Channels, Volume 13, Issue 1 (2019)

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Channels, Volume 13, Issue 1 (2019)

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Research Paper

Article
TRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure
Jaime S. Horton, Takuya Shiraishi, Naghum Alfulaij, Andrea L. Small-Howard, Helen C. Turner, Tatsuki Kurokawa, Yasuo Mori & Alexander J. Stokes
Pages: 1-16
Published online: 12 Dec 2018
AbstractforTRPV1 is a component of the atrial natriuretic signaling complex, and using orally delivered antagonists, presents a valid therapeutic target in the longitudinal reversal and treatment of cardiac hypertrophy and heart failure | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 5018 Views
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Article
Rectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel
Xiying Guo, Haowen Liu, Zhigang Huang, Yanting Wang, Yan Zhang, Lu-Yang Wang, Chunyang Cao, Sheng Wang & Jiuping Ding
Pages: 17-32
Published online: 12 Dec 2018
AbstractforRectification ratio based determination of disulfide bonds of β2 extracellular loop of BK channel | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 1494 Views
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Autocommentary

Article Commentary
Lifting the veils on TMEM16E function
Anna Boccaccio, Eleonora Di Zanni, Antonella Gradogna & Joachim Scholz-Starke
Pages: 33-35
Published online: 17 Jan 2019
First Page PreviewforLifting the veils on TMEM16E function | Full Text | References | PDF (762.5 KB) | EPUB
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Research Paper

Article
Arachidonic acid hyperpolarizes mesenchymal stromal cells from the human adipose tissue by stimulating TREK1 K+ channels
Michail V. Tarasov, Polina D. Kotova, Marina F. Bystrova, Natalia V. Kabanova, Veronika Yu. Sysoeva & Stanislav S. Kolesnikov
Pages: 36-47
Published online: 19 Jan 2019
AbstractforArachidonic acid hyperpolarizes mesenchymal stromal cells from the human adipose tissue by stimulating TREK1 K+ channels | Full Text | References | PDF (3.6 MB) | EPUB | Supplemental
  • 1710 Views
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Open Access
Article
Inhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision
Sonja Lj. Joksimovic, Rebecca R. Donald, Ji-Yong Park & Slobodan M. Todorovic
Pages: 48-61
Published online: 23 Jan 2019
AbstractforInhibition of multiple voltage-gated calcium channels may contribute to spinally mediated analgesia by epipregnanolone in a rat model of surgical paw incision | Full Text | References | PDF (2.9 MB) | EPUB
  • 1650 Views
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Open Access
Article
Correcting the R165K substitution in the first voltage-sensor of CaV1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation
Yousra El Ghaleb, Marta Campiglio & Bernhard E. Flucher
Pages: 62-71
Published online: 03 Feb 2019
AbstractforCorrecting the R165K substitution in the first voltage-sensor of CaV1.1 right-shifts the voltage-dependence of skeletal muscle calcium channel activation | Full Text | References | PDF (3.1 MB) | EPUB
  • 1488 Views
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Open Access
Article
Regional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles
Wei Wang, Rebecca L. Mellor, Jeanne M. Nerbonne & C. William Balke
Pages: 72-87
Published online: 01 Feb 2019
AbstractforRegional differences in the expression of tetrodotoxin-sensitive inward Ca2+ and outward Cs+/K+ currents in mouse and human ventricles | Full Text | References | PDF (5.9 MB) | EPUB | Supplemental
  • 1384 Views
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Open Access

Review

Review
Kv2 channels create endoplasmic reticulum / plasma membrane junctions: a brief history of Kv2 channel subcellular localization
Ben Johnson, Ashley N. Leek & Michael M. Tamkun
Pages: 88-101
Published online: 02 Feb 2019
AbstractforKv2 channels create endoplasmic reticulum / plasma membrane junctions: a brief history of Kv2 channel subcellular localization | Full Text | References | PDF (1.9 MB) | EPUB
  • 3731 Views
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Open Access

