatocytes partly by regulating the miR-486-5p/PIM1 axis and the TGF-β/Smad pathway | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Carboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma
Zhourui Ma, Qianwei Xiong, Hongliang Xia, Wei Liu, Shu Dai, Shizhong Cai, Zhenhong Zhu & Xiangming Yan
Pages: 6448-6458
Published online: 14 Sep 2021
AbstractforCarboplatin activates the cGAS-STING pathway by upregulating the TREX-1 (three prime repair exonuclease 1) expression in human melanoma | Full Text | References | PDF (2.5 MB) | EPUB
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Article
Enzymatic characterization of D-lactate dehydrogenase and application in alanine aminotransferase activity assay kit
Yi Sun, Guosheng Gao & Ting Cai
Pages: 6459-6471
Published online: 13 Sep 2021
AbstractforEnzymatic characterization of D-lactate dehydrogenase and application in alanine aminotransferase activity assay kit | Full Text | References | PDF (1.2 MB) | EPUB
  • 2361 Views
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Article
Gold nanoparticles alleviates the lipopolysaccharide-induced intestinal epithelial barrier dysfunction
Zhen Wang, Yinya Cao, Kangzhen Zhang, Zhirui Guo, Ying Liu, Ping Zhou, Zhengxia Liu & Xiang Lu
Pages: 6472-6483
Published online: 15 Sep 2021
AbstractforGold nanoparticles alleviates the lipopolysaccharide-induced intestinal epithelial barrier dysfunction | Full Text | References | PDF (2.9 MB) | EPUB
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Article
The mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation
Ruibiao Fu, Zhongpeng Li, Rui Zhou, Chaoyang Li, Shuai Shao & Jin Li
Pages: 6484-6498
Published online: 13 Sep 2021
AbstractforThe mechanism of intestinal flora dysregulation mediated by intestinal bacterial biofilm to induce constipation | Full Text | References | PDF (2.1 MB) | EPUB
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Article
Tetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model
Jiazhen Yin, Jiazhen Lin, Jin Yu, Xia Wei, Bin Zhu & Caifeng Zhu
Pages: 6499-6515
Published online: 14 Sep 2021
AbstractforTetrandrine may treat membranous glomerulopathy via P13K/Akt signaling pathway regulation: therapeutic mechanism validation using Heymann nephritis rat model | Full Text | References | PDF (6.6 MB) | EPUB
  • 2021 Views
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Article
Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis
Jie Huang, Jianxiong Ma, Jie Wang, Ke Ma, Kang Zhou, Wenjie Huang, Fan Zhao, Bodong Lv & Qing Hu
Pages: 6516-6528
Published online: 14 Sep 2021
AbstractforWhole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Knockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38
Jian Chen, Luke Zhou, Jie Yang, Hui Xie, Lin Liu & Youwei Li
Pages: 6529-6537
Published online: 14 Sep 2021
AbstractforKnockdown of STK39 suppressed cell proliferation, migration, and invasion in hepatocellular carcinoma by repressing the phosphorylation of mitogen-activated protein kinase p38 | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Quercetin alleviates chronic renal failure by targeting the PI3k/Akt pathway
Haitao Tu, Duanhua Ma, Yuanyuan Luo, Shuifu Tang, Ying Li, Gangyi Chen, Liangliang Wang, Zhengkun Hou, Chuangpeng Shen, Huan Lu, Xun Zhuang & Liangyou Zhang
Pages: 6538-6558
Published online: 16 Sep 2021
AbstractforQuercetin alleviates chronic renal failure by targeting the PI3k/Akt pathway | Full Text | References | PDF (8.5 MB) | EPUB
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Article
Orthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer
Lei Jiang, Zhongqiang Zuo, Jie Lin & Chuanfeng Yang
Pages: 6559-6571
Published online: 24 Sep 2021
AbstractforOrthodenticle homeobox OTX1 is a potential prognostic biomarker for bladder cancer | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Enhancement of nanoparticle-mediated double suicide gene expression driven by ‘E9-hTERT promoter’ switch in dedifferentiated thyroid cancer cells
Aoshuang Chang, Junjun Ling, Huiping Ye, Houyu Zhao & Xianlu Zhuo
Pages: 6572-6578
Published online: 10 Sep 2021
AbstractforEnhancement of nanoparticle-mediated double suicide gene expression driven by ‘E9-hTERT promoter’ switch in dedifferentiated thyroid cancer cells | Full Text | References | PDF (839.5 KB) | EPUB
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Article
Identification of hsa_circ_0002024 as a prognostic competing endogenous RNA (ceRNA) through the hsa_miR_129-5p/Anti-Silencing Function 1B Histone Chaperone (ASF1B) axis in renal cell carcinoma
Zhe Chen, Dehua Ou, Zhuangkai Huang & Peilin Shen
Pages: 6579-6593
Published online: 13 Sep 2021
AbstractforIdentification of hsa_circ_0002024 as a prognostic competing endogenous RNA (ceRNA) through the hsa_miR_129-5p/Anti-Silencing Function 1B Histone Chaperone (ASF1B) axis in renal cell carcinoma | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway
Cheng Wang, Miaomiao Yang, Xi Gu & Yanjing Gu
Pages: 6594-6605
Published online: 13 Sep 2021
AbstractforLemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Ozone protects cardiomyocytes against ischemia/reperfusion injury: Regulating the heat shock protein 70 (HSP70) expression through activating the JAK2/STAT3 Pathway
Shenglong Yu, Huizhuang Guo, Yi Luo & Hanwei Chen
Pages: 6606-6616
Published online: 13 Sep 2021
AbstractforOzone protects cardiomyocytes against ischemia/reperfusion injury: Regulating the heat shock protein 70 (HSP70) expression through activating the JAK2/STAT3 Pathway | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Identification of downstream targets and signaling pathways of long non-coding RNA NR_002794 in human trophoblast cells
Yinyao Ma, Hua Wu, Xuxia Liang, Chun Zhang, Yanhua Ma, Yanfen Wei, Jing Li & Hui Chen
Pages: 6617-6628
Published online: 13 Sep 2021
AbstractforIdentification of downstream targets and signaling pathways of long non-coding RNA NR_002794 in human trophoblast cells | Full Text | References | PDF (1.7 MB) | EPUB
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Article
Long non-coding RNA ARAP1-AS1 contributes to cell proliferation and migration in clear cell renal cell carcinoma via the miR-361-3p/placental growth factor axis
Liping Zhong & Xiuwen Zhong
Pages: 6629-6642
Published online: 13 Sep 2021
AbstractforLong non-coding RNA ARAP1-AS1 contributes to cell proliferation and migration in clear cell renal cell carcinoma via the miR-361-3p/placental growth factor axis | Full Text | References | PDF (9.9 MB) | EPUB
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Article
Four specific biomarkers associated with the progression of glioblastoma multiforme in older adults identified using weighted gene co-expression network analysis
Yushi Yang, Liangzhao Chu, Zhirui Zeng, Shu Xu, Hua Yang, Xuelin Zhang, Jun Jia, Niya Long, Yaxin Hu & Jian Liu
Pages: 6643-6654
Published online: 13 Sep 2021
AbstractforFour specific biomarkers associated with the progression of glioblastoma multiforme in older adults identified using weighted gene co-expression network analysis | Full Text | References | PDF (2 MB) | EPUB
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Article
Identification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease
Yan Jia, Hui Xu, Qi Yu, Lishan Tan & Zuying Xiong
Pages: 6655-6673
Published online: 10 Sep 2021
AbstractforIdentification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease | Full Text | References | PDF (4.9 MB) | EPUB
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Article
Long non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury
Jin Xu, Dong Yu, Xiaolu Bai & Peng Zhang
Pages: 6674-6686
Published online: 10 Oct 2021
AbstractforLong non-coding RNA growth arrest specific transcript 5 acting as a sponge of MicroRNA-188-5p to regulate SMAD family member 2 expression promotes myocardial ischemia-reperfusion injury | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Long noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis
Jiwen Xu, Xiaoyan Liu, Xueting Liu & Yunlai Zhi
Pages: 6687-6702
Published online: 13 Sep 2021
AbstractforLong noncoding RNA KCNMB2-AS1 promotes the development of esophageal cancer by modulating the miR-3194-3p/PYGL axis | Full Text | References | PDF (5.2 MB) | EPUB
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Article
Mechanism of megaloblastic anemia combined with hemolysis
Qiong Wu, Junru Liu, Xiaoxuan Xu, Beihui Huang, Dong Zheng & Juan Li
Pages: 6703-6712
Published online: 19 Sep 2021
AbstractforMechanism of megaloblastic anemia combined with hemolysis | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Long non-coding RNA FGD5-AS1 contributes to cisplatin resistance in hepatocellular carcinoma via sponging microRNA-153-3p by upregulating Twinfilin Actin Binding Protein 1 (TWF1)
Yue Yang, Longqing Shi, Dong Zhang, Di Wu, Yong an, Yue Zhang & Xuemin Chen
Pages: 6713-6723
Published online: 14 Sep 2021
AbstractforLong non-coding RNA FGD5-AS1 contributes to cisplatin resistance in hepatocellular carcinoma via sponging microRNA-153-3p by upregulating Twinfilin Actin Binding Protein 1 (TWF1) | Full Text | References | PDF (3 MB) | EPUB
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Article
Long non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis
Fengfeng Wang, Tengfei Gu, Yao Chen, Yu Chen, Dan Xiong & Yehan Zhu
Pages: 6724-6737
Published online: 13 Sep 2021
AbstractforLong non-coding RNA SOX21-AS1 modulates lung cancer progress upon microRNA miR-24-3p/PIM2 axis | Full Text | References | PDF (4 MB) | EPUB
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Article
Long non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2
Xiaomeng Chen, Hong Ma, Yan Gao, Ye Jin, Wei Ning, Yue Hou & Jianrong Su
Pages: 6738-6747
Published online: 13 Sep 2021
AbstractforLong non-coding RNA AC012668 suppresses non-alcoholic fatty liver disease by competing for microRNA miR-380-5p with lipoprotein-related protein LRP2 | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis
Xiaohui Lu, Haijie Gao, Bo Zhu & Guilan Lin
Pages: 6748-6758
Published online: 21 Sep 2021
AbstractforCircular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis | Full Text | References | PDF (2.7 MB) | EPUB
  • 1889 Views
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Article
A circular RNA, circUSP36, accelerates endothelial cell dysfunction in atherosclerosis by adsorbing miR-637 to enhance WNT4 expression
Jian-guo Huang, Xia Tang, Jiang-jie Wang, Jia Liu, Ping Chen & Yan Sun
Pages: 6759-6770
Published online: 14 Sep 2021
AbstractforA circular RNA, circUSP36, accelerates endothelial cell dysfunction in atherosclerosis by adsorbing miR-637 to enhance WNT4 expression | Full Text | References | PDF (3.1 MB) | EPUB
  • 1558 Views
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Article
miR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1)
Ying Ding, Jingyu Wang & Jun Lu
Pages: 6771-6781
Published online: 13 Sep 2021
AbstractformiR-337-5p promotes the development of cardiac hypertrophy by targeting Ubiquilin-1 (UBQLN1) | Full Text | References | PDF (2.3 MB) | EPUB
  • 1239 Views
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Article
Exosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis
Yan Huang, Bo Liang & Xiangjuan Chen
Pages: 6782-6792
Published online: 13 Sep 2021
AbstractforExosomal circular RNA circ_0074673 regulates the proliferation, migration, and angiogenesis of human umbilical vein endothelial cells via the microRNA-1200/MEOX2 axis | Full Text | References | PDF (2 MB) | EPUB
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Review

Review
Genetic modification for enhancing bacterial cellulose production and its applications
Reeta Rani Singhania, Anil Kumar Patel, Mei-Ling Tsai, Chiu-Wen Chen & Cheng Di Dong
Pages: 6793-6807
Published online: 14 Sep 2021
AbstractforGenetic modification for enhancing bacterial cellulose production and its applications | Full Text | References | PDF (839.9 KB) | EPUB
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Research paper

Article
Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin
Changyong Luo, Yan Li, Xu Liang, Yifan Chen, Qiao Zou, Yurong Kong, Zhengguang Guo, Wei Sun & Xin Wang
Pages: 6808-6820
Published online: 14 Sep 2021
AbstractforSpecial electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin | Full Text | References | PDF (3.4 MB) | EPUB
  • 1440 Views
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Research Paper

