mAbs, Volume 13, Issue 1 (2021)

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mAbs, Volume 13, Issue 1 (2021)

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Activity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer
Darren J. Schofield, Jennifer Percival-Alwyn, Mateusz Rytelewski, John Hood, Raymond Rothstein, Leslie Wetzel, Kelly McGlinchey, Grace Adjei, Amanda Watkins, LeeAnn Machiesky, Weimin Chen, John Andrews, Maria Groves, Michelle Morrow, Ross A. Stewart, Andrew Leinster, Robert W. Wilkinson, Scott A. Hammond, Nadia Luheshi, Claire Dobson & Michael Oberst
Article: 1857100
Published online: 04 Jan 2021
AbstractforActivity of murine surrogate antibodies for durvalumab and tremelimumab lacking effector function and the ability to deplete regulatory T cells in mouse models of cancer | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
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Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman & Philip A. Leighton
Article: 1862451
Published online: 25 Jan 2021
AbstractforCommon light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response
Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Danielle Mandikian, Yonglian Sun, Zhonghua Lin, Kellen Schneider, Pamela Zhang, Rajesh Vij, Danielle Sharpnack, Pamela Chan, Cecile de la Cruz, Jack Sadowsky, Dhaya Seshasayee, James T. Koerber, Thomas H. Pillow, Gail D. Phillips, Rebecca K Rowntree, C. Andrew Boswell, Katherine R. Kozak, Andrew G. Polson, Paul Polakis, Shang-Fan Yu, Peter S. Dragovich & Nicholas J. Agard
Article: 1862452
Published online: 31 Dec 2020
AbstractforPreclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Bispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries
Pallavi Bhatta, Kevin D. Whale, Amy K. Sawtell, Clare L. Thompson, Stephen E. Rapecki, David A. Cook, Breda M. Twomey, Milena Mennecozzi, Laura E. Starkie, Emily M. C. Barry, Shirley J. Peters, Ahmad M. Kamal & Helene M. Finney
Article: 1859049
Published online: 25 Jan 2021
AbstractforBispecific antibody target pair discovery by high-throughput phenotypic screening using in vitro combinatorial Fab libraries | Full Text | References | PDF (12 MB) | EPUB | Supplemental
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Glycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody
David Falck, Marco Thomann, Martin Lechmann, Carolien A. M. Koeleman, Sebastian Malik, Cordula Jany, Manfred Wuhrer & Dietmar Reusch
Article: 1865596
Published online: 31 Dec 2020
AbstractforGlycoform-resolved pharmacokinetic studies in a rat model employing glycoengineered variants of a therapeutic monoclonal antibody | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
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Combining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments
Francesco Nannini, Lenart Senicar, Farhaan Parekh, Khai J. Kong, Alexander Kinna, Reyisa Bughda, James Sillibourne, Xihao Hu, Biao Ma, Yuchen Bai, Mathieu Ferrari, Martin A. Pule & Shimobi C. Onuoha
Article: 1864084
Published online: 31 Dec 2020
AbstractforCombining phage display with SMRTbell next-generation sequencing for the rapid discovery of functional scFv fragments | Full Text | References | PDF (4.5 MB) | EPUB | Supplemental
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Antibodies to watch in 2021
Hélène Kaplon & Janice M. Reichert
Article: 1860476
Published online: 17 Jan 2021
AbstractforAntibodies to watch in 2021 | Full Text | References | PDF (1.2 MB) | EPUB
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Antibody-mediated delivery of LIGHT to the tumor boosts natural killer cells and delays tumor progression
Marco Stringhini, Jacqueline Mock, Vanessa Fontana, Patrizia Murer & Dario Neri
Article: 1868066
Published online: 06 Jan 2021
AbstractforAntibody-mediated delivery of LIGHT to the tumor boosts natural killer cells and delays tumor progression | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Rational selection of building blocks for the assembly of bispecific antibodies
Danyang Gong, Timothy P. Riley, Krzysztof P. Bzymek, Ana R. Correia, Danqing Li, Christopher Spahr, John H. Robinson, Ryan B. Case, Zhulun Wang & Fernando Garces
Article: 1870058
Published online: 05 Jan 2021
AbstractforRational selection of building blocks for the assembly of bispecific antibodies | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
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A computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodies
Eve Richardson, Jacob D. Galson, Paul Kellam, Dominic F. Kelly, Sarah E. Smith, Anne Palser, Simon Watson & Charlotte M. Deane
Article: 1869406
Published online: 11 Jan 2021
AbstractforA computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodies | Full Text | References | PDF (3.8 MB) | EPUB | Supplemental
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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors
Adam R. Root, Gurkan Guntas, Madan Katragadda, James R. Apgar, Jatin Narula, Chew Shun Chang, Sara Hanscom, Matthew McKenna, Jason Wade, Caryl Meade, Weijun Ma, Yongjing Guo, Yan Liu, Weili Duan, Claire Hendershot, Amy C. King, Yan Zhang, Eric Sousa, Amy Tam, Susan Benard, Han Yang, Kerry Kelleher, Fang Jin, Nicole Piche-Nicholas, Sinead E. Keating, Fernando Narciandi, Rosemary Lawrence-Henderson, Maya Arai, Wayne R. Stochaj, Kristine Svenson, Lidia Mosyak, Khetemcnee Lam, Christopher Francis, Kimberly Marquette, Liliana Wroblewska, H. Lily Zhu, Alfredo Darmanin Sheehan, Edward R. LaVallie, Aaron M. D’Antona, Alison Betts, Lindsay King, Edward Rosfjord, Orla Cunningham, Laura Lin, Puja Sapra, Lioudmila Tchistiakova, Divya Mathur & Laird Bloom
Article: 1850395
Published online: 18 Jan 2021
AbstractforDiscovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors | Full Text | References | PDF (7.2 MB) | EPUB | Supplemental
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In memoriam: Jefferson Foote
E. Sally Ward, Peter Jones, Tim Buss, Cristina Rada, Gregory Winter & Richard Willson
Article: 1870059
Published online: 12 Jan 2021
AbstractforIn memoriam: Jefferson Foote | Full Text | References | PDF (1.5 MB) | EPUB
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Ab-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope
Wing Ki Wong, Sarah A. Robinson, Alexander Bujotzek, Guy Georges, Alan P. Lewis, Jiye Shi, James Snowden, Bruck Taddese & Charlotte M. Deane
Article: 1873478
Published online: 15 Jan 2021
AbstractforAb-Ligity: identifying sequence-dissimilar antibodies that bind to the same epitope | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
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Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis
Hsueh-Yuan Chang, Shengjia Wu, Yingyi Li, Wanying Zhang, Matthew Burrell, Carl I. Webster & Dhaval K. Shah
Article: 1874121
Published online: 26 Jan 2021
AbstractforBrain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Review
Innovative approaches to biologic development on the trail of CT-P13: biosimilars, value-added medicines, and biobetters
HoUng Kim, Rieke Alten, Fraser Cummings, Silvio Danese, Geert D’Haens, Paul Emery, Subrata Ghosh, Cyrielle Gilletta de Saint Joseph, JongHyuk Lee, James O. Lindsay, Elena Nikiphorou, Ben Parker, Stefan Schreiber, Steven Simoens, Rene Westhovens, Ji Hoon Jeong & Laurent Peyrin-Biroulet
Article: 1868078
Published online: 08 Feb 2021
AbstractforInnovative approaches to biologic development on the trail of CT-P13: biosimilars, value-added medicines, and biobetters | Full Text | References | PDF (667.2 KB) | EPUB | Supplemental
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One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics
Wei Chen, Fan Yang, Carole Wang, Jatin Narula, Edward Pascua, Irene Ni, Sheng Ding, Xiaodi Deng, Matthew Ling-Hon Chu, Amber Pham, Xiaoyue Jiang, Kevin C. Lindquist, Patrick J. Doonan, Tom Van Blarcom, Yik Andy Yeung & Javier Chaparro-Riggers
Article: 1871171
Published online: 09 Feb 2021
AbstractforOne size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics | Full Text | References | PDF (6.8 MB) | EPUB | Supplemental
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Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody
Sharon M. Campbell, Joseph DeBartolo, James R. Apgar, Lydia Mosyak, Virginie McManus, Sonia Beyer, Eric M. Bennett, Matthew Lambert & Orla Cunningham
Article: 1883239
Published online: 09 Feb 2021
AbstractforCombining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody | Full Text | References | PDF (2.6 MB) | EPUB | Supplemental
  • 4262 Views
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Review