Brief Report

Brief Report
Fluorescence microscopy of piezo1 in droplet hydrogel bilayers
Oskar B. Jaggers, Pietro Ridone, Boris Martinac & Matthew A. B. Baker
Pages: 102-109
Published online: 18 Mar 2019
AbstractforFluorescence microscopy of piezo1 in droplet hydrogel bilayers | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2461 Views
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Research Paper

Article
Overlap of periodic paralysis and paramyotonia congenita caused by SCN4A gene mutations two family reports and literature review
Shan Huang, Wei Zhang, Xueli Chang & Junhong Guo
Pages: 110-119
Published online: 01 Apr 2019
AbstractforOverlap of periodic paralysis and paramyotonia congenita caused by SCN4A gene mutations two family reports and literature review | Full Text | References | PDF (2.2 MB) | EPUB
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Commentary

Article Commentary
CACHD1: A new activity-modifying protein for voltage-gated calcium channels
Gary J. Stephens & Graeme S. Cottrell
Pages: 120-123
Published online: 13 Apr 2019
First Page PreviewforCACHD1: A new activity-modifying protein for voltage-gated calcium channels | Full Text | References | PDF (896.6 KB) | EPUB
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Research Paper

Article
A small viral potassium ion channel with an inherent inward rectification
Denise Eckert, Tobias Schulze, Julian Stahl, Oliver Rauh, James L Van Etten, Brigitte Hertel, Indra Schroeder, Anna Moroni & Gerhard Thiel
Pages: 124-135
Published online: 22 Apr 2019
AbstractforA small viral potassium ion channel with an inherent inward rectification | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
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Open Access
Article
Comparative docking analysis of cholesterol analogs to ion channels to discriminate between stereospecific binding vs. stereospecific response
Nicolas A. Barbera, Baruch Minke & Irena Levitan
Pages: 136-146
Published online: 29 Apr 2019
AbstractforComparative docking analysis of cholesterol analogs to ion channels to discriminate between stereospecific binding vs. stereospecific response | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2085 Views
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Brief Report

Brief Report
Activity of T-type calcium channels is independent of CRMP2 in sensory neurons
Song Cai, Zhiming Shan, Zhongjun Zhang, Aubin Moutal & Rajesh Khanna
Pages: 147-152
Published online: 26 Apr 2019
AbstractforActivity of T-type calcium channels is independent of CRMP2 in sensory neurons | Full Text | References | PDF (1,007.3 KB) | EPUB
  • 1530 Views
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Research Paper

Article
Compound heterozygous CACNA1H mutations associated with severe congenital amyotrophy
Melissa T. Carter, Hugh J. McMillan, Andriy Tomin & Norbert Weiss
Pages: 153-161
Published online: 09 May 2019
AbstractforCompound heterozygous CACNA1H mutations associated with severe congenital amyotrophy | Full Text | References | PDF (3.1 MB) | EPUB
  • 1647 Views
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Open Access

Review

Review
Cannabinoid interactions with ion channels and receptors
Abeline Rose Watkins
Pages: 162-167
Published online: 15 May 2019
AbstractforCannabinoid interactions with ion channels and receptors | Full Text | References | PDF (648.7 KB) | EPUB
  • 5952 Views
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Commentary

Article Commentary
Mechano-electrical transduction in trabecular meshwork involves parallel activation of TRPV4 and TREK-1 channels
Oleg Yarishkin, Jackson M. Baumann & David Križaj
Pages: 168-171
Published online: 04 Jun 2019
First Page PreviewforMechano-electrical transduction in trabecular meshwork involves parallel activation of TRPV4 and TREK-1 channels | Full Text | References | PDF (822.6 KB) | EPUB
  • 1374 Views
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Research Paper

