Cancer Biology & Therapy, Volume 16, Issue 3 (2015)

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Cancer Biology & Therapy, Volume 16, Issue 3 (2015)

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Review

Hes1: a key role in stemness, metastasis and multidrug resistance
Zi-Hao Liu, Xiao-Meng Dai & Bin Du
Pages: 353-359
Published online: 01 Apr 2015
AbstractforHes1: a key role in stemness, metastasis and multidrug resistance | Full Text | References | PDF (264.7 KB)
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Journal Club

Article
Which patients with resectable pancreatic cancer truly benefit from oncological resection: is it destiny or biology?
Lei Zheng & Christopher L Wolfgang
Pages: 360-362
Published online: 01 Apr 2015
AbstractforWhich patients with resectable pancreatic cancer truly benefit from oncological resection: is it destiny or biology? | Full Text | References | PDF (53 KB)
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Meeting Report

4th international conference on tumor progression and therapeutic resistance: meeting report
Varun V Prabhu & Wafik S El-Deiry
Pages: 363-376
Published online: 01 Apr 2015
Abstractfor4th international conference on tumor progression and therapeutic resistance: meeting report | Full Text | References | PDF (173.3 KB)
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Bedside to Bench Report

Article
A case of heterogeneous sensitivity to panitumumab in cetuximab-refractory colorectal adenocarcinoma metastases
Eric Marks, Syed Mujtaba Rizvi, Nabeel Sarwani, Zhaohai Yang & Wafik S El-Deiry
Pages: 377-382
Published online: 01 Apr 2015
AbstractforA case of heterogeneous sensitivity to panitumumab in cetuximab-refractory colorectal adenocarcinoma metastases | Full Text | References | PDF (497 KB)
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Research Paper

Article
Heterozygous deletion of ATG5 in ApcMin/+ mice promotes intestinal adenoma growth and enhances the antitumor efficacy of interferon-gamma
Lu Wang, Yan Wang, Yuyin Lu, Qianyun Zhang & Xianjun Qu
Pages: 383-391
Published online: 01 Apr 2015
AbstractforHeterozygous deletion of ATG5 in ApcMin/+ mice promotes intestinal adenoma growth and enhances the antitumor efficacy of interferon-gamma | Full Text | References | PDF (632.5 KB)
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Article
USP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1
Deepa Kushwaha, Colin O’Leary, Kyle R Cron, Peter Deraska, Kaya Zhu, Alan D D’Andrea & David Kozono
Pages: 392-401
Published online: 01 Apr 2015
AbstractforUSP9X inhibition promotes radiation-induced apoptosis in non-small cell lung cancer cells expressing mid-to-high MCL1 | Full Text | References | PDF (868.3 KB) | Supplemental
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Article
PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition
Samuel W Brady, Jian Zhang, Ming-Horng Tsai & Dihua Yu
Pages: 402-411
Published online: 01 Apr 2015
AbstractforPI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition | Full Text | References | PDF (628.5 KB) | Supplemental
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Article
Inauhzin(c) Inactivates c-Myc Independently of p53
Ji Hoon Jung, Jun-Ming Liao, Qi Zhang, Shelya Zeng, Daniel Nguyen, Qian Hao, Xiang Zhou, Bo Cao, Sung-Hoon Kim & Hua Lu
Pages: 412-419
Published online: 01 Apr 2015
AbstractforInauhzin(c) Inactivates c-Myc Independently of p53 | Full Text | References | PDF (533.2 KB)
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Article
Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells
Yanchun Wang, Zhongguang Luo, Yongfu Pan, Weige Wang, Xiaoyan Zhou, Lak Shin Jeong, Yiwei Chu, Jie Liu & Lijun Jia
Pages: 420-429
Published online: 01 Apr 2015
AbstractforTargeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells | Full Text | References | PDF (861 KB)
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Article
COX-2 dependent regulation of mechanotransduction in human breast cancer cells
A-Rum Yoon, Ioannis Stasinopoulos, Jae Hun Kim, Hwan Mee Yong, Onur Kilic, Denis Wirtz, Zaver M Bhujwalla & Steven S An
Pages: 430-437
Published online: 01 Apr 2015
AbstractforCOX-2 dependent regulation of mechanotransduction in human breast cancer cells | Full Text | References | PDF (614.8 KB) | Supplemental
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Article
Efficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer
Jessica D Sun, Qian Liu, Dharmendra Ahluwalia, Wenwu Li, Fanying Meng, Yan Wang, Deepthi Bhupathi, Ayesha S Ruprell & Charles P Hart
Pages: 438-449
Published online: 01 Apr 2015
AbstractforEfficacy and safety of the hypoxia-activated prodrug TH-302 in combination with gemcitabine and nab-paclitaxel in human tumor xenograft models of pancreatic cancer | Full Text | References | PDF (1,016.8 KB) | Supplemental
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Article
Methionine Enkephalin (MENK) Inhibits tumor growth through regulating CD4+Foxp3+ Regulatory T cells (Tregs) in mice
Xuan Li, Yiming Meng, Nicolas P Plotnikoff, Gene Youkilis, Noreen Griffin, Enhua Wang, Changlong Lu & Fengping Shan
Pages: 450-459
Published online: 01 Apr 2015
AbstractforMethionine Enkephalin (MENK) Inhibits tumor growth through regulating CD4+Foxp3+ Regulatory T cells (Tregs) in mice | Full Text | References | PDF (859.2 KB)
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Article
Tumor suppression by resistant maltodextrin, Fibersol-2
Eui Young So, Mutsuko Ouchi, Sara Cuesta-Sancho, Susan Losee Olson, Dirk Reif, Kazuhiro Shimomura & Toru Ouchi
Pages: 460-465
Published online: 01 Apr 2015
AbstractforTumor suppression by resistant maltodextrin, Fibersol-2 | Full Text | References | PDF (666.8 KB)
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Article
Inhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells
Lei Jiang, Lingzhi Xu, Jiajun Xie, Sisi Li, Yanchun Guan, Yan Zhang, Zhijie Hou, Tao Guo, Xin Shu, Chang Wang, Wenjun Fan, Yang Si, Ya Yang, Zhijie Kang, Meiyun Fang & Quentin Liu
Pages: 466-476
Published online: 01 Apr 2015
AbstractforInhibition of autophagy overcomes glucocorticoid resistance in lymphoid malignant cells | Full Text | References | PDF (1.1 MB) | Supplemental
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Article
Trk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo
Zhijie Li, Yi Zhang, Yuxin Tong, Jenna Tong & Carol J Thiele
Pages: 477-483
Published online: 01 Apr 2015
AbstractforTrk inhibitor attenuates the BDNF/TrkB-induced protection of neuroblastoma cells from etoposide in vitro and in vivo | Full Text | References | PDF (510.3 KB)
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Article
Insulin priming effect on estradiol-induced breast cancer metabolism and growth
Peninah M Wairagu, Ai NH Phan, Min-Kyu Kim, Jeongwoo Han, Hyun-Won Kim, Jong-Whan Choi, Ki Woo Kim, Seung-Kuy Cha, Kwang Hwa Park & Yangsik Jeong
Pages: 484-492
Published online: 01 Apr 2015
AbstractforInsulin priming effect on estradiol-induced breast cancer metabolism and growth | Full Text | References | PDF (614.8 KB)
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