Review
Coming together at the hinges: Therapeutic prospects of IgG3
Thach H. Chu, Edward F. Patz Jr & Margaret E. Ackerman
Article: 1882028
Published online: 19 Feb 2021
AbstractforComing together at the hinges: Therapeutic prospects of IgG3 | Full Text | References | PDF (2 MB) | EPUB
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Off-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys
Lise I. Loberg, Meha Chhaya, Alexander Ibraghimov, Edit Tarcsa, Andreas Striebinger, Andreas Popp, Lili Huang, Frank Oellien & Stefan Barghorn
Article: 1887628
Published online: 17 Feb 2021
AbstractforOff-target binding of an anti-amyloid beta monoclonal antibody to platelet factor 4 causes acute and chronic toxicity in cynomolgus monkeys | Full Text | References | PDF (2.9 MB) | EPUB
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Identification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding
Rachel Liuqing Shi, Gang Xiao, Thomas M. Dillon, Arnold McAuley, Margaret S. Ricci & Pavel V. Bondarenko
Article: 1887612
Published online: 21 Feb 2021
AbstractforIdentification of critical chemical modifications by size exclusion chromatography of stressed antibody-target complexes with competitive binding | Full Text | References | PDF (2.9 MB) | EPUB | Supplemental
  • 3445 Views
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Identification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes
Pavel V. Bondarenko, Andrew C. Nichols, Gang Xiao, Rachel Liuqing Shi, Pik Kay Chan, Thomas M Dillon, Fernando Garces, David J. Semin & Margaret S. Ricci
Article: 1887629
Published online: 21 Feb 2021
AbstractforIdentification of critical chemical modifications and paratope mapping by size exclusion chromatography of stressed antibody-target complexes | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 3282 Views
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Functional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control
Qiang Liu, Pankaj Garg, Burcu Hasdemir, Linya Wang, Emily Tuscano, Emily Sever, Erica Keane, Ana G Lujan Hernandez, Tom Z. Yuan, Eric Kwan, Joyce Lai, Greg Szot, Sreenivasan Paruthiyil, Fumiko Axelrod & Aaron K. Sato
Article: 1893425
Published online: 12 Mar 2021
AbstractforFunctional GLP-1R antibodies identified from a synthetic GPCR-focused library demonstrate potent blood glucose control | Full Text | References | PDF (3.4 MB) | EPUB | Supplemental
  • 7744 Views
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Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation
Bingchuan Wei, Xuan Gao, Lance Cadang, Saeed Izadi, Peilu Liu, Hui-Min Zhang, Elizabeth Hecht, Jeongsup Shim, Gordon Magill, Juan Rincon Pabon, Lu Dai, Wilson Phung, Elaine Lin, Christopher Wang, Kevin Whang, Sean Sanchez, Jose Oropeza Jr, Julien Camperi, Jennifer Zhang, Wendy Sandoval, Yonghua Taylor Zhang & Guoying Jiang
Article: 1893427
Published online: 08 Mar 2021
AbstractforFc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 4104 Views
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TNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL
Harbani K. Malik-Chaudhry, Kirthana Prabhakar, Harshad S. Ugamraj, Andrew A. Boudreau, Benjamin Buelow, Kevin Dang, Laura M. Davison, Katherine E. Harris, Brett Jorgensen, Heather Ogana, Duy Pham, Ute Schellenberger, Wim Van Schooten, Roland Buelow, Suhasini Iyer, Nathan D. Trinklein & Udaya S. Rangaswamy
Article: 1890411
Published online: 04 Apr 2021
AbstractforTNB-486 induces potent tumor cell cytotoxicity coupled with low cytokine release in preclinical models of B-NHL | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 5866 Views
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Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2
Shion A. Lim, Josef A. Gramespacher, Katarina Pance, Nicholas J. Rettko, Paige Solomon, Jing Jin, Irene Lui, Susanna K. Elledge, Jia Liu, Colton J. Bracken, Graham Simmons, Xin X. Zhou, Kevin K. Leung & James A. Wells
Article: 1893426
Published online: 05 Mar 2021
AbstractforBispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2 | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 4203 Views
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Extended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo
Simone Mester, Mitchell Evers, Saskia Meyer, Jeannette Nilsen, Victor Greiff, Inger Sandlie, Jeanette Leusen & Jan Terje Andersen
Article: 1893888
Published online: 10 Mar 2021
AbstractforExtended plasma half-life of albumin-binding domain fused human IgA upon pH-dependent albumin engagement of human FcRn in vitro and in vivo | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 6817 Views
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Data mining patented antibody sequences
Konrad Krawczyk, Andrew Buchanan & Paolo Marcatili
Article: 1892366
Published online: 15 Mar 2021
AbstractforData mining patented antibody sequences | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 7016 Views
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Immunogenicity risk assessment for biotherapeutics through in vitro detection of CD134 and CD137 on T helper cells
Sivan Cohen, Srividya Myneni, Anna Batt, Joyce Guerrero, Jochen Brumm & Shan Chung
Article: 1898831
Published online: 17 Mar 2021
AbstractforImmunogenicity risk assessment for biotherapeutics through in vitro detection of CD134 and CD137 on T helper cells | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 5204 Views
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A bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3
Alexander Rau, Katharina Kocher, Mirjam Rommel, Lennart Kühl, Maximilian Albrecht, Hannes Gotthard, Nadine Aschmoneit, Bettina Noll, Monilola A. Olayioye, Roland E. Kontermann & Oliver Seifert
Article: 1902034
Published online: 22 Mar 2021
AbstractforA bivalent, bispecific Dab-Fc antibody molecule for dual targeting of HER2 and HER3 | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 4002 Views
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Review