Article
Diverse TRPV1 responses to cannabinoids
J. Starkus, C. Jansen, L. M. N. Shimoda, A. J. Stokes, A. L. Small-Howard & H. Turner
Pages: 172-191
Published online: 04 Jun 2019
AbstractforDiverse TRPV1 responses to cannabinoids | Full Text | References | PDF (5 MB) | EPUB
  • 5134 Views
  • 35 CrossRef citations
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Open Access
Article
Stimulation of TRPA1 attenuates ischemia-induced cardiomyocyte cell death through an eNOS-mediated mechanism
Spencer R. Andrei, Monica Ghosh, Pritam Sinharoy & Derek S. Damron
Pages: 192-206
Published online: 04 Jun 2019
AbstractforStimulation of TRPA1 attenuates ischemia-induced cardiomyocyte cell death through an eNOS-mediated mechanism | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 1649 Views
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Open Access

Review

Review
TRP ion channels: Proteins with conformational flexibility
Ana Elena López-Romero, Ileana Hernández-Araiza, Francisco Torres-Quiroz, Luis B. Tovar-Y-Romo, León D. Islas & Tamara Rosenbaum
Pages: 207-226
Published online: 11 Jun 2019
AbstractforTRP ion channels: Proteins with conformational flexibility | Full Text | References | PDF (3.3 MB) | EPUB
  • 3251 Views
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Open Access
Review
Airway regeneration using iPS cell-derived airway epithelial cells with Cl- channel function
Susumu Yoshie, Koichi Omori & Akihiro Hazama
Pages: 227-234
Published online: 14 Jun 2019
AbstractforAirway regeneration using iPS cell-derived airway epithelial cells with Cl- channel function | Full Text | References | PDF (1.2 MB) | EPUB
  • 3393 Views
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Open Access
Review
The potential role of TRPV1 in pulmonary hypertension: Angel or demon?
Xin Zhang, Lifang Ye, Yu Huang, Xueyan Ding & Lihong Wang
Pages: 235-246
Published online: 17 Jun 2019
AbstractforThe potential role of TRPV1 in pulmonary hypertension: Angel or demon? | Full Text | References | PDF (1.4 MB) | EPUB
  • 3065 Views
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Review
The role of oligodendrocyte gap junctions in neuroinflammation
Christos Papaneophytou, Elena Georgiou & Kleopas A. Kleopa
Pages: 247-263
Published online: 23 Jun 2019
AbstractforThe role of oligodendrocyte gap junctions in neuroinflammation | Full Text | References | PDF (3.2 MB) | EPUB
  • 2557 Views
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Research Paper

Article
In vitro exposure to Hymenoptera venom and constituents activates discrete ionotropic pathways in mast cells
C. Jansen, L. M.N. Shimoda, J. Starkus, I. Lange, N. Rysavy, K. Maaetoft-Udsen, C. Tobita, A.J. Stokes & H Turner
Pages: 264-286
Published online: 25 Jun 2019
AbstractforIn vitro exposure to Hymenoptera venom and constituents activates discrete ionotropic pathways in mast cells | Full Text | References | PDF (4.8 MB) | EPUB
  • 1499 Views
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Open Access
Article
SCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity
Peter R. Strege, Arnaldo Mercado-Perez, Amelia Mazzone, Yuri A. Saito, Cheryl E. Bernard, Gianrico Farrugia & Arthur Beyder
Pages: 287-298
Published online: 02 Jul 2019
AbstractforSCN5A mutation G615E results in NaV1.5 voltage-gated sodium channels with normal voltage-dependent function yet loss of mechanosensitivity | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 1882 Views
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Open Access

Review

Review
Kv1.1 channel subunits in the control of neurocardiac function
Edward Glasscock
Pages: 299-307
Published online: 28 Jun 2019
AbstractforKv1.1 channel subunits in the control of neurocardiac function | Full Text | References | PDF (1.3 MB) | EPUB
  • 2482 Views
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Commentary