Article
Construction of a 5-feature gene model by support vector machine for classifying osteoporosis samples
Minwei Hu, Ling Zou, Jiong Lu, Zeyu Yang, Yinan Chen, Yaozeng Xu & Changhui Sun
Pages: 6821-6830
Published online: 08 Oct 2021
AbstractforConstruction of a 5-feature gene model by support vector machine for classifying osteoporosis samples | Full Text | References | PDF (1.5 MB) | EPUB
  • 1940 Views
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Article
Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis
Yin Zhang, Meng Pan, Chun-Yuan Li, Jing-ying Li, Wei Ge, Lai Xu & Yi Xiao
Pages: 6831-6843
Published online: 29 Sep 2021
AbstractforExploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis | Full Text | References | PDF (1.9 MB) | EPUB
  • 1950 Views
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Article
Study of calcitriol anti-aging effects on human natural killer cells in vitro
Weiran Li, Xu Che, Xuemei Chen, Meiling Zhou, Xiaoping Luo & Tao Liu
Pages: 6844-6854
Published online: 21 Sep 2021
AbstractforStudy of calcitriol anti-aging effects on human natural killer cells in vitro | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Chrysophanol Induced Glioma Cells Apoptosis via Activation of Mitochondrial Apoptosis Pathway
Jia Gu, Sunil Rauniyar, Yan Wang, Wenjian Zhan, Chengkun Ye, Shaogan Ji & Guanzheng Liu
Pages: 6855-6868
Published online: 14 Sep 2021
AbstractforChrysophanol Induced Glioma Cells Apoptosis via Activation of Mitochondrial Apoptosis Pathway | Full Text | References | PDF (3.1 MB) | EPUB
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Article
E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene
Rongheng Liao, Bo Xie, Jun Cui, Zhen Qi, Song Xue & Yongyi Wang
Pages: 6869-6877
Published online: 14 Sep 2021
AbstractforE2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-β1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene | Full Text | References | PDF (1.9 MB) | EPUB
  • 1794 Views
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Article
Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axis
Lihua Zhu, Lijuan Shi, Wenfeng Ye, Shuping Li, Xinmei Liu & Zonghao Zhu
Pages: 6878-6890
Published online: 14 Sep 2021
AbstractforCircular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axis | Full Text | References | PDF (3.2 MB) | EPUB
  • 1890 Views
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Article
Lumican silencing alleviates tumor necrosis factor-α-induced nucleus pulposus cell inflammation and senescence by inhibiting apoptosis signal regulating kinase 1/p38 signaling pathway via inactivating Fas ligand expression
Zhenqiang Li, Chengfeng Sun, Maosong Chen & Boding Wang
Pages: 6891-6901
Published online: 13 Sep 2021
AbstractforLumican silencing alleviates tumor necrosis factor-α-induced nucleus pulposus cell inflammation and senescence by inhibiting apoptosis signal regulating kinase 1/p38 signaling pathway via inactivating Fas ligand expression | Full Text | References | PDF (3.2 MB) | EPUB
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Article
MicroRNA miR-495 regulates the development of Hepatocellular Carcinoma by targeting C1q/tumor necrosis factor-related protein-3 (CTRP3)
Ruiguang Zhang, Chunxia Guo, Ting Liu, Wenting Li & Xiliu Chen
Pages: 6902-6912
Published online: 13 Sep 2021
AbstractforMicroRNA miR-495 regulates the development of Hepatocellular Carcinoma by targeting C1q/tumor necrosis factor-related protein-3 (CTRP3) | Full Text | References | PDF (2.7 MB) | EPUB
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Article
lncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis
Zhen Xie, Shuai Liu, Shicheng Chu, Yiqun Liu, Bingtao Huang & Qingguang Zhang
Pages: 6913-6922
Published online: 13 Sep 2021
AbstractforlncRNA RMRP predicts poor prognosis and mediates tumor progression of esophageal squamous cell carcinoma by regulating miR-613/ neuropilin 2 (NRP2) axis | Full Text | References | PDF (1.2 MB) | EPUB
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Review

Review
Multifaceted roles of CCL20 (C-C motif chemokine ligand 20): mechanisms and communication networks in breast cancer progression
Louis Boafo Kwantwi, Shujing Wang, Youjing Sheng & Qiang Wu
Pages: 6923-6934
Published online: 27 Sep 2021
AbstractforMultifaceted roles of CCL20 (C-C motif chemokine ligand 20): mechanisms and communication networks in breast cancer progression | Full Text | References | PDF (653.4 KB) | EPUB
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Research Paper

Article
Alteration of long non-coding RNAs and mRNAs expression profiles by compound heterozygous ASXL3 mutations in the mouse brain
Songhui Zhang, Fang Fu, Li Zhen, Ru Li & Can Liao
Pages: 6935-6951
Published online: 24 Sep 2021
AbstractforAlteration of long non-coding RNAs and mRNAs expression profiles by compound heterozygous ASXL3 mutations in the mouse brain | Full Text | References | PDF (3 MB) | EPUB
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Article
Over-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway
Zhen Huang, Guofeng Su, Xiaoxia Bi, Libo Zhang, Zhuohui Xu & Ge Wang
Pages: 6952-6966
Published online: 13 Sep 2021
AbstractforOver-expression of long non-coding RNA insulin-like growth factor 2-antisense suppressed hepatocellular carcinoma cell proliferation and metastasis by regulating the microRNA-520h/cyclin-dependent kinase inhibitor 1A signaling pathway | Full Text | References | PDF (2.7 MB) | EPUB
  • 1402 Views
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Article
The microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma
Yi Luo, Xiu Qu, Dan Kan & Binlin Cai
Pages: 6967-6980
Published online: 13 Sep 2021
AbstractforThe microRNA-451a/chromosome segregation 1-like axis suppresses cell proliferation, migration, and invasion and induces apoptosis in nasopharyngeal carcinoma | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Investigation of bacterial diversity in Cajanus cajan-planted gangue soil via high-throughput sequencing
Shiming Han, Yuexia Wang, Yuan Li & Kaiyi Shi
Pages: 6981-6995
Published online: 21 Sep 2021
AbstractforInvestigation of bacterial diversity in Cajanus cajan-planted gangue soil via high-throughput sequencing | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Tumor-associated neutrophils activated by tumor-derived CCL20 (C-C motif chemokine ligand 20) promote T cell immunosuppression via programmed death-ligand 1 (PD-L1) in breast cancer
Louis Boafo Kwantwi, Shujing Wang, Wenjun Zhang, Weidong Peng, Zeyu Cai, Youjing Sheng, Han Xiao, Xian Wang & Qiang Wu
Pages: 6996-7006
Published online: 14 Sep 2021
AbstractforTumor-associated neutrophils activated by tumor-derived CCL20 (C-C motif chemokine ligand 20) promote T cell immunosuppression via programmed death-ligand 1 (PD-L1) in breast cancer | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression
Chunyan Cai, Xing Peng & Yumei Zhang
Pages: 7007-7019
Published online: 23 Sep 2021
AbstractforDownregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression | Full Text | References | PDF (4.3 MB) | EPUB
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Article
Transcription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation
Xiaoliang Mei, Hao Din, Jianning Zhao, Jian Tong & Wei Zhu
Pages: 7020-7032
Published online: 23 Sep 2021
AbstractforTranscription factor Krüppel-like factor 5-regulated N-myc downstream-regulated gene 2 reduces IL-1β-induced chondrocyte inflammatory injury and extracellular matrix degradation | Full Text | References | PDF (3.8 MB) | EPUB
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Research Article

Article
Enamel matrix derivative (EMD) enhances the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs)
Lu Cheng, Ying Li, Qian Xia, MaoHua Meng, ZhaoYang Ye, ZhengLong Tang, HongChao Feng, Xin Chen, HeLin Chen, Xiao Zeng, Yi Luo & Qiang Dong
Pages: 7033-7045
Published online: 30 Sep 2021
AbstractforEnamel matrix derivative (EMD) enhances the osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) | Full Text | References | PDF (2.2 MB) | EPUB
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Article
The gut microbial diversity of colon cancer patients and the clinical significance
Tengfei He, Xiaohui Cheng & Chungen Xing
Pages: 7046-7060
Published online: 23 Sep 2021
AbstractforThe gut microbial diversity of colon cancer patients and the clinical significance | Full Text | References | PDF (3.4 MB) | EPUB
  • 2812 Views
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Article
Integrated Analysis of DNA methylation and transcriptome profile to identify key features of age-related macular degeneration
Zhijie Wang, Yinhua Huang, Feixue Chu, Kai Liao, Zekai Cui, Jiansu Chen & Shibo Tang
Pages: 7061-7078
Published online: 27 Sep 2021
AbstractforIntegrated Analysis of DNA methylation and transcriptome profile to identify key features of age-related macular degeneration | Full Text | References | PDF (3.3 MB) | EPUB
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Article
miR-186-3p attenuates the tumorigenesis of cervical cancer via targeting insulin-like growth factor 1 to suppress PI3K-Akt signaling pathway
Xiurong Lu, Xiao Song, Xiaohui Hao, Xiaoyu Liu, Xianyu Zhang, Na Yuan, Huan Ma & Zhilin Zhang
Pages: 7079-7092
Published online: 23 Sep 2021
AbstractformiR-186-3p attenuates the tumorigenesis of cervical cancer via targeting insulin-like growth factor 1 to suppress PI3K-Akt signaling pathway | Full Text | References | PDF (7.4 MB) | EPUB
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Article
Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway
Lin Sun, Yan Wei & Junli Wang
Pages: 7093-7107
Published online: 21 Sep 2021
AbstractforCircular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway | Full Text | References | PDF (4.5 MB) | EPUB
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Article
Long intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase
Fei Liu, Jiazhang Wei, Yanrong Hao, Jiao Lan, Wei Li, Jingjin Weng, Min Li, Cheng Su, Bing Li, Mingzheng Mo, Fengzhu Tang, Yongli Wang, Yong Yang, Wei Jiao & Shenhong Qu
Pages: 7108-7119
Published online: 21 Sep 2021
AbstractforLong intergenic non-protein coding RNA 02570 promotes nasopharyngeal carcinoma progression by adsorbing microRNA miR-4649-3p thereby upregulating both sterol regulatory element binding protein 1, and fatty acid synthase | Full Text | References | PDF (2.9 MB) | EPUB
  • 1362 Views
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Article
Upregulated expression of long non-coding RNA MEG3 serves as a prognostic biomarker in severe pneumonia children and its regulatory mechanism
Jie Guo, Ning Zhang, Guozhi Liu, Aimei Zhang, Xin Liu & Jie Zheng
Pages: 7120-7131
Published online: 24 Sep 2021
AbstractforUpregulated expression of long non-coding RNA MEG3 serves as a prognostic biomarker in severe pneumonia children and its regulatory mechanism | Full Text | References | PDF (1.6 MB) | EPUB
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Article
Ubiquilin 1 suppresses the cancer stem cell–like traits of non-small cell lung cancer cells by regulating reactive oxygen species homeostasis
Ting Liu, Qianqian Ma, Wenjie Li, Yan Hu, Jun Yang & Qi Yao
Pages: 7132-7144
Published online: 21 Sep 2021
AbstractforUbiquilin 1 suppresses the cancer stem cell–like traits of non-small cell lung cancer cells by regulating reactive oxygen species homeostasis | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Effects of two inhibitors of metabolic glutamate receptor 5 on expression of endogenous homer scaffold protein 1 in the auditory cortex of mice with tinnitus
Weiwei Yan, Hongfei Zhu, Bianbian Yu, Xin Ma, Hang Liang, Shuyan Zhao & Kebin Deng
Pages: 7145-7153
Published online: 21 Sep 2021
AbstractforEffects of two inhibitors of metabolic glutamate receptor 5 on expression of endogenous homer scaffold protein 1 in the auditory cortex of mice with tinnitus | Full Text | References | PDF (1.2 MB) | EPUB
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Article
Identification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis
Shangshang Hu, Jinyan Zhang, Xiaoyu Fang, Guoqing Guo, Jing Dai, Zhiyong Sheng, Dongdong Li, Jiasheng Chen, Li Zhang, Chuanmiao Liu & Yu Gao
Pages: 7154-7166
Published online: 21 Sep 2021
AbstractforIdentification of microRNA hsa-miR-30c-5p as an inhibitory factor in the progression of hepatocellular carcinoma and investigation of its regulatory network via comprehensive analysis | Full Text | References | PDF (3 MB) | EPUB
  • 1649 Views
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Article
Differentiated expression of long non-coding RNA-small nucleolar RNA host gene 8 in atherosclerosis and its molecular mechanism
Shuang Wang, Jianchao Li, Aimei Chen & He Song
Pages: 7167-7176
Published online: 24 Sep 2021
AbstractforDifferentiated expression of long non-coding RNA-small nucleolar RNA host gene 8 in atherosclerosis and its molecular mechanism | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Exosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis
Shen Li, Zhiyan Shi, Suwei Fu, Qingfu Li, Bei Li, Lixiao Sang & Donghong Wu
Pages: 7177-7193
Published online: 21 Sep 2021
AbstractforExosomal-mediated transfer of APCDD1L-AS1 induces 5-fluorouracil resistance in oral squamous cell carcinoma via miR-1224-5p/nuclear receptor binding SET domain protein 2 (NSD2) axis | Full Text | References | PDF (5 MB) | EPUB
  • 1862 Views
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Article
Protective effects of Schisandrin B against D-GalN-induced cell apoptosis in human hepatocyte (L02) cells via modulating Bcl-2 and Bax
Yanwu Hu, Haitao Li, Ruili Li, Yue Tian & Zijing Wu
Pages: 7194-7203
Published online: 21 Sep 2021
AbstractforProtective effects of Schisandrin B against D-GalN-induced cell apoptosis in human hepatocyte (L02) cells via modulating Bcl-2 and Bax | Full Text | References | PDF (1.6 MB) | EPUB
  • 1359 Views
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Article
Soy isoflavones alleviate polycystic ovary syndrome in rats by regulating NF- κB signaling pathway
Xiaohong Ma, Xiaorong Li, LiLi Ma, Yan Chen & Shengyu He
Pages: 7204-7212
Published online: 21 Sep 2021
AbstractforSoy isoflavones alleviate polycystic ovary syndrome in rats by regulating NF- κB signaling pathway | Full Text | References | PDF (1,010.9 KB) | EPUB
  • 3275 Views
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Article
Knockdown of Tripartite motif-containing 22 (TRIM22)relieved the apoptosis of lens epithelial cells by suppressing the expression of TNF receptor-associated factor 6 (TRAF6)
Kai Meng & Chengbo Fang
Pages: 7213-7222
Published online: 24 Sep 2021
AbstractforKnockdown of Tripartite motif-containing 22 (TRIM22)relieved the apoptosis of lens epithelial cells by suppressing the expression of TNF receptor-associated factor 6 (TRAF6) | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Low-dose cyclooxygenase-2 (COX-2) inhibitor celecoxib plays a protective role in the rat model of neonatal necrotizing enterocolitis
Ling Sun
Pages: 7223-7234
Published online: 21 Sep 2021
AbstractforLow-dose cyclooxygenase-2 (COX-2) inhibitor celecoxib plays a protective role in the rat model of neonatal necrotizing enterocolitis | Full Text | References | PDF (2 MB) | EPUB
  • 1287 Views
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Article
Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities
Haoyue Yang, Ronge Xing, Song Liu, Huahua Yu & Pengcheng Li
Pages: 7235-7247
Published online: 27 Sep 2021
AbstractforRole of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities | Full Text | References | PDF (2.6 MB) | EPUB
  • 1580 Views
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Article
Identification and validation of seven RNA binding protein genes as a prognostic signature in oral cavity squamous cell carcinoma
Zijing Huang, Tianjun Lan, Junjie Wang, Zhifeng Chen & Xiaolei Zhang
Pages: 7248-7262
Published online: 29 Sep 2021
AbstractforIdentification and validation of seven RNA binding protein genes as a prognostic signature in oral cavity squamous cell carcinoma | Full Text | References | PDF (3.5 MB) | EPUB
  • 1895 Views
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Article
Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased
Hai-Tao Yang, Wen-Juan Xiu, Jing-Kun Liu, Yi Yang, Xian-Geng Hou, Ying-Ying Zheng, Ting-Ting Wu, Chen-Xin Wu & Xiang Xie
Pages: 7263-7275
Published online: 30 Sep 2021
AbstractforGut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased | Full Text | References | PDF (2 MB) | EPUB
  • 3017 Views
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Reviews