Review
Developments and opportunities in continuous biopharmaceutical manufacturing
Ohnmar Khanal & Abraham M. Lenhoff
Article: 1903664
Published online: 11 Apr 2021
AbstractforDevelopments and opportunities in continuous biopharmaceutical manufacturing | Full Text | References | PDF (1.2 MB) | EPUB
  • 10655 Views
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Report

Report
Calculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters
Pin-Kuang Lai, James W. Swan & Bernhardt L. Trout
Article: 1907882
Published online: 09 Apr 2021
AbstractforCalculation of therapeutic antibody viscosity with coarse-grained models, hydrodynamic calculations and machine learning-based parameters | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 4024 Views
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A platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies
Ruijun Zhang, Ponraj Prabakaran, Xiaocong Yu, Brian C. Mackness, Ekaterina Boudanova, Joern Hopke, Jose Sancho, Jacqueline Saleh, HyunSuk Cho, Ningning Zhang, Helene Simonds-Mannes, Samuel D. Stimple, Dietmar Hoffmann, Anna Park, Partha S. Chowdhury & Sambasiva P. Rao
Article: 1904546
Published online: 25 Apr 2021
AbstractforA platform-agnostic, function first-based antibody discovery strategy using plasmid-free mammalian expression of antibodies | Full Text | References | PDF (1.4 MB) | EPUB
  • 5464 Views
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Rigid monoclonal antibodies improve detection of SARS-CoV-2 nucleocapsid protein
Curtis D. Hodge, Daniel. J. Rosenberg, Patricia Grob, Mateusz Wilamowski, Andrzej Joachimiak, Greg L. Hura & Michal Hammel
Article: 1905978
Published online: 12 Apr 2021
AbstractforRigid monoclonal antibodies improve detection of SARS-CoV-2 nucleocapsid protein | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 3570 Views
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Protective antibodies against human parainfluenza virus type 3 infection
Jim Boonyaratanakornkit, Suruchi Singh, Connor Weidle, Justas Rodarte, Ramasamy Bakthavatsalam, Jonathan Perkins, Guillaume B.E. Stewart-Jones, Peter D. Kwong, Andrew T. McGuire, Marie Pancera & Justin J. Taylor
Article: 1912884
Published online: 20 Apr 2021
AbstractforProtective antibodies against human parainfluenza virus type 3 infection | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 3483 Views
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Development of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1
Weimin Chen, Madhu Pandey, Hong Sun, Andrea Rolong, Mingyan Cao, Dengfeng Liu, Jihong Wang, Lingmin Zeng, Alan Hunter & Shihua Lin
Article: 1914359
Published online: 18 Apr 2021
AbstractforDevelopment of a mechanism of action-reflective, dual target cell-based reporter bioassay for a bispecific monoclonal antibody targeting human CTLA-4 and PD-1 | Full Text | References | PDF (1.5 MB) | EPUB
  • 3628 Views
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Report
Anti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models
Emilia Rabia, Véronique Garambois, Julie Hubert, Marine Bruciamacchie, Nelly Pirot, Hélène Delpech, Morgane Broyon, Charles Theillet, Pierre-Emmanuel Colombo, Nadia Vie, Diego Tosi, Celine Gongora, Lakhdar Khellaf, Marta Jarlier, Nina Radosevic-Robin, Thierry Chardès, André Pèlegrin & Christel Larbouret
Article: 1914883
Published online: 20 Apr 2021
AbstractforAnti-tumoral activity of the Pan-HER (Sym013) antibody mixture in gemcitabine-resistant pancreatic cancer models | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 2222 Views
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N-terminal selective conjugation method widens the therapeutic window of antibody–drug conjugates by improving tolerability and stability
Min Ji Ko, Daehae Song, Juhee Kim, Jae Yong Kim, Jaehyun Eom, Byungje Sung, Yong-Gyu Son, Young Min Kim, Sang Hoon Lee, Weon-Kyoo You & Jinwon Jung
Article: 1914885
Published online: 27 Apr 2021
AbstractforN-terminal selective conjugation method widens the therapeutic window of antibody–drug conjugates by improving tolerability and stability | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3707 Views
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Targeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL
Carlos Cuesta-Mateos, Raquel Juárez-Sánchez, Tamara Mateu-Albero, Javier Loscertales, Wim Mol, Fernando Terrón & Cecilia Muñoz-Calleja
Article: 1917484
Published online: 04 May 2021
AbstractforTargeting cancer homing into the lymph node with a novel anti-CCR7 therapeutic antibody: the paradigm of CLL | Full Text | References | PDF (3.7 MB) | EPUB | Supplemental
  • 2548 Views
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Review