Article Commentary
pHluorin-tagged TRPV1 shines light on capsaicin tachyphylaxis
Francina Agosti & Christophe Altier
Pages: 308-310
Published online: 08 Jul 2019
First Page PreviewforpHluorin-tagged TRPV1 shines light on capsaicin tachyphylaxis | Full Text | References | PDF (944.9 KB) | EPUB
  • 1320 Views
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Research Paper

Article
No transcriptional evidence for active Nav channels in two classes of cancer cell
Supanida Hompoonsup, David Chambers, Patrick Doherty & Gareth Williams
Pages: 311-320
Published online: 22 Jul 2019
AbstractforNo transcriptional evidence for active Nav channels in two classes of cancer cell | Full Text | References | PDF (3.5 MB) | EPUB
  • 1543 Views
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Open Access

Research paper

Article
Silencing of KCNA1 suppresses the cervical cancer development via mitochondria damage
Li Liu, Yumei Chen, Qingyuan Zhang & Changzhong Li
Pages: 321-330
Published online: 27 Jul 2019
AbstractforSilencing of KCNA1 suppresses the cervical cancer development via mitochondria damage | Full Text | References | PDF (3.1 MB) | EPUB
  • 1693 Views
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Review

Review
Role of the voltage sensor module in Nav domain IV on fast inactivation in sodium channelopathies: The implication of closed-state inactivation
Tadashi Nakajima, Yoshiaki Kaneko, Tommy Dharmawan & Masahiko Kurabayashi
Pages: 331-343
Published online: 05 Aug 2019
AbstractforRole of the voltage sensor module in Nav domain IV on fast inactivation in sodium channelopathies: The implication of closed-state inactivation | Full Text | References | PDF (1.2 MB) | EPUB
  • 1818 Views
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Research Paper

Article
Myrcene and terpene regulation of TRPV1
C. Jansen, L.M.N Shimoda, J.K. Kawakami, L. Ang, A.J. Bacani, J.D. Baker, C. Badowski, M. Speck, A.J. Stokes, A.L. Small-Howard & H Turner
Pages: 344-366
Published online: 26 Aug 2019
AbstractforMyrcene and terpene regulation of TRPV1 | Full Text | References | PDF (5.3 MB) | EPUB | Supplemental
  • 7649 Views
  • 45 CrossRef citations
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Open Access

Review

Review
Acid-sensing ion channels mediate the degeneration of intervertebral disc via various pathways—A systematic review
Yingjun Guo, Yang Meng, Hao Liu, Beiyu Wang, Chen Ding, Xin Rong, Yi Yang & Ying Hong
Pages: 367-373
Published online: 17 Sep 2019
AbstractforAcid-sensing ion channels mediate the degeneration of intervertebral disc via various pathways—A systematic review | Full Text | References | PDF (1.2 MB) | EPUB
  • 1813 Views
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Review
TRPML1 and RAS-driven cancers – exploring a link with great therapeutic potential
Jewon Jung & Kartik Venkatachalam
Pages: 374-381
Published online: 17 Sep 2019
AbstractforTRPML1 and RAS-driven cancers – exploring a link with great therapeutic potential | Full Text | References | PDF (1.5 MB) | EPUB
  • 2099 Views
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Research Paper

Article
Voltage vs. Ligand II: Structural insights of the intrinsic flexibility in cyclic nucleotide-gated channels
Sergio Romero-Romero, Gustavo Martínez-Delgado & Daniel Balleza
Pages: 382-399
Published online: 25 Sep 2019
AbstractforVoltage vs. Ligand II: Structural insights of the intrinsic flexibility in cyclic nucleotide-gated channels | Full Text | References | PDF (6.7 MB) | EPUB | Supplemental
  • 1730 Views
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Review

Review
Voltage gated sodium channels in cancer and their potential mechanisms of action
Madeline Angus & Peter Ruben
Pages: 400-409
Published online: 24 Sep 2019
AbstractforVoltage gated sodium channels in cancer and their potential mechanisms of action | Full Text | References | PDF (964.4 KB) | EPUB
  • 3646 Views
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Research Paper