Review
The significance of Stanniocalcin 2 in malignancies and mechanisms
Shasha Li, Qian Huang, Dongliang Li, Lizhi Lv, Yi Li & Zhixian Wu
Pages: 7276-7285
Published online: 06 Oct 2021
AbstractforThe significance of Stanniocalcin 2 in malignancies and mechanisms | Full Text | References | PDF (760.3 KB) | EPUB
  • 1977 Views
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Article
YEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma
Tong Sha, Jia Li, Shiqun Sun, Jianing Li, Xuetao Zhao, Zehua Li & Zhi Cui
Pages: 7286-7296
Published online: 29 Sep 2021
AbstractforYEATS domain-containing 2 (YEATS2), targeted by microRNA miR-378a-5p, regulates growth and metastasis in head and neck squamous cell carcinoma | Full Text | References | PDF (2 MB) | EPUB
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Review
Sustainable mitigation of heavy metals from effluents: Toxicity and fate with recent technological advancements
Vivek Kumar Gaur, Poonam Sharma, Prachi Gaur, Sunita Varjani, Huu Hao Ngo, Wenshan Guo, Preeti Chaturvedi & Reeta Rani Singhania
Pages: 7297-7313
Published online: 27 Sep 2021
AbstractforSustainable mitigation of heavy metals from effluents: Toxicity and fate with recent technological advancements | Full Text | References | PDF (1 MB) | EPUB
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Article
Knockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL)
Liufang He, Hui Yang, Jinxing Feng, Tingyan Wei, Yong Huang, Xueli Zhang & Zhangxing Wang
Pages: 7314-7324
Published online: 27 Sep 2021
AbstractforKnockdown of G protein-coupled receptor-17 (GPR17) facilitates the regeneration and repair of myelin sheath post-periventricular leukomalacia (PVL) | Full Text | References | PDF (1.8 MB) | EPUB
  • 1304 Views
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Article
MicroRNA-195-3p inhibits cyclin dependent kinase 1 to induce radiosensitivity in nasopharyngeal carcinoma
Fuchuan Xie, Wei Xiao, Yunming Tian, Yuhong Lan, Chi Zhang & Li Bai
Pages: 7325-7334
Published online: 29 Sep 2021
AbstractforMicroRNA-195-3p inhibits cyclin dependent kinase 1 to induce radiosensitivity in nasopharyngeal carcinoma | Full Text | References | PDF (1.8 MB) | EPUB
  • 1337 Views
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Article
Chaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway
Xu Danni, Zeng Jiangzheng, Sun Huamao, Pan Yinglian, Yang Changcheng & Lu Yanda
Pages: 7335-7347
Published online: 06 Oct 2021
AbstractforChaperonin containing TCP1 subunit 3 (CCT3) promotes cisplatin resistance of lung adenocarcinoma cells through targeting the Janus kinase 2/signal transducers and activators of transcription 3 (JAK2/STAT3) pathway | Full Text | References | PDF (1.9 MB) | EPUB
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Article
LncRNA CRNDE exacerbates neuropathic pain in chronic constriction injury-induced(CCI) rats through regulating miR-146a-5p/WNT5A pathway
Qiangze Zhang, Dongxia Zhu & Qiang Li
Pages: 7348-7359
Published online: 06 Oct 2021
AbstractforLncRNA CRNDE exacerbates neuropathic pain in chronic constriction injury-induced(CCI) rats through regulating miR-146a-5p/WNT5A pathway | Full Text | References | PDF (2.2 MB) | EPUB
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Article
Impact of hepatocyte-specific deletion of staphylococcal nuclease and tudor domain containing 1 (SND1) on liver insulin resistance and acute liver failure of mice
Chunyan Zhao, Xiaoteng Cui, Yan Zhao, Baoxin Qian, Nan Zhang, Lingbiao Xin, Chuanbo Ha, Jie Yang, Xinting Wang & Xingjie Gao
Pages: 7360-7375
Published online: 05 Oct 2021
AbstractforImpact of hepatocyte-specific deletion of staphylococcal nuclease and tudor domain containing 1 (SND1) on liver insulin resistance and acute liver failure of mice | Full Text | References | PDF (5.6 MB) | EPUB
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Reviews

Review
Antibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods
Qiulian Yang, Yuan Gao, Jian Ke, Pau Loke Show, Yuhui Ge, Yanhua Liu, Ruixin Guo & Jianqiu Chen
Pages: 7376-7416
Published online: 06 Oct 2021
AbstractforAntibiotics: An overview on the environmental occurrence, toxicity, degradation, and removal methods | Full Text | References | PDF (2.1 MB) | EPUB
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Research Paper

Article
Exploration of the prognostic signature reflecting tumor microenvironment of lung adenocarcinoma based on immunologically relevant genes
Wei Wu, Liye Jia, Yanan Zhang, Juanjuan Zhao, Yunyun Dong & Yan Qiang
Pages: 7417-7431
Published online: 06 Oct 2021
AbstractforExploration of the prognostic signature reflecting tumor microenvironment of lung adenocarcinoma based on immunologically relevant genes | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Ibrutinib ameliorates cerebral ischemia/reperfusion injury through autophagy activation and PI3K/Akt/mTOR signaling pathway in diabetic mice
Lei Jin, Yun Mo, Er-Li Yue, Yuan Liu & Kang-Yong Liu
Pages: 7432-7445
Published online: 04 Oct 2021
AbstractforIbrutinib ameliorates cerebral ischemia/reperfusion injury through autophagy activation and PI3K/Akt/mTOR signaling pathway in diabetic mice | Full Text | References | PDF (2.5 MB) | EPUB
  • 2190 Views
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Article
Long non-coding RNA SNHG22 facilitates hepatocellular carcinoma tumorigenesis and angiogenesis via DNA methylation of microRNA miR-16-5p
Yinxin Zhang, Changliang Lu & Haiwei Cui
Pages: 7446-7458
Published online: 15 Oct 2021
AbstractforLong non-coding RNA SNHG22 facilitates hepatocellular carcinoma tumorigenesis and angiogenesis via DNA methylation of microRNA miR-16-5p | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Low expression of TCP1 (T-Complex 1) and PSMC1 (Proteasome 26S subunit, ATPase 1) in heterotopic ossification during ankylosing spondylitis
Xiao-lin Zhong, Bang-Ping Qian, Ji-chen Huang, Shi-zhou Zhao, Yao Li & Yong Qiu
Pages: 7459-7469
Published online: 06 Oct 2021
AbstractforLow expression of TCP1 (T-Complex 1) and PSMC1 (Proteasome 26S subunit, ATPase 1) in heterotopic ossification during ankylosing spondylitis | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Upregulation of ubiquitin conjugating enzyme E2B (Ube2b) ameliorates neuropathic pain by regulating Kcna2 (potassium voltage-gated channel subfamily A member 2) in primary afferent neurons
Yuanzhi Peng, Qingqing Zhang, Hao Cheng, Guizhen Yan & Chunli Xing
Pages: 7470-7480
Published online: 10 Oct 2021
AbstractforUpregulation of ubiquitin conjugating enzyme E2B (Ube2b) ameliorates neuropathic pain by regulating Kcna2 (potassium voltage-gated channel subfamily A member 2) in primary afferent neurons | Full Text | References | PDF (2.6 MB) | EPUB
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Article
The protective effects of Pimavanserin against cerebral ischemia-induced brain injury
Xiang Li & Xiaoyan Tian
Pages: 7481-7494
Published online: 04 Oct 2021
AbstractforThe protective effects of Pimavanserin against cerebral ischemia-induced brain injury | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Enhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis
Zandong Zhao, Jie Yang, Liang zhang & Yunping Zhou
Pages: 7495-7507
Published online: 04 Oct 2021
AbstractforEnhancement of DUSP14 (dual specificity phosphatase 14) limits osteoarthritis progression by alleviating chondrocyte injury, inflammation and metabolic homeostasis | Full Text | References | PDF (2.6 MB) | EPUB
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Article
Downregulation of circ-UBAP2 ameliorates oxidative stress and dysfunctions of human retinal microvascular endothelial cells (hRMECs) via miR-589-5p/EGR1 axis
Yu Jiewei, Zhou jingjing, Xue jingjing & Zhang Guilan
Pages: 7508-7518
Published online: 05 Oct 2021
AbstractforDownregulation of circ-UBAP2 ameliorates oxidative stress and dysfunctions of human retinal microvascular endothelial cells (hRMECs) via miR-589-5p/EGR1 axis | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Upregulation of microRNA miR-652-3p is a prognostic risk factor for hepatocellular carcinoma and regulates cell proliferation, migration, and invasion
Xiaobin Chi, Yi Jiang, Yongbiao Chen, Lizhi Lv, Jianwei Chen, Fang Yang, Xiaojin Zhang, Fan Pan & Qiucheng Cai
Pages: 7519-7528
Published online: 05 Oct 2021
AbstractforUpregulation of microRNA miR-652-3p is a prognostic risk factor for hepatocellular carcinoma and regulates cell proliferation, migration, and invasion | Full Text | References | PDF (1.6 MB) | EPUB
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Reviews

