Cancer Biology & Therapy, Volume 20, Issue 4 (2019)

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Cancer Biology & Therapy, Volume 20, Issue 4 (2019)

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Bedside to Bench Report

Report
Afatinib treatment for her-2 amplified metastatic colorectal cancer based on patient-derived xenograft models and next generation sequencing
Mengyuan Yang, Xuefeng Fang, Jun Li, Dong Xu, Qian Xiao, Shaojun Yu, Hanguang Hu, Shanshan Weng, Kefeng Ding & Ying Yuan
Pages: 391-396
Published online: 11 Oct 2018
AbstractforAfatinib treatment for her-2 amplified metastatic colorectal cancer based on patient-derived xenograft models and next generation sequencing | Full Text | References | PDF (1.3 MB) | EPUB
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Report
New onset acute promyelocytic Leukemia during pregnancy: report of 2 cases
Huiyang Li, Cha Han, Ke Li, Jie Li, Yingmei Wang & Fengxia Xue
Pages: 397-401
Published online: 19 Nov 2018
AbstractforNew onset acute promyelocytic Leukemia during pregnancy: report of 2 cases | Full Text | References | PDF (543.6 KB) | EPUB
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Report
Identification of a novel PDGFRA point mutation at p.P6L as a potential molecular target of imatinib in an eosinophilia patient showing genetic heterogeneity
Miaomiao Zhao, Qiuling Wu, Linghui Xia, Min Zhang, Jianqing Yang, Yaya Li, Shichun Tu & Yadan Wang
Pages: 402-407
Published online: 25 Oct 2018
AbstractforIdentification of a novel PDGFRA point mutation at p.P6L as a potential molecular target of imatinib in an eosinophilia patient showing genetic heterogeneity | Full Text | References | PDF (1,006.6 KB) | EPUB
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Report
Tumor regression after combination of radiation and PD-1 antibody nivolumab treatment in a patient with metastatic mediastinal leiomyosarcoma: a case report
Chen Xi, Zhang Wencheng, Qian Dong, Guan Yong, Yan Cihui, Wang Yuwen, Zhang Hualei, Er Puchun, Pang Qingsong & Wang Ping
Pages: 408-412
Published online: 02 Nov 2018
AbstractforTumor regression after combination of radiation and PD-1 antibody nivolumab treatment in a patient with metastatic mediastinal leiomyosarcoma: a case report | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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Research Paper