Article
Heteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1−/- mice
Harry Z.E. Greenberg, Simonette R.E. Carlton-Carew, Alexander K. Zargaran, Kazi S. Jahan, Lutz Birnbaumer & Anthony P. Albert
Pages: 410-423
Published online: 11 Oct 2019
AbstractforHeteromeric TRPV4/TRPC1 channels mediate calcium-sensing receptor-induced relaxations and nitric oxide production in mesenteric arteries: comparative study using wild-type and TRPC1−/- mice | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 1587 Views
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Article
The influence of membrane bilayer thickness on KcsA channel activity
Karen M. Callahan, Benoit Mondou, Louis Sasseville, Jean-Louis Schwartz & Nazzareno D’Avanzo
Pages: 424-439
Published online: 13 Oct 2019
AbstractforThe influence of membrane bilayer thickness on KcsA channel activity | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 1654 Views
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Article
Anterograde trafficking signals in GABAA subunits are required for functional expression
Jessica L. Nuwer & Mark W. Fleck
Pages: 440-454
Published online: 15 Oct 2019
AbstractforAnterograde trafficking signals in GABAA subunits are required for functional expression | Full Text | References | PDF (2.3 MB) | EPUB
  • 1174 Views
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Article
Voltage vs. Ligand I: Structural basis of the intrinsic flexibility of S3 segment and its significance in ion channel activation
Daniel Balleza, Mario E. Rosas & Sergio Romero-Romero
Pages: 455-476
Published online: 24 Oct 2019
AbstractforVoltage vs. Ligand I: Structural basis of the intrinsic flexibility of S3 segment and its significance in ion channel activation | Full Text | References | PDF (4.2 MB) | EPUB | Supplemental
  • 2150 Views
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Review

Review
Ion channels as potential redox sensors in lysosomes
Jie Yu & Junsheng Yang
Pages: 477-482
Published online: 30 Oct 2019
AbstractforIon channels as potential redox sensors in lysosomes | Full Text | References | PDF (810.2 KB) | EPUB
  • 1685 Views
  • 6 CrossRef citations
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Research Paper

Article
A conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity
Bin Hu, Wen-Ping Zeng, Xia Li, Umar Al-Sheikh, San-You Chen & Jiuping Ding
Pages: 483-497
Published online: 03 Nov 2019
AbstractforA conserved arginine/lysine-based motif promotes ER export of KCNE1 and KCNE2 to regulate KCNQ1 channel activity | Full Text | References | PDF (5.4 MB) | EPUB | Supplemental
  • 1285 Views
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Brief report

Brief Report
Evaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief
Aubin Moutal, Zhiming Shan, Victor G. Miranda, Liberty François-Moutal, Cynthia L. Madura, May Khanna & Rajesh Khanna
Pages: 498-504
Published online: 02 Nov 2019
AbstractforEvaluation of edonerpic maleate as a CRMP2 inhibitor for pain relief | Full Text | References | PDF (1.1 MB) | EPUB
  • 1471 Views
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Review

Review
Elementary calcium signaling in arterial smooth muscle
Gang Fan, Yingqiu Cui, Maik Gollasch & Mario Kassmann
Pages: 505-519
Published online: 04 Dec 2019
AbstractforElementary calcium signaling in arterial smooth muscle | Full Text | References | PDF (3 MB) | EPUB
  • 2568 Views
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Review
PI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias
Pavel Zhabyeyev, Xueyi Chen, Bart Vanhaesebroeck & Gavin Y. Oudit
Pages: 520-532
Published online: 02 Dec 2019
AbstractforPI3Kα in cardioprotection: Cytoskeleton, late Na+ current, and mechanism of arrhythmias | Full Text | References | PDF (1.2 MB) | EPUB
  • 1251 Views
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