Review
Discovery-stage identification of drug-like antibodies using emerging experimental and computational methods
Emily K. Makowski, Lina Wu, Priyanka Gupta & Peter M. Tessier
Article: 1895540
Published online: 27 Jul 2021
AbstractforDiscovery-stage identification of drug-like antibodies using emerging experimental and computational methods | Full Text | References | PDF (2.5 MB) | EPUB
  • 6091 Views
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Report

Report
Simlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy
Inja Waldhauer, Valeria Gonzalez-Nicolini, Anne Freimoser-Grundschober, Tapan K Nayak, Linda Fahrni, Ralf J. Hosse, Danny Gerrits, Edwin J. W. Geven, Johannes Sam, Sabine Lang, Esther Bommer, Virginie Steinhart, Elisabeth Husar, Sara Colombetti, Erwin Van Puijenbroek, Markus Neubauer, J. Mark Cline, Pradeep K. Garg, Gregory Dugan, Federica Cavallo, Gonzalo Acuna, Jehad Charo, Volker Teichgräber, Stefan Evers, Otto C. Boerman, Marina Bacac, Ekkehard Moessner, Pablo Umaña & Christian Klein
Article: 1913791
Published online: 11 May 2021
AbstractforSimlukafusp alfa (FAP-IL2v) immunocytokine is a versatile combination partner for cancer immunotherapy | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 9454 Views
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Reports

Article
Collecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion
Florie Le Prieult, Erica Barini, Loic Laplanche, Kerstin Schlegel & Mario Mezler
Article: 1918819
Published online: 16 May 2021
AbstractforCollecting antibodies and large molecule biomarkers in mouse interstitial brain fluid: a comparison of microdialysis and cerebral open flow microperfusion | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2840 Views
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Report

Report
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies
Romain Rouet, Ohan Mazigi, Gregory J. Walker, David B. Langley, Meghna Sobti, Peter Schofield, Helen Lenthall, Jennifer Jackson, Stephanie Ubiparipovic, Jake Y. Henry, Arunasingam Abayasingam, Deborah Burnett, Anthony Kelleher, Robert Brink, Rowena A. Bull, Stuart Turville, Alastair G. Stewart, Christopher C. Goodnow, William D. Rawlinson & Daniel Christ
Article: 1922134
Published online: 24 May 2021
AbstractforPotent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies | Full Text | References | PDF (3.3 MB) | EPUB | Supplemental
  • 3566 Views
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Article Commentary
Animal immunization merges with innovative technologies: A new paradigm shift in antibody discovery
Ponraj Prabakaran, Sambasiva P Rao & Maria Wendt
Article: 1924347
Published online: 05 May 2021
AbstractforAnimal immunization merges with innovative technologies: A new paradigm shift in antibody discovery | Full Text | References | PDF (375 KB) | EPUB
  • 4280 Views
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Review

Review
Ensembles in solution as a new paradigm for antibody structure prediction and design
Monica L. Fernández-Quintero, Guy Georges, Janos M. Varga & Klaus R. Liedl
Article: 1923122
Published online: 25 May 2021
AbstractforEnsembles in solution as a new paradigm for antibody structure prediction and design | Full Text | References | PDF (870.1 KB) | EPUB
  • 3665 Views
  • 11 CrossRef citations
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Report

Report
The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein
Takuo Suzuki, Noritaka Hashii, Minoru Tada & Akiko Ishii-Watabe
Article: 1923366
Published online: 25 May 2021
AbstractforThe influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein | Full Text | References | PDF (4 MB) | EPUB | Supplemental
  • 5511 Views
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Short Communications

Article
501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro
Haolin Liu, Pengcheng Wei, Qianqian Zhang, Zhongzhou Chen, Katja Aviszus, Walter Downing, Shelley Peterson, Lyndon Reynoso, Gregory P. Downey, Stephen K. Frankel, John Kappler, Philippa Marrack & Gongyi Zhang
Article: 1919285
Published online: 01 Jun 2021
Abstractfor501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro | Full Text | References | PDF (1 MB) | EPUB
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Reports

Report
A human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351
Chunyin Gu, Xiaodan Cao, Zongda Wang, Xue Hu, Yanfeng Yao, Yiwu Zhou, Peipei Liu, Xiaowu Liu, Ge Gao, Xiao Hu, Yecheng Zhang, Zhen Chen, Li Gao, Yun Peng, Fangfang Jia, Chao Shan, Li Yu, Kunpeng Liu, Nan Li, Weiwei Guo, Guoping Jiang, Juan Min, Jianjian Zhang, Lu Yang, Meng Shi, Tianquan Hou, Yanan Li, Weichen Liang, Guoqiao Lu, Congyi Yang, Yuting Wang, Kaiwen Xia, Zheng Xiao, Jianhua Xue, Xueyi Huang, Xin Chen, Haixia Ma, Donglin Song, Zhongzong Pan, Xueping Wang, Haibing Guo, Hong Liang, Zhiming Yuan, Wuxiang Guan & Su-Jun Deng
Article: 1930636
Published online: 07 Jun 2021
AbstractforA human antibody of potent efficacy against SARS-CoV-2 in rhesus macaques showed strong blocking activity to B.1.351 | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 3307 Views
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Report

Report
Identifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodies
Boris Grinshpun, Nels Thorsteinson, Joao NS Pereira, Friedrich Rippmann, David Nannemann, Vanita D. Sood & Yves Fomekong Nanfack
Article: 1932230
Published online: 11 Jun 2021
AbstractforIdentifying biophysical assays and in silico properties that enrich for slow clearance in clinical-stage therapeutic antibodies | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 6511 Views
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Correction

Correction
Correction
Article: 1935652
Published online: 05 Jul 2021
CitationforCorrection | Full Text | PDF (176.1 KB) | EPUB
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Report

Report
A T cell redirection platform for co-targeting dual antigens on solid tumors
Leonie Enderle, Karim H. Shalaby, Maryna Gorelik, Alexander Weiss, Levi L. Blazer, Marcin Paduch, Lia Cardarelli, Anthony Kossiakoff, Jarrett J. Adams & Sachdev S. Sidhu
Article: 1933690
Published online: 30 Jun 2021
AbstractforA T cell redirection platform for co-targeting dual antigens on solid tumors | Full Text | References | PDF (3.2 MB) | EPUB | Supplemental
  • 3165 Views
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Meeting Report