Review
A critical review on microbial carbonate precipitation via denitrification process in building materials
Surabhi Jain, Chaolin Fang & Varenyam Achal
Pages: 7529-7551
Published online: 15 Oct 2021
AbstractforA critical review on microbial carbonate precipitation via denitrification process in building materials | Full Text | References | PDF (833.9 KB) | EPUB
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Research Paper

Article
The protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway
Ping Zhang, Zhiqiang Cui & Shuai Li
Pages: 7552-7562
Published online: 04 Oct 2021
AbstractforThe protective effects of S14G-humanin (HNG) against lipopolysaccharide (LPS)- induced inflammatory response in human dental pulp cells (hDPCs) mediated by the TLR4/MyD88/NF-κB pathway | Full Text | References | PDF (1.6 MB) | EPUB
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Article
KLF9 (Kruppel Like Factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells
Jiahua Xing, Ziqi Jia, Yichi Xu, Muzi Chen, Zheng Yang, Youbai Chen & Yan Han
Pages: 7563-7576
Published online: 06 Oct 2021
AbstractforKLF9 (Kruppel Like Factor 9) induced PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3) downregulation inhibits the proliferation, metastasis and aerobic glycolysis of cutaneous squamous cell carcinoma cells | Full Text | References | PDF (4.3 MB) | EPUB
  • 3096 Views
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Reviews

Review
Physiology of microalgal biofilm: a review on prediction of adhesion on substrates
Yi Tong Cheah & Derek Juinn Chieh Chan
Pages: 7577-7599
Published online: 04 Oct 2021
AbstractforPhysiology of microalgal biofilm: a review on prediction of adhesion on substrates | Full Text | References | PDF (1.3 MB) | EPUB
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Research Paper

Article
Preparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure
Jinwei Guo, Zhixiang Zhang & Jincan Zhu
Pages: 7600-7615
Published online: 06 Oct 2021
AbstractforPreparation of MED1(transcription mediator subunit) gene nanocarrier and its mechanism of action on liver cell regeneration in chronic acute liver failure | Full Text | References | PDF (2.8 MB) | EPUB
  • 1064 Views
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Article
A seven-gene signature and the C–C motif chemokine receptor family genes are the sarcoma-related immune genes
Jiarui Chen, Tuo Liang, Jiemei Cen, Jie Jiang, Shixin Pan, Shengsheng Huang, Liyi Chen, Xuhua Sun, Hao Li, Tianyou Chen, Wei Liang, Shian Liao, Chaojie Yu, Yuanlin Yao, Zhen Ye, Wuhua Chen, Hao Guo, Xinli Zhan & Chong Liu
Pages: 7616-7630
Published online: 04 Oct 2021
AbstractforA seven-gene signature and the C–C motif chemokine receptor family genes are the sarcoma-related immune genes | Full Text | References | PDF (3.8 MB) | EPUB
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Article
Circular RNA circPRKDC promotes tumorigenesis of gastric cancer via modulating insulin receptor substrate 2 (IRS2) and mediating microRNA-493-5p
Zhipeng Liu, Yangang Wang & Yunlong Ding
Pages: 7631-7643
Published online: 04 Oct 2021
AbstractforCircular RNA circPRKDC promotes tumorigenesis of gastric cancer via modulating insulin receptor substrate 2 (IRS2) and mediating microRNA-493-5p | Full Text | References | PDF (3.7 MB) | EPUB
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Article
Reg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer
Liang Wang, Hongfang Tuo, Zhe Song, Wei Li & Yanhui Peng
Pages: 7644-7655
Published online: 04 Oct 2021
AbstractforReg3A (regenerating family member 3 alpha) acts as a tumor suppressor by targeting DMBT1 (deleted in malignant brain tumors 1) in gastric cancer | Full Text | References | PDF (3.3 MB) | EPUB
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Article
LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14)
Qiang Zhao, Sheng Chen & Lu Chen
Pages: 7656-7665
Published online: 04 Oct 2021
AbstractforLETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) silence reduces the proliferation, invasion, migration and angiogenesis in esophageal squamous cell carcinoma via KIF14 (kinesin family member 14) | Full Text | References | PDF (3.2 MB) | EPUB
  • 1105 Views
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Article
Silencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A
Xiujuan Huang, Hongxia Dong, Yang Liu, Fen Yu, Shunshi Yang, Zhen Chen & Jueying Li
Pages: 7666-7677
Published online: 06 Oct 2021
AbstractforSilencing of let-7b-5p inhibits ovarian cancer cell proliferation and stemness characteristics by Asp-Glu-Ala-Asp-box helicase 19A | Full Text | References | PDF (2.1 MB) | EPUB
  • 1211 Views
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Article
Bio-informatics and in Vitro Experiments Reveal the Mechanism of Schisandrin A Against MDA-MB-231 cells
Ling Chen, Li-Quan Ren, Zhong Liu, Xin Liu, Han Tu & Xu-Ying Huang
Pages: 7678-7693
Published online: 27 Oct 2021
AbstractforBio-informatics and in Vitro Experiments Reveal the Mechanism of Schisandrin A Against MDA-MB-231 cells | Full Text | References | PDF (5.6 MB) | EPUB
  • 1931 Views
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Article
Zhike Pingchuan Granule suppresses interleukin (IL)-6 or the medium of M2 macrophages induced apoptosis in human bronchial epithelial cells
Yumei Ren, Yongbin Yan, Lei Zhen, Caihong Cao, Quan Wang, Yingying Zhang & Shan Zhu
Pages: 7694-7703
Published online: 05 Oct 2021
AbstractforZhike Pingchuan Granule suppresses interleukin (IL)-6 or the medium of M2 macrophages induced apoptosis in human bronchial epithelial cells | Full Text | References | PDF (1.5 MB) | EPUB
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Article
Circular RNA circCRKL inhibits the proliferation of acute myeloid leukemia cells via the miR-196a-5p/miR-196b-5p/p27 axis
Wen Liu & Fanjun Cheng
Pages: 7704-7713
Published online: 07 Oct 2021
AbstractforCircular RNA circCRKL inhibits the proliferation of acute myeloid leukemia cells via the miR-196a-5p/miR-196b-5p/p27 axis | Full Text | References | PDF (2.2 MB) | EPUB
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Article
LncRNA ROR/miR-145-5p axis modulates the osteoblasts proliferation and apoptosis in osteoporosis
Yin Fu, Xiaoyang Hu, Yanyu Gao, Kai Li, Qiang Fu, Qingpeng Liu, Dan Liu, Zhijia Zhang & Jiutao Qiao
Pages: 7714-7723
Published online: 07 Oct 2021
AbstractforLncRNA ROR/miR-145-5p axis modulates the osteoblasts proliferation and apoptosis in osteoporosis | Full Text | References | PDF (806.5 KB) | EPUB
  • 2009 Views
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Article
Long non-coding RNA TTN-AS1/microRNA-199a-3p/runt-related transcription factor 1 gene axis regulates the progression of oral squamous cell carcinoma
Zhongzhi Jin & Shengjun Jiang
Pages: 7724-7736
Published online: 04 Oct 2021
AbstractforLong non-coding RNA TTN-AS1/microRNA-199a-3p/runt-related transcription factor 1 gene axis regulates the progression of oral squamous cell carcinoma | Full Text | References | PDF (3.1 MB) | EPUB
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Article
MicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2)
Jinlong Xu, Jinmei Wang, Lili Liu, Lin Chen, Songliu Hu & Feng Liu
Pages: 7737-7746
Published online: 04 Oct 2021
AbstractforMicroRNA -196b is related to the overall survival of patients with esophageal squamous cell carcinoma and facilitates tumor progression by regulating SOCS2 (Suppressor Of Cytokine Signaling 2) | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Astragaloside IV attenuates hypoxia/reoxygenation injury-induced apoptosis of type II alveolar epithelial cells through miR-21-5p
Hang Li, Chang Yao, Kaihu Shi, Yang Zhao, Jin Du, Dinghui Hu & Zuntao Liu
Pages: 7747-7754
Published online: 07 Oct 2021
AbstractforAstragaloside IV attenuates hypoxia/reoxygenation injury-induced apoptosis of type II alveolar epithelial cells through miR-21-5p | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Targeting PD-L1 (Programmed death-ligand 1) and inhibiting the expression of IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2) affect the proliferation and apoptosis of hypopharyngeal carcinoma cells
Xudong Yang & Jisheng Liu
Pages: 7755-7764
Published online: 05 Oct 2021
AbstractforTargeting PD-L1 (Programmed death-ligand 1) and inhibiting the expression of IGF2BP2 (Insulin-like growth factor 2 mRNA-binding protein 2) affect the proliferation and apoptosis of hypopharyngeal carcinoma cells | Full Text | References | PDF (1.8 MB) | EPUB
  • 3357 Views
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Article
Early 2 factor (E2F) transcription factors contribute to malignant progression and have clinical prognostic value in lower-grade glioma
Haitao Luo, Chuming Tao, Xiaoyan Long, Xingen Zhu & Kai Huang
Pages: 7765-7779
Published online: 07 Oct 2021
AbstractforEarly 2 factor (E2F) transcription factors contribute to malignant progression and have clinical prognostic value in lower-grade glioma | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Long non-coding RNA LINC01207 promotes cell proliferation and migration but suppresses apoptosis and autophagy in oral squamous cell carcinoma by the microRNA-1301-3p/lactate dehydrogenase isoform A axis
Xiaolin Lu, Liling Chen, Yang Li, Rong Huang, Xiangfeng Meng & Fangfang Sun
Pages: 7780-7793
Published online: 06 Oct 2021
AbstractforLong non-coding RNA LINC01207 promotes cell proliferation and migration but suppresses apoptosis and autophagy in oral squamous cell carcinoma by the microRNA-1301-3p/lactate dehydrogenase isoform A axis | Full Text | References | PDF (5.9 MB) | EPUB
  • 1571 Views
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Article
Baicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage
Bao Zheng, Xiwei Zhou, Lujun Pang, Yanjun Che & Xin Qi
Pages: 7794-7804
Published online: 27 Oct 2021
AbstractforBaicalin suppresses autophagy-dependent ferroptosis in early brain injury after subarachnoid hemorrhage | Full Text | References | PDF (2.2 MB) | EPUB
  • 3102 Views
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Article
A new prognostic risk model based on autophagy-related genes in kidney renal clear cell carcinoma
Guangzhen Wu, Yingkun Xu, Huayu Zhang, Zihao Ruan, Peizhi Zhang, Zicheng Wang, Han Gao, Xiangyu Che, Qinghua Xia & Feng Chen
Pages: 7805-7819
Published online: 12 Oct 2021
AbstractforA new prognostic risk model based on autophagy-related genes in kidney renal clear cell carcinoma | Full Text | References | PDF (4.5 MB) | EPUB
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Reviews

Review
Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma
Xiaoxu Wang, Hui Chen, Jingjing Liu, Linlin Gai, Xinyi Yan, Zhiliang Guo & Fengxia Liu
Pages: 7820-7836
Published online: 11 Oct 2021
AbstractforEmerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma | Full Text | References | PDF (976.9 KB) | EPUB
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Research Paper