Article
Upregulation of long non-coding RNA NNT-AS1 promotes osteosarcoma progression by inhibiting the tumor suppressive miR-320a
Changhui Li, Shouyun Zhang, Tongguo Qiu, Yuanji Wang, David M. Ricketts & Chao Qi
Pages: 413-422
Published online: 29 Nov 2018
AbstractforUpregulation of long non-coding RNA NNT-AS1 promotes osteosarcoma progression by inhibiting the tumor suppressive miR-320a | Full Text | References | PDF (2 MB) | EPUB
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Article
PDGFRα expression as a novel therapeutic marker in well-differentiated neuroendocrine tumors
Elisabetta Cavalcanti, Antonia Ignazzi, Francesco De Michele & Maria Lucia Caruso
Pages: 423-430
Published online: 22 Oct 2018
AbstractforPDGFRα expression as a novel therapeutic marker in well-differentiated neuroendocrine tumors | Full Text | References | PDF (2.4 MB) | EPUB
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Article
Successful treatment of a BRAF V600E-mutant extracranial metastatic anaplastic oligoastrocytoma with vemurafenib and everolimus
Liangliang Shi, Zhenwei Zou, Qian Ding, Qing Liu, Hongxia Zhou, Xiaohua Hong & Gang Peng
Pages: 431-434
Published online: 21 Nov 2018
AbstractforSuccessful treatment of a BRAF V600E-mutant extracranial metastatic anaplastic oligoastrocytoma with vemurafenib and everolimus | Full Text | References | PDF (600.3 KB) | EPUB
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Article
RasGRF2 promotes migration and invasion of colorectal cancer cells by modulating expression of MMP9 through Src/Akt/NF-κB pathway
Peifen Lu, Junjun Chen, Lihong Yan, Lijun Yang, Litao Zhang, Jie Dai, Zixuan Hao, Tao Bai, Yanfeng Xi, Yahui Li, Zhiming Kang, Jun Xv, Gongqin Sun & Tao Yang
Pages: 435-443
Published online: 25 Oct 2018
AbstractforRasGRF2 promotes migration and invasion of colorectal cancer cells by modulating expression of MMP9 through Src/Akt/NF-κB pathway | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1242 Views
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Article
STAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway
Zhe Liu, Hong Li, Sumeng Fan, Hui Lin & Wenwei Lian
Pages: 444-453
Published online: 07 Nov 2018
AbstractforSTAT3-induced upregulation of long noncoding RNA HNF1A-AS1 promotes the progression of oral squamous cell carcinoma via activating Notch signaling pathway | Full Text | References | PDF (2 MB) | EPUB
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Article
Crosstalk between TF/FVIIa and EGFR signaling in colorectal cancer cells
He-kai Chen, Xin Wang, Yuan-lian Wan & Jian­-qiang Tang
Pages: 454-460
Published online: 21 Nov 2018
AbstractforCrosstalk between TF/FVIIa and EGFR signaling in colorectal cancer cells | Full Text | References | PDF (1.1 MB) | EPUB
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Article
Knockdown of linc00152 inhibits the progression of gastric cancer by regulating microRNA-193b-3p/ETS1 axis
Haifang Wang, Wenxiang Chen, Peng Yang, Jun Zhou, Kaiyuan Wang & Qingchun Tao
Pages: 461-473
Published online: 07 Nov 2018
AbstractforKnockdown of linc00152 inhibits the progression of gastric cancer by regulating microRNA-193b-3p/ETS1 axis | Full Text | References | PDF (2.9 MB) | EPUB
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Article
Discovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties
Bhanvi Mishra, Sufang Zhang, Hong Zhao, Zbigniew Darzynkiewicz, Ernest Y.C. Lee, Marietta Y.W.T. Lee & Zhongtao Zhang
Pages: 474-486
Published online: 14 Nov 2018
AbstractforDiscovery of a novel DNA polymerase inhibitor and characterization of its antiproliferative properties | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 4339 Views
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Open Access
Article
Effects of high fat diet-induced obesity on mammary tumorigenesis in the PyMT/MMTV murine model
Taryn L. Cranford, Kandy T. Velázquez, Reilly T. Enos, Alexander T. Sougiannis, Jackie E Bader, Meredith S. Carson, Rebecca R. Bellone, Ioulia Chatzistamou, Mitzi Nagarkatti & E. Angela Murphy
Pages: 487-496
Published online: 02 Nov 2018
AbstractforEffects of high fat diet-induced obesity on mammary tumorigenesis in the PyMT/MMTV murine model | Full Text | References | PDF (1.5 MB) | EPUB
  • 1743 Views
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Article
The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer
Xueru Zhu, Yiwei Wang, Wenji Xue, Ruifen Wang, Lifeng Wang, Mei-Ling Zhu & Leizhen Zheng
Pages: 497-504
Published online: 31 Oct 2018
AbstractforThe VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer | Full Text | References | PDF (1 MB) | EPUB | Supplemental
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Article
Dynamic changes of different phenotypic and genetic circulating tumor cells as a biomarker for evaluating the prognosis of RCC
Zhen-Long Wang, Peng Zhang, He-Cheng Li, Xiao-Jie Yang, Ya-Ping Zhang, Zhao-Lun Li, Li Xue, Yu-Quan Xue, Hong-Liang Li, Qi Chen & Tie Chong
Pages: 505-512
Published online: 25 Oct 2018
AbstractforDynamic changes of different phenotypic and genetic circulating tumor cells as a biomarker for evaluating the prognosis of RCC | Full Text | References | PDF (1.3 MB) | EPUB
  • 1209 Views
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Article
2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines
Dayong Zheng, Xing Chang, Yang Liu, Jingwen Xu, Wenfeng Gou, Zengqiang Li, Daiying Zuo, Weige Zhang & Yingliang Wu
Pages: 513-523
Published online: 04 Dec 2018
Abstractfor2-Methoxy-5((3,4,5-trimethosyphenyl)seleninyl) phenol reverses EGF-induced cell migration and invasion through down-regulation of MDM2 in breast cancer cell lines | Full Text | References | PDF (2 MB) | EPUB
  • 718 Views
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Article
LncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5
Mingbao Zhang, Yue Li, Hongbo Wang, Weihua Yu, Sen Lin & Jianqiang Guo
Pages: 524-536
Published online: 05 Nov 2018
AbstractforLncRNA SNHG5 affects cell proliferation, metastasis and migration of colorectal cancer through regulating miR-132-3p/CREB5 | Full Text | References | PDF (3.2 MB) | EPUB
  • 1726 Views
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Article
Knockdown of FOXP1 promotes the development of lung adenocarcinoma
Hua Sheng, Xiangyang Li & Yi Xu
Pages: 537-545
Published online: 08 Nov 2018
AbstractforKnockdown of FOXP1 promotes the development of lung adenocarcinoma | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
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Article
Detecting and phenotyping of aneuploid circulating tumor cells in patients with various malignancies
Zhenlong Ye, Yongmei Ding, Zhuo Chen, Zhong Li, Shuo Ma, Zenghui Xu, Liang Cheng, Xinyue Wang, Xiaoxia Zhang, Na Ding, Qian Zhang & Qijun Qian
Pages: 546-551
Published online: 20 Dec 2018
AbstractforDetecting and phenotyping of aneuploid circulating tumor cells in patients with various malignancies | Full Text | References | PDF (824.5 KB) | EPUB | Supplemental
  • 1746 Views
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Article
Long non-coding RNA ARAP1-AS1 promotes the progression of bladder cancer by regulating miR-4735-3p/NOTCH2 axis
Jingfei Teng, Xing Ai, Zhuomin Jia, Kai Wang, Yawei Guan & Yanjie Guo
Pages: 552-561
Published online: 07 Nov 2018
AbstractforLong non-coding RNA ARAP1-AS1 promotes the progression of bladder cancer by regulating miR-4735-3p/NOTCH2 axis | Full Text | References | PDF (2.1 MB) | EPUB
  • 978 Views
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Article
Unique genomic profiles obtained from cerebrospinal fluid cell-free DNA of non-small cell lung cancer patients with leptomeningeal metastases
Shenpeng Ying, Honggang Ke, Yan Ding, Yanmei Liu, Xiaowan Tang, Dongyong Yang, Min Li, Junjun Liu, Bing Yu, Jianxing Xiang, Xinru Mao, Han Han-Zhang, Wei Hu & Lili Chen
Pages: 562-570
Published online: 05 Nov 2018
AbstractforUnique genomic profiles obtained from cerebrospinal fluid cell-free DNA of non-small cell lung cancer patients with leptomeningeal metastases | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1348 Views
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Article
Discovery platform for inhibitors of IgH gene enhancer activity
Nathan G. Dolloff
Pages: 571-581
Published online: 27 Nov 2018
AbstractforDiscovery platform for inhibitors of IgH gene enhancer activity | Full Text | References | PDF (1.4 MB) | EPUB
  • 1073 Views
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