Article
Challenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership Meeting
Thomas Kissner, Guenter Blaich, Andreas Baumann, Sven Kronenberg, Adam Hey, Andrea Kiessling, Petra M. Schmitt, Wouter Driessen, Chantal Carrez, Daniel Kramer, Jennifer Fretland, Wolfgang F. Richter, Tobias Paehler, Ulrike Hopfer & Benno Rattel
Article: 1938796
Published online: 09 Jul 2021
AbstractforChallenges of non-clinical safety testing for biologics: A Report of the 9th BioSafe European Annual General Membership Meeting | Full Text | References | PDF (720.4 KB) | EPUB
  • 4968 Views
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Report

Report
Stability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation
Jack E. Bramham, Stephanie A. Davies, Adrian Podmore & Alexander P. Golovanov
Article: 1940666
Published online: 05 Jul 2021
AbstractforStability of a high-concentration monoclonal antibody solution produced by liquid–liquid phase separation | Full Text | References | PDF (1,005.1 KB) | EPUB | Supplemental
  • 4800 Views
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Report
An integrated approach for characterizing immunogenic responses toward a bispecific antibody
Sivan Cohen, Shan Chung, Christoph Spiess, Victor Lundin, Eric Stefanich, Steven T. Laing, Vanessa Clark, Jochen Brumm, Ying Zhou, Catherine Huang, Joyce Guerrero, Srividya Myneni, Rajbharan Yadav, Ketevan Siradze & Kun Peng
Article: 1944017
Published online: 05 Jul 2021
AbstractforAn integrated approach for characterizing immunogenic responses toward a bispecific antibody | Full Text | References | PDF (757.6 KB) | EPUB | Supplemental
  • 4203 Views
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Reports

Report
Preclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors
Susanne Wingert, Uwe Reusch, Stefan Knackmuss, Michael Kluge, Michael Damrat, Jens Pahl, Ute Schniegler-Mattox, Thomas Mueller, Ivica Fucek, Kristina Ellwanger, Michael Tesar, Torsten Haneke, Joachim Koch, Martin Treder, Wolfgang Fischer & Erich Rajkovic
Article: 1950264
Published online: 30 Jul 2021
AbstractforPreclinical evaluation of AFM24, a novel CD16A-specific innate immune cell engager targeting EGFR-positive tumors | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
  • 9843 Views
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Perspectives

Article Commentary
Animal- versus in vitro-derived antibodies: avoiding the extremes
Andrew R.M. Bradbury, Stefan Dübel, Achim Knappik & Andreas Plückthun
Article: 1950265
Published online: 19 Jul 2021
AbstractforAnimal- versus in vitro-derived antibodies: avoiding the extremes | Full Text | References | PDF (239.8 KB) | EPUB
  • 3150 Views
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Review

Review
The therapeutic potential of sialylated Fc domains of human IgG
Richard J. Pleass
Article: 1953220
Published online: 21 Jul 2021
AbstractforThe therapeutic potential of sialylated Fc domains of human IgG | Full Text | References | PDF (2.4 MB) | EPUB
  • 3944 Views
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Review
Targeting cancer with antibody-drug conjugates: Promises and challenges
Alexis Q. Dean, Shen Luo, Julianne D. Twomey & Baolin Zhang
Article: 1951427
Published online: 22 Jul 2021
AbstractforTargeting cancer with antibody-drug conjugates: Promises and challenges | Full Text | References | PDF (2.6 MB) | EPUB
  • 27814 Views
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Report

Report
A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention
Young D. Kwon, Mangaiarkarasi Asokan, Jason Gorman, Baoshan Zhang, Qingbo Liu, Mark K. Louder, Bob C. Lin, Krisha McKee, Amarendra Pegu, Raffaello Verardi, Eun Sung Yang, VRC Production Program, Kevin Carlton, Nicole A. Doria-Rose, Paolo Lusso, John R. Mascola & Peter D. Kwong
Article: 1946918
Published online: 30 Jul 2021
AbstractforA matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention | Full Text | References | PDF (5.7 MB) | EPUB | Supplemental
  • 2852 Views
  • 6 CrossRef citations
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Report
Highly sensitive detection of antibody nonspecific interactions using flow cytometry
Emily K. Makowski, Lina Wu, Alec A. Desai & Peter M. Tessier
Article: 1951426
Published online: 27 Jul 2021
AbstractforHighly sensitive detection of antibody nonspecific interactions using flow cytometry | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 6154 Views
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Reports

Report
Characterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV
Wen Jiang, Junchao Wang, Shasha Jiao, Chenjian Gu, Wei Xu, Ben Chen, Rongjuan Wang, Huilin Chen, Youhua Xie, An Wang, Gang Li, Dadi Zeng, Jinchao Zhang, Min Zhang, Shuang Wang, Mingzhu Wang & Xun Gui
Article: 1953683
Published online: 27 Jul 2021
AbstractforCharacterization of MW06, a human monoclonal antibody with cross-neutralization activity against both SARS-CoV-2 and SARS-CoV | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
  • 3191 Views
  • 15 CrossRef citations
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Report
Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models
Sujatha Kumar, Srimoyee Ghosh, Geeta Sharma, Zebin Wang, Marilyn R. Kehry, Margaret H. Marino, Tamlyn Y. Neben, Sharon Lu, Shouqi Luo, Simon Roberts, Sridhar Ramaswamy, Hadi Danaee & David Jenkins
Article: 1954136
Published online: 27 Jul 2021
AbstractforPreclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 6715 Views
  • 15 CrossRef citations
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Report