Article
Bioinformatics-based identification of SPNS3 (Spinster homolog 3) as a prognostic biomarker of apoptosis resistance in acute myeloid leukemia
Yang Hong, Xiaopeng Tian, Mengmiao Wang, Cheng Chen & Aining Sun
Pages: 7837-7848
Published online: 05 Oct 2021
AbstractforBioinformatics-based identification of SPNS3 (Spinster homolog 3) as a prognostic biomarker of apoptosis resistance in acute myeloid leukemia | Full Text | References | PDF (2 MB) | EPUB
  • 2124 Views
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Article
MicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling
Xia Zhao, Xiang-cheng Zhang, Kui Zang & Zhi-hao Yu
Pages: 7849-7858
Published online: 11 Oct 2021
AbstractforMicroRNA miR-19b-3p mediated G protein γ subunit 7 (GNG7) loss contributes lung adenocarcinoma progression through activating Hedgehog signaling | Full Text | References | PDF (4.1 MB) | EPUB
  • 893 Views
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Article
miR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2
Hui Liu, Yanfeng Wang, Yi Wang, Daoyuan Wu & He Zhang
Pages: 7859-7871
Published online: 10 Oct 2021
AbstractformiR-199a-3p plays an anti-tumorigenic role in lung adenocarcinoma by suppressing anterior gradient 2 | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Remifentanil pretreatment ameliorates H/R-induced cardiac microvascular endothelial cell dysfunction by regulating the PI3K/Akt/HIF-1α signaling pathway
Xiaojun Li, Zhenping Gui, Huizi Liu, Shaojie Qian, Yanan Jia & Xiaopan Luo
Pages: 7872-7881
Published online: 06 Oct 2021
AbstractforRemifentanil pretreatment ameliorates H/R-induced cardiac microvascular endothelial cell dysfunction by regulating the PI3K/Akt/HIF-1α signaling pathway | Full Text | References | PDF (1.5 MB) | EPUB
  • 1652 Views
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Article
CHI3L1 (Chitinase 3 Like 1) upregulation is associated with macrophage signatures in esophageal cancer
Jing Huang, Zhenlin Gu, Yingying Xu, Lei Jiang, Weiguo Zhu & Wanwei Wang
Pages: 7882-7892
Published online: 06 Oct 2021
AbstractforCHI3L1 (Chitinase 3 Like 1) upregulation is associated with macrophage signatures in esophageal cancer | Full Text | References | PDF (1.4 MB) | EPUB
  • 2217 Views
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Article
Sevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis
Xi’an Bao, Yibo Peng, Jun Shen & Longqiu Yang
Pages: 7893-7906
Published online: 30 Oct 2021
AbstractforSevoflurane inhibits progression of glioma via regulating the HMMR antisense RNA 1/microRNA-7/cyclin dependent kinase 4 axis | Full Text | References | PDF (1.8 MB) | EPUB
  • 1154 Views
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Article
Long non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2
Baoshan Ning, Songya Guo & Yine Mei
Pages: 7907-7919
Published online: 06 Oct 2021
AbstractforLong non-coding RNA CASC9 promotes tumor progression in oral squamous cell carcinoma by regulating microRNA-545-3p/laminin subunit gamma 2 | Full Text | References | PDF (5.2 MB) | EPUB
  • 1153 Views
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Article
Effects of dexmedetomidine on postoperative cognitive function of sleep deprivation rats based on changes in inflammatory response
Bin Guo, Chan Chen, Lin Yang & Rong Zhu
Pages: 7920-7928
Published online: 08 Oct 2021
AbstractforEffects of dexmedetomidine on postoperative cognitive function of sleep deprivation rats based on changes in inflammatory response | Full Text | References | PDF (1.4 MB) | EPUB
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Review
Blood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems
Limei Xu, Yujie Liang, Xiao Xu, Jiang Xia, Caining Wen, Peng Zhang & Li Duan
Pages: 7929-7940
Published online: 08 Oct 2021
AbstractforBlood cell-derived extracellular vesicles: diagnostic biomarkers and smart delivery systems | Full Text | References | PDF (2 MB) | EPUB
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Research Paper

Article
Overexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma
Weijie Jiang, Tao Wu, Xuan Shi & Jiawen Xu
Pages: 7941-7949
Published online: 06 Oct 2021
AbstractforOverexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma | Full Text | References | PDF (1.7 MB) | EPUB
  • 2226 Views
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Article
Identification of important genes related to ferroptosis and hypoxia in acute myocardial infarction based on WGCNA
Kai Liu, Shaoxi Chen & Ruoyi Lu
Pages: 7950-7963
Published online: 10 Oct 2021
AbstractforIdentification of important genes related to ferroptosis and hypoxia in acute myocardial infarction based on WGCNA | Full Text | References | PDF (4.1 MB) | EPUB
  • 10669 Views
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Article
Long non-coding RNA LOC107985656 represses the proliferation of hepatocellular carcinoma cells through activation of the tumor-suppressive Hippo pathway
Yu Zeng, Qin Xu & Nan Xu
Pages: 7964-7974
Published online: 08 Oct 2021
AbstractforLong non-coding RNA LOC107985656 represses the proliferation of hepatocellular carcinoma cells through activation of the tumor-suppressive Hippo pathway | Full Text | References | PDF (1.8 MB) | EPUB
  • 1808 Views
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Article
Protective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways
Jie Deng, Min Huang & Hao Wu
Pages: 7975-7984
Published online: 08 Oct 2021
AbstractforProtective effect of limonin against doxorubicin-induced cardiotoxicity via activating nuclear factor - like 2 and Sirtuin 2 signaling pathways | Full Text | References | PDF (2.3 MB) | EPUB
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Article
High-altitude hypoxia exacerbates dextran sulfate sodium (DSS)-induced colitis by upregulating Th1 and Th17 lymphocytes
Mohammed Gamah, Murad Alahdal, Yu Zhang, Yiling Zhou, Qiaorong Ji, Zhouyang Yuan, Ying Han, Xiangqun Shen, Yanming Ren & Wei Zhang
Pages: 7985-7994
Published online: 19 Oct 2021
AbstractforHigh-altitude hypoxia exacerbates dextran sulfate sodium (DSS)-induced colitis by upregulating Th1 and Th17 lymphocytes | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Transcription factor 3 (TCF3) combined with histone deacetylase 3 (HDAC3) down-regulates microRNA-101 to promote Burkitt lymphoma cell proliferation and inhibit apoptosis
Lihua Dong, Jingjing Huang, Peng Zu, Jing Liu, Xue Gao, Jianwei Du & Yufu Li
Pages: 7995-8005
Published online: 17 Oct 2021
AbstractforTranscription factor 3 (TCF3) combined with histone deacetylase 3 (HDAC3) down-regulates microRNA-101 to promote Burkitt lymphoma cell proliferation and inhibit apoptosis | Full Text | References | PDF (1.5 MB) | EPUB
  • 1189 Views
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Article
LncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling
Min Sun, Yanan Chen, Xiaobei Liu & Yajie Cui
Pages: 8006-8019
Published online: 19 Oct 2021
AbstractforLncRNACASC9 promotes proliferation, metastasis, and cell cycle inovarian carcinoma cells through cyclinG1/TP53/MMP7 signaling | Full Text | References | PDF (2.6 MB) | EPUB
  • 1322 Views
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Article
MicroRNA-485-5p inhibits glioblastoma progression by suppressing E2F transcription factor 1 under cisplatin treatment
Conggang Huang, Lan Ma, Faliang Duan, Ruixue Li, Yanguo Zhang, Yuan Wang, Ming Luo, Zhuqiang He & Zhihua Luo
Pages: 8020-8030
Published online: 02 Nov 2021
AbstractforMicroRNA-485-5p inhibits glioblastoma progression by suppressing E2F transcription factor 1 under cisplatin treatment | Full Text | References | PDF (4.2 MB) | EPUB
  • 906 Views
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Article
Preparation of controlled degradation of insulin-like growth factor 1/spider silk protein nanofibrous membrane and its effect on endothelial progenitor cell viability
Lifang Chen, Yulang Huang, Rongfeng Yang, Jian Xiao, Jiajia Gao, Debao Zhang, Duanwen Cao & Xiao Ke
Pages: 8031-8042
Published online: 20 Oct 2021
AbstractforPreparation of controlled degradation of insulin-like growth factor 1/spider silk protein nanofibrous membrane and its effect on endothelial progenitor cell viability | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Fungicides alter the distribution and diversity of bacterial and fungal communities in ginseng fields
Guilong Ma, Xinxin Gao, Jie Nan, Tingting Zhang, Xiaobao Xie & Qi Cai
Pages: 8043-8056
Published online: 19 Oct 2021
AbstractforFungicides alter the distribution and diversity of bacterial and fungal communities in ginseng fields | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Liraglutide blocks the proliferation, migration and phenotypic switching of Homocysteine (Hcy)-induced vascular smooth muscle cells (VSMCs) by suppressing proprotein convertase subtilisin kexin9 (PCSK9)/ low-density lipoprotein receptor (LDLR)
Jingquan Ji, Ming Feng, Xiaohong Niu, Xinyu Zhang & Yilei Wang
Pages: 8057-8066
Published online: 19 Oct 2021
AbstractforLiraglutide blocks the proliferation, migration and phenotypic switching of Homocysteine (Hcy)-induced vascular smooth muscle cells (VSMCs) by suppressing proprotein convertase subtilisin kexin9 (PCSK9)/ low-density lipoprotein receptor (LDLR) | Full Text | References | PDF (2.7 MB) | EPUB
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Article
Exosomal lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)contributes to the progression of allergic rhinitis via modulating microRNA-511/Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) axis
Tao Wang, Weiyu Cai, Qinwei Wu, Dong Chen, Peihua Wang & Zhou Xu
Pages: 8067-8079
Published online: 21 Oct 2021
AbstractforExosomal lncRNA Nuclear Paraspeckle Assembly Transcript 1 (NEAT1)contributes to the progression of allergic rhinitis via modulating microRNA-511/Nuclear Receptor Subfamily 4 Group A Member 2 (NR4A2) axis | Full Text | References | PDF (4 MB) | EPUB
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Article
Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) promotes the inflammation and apoptosis of otitis media with effusion through targeting microRNA (miR)-495 and activation of p38 MAPK signaling pathway
Yajuan Hu, Hongjun Dong, Jingjing Huang, Jie Huang, Dandan Tao, Chao Huang, Lei Hu, Hao Xu & Yan Sun
Pages: 8080-8088
Published online: 01 Nov 2021
AbstractforLong non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) promotes the inflammation and apoptosis of otitis media with effusion through targeting microRNA (miR)-495 and activation of p38 MAPK signaling pathway | Full Text | References | PDF (1,016.2 KB) | EPUB
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Article
Interference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling
Ling Xu, Chaoxiang Xu, Xiaoxin Lin, Huiyao Lu & Yinlian Cai
Pages: 8089-8099
Published online: 18 Oct 2021
AbstractforInterference with lysophosphatidic acid receptor 5 ameliorates oxidized low-density lipoprotein-induced human umbilical vein endothelial cell injury by inactivating NOD-like receptor family, pyrin domain containing 3 inflammasome signaling | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Long non-coding RNA LINC00958 promotes colorectal cancer progression by enhancing the expression of LEM domain containing 1 via microRNA miR-3064-5p
Zhaoxia Luo, Shunxin Hao, Jian Yuan, Kai Zhu, Shuo Liu, Jing Zhang & Lei Yao
Pages: 8100-8115
Published online: 21 Oct 2021
AbstractforLong non-coding RNA LINC00958 promotes colorectal cancer progression by enhancing the expression of LEM domain containing 1 via microRNA miR-3064-5p | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Angiopoietin-2 silence alleviates lipopolysaccharide-induced inflammation, barrier dysfunction and endoplasmic reticulum stress of intestinal epithelial cells by blocking Notch signaling pathway
Liying Dai, Shuangshuang Jie, Shaohua Bi, Qing Qing, Jun Chen & Le Wang
Pages: 8116-8124
Published online: 18 Oct 2021
AbstractforAngiopoietin-2 silence alleviates lipopolysaccharide-induced inflammation, barrier dysfunction and endoplasmic reticulum stress of intestinal epithelial cells by blocking Notch signaling pathway | Full Text | References | PDF (1.9 MB) | EPUB
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Article
Downregulation of long non-coding RNA PVT1 enhances fracture healing via regulating microRNA-497-5p/HMGA2 axis
Xiang Ji, Zhiqing Li, Wei Wang & Jun Chen
Pages: 8125-8134
Published online: 20 Oct 2021
AbstractforDownregulation of long non-coding RNA PVT1 enhances fracture healing via regulating microRNA-497-5p/HMGA2 axis | Full Text | References | PDF (866.5 KB) | EPUB
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Article
Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway
Ting Song & Wei Da Chen
Pages: 8135-8146
Published online: 21 Oct 2021
AbstractforBerberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway | Full Text | References | PDF (3.2 MB) | EPUB
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Article
Decreased SLC39A1 (Solute carrier family 39 member 1) expression predicts unfavorable prognosis in patients with early-stage hepatocellular carcinoma
Qinglin Zhang, Jiadong Pan, Fangmei An, He Nie & Qiang Zhan
Pages: 8147-8156
Published online: 21 Oct 2021
AbstractforDecreased SLC39A1 (Solute carrier family 39 member 1) expression predicts unfavorable prognosis in patients with early-stage hepatocellular carcinoma | Full Text | References | PDF (1.9 MB) | EPUB
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Research Paper

Article
Bone mesenchymal stem cell-derived extracellular vesicles deliver microRNA-23b to alleviate spinal cord injury by targeting toll-like receptor TLR4 and inhibiting NF-κB pathway activation
Hongfei Nie & Zhensong Jiang
Pages: 8157-8172
Published online: 18 Oct 2021
AbstractforBone mesenchymal stem cell-derived extracellular vesicles deliver microRNA-23b to alleviate spinal cord injury by targeting toll-like receptor TLR4 and inhibiting NF-κB pathway activation | Full Text | References | PDF (3 MB) | EPUB
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Article
MicroRNA-15a-5p plays a role in osteogenic MC3T3-E1 cells differentiation by targeting PDCD4 (programmed cell death 4) via Wnt/β-catenin dependent signaling pathway
Qiang Wang, Yiming Miao, Zhiyuan Qian, Lidong Chen, Tong Lu, Yue Xu, Xiaowei Jiang & Yingchao Shen
Pages: 8173-8185
Published online: 21 Oct 2021
AbstractforMicroRNA-15a-5p plays a role in osteogenic MC3T3-E1 cells differentiation by targeting PDCD4 (programmed cell death 4) via Wnt/β-catenin dependent signaling pathway | Full Text | References | PDF (2.9 MB) | EPUB
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Reviews

Review
Mechanism of cargo sorting into small extracellular vesicles
Yiwen Chen, Yuxue Zhao, Yiqian Yin, Xiaonan Jia & Lingxiang Mao
Pages: 8186-8201
Published online: 18 Oct 2021
AbstractforMechanism of cargo sorting into small extracellular vesicles | Full Text | References | PDF (408.6 KB) | EPUB
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Article
Circular RNA circCOL6A3_030 is involved in the metastasis of gastric cancer by encoding polypeptide
circCOL6A3_030 promotes metastasis.
Xiaoge Geng, Jingya Wang, Chenjing Zhang, Xiaolu Zhou, Jiyong Jing & Wensheng Pan
Pages: 8202-8216
Published online: 27 Oct 2021
AbstractforCircular RNA circCOL6A3_030 is involved in the metastasis of gastric cancer by encoding polypeptide | Full Text | References | PDF (4.1 MB) | EPUB
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Article
LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis
Yanqing Feng, Gang Wei, Linfei Zhang, Huadong Zhou, Wei Wang, Peng Guo, Caitao Cheng, Lei Ji, Qinghe Cai, Yong Feng & Huahua Tu
Pages: 8217-8232
Published online: 27 Oct 2021
AbstractforLncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis | Full Text | References | PDF (4.1 MB) | EPUB
  • 1972 Views
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Article
Firmicutes and Blautia in gut microbiota lessened in chronic liver diseases and hepatocellular carcinoma patients: a pilot study
Tianyou Chen, Rongrong Ding, Xiaorong Chen, Yunfei Lu, Jia Shi, Ying Lü, Bozong Tang, Wensi Zhang, Chen Ye, Min Yuan & Zongguo Yang
Pages: 8233-8246
Published online: 19 Oct 2021
AbstractforFirmicutes and Blautia in gut microbiota lessened in chronic liver diseases and hepatocellular carcinoma patients: a pilot study | Full Text | References | PDF (3.3 MB) | EPUB
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Reviews

Review
Advances in biomaterial production from animal derived waste
Ayon Tarafdar, Vivek Kumar Gaur, Neha Rawat, Pratik Ramesh Wankhade, Gyanendra Kumar Gaur, Mukesh Kumar Awasthi, Narashans Alok Sagar & Ranjna Sirohi
Pages: 8247-8258
Published online: 23 Nov 2021
AbstractforAdvances in biomaterial production from animal derived waste | Full Text | References | PDF (619 KB) | EPUB
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Review
Role of adaptin protein complexes in intracellular trafficking and their impact on diseases
Juhyun Shin, Arti Nile & Jae-Wook Oh
Pages: 8259-8278
Published online: 21 Oct 2021
AbstractforRole of adaptin protein complexes in intracellular trafficking and their impact on diseases | Full Text | References | PDF (993.3 KB) | EPUB
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Article
Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2)
Long Pei, Xianqiang Lv, Gaopei Jia, Xiaoliang Tan, Ming Li & Aili Zhang
Pages: 8279-8295
Published online: 21 Oct 2021
AbstractforSilencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2) | Full Text | References | PDF (4.7 MB) | EPUB
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Article
Silencing Aurora-kinase-A (AURKA) reinforced the sensitivity of diffuse large B-cell lymphoma cells to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) via suppressing β-Catenin and RAS-extracellular signal-regulated protein kinase (ERK1/2) pathway
Shaoxiong Wang & Li Sun
Pages: 8296-8308
Published online: 17 Oct 2021
AbstractforSilencing Aurora-kinase-A (AURKA) reinforced the sensitivity of diffuse large B-cell lymphoma cells to cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) via suppressing β-Catenin and RAS-extracellular signal-regulated protein kinase (ERK1/2) pathway | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients
Zheng Zhou, Jiasheng Cao, Xiaoming Liu & Mingsong Li
Pages: 8309-8324
Published online: 21 Oct 2021
AbstractforEvidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients | Full Text | References | PDF (2.7 MB) | EPUB
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Review Article
Yeasts in nanotechnology-enabled oral vaccine and gene delivery
Elena Alexander
Pages: 8325-8335
Published online: 27 Oct 2021
AbstractforYeasts in nanotechnology-enabled oral vaccine and gene delivery | Full Text | References | PDF (1.5 MB) | EPUB
  • 8327 Views
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Article
Protein phosphatase 1 regulatory subunit 3G (PPP1R3G) correlates with poor prognosis and immune infiltration in lung adenocarcinoma
Xingli Zhuo, Lan Chen, Zongwei Lai, Jiansheng Liu, Shengjun Li, Ahu Hu & Yuansheng Lin
Pages: 8336-8346
Published online: 21 Oct 2021
AbstractforProtein phosphatase 1 regulatory subunit 3G (PPP1R3G) correlates with poor prognosis and immune infiltration in lung adenocarcinoma | Full Text | References | PDF (2.2 MB) | EPUB
  • 1627 Views
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Article
Blocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis
Shizhen Zheng, Chao Wang, Hao Yan & Yuejun Du
Pages: 8347-8357
Published online: 19 Oct 2021
AbstractforBlocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis | Full Text | References | PDF (2.3 MB) | EPUB
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Article
Cabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS)
Lina You & Haidong Jiang
Pages: 8358-8369
Published online: 21 Oct 2021
AbstractforCabergoline possesses a beneficial effect on blood-brain barrier (BBB) integrity against lipopolysaccharide (LPS) | Full Text | References | PDF (1.4 MB) | EPUB
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Article
The angiotensin-converting enzyme inhibitor, captopril, suppressed hepatic stellate cell activation via NF-kappaB or wnt3α/β-catenin pathway
Zhaodi Gu, Linjun Fang & Peijun Ma
Pages: 8370-8377
Published online: 20 Oct 2021
AbstractforThe angiotensin-converting enzyme inhibitor, captopril, suppressed hepatic stellate cell activation via NF-kappaB or wnt3α/β-catenin pathway | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Tumor suppressing role of serum-derived exosomal microRNA-15a in osteosarcoma cells through the GATA binding protein 2/murine double minute 2 axis and the p53 signaling pathway
Chunyu Wu, Zhigang Li, Guang Feng, Liqin Wang, Jingri Xie, Yang Jin, Long Wang & Songjiang Liu
Pages: 8378-8395
Published online: 21 Oct 2021
AbstractforTumor suppressing role of serum-derived exosomal microRNA-15a in osteosarcoma cells through the GATA binding protein 2/murine double minute 2 axis and the p53 signaling pathway | Full Text | References | PDF (4.3 MB) | EPUB
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Article
Protein tyrosine phosphatase 1B(PTP1B) promotes melanoma cells progression through Src activation
Qiang Wang, Yuyan Pan, Liping Zhao, Fazhi Qi & Jiaqi Liu
Pages: 8396-8406
Published online: 25 Oct 2021
AbstractforProtein tyrosine phosphatase 1B(PTP1B) promotes melanoma cells progression through Src activation | Full Text | References | PDF (3.9 MB) | EPUB
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Article
MiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1)
Guang-Lin Song, Ming Xiao, Xiao-Ya Wan, Jun Deng, Jun-Da Ling, Ying-Guo Tian, Min Li, Jie Yin, Ren-Ying Zheng, Yi Tang & Gui-Yuan Liu
Pages: 8407-8418
Published online: 18 Oct 2021
AbstractforMiR-130a-3p suppresses colorectal cancer growth by targeting Wnt Family Member 1 (WNT1) | Full Text | References | PDF (2.5 MB) | EPUB
  • 1189 Views
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Article
Identification of a prognostic chemoresistance-related gene signature associated with immune microenvironment in breast cancer
Mingzhou Liu, Qiaoyan Li & Ningmin Zhao
Pages: 8419-8434
Published online: 18 Oct 2021
AbstractforIdentification of a prognostic chemoresistance-related gene signature associated with immune microenvironment in breast cancer | Full Text | References | PDF (3.3 MB) | EPUB
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Article
Up-regulation of microRNA miR-101-3p enhances sensitivity to cisplatin via regulation of small interfering RNA (siRNA) Anti-human AGT4D and autophagy in non-small-cell lung carcinoma (NSCLC)
Dong Cui, Yu Feng & Rulin Qian
Pages: 8435-8446
Published online: 25 Oct 2021
AbstractforUp-regulation of microRNA miR-101-3p enhances sensitivity to cisplatin via regulation of small interfering RNA (siRNA) Anti-human AGT4D and autophagy in non-small-cell lung carcinoma (NSCLC) | Full Text | References | PDF (3.1 MB) | EPUB
  • 1246 Views
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Article
Tranilast inhibits angiotensin II-induced myocardial fibrosis through S100A11/ transforming growth factor-β (TGF-β1)/Smad axis
Youquan Chen, Ming Huang, Yi Yan & Dequan He
Pages: 8447-8456
Published online: 18 Oct 2021
AbstractforTranilast inhibits angiotensin II-induced myocardial fibrosis through S100A11/ transforming growth factor-β (TGF-β1)/Smad axis | Full Text | References | PDF (2.7 MB) | EPUB
  • 1700 Views
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Article
MiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells
Jia Liu, Sili Yan, Jun Hu, Dong Ding, Yang Liu, Xia Li, Hai Song Pan, Gengxin Liu, Bo Wu & Yu Liu
Pages: 8457-8467
Published online: 20 Oct 2021
AbstractforMiRNA-4537 functions as a tumor suppressor in gastric cancer and increases the radiosensitivity of gastric cancer cells | Full Text | References | PDF (2.2 MB) | EPUB
  • 1264 Views
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Article
Genetic association of the epidermal growth factor gene polymorphisms with peri-implantitis risk in Chinese population
Zhongfu Chang, Dandan Jiang, Shikun Zhang, Dongdong Pei, Zhirong Zhang, Lihua Zhang, Jianying Cai & Jun Cao
Pages: 8468-8475
Published online: 20 Oct 2021
AbstractforGenetic association of the epidermal growth factor gene polymorphisms with peri-implantitis risk in Chinese population | Full Text | References | PDF (374.3 KB) | EPUB
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Article
Montelukast attenuates interleukin IL-1β-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2)
Zongwei Li, Jianming Wang & Yumin Ma
Pages: 8476-8484
Published online: 25 Oct 2021
AbstractforMontelukast attenuates interleukin IL-1β-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel Like Factor 2) | Full Text | References | PDF (2.1 MB) | EPUB
  • 2060 Views
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Article
Tubulin polymerization promoting protein family member 3 (TPPP3) overexpression inhibits cell proliferation and invasion in nasopharyngeal carcinoma
Qisheng Su, Zheng Yang, Xiaobin Guo, Wuning Mo & Xiaohong Li
Pages: 8485-8495
Published online: 20 Oct 2021
AbstractforTubulin polymerization promoting protein family member 3 (TPPP3) overexpression inhibits cell proliferation and invasion in nasopharyngeal carcinoma | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Clinical value of microRNA-378a-3p in sepsis and its role in sepsis-induced inflammation and cardiac dysfunction
Qing Wang, Kuo Liu & Changming Jin
Pages: 8496-8504
Published online: 21 Oct 2021
AbstractforClinical value of microRNA-378a-3p in sepsis and its role in sepsis-induced inflammation and cardiac dysfunction | Full Text | References | PDF (696 KB) | EPUB
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Review
Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis
Weihao Kong, Meng Wei, Rongqiang Liu, Jianlin Zhang & Xingyu Wang
Pages: 8505-8514
Published online: 22 Oct 2021
AbstractforPrognostic value of CD169-positive macrophages in various tumors: a meta-analysis | Full Text | References | PDF (536.5 KB) | EPUB
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Article
Interferon alpha-inducible protein 27 (IFI27) is a prognostic marker for pancreatic cancer based on comprehensive bioinformatics analysis
Shu Huang, Jinglin Zhao, Jianxin Song, Yanqiong Li, Rongxia Zuo, Yalian Sa, Zhihui Ma & Hongmei OuYang
Pages: 8515-8528
Published online: 21 Oct 2021
AbstractforInterferon alpha-inducible protein 27 (IFI27) is a prognostic marker for pancreatic cancer based on comprehensive bioinformatics analysis | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Transcriptomic analyses and experimental verification reveal potential biomarkers and biological pathways of urinary tract infection
Wenbo Yang, Peng Liu, Yuling Zheng, Zhongtian Wang, Wenhua Huang, Hua jiang, Qingyu Lv, Yuhao Ren, Yongqiang Jiang & Liping Sun
Pages: 8529-8539
Published online: 21 Oct 2021
AbstractforTranscriptomic analyses and experimental verification reveal potential biomarkers and biological pathways of urinary tract infection | Full Text | References | PDF (2.8 MB) | EPUB
  • 1456 Views
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Article
Tripterygium glycoside ameliorates neuroinflammation in a mouse model of Aβ25-35-induced Alzheimer’s disease by inhibiting the phosphorylation of IκBα and p38
Liang Tang, Qin Xiang, Ju Xiang, Yan Zhang & Jianming Li
Pages: 8540-8554
Published online: 19 Oct 2021
AbstractforTripterygium glycoside ameliorates neuroinflammation in a mouse model of Aβ25-35-induced Alzheimer’s disease by inhibiting the phosphorylation of IκBα and p38 | Full Text | References | PDF (7.1 MB) | EPUB
  • 1629 Views
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Article
MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1
Yan Li, Nianling Yao, Yan Gao, Yunping Wang, Lu Bai, Jia Xu & Haixu Wang
Pages: 8555-8569
Published online: 21 Oct 2021
AbstractforMiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1 | Full Text | References | PDF (2.4 MB) | EPUB
  • 2135 Views
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Article
Long noncoding RNA SRY-box transcription factor 2 overlapping transcript participates in Parkinson’s disease by regulating the microRNA-942-5p/nuclear apoptosis-inducing factor 1 axis
Yabi Guo, Yanyang Liu, Hong Wang & Peijun Liu
Pages: 8570-8582
Published online: 20 Oct 2021
AbstractforLong noncoding RNA SRY-box transcription factor 2 overlapping transcript participates in Parkinson’s disease by regulating the microRNA-942-5p/nuclear apoptosis-inducing factor 1 axis | Full Text | References | PDF (3.9 MB) | EPUB
  • 1422 Views
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Article
Apremilast mitigates interleukin (IL)-13-induced inflammatory response and mucin production in human nasal epithelial cells (hNECs)
Jia Liang, RuoXiao Zhuang, XueYao Sun, Feng Zhang & Bin Zou
Pages: 8583-8593
Published online: 18 Oct 2021
AbstractforApremilast mitigates interleukin (IL)-13-induced inflammatory response and mucin production in human nasal epithelial cells (hNECs) | Full Text | References | PDF (1.6 MB) | EPUB
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review