Report
Host cell protein detection gap risk mitigation: quantitative IAC-MS for ELISA antibody reagent coverage determination
Daniel M. Waldera-Lupa, Yvonne Jasper, Pia Köhne, Ronja Schwichtenhövel, Heiner Falkenberg, Thomas Flad, Peter Happersberger, Bernd Reisinger, Alireza Dehghani, Roland Moussa & Thomas Waerner
Article: 1955432
Published online: 04 Aug 2021
AbstractforHost cell protein detection gap risk mitigation: quantitative IAC-MS for ELISA antibody reagent coverage determination | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 3250 Views
  • 5 CrossRef citations
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Report
An end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics
Norbert Furtmann, Marion Schneider, Nadja Spindler, Bjoern Steinmann, Ziyu Li, Ingo Focken, Joachim Meyer, Dilyana Dimova, Katja Kroll, Wulf Dirk Leuschner, Audrey Debeaumont, Magali Mathieu, Christian Lange, Werner Dittrich, Jochen Kruip, Thorsten Schmidt & Joerg Birkenfeld
Article: 1955433
Published online: 12 Aug 2021
AbstractforAn end-to-end automated platform process for high-throughput engineering of next-generation multi-specific antibody therapeutics | Full Text | References | PDF (4.4 MB) | EPUB | Supplemental
  • 13119 Views
  • 3 CrossRef citations
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Report
Host cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development
Rosalynn Molden, Mengqi Hu, Sook Yen E, Diana Saggese, James Reilly, John Mattila, Haibo Qiu, Gang Chen, Hanne Bak & Ning Li
Article: 1955811
Published online: 07 Aug 2021
AbstractforHost cell protein profiling of commercial therapeutic protein drugs as a benchmark for monoclonal antibody-based therapeutic protein development | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 8096 Views
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Report
Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein
Wayne Harshbarger, Priyanka D. Abeyrathne, Sai Tian, Ying Huang, Sumana Chandramouli, Matthew James Bottomley & Enrico Malito
Article: 1955812
Published online: 23 Aug 2021
AbstractforImproved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein | Full Text | References | PDF (4.7 MB) | EPUB | Supplemental
  • 3501 Views
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Reports

Report
Targeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model
Parul Gupta, Ziyue Karen Jiang, Bing Yang, Lisa Manzuk, Edward Rosfjord, Johnny Yao, Luanna Lemon, Kavon Noorbehesht, John David, Sujiet Puthenveetil, Jeffrey M. Casavant, Elwira Muszynska, Fengping Li, Mauricio Leal, Puja Sapra & Anand Giddabasappa
Article: 1958662
Published online: 04 Aug 2021
AbstractforTargeting and pharmacology of an anti-IL13Rα2 antibody and antibody-drug conjugate in a melanoma xenograft model | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
  • 2712 Views
  • 5 CrossRef citations
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Report
Development of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies
Maxwell A. Stefan, Yooli K. Light, Jennifer L. Schwedler, Peter R. McIlroy, Colleen M. Courtney, Edwin A. Saada, Christine E. Thatcher, Ashlee M. Phillips, Feliza A. Bourguet, Catherine M. Mageeney, Summer A. McCloy, Nicole M. Collette, Oscar A. Negrete, Joseph S. Schoeniger, Dina R. Weilhammer & Brooke Harmon
Article: 1958663
Published online: 04 Aug 2021
AbstractforDevelopment of potent and effective synthetic SARS-CoV-2 neutralizing nanobodies | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 3648 Views
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Correction

Correction
Correction
Article: 1966993
Published online: 25 Aug 2021
CitationforCorrection | Full Text | PDF (510.9 KB) | EPUB
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Report

Report
Sensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies
Salla Valtonen, Emmiliisa Vuorinen, Ville Eskonen, Morteza Malakoutikhah, Kari Kopra & Harri Härmä
Article: 1955810
Published online: 30 Aug 2021
AbstractforSensitive, homogeneous, and label-free protein-probe assay for antibody aggregation and thermal stability studies | Full Text | References | PDF (912.2 KB) | EPUB | Supplemental
  • 2486 Views
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Report
Accurate determination of epitope for antibodies with unknown 3D structures
Shifa Tahir, Thomas Bourquard, Astrid Musnier, Yann Jullian, Yannick Corde, Zakaria Omahdi, Laetitia Mathias, Eric Reiter, Pascale Crépieux, Gilles Bruneau & Anne Poupon
Article: 1961349
Published online: 25 Aug 2021
AbstractforAccurate determination of epitope for antibodies with unknown 3D structures | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 3889 Views
  • 3 CrossRef citations
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Reports

Report
Untargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction
Seo-Young Park, Susan Egan, Anthony J. Cura, Kathryn L. Aron, Xuankuo Xu, Mengyuan Zheng, Michael Borys, Sanchayita Ghose, Zhengjian Li & Kyongbum Lee
Article: 1963094
Published online: 23 Aug 2021
AbstractforUntargeted proteomics reveals upregulation of stress response pathways during CHO-based monoclonal antibody manufacturing process leading to disulfide bond reduction | Full Text | References | PDF (2.2 MB) | EPUB | Supplemental
  • 2839 Views
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Report

Report
A non-clinical comparative study of IL-23 antibodies in psoriasis
Li Zhou, Yibing Wang, Qi Wan, Fei Wu, Jeffrey Barbon, Robert Dunstan, Stephen Gauld, Mark Konrad, Laura Leys, Richard McCarthy, Marian Namovic, Christine Nelson, Gary Overmeyer, Denise Perron, Zhi Su, Leyu Wang, Susan Westmoreland, Jun Zhang, Rui Zhu & Geertruida Veldman
Article: 1964420
Published online: 30 Aug 2021
AbstractforA non-clinical comparative study of IL-23 antibodies in psoriasis | Full Text | References | PDF (2 MB) | EPUB | Supplemental
  • 10040 Views
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Review

Review
Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings
Eva Germovsek, Ming Cheng & Craig Giragossian
Article: 1964935
Published online: 16 Sep 2021
AbstractforAllometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings | Full Text | References | PDF (1.5 MB) | EPUB | Supplemental
  • 7216 Views
  • 6 CrossRef citations
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Review
Ten years in the making: application of CrossMab technology for the development of therapeutic bispecific antibodies and antibody fusion proteins
Marlena Surowka, Wolfgang Schaefer & Christian Klein
Article: 1967714
Published online: 07 Sep 2021
AbstractforTen years in the making: application of CrossMab technology for the development of therapeutic bispecific antibodies and antibody fusion proteins | Full Text | References | PDF (847.7 KB) | EPUB
  • 12305 Views
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Reports

Report
Characterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugate
Difei Qiu, Yande Huang, Naresh Chennamsetty, Scott A. Miller & Michael Hay
Article: 1974150
Published online: 05 Sep 2021
AbstractforCharacterizing and understanding the formation of cysteine conjugates and other by-products in a random, lysine-linked antibody drug conjugate | Full Text | References | PDF (2.1 MB) | EPUB
  • 3119 Views
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Report

Report
Selective depletion of radiolabeled HER2-specific antibody for contrast improvement during PET
Priyanka Khare, Wei Sun, Sreevidhya Ramakrishnan, Rafal Swiercz, Guiyang Hao, Su-Tang Lo, Kien Nham, Xiankai Sun, Raimund J. Ober & E. Sally Ward
Article: 1976705
Published online: 30 Sep 2021
AbstractforSelective depletion of radiolabeled HER2-specific antibody for contrast improvement during PET | Full Text | References | PDF (1,022.4 KB) | EPUB | Supplemental
  • 1698 Views
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Report
Versatile and rapid microfluidics-assisted antibody discovery
Ramona Gaa, Emmanuel Menang-Ndi, Shruti Pratapa, Christine Nguyen, Satyendra Kumar & Achim Doerner
Article: 1978130
Published online: 29 Sep 2021
AbstractforVersatile and rapid microfluidics-assisted antibody discovery | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 5620 Views
  • 7 CrossRef citations
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Report
Enhancing the multi-attribute method through an automated and high-throughput sample preparation
Pongkwan Sitasuwan, Thomas W. Powers, Tiffany Medwid, Yuting Huang, Bradley Bare & L. Andrew Lee
Article: 1978131
Published online: 29 Sep 2021
AbstractforEnhancing the multi-attribute method through an automated and high-throughput sample preparation | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 3508 Views
  • 11 CrossRef citations
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Report
Quantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments
David Ban, Cory T. Rice & Mark A. McCoy
Article: 1978132
Published online: 06 Oct 2021
AbstractforQuantification of natural abundance NMR data differentiates the solution behavior of monoclonal antibodies and their fragments | Full Text | References | PDF (1.6 MB) | EPUB | Supplemental
  • 1472 Views
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Report
Antibody blockade of CD96 by distinct molecular mechanisms
Peter S. Lee, Bryant Chau, Ishita Barman, Christine Bee, Aarti Jashnani, Jason M. Hogan, Barbara Aguilar, Gavin Dollinger, Arvind Rajpal & Pavel Strop
Article: 1979800
Published online: 01 Oct 2021
AbstractforAntibody blockade of CD96 by distinct molecular mechanisms | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 2459 Views
  • 1 CrossRef citations
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Report
Antibody mix-and-read assays based on fluorescence intensity probes
Ujwal Patil, Atul Goyal, Binh Vu, Yanyun Liu, Vijay Maranholkar, Katerina Kourentzi, James M. Briggs & Richard C. Willson
Article: 1980178
Published online: 18 Oct 2021
AbstractforAntibody mix-and-read assays based on fluorescence intensity probes | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 1932 Views
  • 1 CrossRef citations
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Report
Structure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics
Nels Thorsteinson, John R. Gunn, Kenneth Kelly, Will Long & Paul Labute
Article: 1981805
Published online: 10 Oct 2021
AbstractforStructure-based charge calculations for predicting isoelectric point, viscosity, clearance, and profiling antibody therapeutics | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 7261 Views
  • 13 CrossRef citations
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Report
Drug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries
Andre Azevedo Reis Teixeira, Michael Frank Erasmus, Sara D’Angelo, Leslie Naranjo, Fortunato Ferrara, Camila Leal-Lopes, Oliver Durrant, Cecile Galmiche, Aleardo Morelli, Anthony Scott-Tucker & Andrew Raymon Morton Bradbury
Article: 1980942
Published online: 01 Dec 2021
AbstractforDrug-like antibodies with high affinity, diversity and developability directly from next-generation antibody libraries | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 8609 Views
  • 11 CrossRef citations
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Report
Identification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodies
Mingyan Cao, Yang Jiao, Conner Parthemore, Samuel Korman, Jiao Ma, Alan Hunter, Greg Kilby & Xiaoyu Chen
Article: 1981806
Published online: 01 Nov 2021
AbstractforIdentification of a CE-SDS shoulder peak as disulfide-linked fragments from common CH2 cleavages in IgGs and IgG-like bispecific antibodies | Full Text | References | PDF (2.7 MB) | EPUB | Supplemental
  • 6201 Views
  • 1 CrossRef citations
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Report
Fc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography–mass spectrometry
Steffen Lippold, Alexander Knaupp, Arnoud H. de Ru, Rayman T. N. Tjokrodirijo, Peter A. van Veelen, Erwin van Puijenbroek, Steven W. de Taeye, Dietmar Reusch, Gestur Vidarsson, Manfred Wuhrer, Tilman Schlothauer & David Falck
Article: 1982847
Published online: 21 Oct 2021
AbstractforFc gamma receptor IIIb binding of individual antibody proteoforms resolved by affinity chromatography–mass spectrometry | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
  • 2532 Views
  • 5 CrossRef citations
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reports

Article
Bifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment
Ian White, Ninkka Tamot, Rajitha Doddareddy, Jason Ho, Qun Jiao, Paul B. Harvilla, Tong-Yuan Yang, Brian Geist, M. Jack Borrok, Matthew D. Truppo, Rajkumar Ganesan, Partha Chowdhury & Adam Zwolak
Article: 1987180
Published online: 25 Oct 2021
AbstractforBifunctional molecules targeting SARS-CoV-2 spike and the polymeric Ig receptor display neutralization activity and mucosal enrichment | Full Text | References | PDF (2.1 MB) | EPUB | Supplemental
  • 2790 Views
  • 3 CrossRef citations
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Reports

Article
Novel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice
Bhupal Ban, Rodell C. Barrientos, Therese Oertel, Essie Komla, Connor Whalen, Megan Sopko, Yingjian You, Partha Banerjee, Agnieszka Sulima, Arthur E. Jacobson, Kenner C. Rice, Gary R. Matyas & Vidadi Yusibov
Article: 1991552
Published online: 25 Oct 2021
AbstractforNovel chimeric monoclonal antibodies that block fentanyl effects and alter fentanyl biodistribution in mice | Full Text | References | PDF (1.9 MB) | EPUB | Supplemental
  • 2869 Views
  • 7 CrossRef citations
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Report

Report
Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions
Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman & Bernhardt L. Trout
Article: 1991256
Published online: 08 Nov 2021
AbstractforDifferences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
  • 6058 Views
  • 6 CrossRef citations
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Reports