Review
Recent findings and applications of biomedical engineering for COVID-19 diagnosis: a critical review
Le Minh Bui, Huong Thi Thu Phung, Thuy-Tien Ho Thi, Vijai Singh, Rupesh Maurya, Khushal Khambhati, Chia-Ching Wu, Md Jamal Uddin, Do Minh Trung & Dinh Toi Chu
Pages: 8594-8613
Published online: 18 Oct 2021
AbstractforRecent findings and applications of biomedical engineering for COVID-19 diagnosis: a critical review | Full Text | References | PDF (876.2 KB) | EPUB
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Article
Predictive value of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) combined with D-dimer for no-reflow phenomenon in patients with acute coronary syndrome after emergency of percutaneous coronary intervention
Yujing Diao, Meifeng Yin, Baoguo Zhang & Bin Sun
Pages: 8614-8621
Published online: 26 Oct 2021
AbstractforPredictive value of N-terminal pro-B-type natriuretic peptide (NT-pro BNP) combined with D-dimer for no-reflow phenomenon in patients with acute coronary syndrome after emergency of percutaneous coronary intervention | Full Text | References | PDF (426.5 KB) | EPUB
  • 1061 Views
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Article
miR-7/EGFR/MEGF9 axis regulates cartilage degradation in osteoarthritis via PI3K/AKT/mTOR signaling pathway
Lifeng Jiang, Xindie Zhou, Kai Xu, Pengfei Hu, Jiapeng Bao, Jin Li, Junfeng Zhu & Lidong Wu
Pages: 8622-8634
Published online: 18 Oct 2021
AbstractformiR-7/EGFR/MEGF9 axis regulates cartilage degradation in osteoarthritis via PI3K/AKT/mTOR signaling pathway | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Solid lipid nanoparticle delivery of rhynchophylline enhanced the efficiency of allergic asthma treatment via the upregulation of suppressor of cytokine signaling 1 by repressing the p38 signaling pathway
Chuanfeng Lv, Hui Li, Hongxia Cui, Qianyu Bi & Meng Wang
Pages: 8635-8649
Published online: 21 Oct 2021
AbstractforSolid lipid nanoparticle delivery of rhynchophylline enhanced the efficiency of allergic asthma treatment via the upregulation of suppressor of cytokine signaling 1 by repressing the p38 signaling pathway | Full Text | References | PDF (2.6 MB) | EPUB
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Article
The alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma
Weihua Fan, Xia Yu, Kunrong Li & Mingtao Zhu
Pages: 8650-8657
Published online: 18 Oct 2021
AbstractforThe alerting expression of microRNA-411 predicts clinical prognosis and regulates tumor progression of glioblastoma | Full Text | References | PDF (1.5 MB) | EPUB
  • 1060 Views
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Article
Dysregulation of miR-637 serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of the cerebral ischemic event
Ting Zhang & Ruijie Liu
Pages: 8658-8665
Published online: 18 Oct 2021
AbstractforDysregulation of miR-637 serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of the cerebral ischemic event | Full Text | References | PDF (552.4 KB) | EPUB
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Article
Hypoxia promotes the proliferation of mouse liver sinusoidal endothelial cells: miRNA–mRNA expression analysis
Zhe Qing, Hanfei Huang, Qun Luo, Jie Lin, Shikun Yang, Tao Liu, Zhong Zeng & Tingfeng Ming
Pages: 8666-8678
Published online: 21 Oct 2021
AbstractforHypoxia promotes the proliferation of mouse liver sinusoidal endothelial cells: miRNA–mRNA expression analysis | Full Text | References | PDF (7.7 MB) | EPUB
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Article
AZD3759 inhibits glioma through the blockade of the epidermal growth factor receptor and Janus kinase pathways
Wei Yin, Ke Zhang, Qinghua Deng, Qingqing Yu, Yanjiao Mao, Ruping Zhao & Shenglin Ma
Pages: 8679-8689
Published online: 25 Oct 2021
AbstractforAZD3759 inhibits glioma through the blockade of the epidermal growth factor receptor and Janus kinase pathways | Full Text | References | PDF (2.6 MB) | EPUB
  • 1500 Views
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Article
Identification of circRNA_001846 as putative non–small cell lung cancer biomarker
Fan Yang, Chunlan Ma, Jing Qiu, Xiaoli Feng & Kai Yang
Pages: 8690-8697
Published online: 25 Oct 2021
AbstractforIdentification of circRNA_001846 as putative non–small cell lung cancer biomarker | Full Text | References | PDF (1 MB) | EPUB
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Article
Long non-coding RNA FENDRR inhibits the stemenss of colorectal cancer cells through directly binding to Sox2 RNA
Xin Zhao, Jincheng Wu, Yongwen Li, Feng Ye & Chunyue Wang
Pages: 8698-8708
Published online: 26 Oct 2021
AbstractforLong non-coding RNA FENDRR inhibits the stemenss of colorectal cancer cells through directly binding to Sox2 RNA | Full Text | References | PDF (3.1 MB) | EPUB
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Article
Long non-coding RNA (LncRNA) CASC9/microRNA(miR)-590–3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer
Jingzhi Chang, Yuxia Zhang, Xin Ye, Hui Guo, Kun Lu, Qing Liu & Yli Guo
Pages: 8709-8723
Published online: 28 Oct 2021
AbstractforLong non-coding RNA (LncRNA) CASC9/microRNA(miR)-590–3p/sine oculis homeobox 1 (SIX1)/NF-κB axis promotes proliferation and migration in breast cancer | Full Text | References | PDF (4.4 MB) | EPUB
  • 1211 Views
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Article
Long non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p
Yue Zhao & Rui Yao
Pages: 8724-8737
Published online: 26 Oct 2021
AbstractforLong non-coding RNA HOXA-AS3 promotes cell proliferation of oral squamous cell carcinoma through sponging microRNA miR-218-5p | Full Text | References | PDF (2.8 MB) | EPUB
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Article
Glycolysis related gene expression signature in predicting prognosis of laryngeal squamous cell carcinoma
Hui-Ching Lau, Yujie Shen, Qiang Huang, Hui-Ying Huang & Liang Zhou
Pages: 8738-8752
Published online: 29 Oct 2021
AbstractforGlycolysis related gene expression signature in predicting prognosis of laryngeal squamous cell carcinoma | Full Text | References | PDF (2 MB) | EPUB
  • 1871 Views
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Article
Long non-coding RNA KCNQ1OT1 facilitates the progression of cervical cancer and tumor growth through modulating miR-296-5p/HYOU1 axis
Jun Liu & Yingmei Wang
Pages: 8753-8767
Published online: 27 Oct 2021
AbstractforLong non-coding RNA KCNQ1OT1 facilitates the progression of cervical cancer and tumor growth through modulating miR-296-5p/HYOU1 axis | Full Text | References | PDF (5.3 MB) | EPUB
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Article
Silencing of long non-coding RNA NEAT1 improves Treg/Th17 imbalance in preeclampsia via the miR-485-5p/AIM2 axis
Jiying Chen, Yonggang Zhang, Wenqing Tan, Hanchao Gao, Shuixiu Xiao, Jinhua Gao & Zhiying Zhu
Pages: 8768-8777
Published online: 26 Oct 2021
AbstractforSilencing of long non-coding RNA NEAT1 improves Treg/Th17 imbalance in preeclampsia via the miR-485-5p/AIM2 axis | Full Text | References | PDF (1.8 MB) | EPUB
  • 1516 Views
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Article
Discovery of novel serum metabolic biomarkers in patients with polycystic ovarian syndrome and premature ovarian failure
Jiying Chen, Qinger Zhou, Yonggang Zhang, Wenqing Tan, Hanchao Gao, Liying Zhou, Shuixiu Xiao, Jinhua Gao, Jing Li & Zhiying Zhu
Pages: 8778-8792
Published online: 26 Oct 2021
AbstractforDiscovery of novel serum metabolic biomarkers in patients with polycystic ovarian syndrome and premature ovarian failure | Full Text | References | PDF (2.1 MB) | EPUB
  • 2243 Views
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Article
Circular RNA hsa_circ_0000751 serves as a microRNA-488 sponge to suppress gastric cancer progression via ubiquinol-cytochrome c reductase core protein 2 regulation
Danwen Wang, Fei Su & Maohui Feng
Pages: 8793-8808
Published online: 27 Oct 2021
AbstractforCircular RNA hsa_circ_0000751 serves as a microRNA-488 sponge to suppress gastric cancer progression via ubiquinol-cytochrome c reductase core protein 2 regulation | Full Text | References | PDF (4 MB) | EPUB
  • 1521 Views
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Article
The Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear
Hongwei Zheng, Wenlun Wang, Shichang Li & Lin Han
Pages: 8809-8821
Published online: 26 Oct 2021
AbstractforThe Effect of Zbxz23ir-21 NANO(nanomaterials) Delivery Vector on Apoptosis and PTEN(phosphatase and tensin homolog deleted on chromosome ten)/PI3K(Intracellular phosphatidylinositol kinase)/AKT(related to the A and C kinase) in Children with CHOLESTEATOMA in Middle Ear | Full Text | References | PDF (688 KB) | EPUB
  • 1078 Views
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Article
Orosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9
Luo Qiong & Jun Yin
Pages: 8822-8832
Published online: 27 Oct 2021
AbstractforOrosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9 | Full Text | References | PDF (2 MB) | EPUB
  • 1424 Views
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Article
Associations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy
Xiaogang Liu, Weixi Xu, Chengyuan Yu, Mingao Wang, Ruichan Liu & Rujuan Xie
Pages: 8833-8844
Published online: 29 Oct 2021
AbstractforAssociations between m-type phospholipase A2 receptor,human leukocyte antigen gene polymorphisms and idiopathic membranous nephropathy | Full Text | References | PDF (570 KB) | EPUB
  • 1436 Views
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Article
Identification and validation of potential novel biomarkers for oral squamous cell carcinoma
Mengxue Zhang, Xiao Chen, He Chen, Minyue Zhou, Yaoqiang Liu, Yali Hou, Minhai Nie & Xuqian Liu
Pages: 8845-8862
Published online: 26 Oct 2021
AbstractforIdentification and validation of potential novel biomarkers for oral squamous cell carcinoma | Full Text | References | PDF (5.2 MB) | EPUB
  • 2146 Views
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Article
Homebrewed psilocybin: can new routes for pharmaceutical psilocybin production enable recreational use?
William J. Gibbons Jr., Madeline G. McKinney, Philip J. O’Dell, Brooke A. Bollinger & J. Andrew Jones
Pages: 8863-8871
Published online: 26 Oct 2021
AbstractforHomebrewed psilocybin: can new routes for pharmaceutical psilocybin production enable recreational use? | Full Text | References | PDF (579.6 KB) | EPUB
  • 19476 Views
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Article
Neutrophils correlate with hypoxia microenvironment and promote progression of non-small-cell lung cancer
Chunyan Zhang, Bingxiang Tang, Jianping Hu, Xiang Fang, Hongzhi Bian, Junlei Han, Congxia Hou & Fang Sun
Pages: 8872-8884
Published online: 26 Oct 2021
AbstractforNeutrophils correlate with hypoxia microenvironment and promote progression of non-small-cell lung cancer | Full Text | References | PDF (3.3 MB) | EPUB
  • 3404 Views
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Research paper

Article
Pseudogene fms-related tyrosine kinase 1 pseudogene 1 (FLT1P1) cooperates with RNA binding protein dyskeratosis congenita 1 (DKC1) to restrain trophoblast cell proliferation and angiogenesis by targeting fms-related tyrosine kinase 1 (FLT1) in preeclampsia
Zhenjing Chi, Yanlan Sun, Zhou Yu, Fenmei Zhou, Hairong Wang & Muling Zhang
Pages: 8885-8897
Published online: 26 Oct 2021
AbstractforPseudogene fms-related tyrosine kinase 1 pseudogene 1 (FLT1P1) cooperates with RNA binding protein dyskeratosis congenita 1 (DKC1) to restrain trophoblast cell proliferation and angiogenesis by targeting fms-related tyrosine kinase 1 (FLT1) in preeclampsia | Full Text | References | PDF (2.2 MB) | EPUB
  • 1124 Views
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Article
LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α
Jiajie Feng, Jiachen Zhan & Shuangshuang Ma
Pages: 8897-8907
Published online: 25 Oct 2021
AbstractforLRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α | Full Text | References | PDF (2.2 MB) | EPUB
  • 3203 Views
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Article
β-galactosidase GALA from Bacillus circulans with high transgalactosylation activity
Yaru Yan, Weishi Guan, Xiaoyi Li, Kaier Gao, Xinxin Xu, Bo Liu, Wei Zhang & Yuhong Zhang
Pages: 8908-8919
Published online: 01 Nov 2021
Abstractforβ-galactosidase GALA from Bacillus circulans with high transgalactosylation activity | Full Text | References | PDF (1.2 MB) | EPUB
  • 1789 Views
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Article
Circular RNA hsa_circ_0005567 overexpression promotes M2 type macrophage polarization through miR-492/SOCS2 axis to inhibit osteoarthritis progression
Jinling Zhang, Fangyue Cheng, Genxiang Rong, Zhi Tang & Binjie Gui
Pages: 8920-8930
Published online: 25 Oct 2021
AbstractforCircular RNA hsa_circ_0005567 overexpression promotes M2 type macrophage polarization through miR-492/SOCS2 axis to inhibit osteoarthritis progression | Full Text | References | PDF (1.6 MB) | EPUB
  • 2030 Views
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Article
25(OH)-Vitamin D alleviates neonatal infectious pneumonia via regulating TGFβ-mediated nuclear translocation mechanism of YAP/TAZ
Qi Sun, Yiwen Gao, Lina Qiao, Yi Yuan & Qian Liu
Pages: 8931-8942
Published online: 27 Oct 2021
Abstractfor25(OH)-Vitamin D alleviates neonatal infectious pneumonia via regulating TGFβ-mediated nuclear translocation mechanism of YAP/TAZ | Full Text | References | PDF (1.5 MB) | EPUB
  • 1304 Views
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Article
Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
Yonghui Liu, Chengwen Zhao, Jing Sun, Guihua Wang, Shaoqing Ju, Chen Qian & Xudong Wang
Pages: 8943-8952
Published online: 26 Oct 2021
AbstractforOverexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer | Full Text | References | PDF (1.4 MB) | EPUB
  • 1232 Views
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Article
Circular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5’-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner
Cuiyun Zhou, Xiaoqiong Huang, Xia Li & Yan Xiong
Pages: 8953-8964
Published online: 28 Oct 2021
AbstractforCircular RNA erythrocyte membrane protein band 4.1 assuages ultraviolet irradiation-induced apoptosis of lens epithelial cells by stimulating 5’-bisphosphate nucleotidase 1 in a miR-24-3p-dependent manner | Full Text | References | PDF (2 MB) | EPUB
  • 1109 Views
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Article
High expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma
Gaoda Ju, Cheng Xu, Kai Zeng, Tianhao Zhou & Lijuan Zang
Pages: 8965-8979
Published online: 26 Oct 2021
AbstractforHigh expression of transmembrane P24 trafficking protein 9 predicts poor prognosis in breast carcinoma | Full Text | References | PDF (5.5 MB) | EPUB
  • 1474 Views
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Article
POU class 2 homeobox associating factor 1 (POU2AF1) participates in abdominal aortic aneurysm enlargement based on integrated bioinformatics analysis
Jinze Meng, Hao Wen, Xintong Li, Boyang Luan, Shiqiang Gong, Jie Wen, Yifei Wang & Lei Wang
Pages: 8980-8993
Published online: 26 Oct 2021
AbstractforPOU class 2 homeobox associating factor 1 (POU2AF1) participates in abdominal aortic aneurysm enlargement based on integrated bioinformatics analysis | Full Text | References | PDF (3.1 MB) | EPUB
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Article
The long non-coding RNA NNT-AS1 promotes clear cell renal cell carcinoma progression via regulation of the miR-137/ Y-box binding protein 1 axis
Yadi Zhou, Zhenghao Zhang, Mingyi Wo & Wenfang Xu
Pages: 8994-9005
Published online: 25 Nov 2021
AbstractforThe long non-coding RNA NNT-AS1 promotes clear cell renal cell carcinoma progression via regulation of the miR-137/ Y-box binding protein 1 axis | Full Text | References | PDF (3 MB) | EPUB
  • 1367 Views
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Article
Up-regulation of S100P predicts the poor long-term survival and construction of prognostic signature for survival and immunotherapy in patients with pancreatic cancer
Wenbo Zou, Lincheng Li, Zizheng Wang, Nan Jiang, Fei Wang, Minggen Hu & Rong Liu
Pages: 9006-9020
Published online: 27 Oct 2021
AbstractforUp-regulation of S100P predicts the poor long-term survival and construction of prognostic signature for survival and immunotherapy in patients with pancreatic cancer | Full Text | References | PDF (3.2 MB) | EPUB
  • 2241 Views
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Article
Aquaporin 4 inhibition alleviates myocardial ischemia-reperfusion injury by restraining cardiomyocyte pyroptosis
Qiong Jiang, Xianfeng Dong, Danqing Hu, Lejun Chen & Yukun Luo
Pages: 9021-9030
Published online: 29 Oct 2021
AbstractforAquaporin 4 inhibition alleviates myocardial ischemia-reperfusion injury by restraining cardiomyocyte pyroptosis | Full Text | References | PDF (1.8 MB) | EPUB
  • 3004 Views
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Article
Comparative analysis of circRNA expression profile and circRNA-miRNA-mRNA regulatory network between palmitic and stearic acid-induced lipotoxicity to pancreatic β cells
Yunjin Zhang, Qingrui Zhao, Shenghan Su, Lingfeng Dan, Xuebei Li, Yu Wang, Yuqing Lin, Zhen Tian, Changhao Sun & Huimin Lu
Pages: 9031-9045
Published online: 29 Oct 2021
AbstractforComparative analysis of circRNA expression profile and circRNA-miRNA-mRNA regulatory network between palmitic and stearic acid-induced lipotoxicity to pancreatic β cells | Full Text | References | PDF (2.8 MB) | EPUB
  • 1898 Views
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Article
Long intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis
Xia Wu, Cui Kong & Yilei Wu
Pages: 9046-9057
Published online: 28 Oct 2021
AbstractforLong intergenic non-protein coding RNA 1094 (LINC01094) promotes the progression of breast cancer (BC) by regulating the microRNA-340-5p (miR-340-5p)/E2F transcription factor 3 (E2F3) axis | Full Text | References | PDF (3 MB) | EPUB
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Article
Circular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial–mesenchymal transition
QunXue Su, Hao Shen, Bei Gu & Ning Zhu
Pages: 9058-9069
Published online: 26 Oct 2021
AbstractforCircular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial–mesenchymal transition | Full Text | References | PDF (2.8 MB) | EPUB
  • 1231 Views
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Article
Valsartan alleviates the blood–brain barrier dysfunction in db/db diabetic mice
Longxue Cai, Wenfeng Li, Renqing Zeng, Zuohong Cao, Qicai Guo, Qi Huang & Xianfa Liu
Pages: 9070-9080
Published online: 26 Oct 2021
AbstractforValsartan alleviates the blood–brain barrier dysfunction in db/db diabetic mice | Full Text | References | PDF (1.7 MB) | EPUB
  • 2094 Views
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Article
Circular RNA FOXP1 relieves trophoblastic cell dysfunction in recurrent pregnancy loss via the miR-143-3p/S100A11 cascade
Yuan Gao, Yukun Tang, Qian Sun, Guixue Guan, Xiaoyan Wu, Fan Shi, Zihao Zhou & Wen Yang
Pages: 9081-9093
Published online: 26 Oct 2021
AbstractforCircular RNA FOXP1 relieves trophoblastic cell dysfunction in recurrent pregnancy loss via the miR-143-3p/S100A11 cascade | Full Text | References | PDF (4.2 MB) | EPUB
  • 1634 Views
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Article
microRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1
Bin Yang, Huifeng Diao, Pu Wang, Fengju Guan & Hechen Liu
Pages: 9094-9102
Published online: 27 Oct 2021
AbstractformicroRNA-877-5p exerts tumor-suppressive functions in prostate cancer through repressing transcription of forkhead box M1 | Full Text | References | PDF (749.4 KB) | EPUB
  • 924 Views
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Article
Alterations of oral microbiota in patients with panic disorder
Zunli Xie, Weiqing Jiang, Mingzhu Deng, Wei Wang, Xian Xie, Xia Feng, Yinping Shi, Xueyan Zhang, Dong Song, Ziyu Yuan & Yonggang Wang
Pages: 9103-9112
Published online: 26 Oct 2021
AbstractforAlterations of oral microbiota in patients with panic disorder | Full Text | References | PDF (2.1 MB) | EPUB
  • 2198 Views
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