Article
An efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag
Short title: Controlled bioconjugation via O-glycan engineering
Thomas V. Murray, Kasia Kozakowska-McDonnell, Adam Tibbles, Annabel Taylor, Daniel Higazi, Emmanuel Rossy, Alessandra Rossi, Sivaneswary Genapathy, Giulia Tamburrino, Nicola Rath, Natalie Tigue, Vivian Lindo, Tristan Vaughan & Monika A. Papworth
Article: 1992068
Published online: 16 Nov 2021
AbstractforAn efficient system for bioconjugation based on a widely applicable engineered O-glycosylation tag | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
  • 2783 Views
  • 1 CrossRef citations
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Report
Nonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathies
Lone Fjord-Larsen, Annemette Thougaard, Karen Malene Wegener, Joan Christiansen, Frank Larsen, Lise Maj Schrøder-Hansen, Marianne Kaarde & Dorte Kornerup Ditlevsen
Article: 1994690
Published online: 28 Oct 2021
AbstractforNonclinical safety evaluation, pharmacokinetics, and target engagement of Lu AF82422, a monoclonal IgG1 antibody against alpha-synuclein in development for treatment of synucleinopathies | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 3034 Views
  • 6 CrossRef citations
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Review

Review
Viro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics
Roland E. Kontermann, Guy Ungerechts & Dirk M. Nettelbeck
Article: 1982447
Published online: 08 Nov 2021
AbstractforViro-antibody therapy: engineering oncolytic viruses for genetic delivery of diverse antibody-based biotherapeutics | Full Text | References | PDF (1.8 MB) | EPUB
  • 3120 Views
  • 6 CrossRef citations
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Report

Report
Preclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer
Hong Xiang, Abigael G. Chan, Ago Ahene, David I. Bellovin, Rong Deng, Amy W. Hsu, Ursula Jeffry, Servando Palencia, Janine Powers, James Zanghi & Helen Collins
Article: 1981202
Published online: 01 Nov 2021
AbstractforPreclinical characterization of bemarituzumab, an anti-FGFR2b antibody for the treatment of cancer | Full Text | References | PDF (2 MB) | EPUB
  • 4662 Views
  • 5 CrossRef citations
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Reports

Report
Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies
Shufang Liu, Ashwni Verma, Hubert Kettenberger, Wolfgang F. Richter & Dhaval K. Shah
Article: 1993769
Published online: 28 Oct 2021
AbstractforEffect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies | Full Text | References | PDF (1.7 MB) | EPUB | Supplemental
  • 4497 Views
  • 10 CrossRef citations
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Report
Impact of IgG subclass on molecular properties of monoclonal antibodies
Yu Tang, Paul Cain, Victor Anguiano, James J. Shih, Qing Chai & Yiqing Feng
Article: 1993768
Published online: 11 Nov 2021
AbstractforImpact of IgG subclass on molecular properties of monoclonal antibodies | Full Text | References | PDF (1.4 MB) | EPUB | Supplemental
  • 6564 Views
  • 11 CrossRef citations
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Article
The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance
Eugenia Opolka-Hoffmann, Gregor Jordan, Michael Otteneder, Robin Kieferle, Martin Lechmann, Gerhard Winter & Roland F. Staack
Article: 1995929
Published online: 11 Nov 2021
AbstractforThe impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance | Full Text | References | PDF (1.3 MB) | EPUB | Supplemental
  • 5653 Views
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Review

Review Article
Current strategies for detecting functional convergence across B-cell receptor repertoires
Matthew I. J. Raybould, Anthony R. Rees & Charlotte M. Deane
Article: 1996732
Published online: 16 Nov 2021
AbstractforCurrent strategies for detecting functional convergence across B-cell receptor repertoires | Full Text | References | PDF (885.1 KB) | EPUB
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Report

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Hydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX
Joey G. Sheff, John F. Kelly, Anna Robotham, Traian Sulea, Félix Malenfant, Denis L’Abbé, Mélanie Duchesne, Alex Pelletier, Jean Lefebvre, Andrea Acel, Marie Parat, Mylene Gosselin, Cunle Wu, Yves Fortin, Jason Baardsnes, Henk Van Faassen, Shannon Awrey, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar & Anne E.G. Lenferink
Article: 1997072
Published online: 23 Nov 2021
AbstractforHydrogen-deuterium exchange mass spectrometry reveals three unique binding responses of mAbs directed to the catalytic domain of hCAIX | Full Text | References | PDF (2.5 MB) | EPUB | Supplemental
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Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX
Anne E.G. Lenferink, Paul C. McDonald, Christiane Cantin, Suzanne Grothé, Mylene Gosselin, Jason Baardsnes, Myriam Banville, Paul Lachance, Alma Robert, Yuneivy Cepero-Donates, Stevo Radinovic, Patrick Salois, Marie Parat, Hafida Oamari, Annie Dulude, Mehul Patel, Martin Lafrance, Andrea Acel, Nathalie Bousquet-Gagnon, Denis L’Abbé, Alex Pelletier, Félix Malenfant, Maria Jaramillo, Maureen O’Connor-Mccourt, Cunle Wu, Yves Durocher, Mélanie Duchesne, Christine Gadoury, Anne Marcil, Yves Fortin, Beatrice Paul-Roc, Maurizio Acchione, Shawn C. Chafe, Oksana Nemirovsky, Joseph Lau, Francois Bénard & Shoukat Dedhar
Article: 1999194
Published online: 21 Nov 2021
AbstractforIsolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX | Full Text | References | PDF (3.9 MB) | EPUB | Supplemental
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Review

Review
Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns
Orla Cunningham, Martin Scott, Zhaohui Sunny Zhou & William J.J. Finlay
Article: 1999195
Published online: 15 Nov 2021
AbstractforPolyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns | Full Text | References | PDF (1.5 MB) | EPUB
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Development of a robust and semi-automated two-step antibody purification process
Xiaomin Yang, Richard Yuan, Christopher Garcia, Jessica Berry, Denisa Foster, Dongmei He, Gui-Feng Zhang & Bryan E. Jones
Article: 2000348
Published online: 15 Nov 2021
AbstractforDevelopment of a robust and semi-automated two-step antibody purification process | Full Text | References | PDF (1.2 MB) | EPUB | Supplemental
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Agonistic nanobodies and antibodies to human VISTA
Yu-Heng Vivian Ma, Amanda Sparkes, Ema Romão, Shrayasee Saha & Jean Gariépy
Article: 2003281
Published online: 24 Nov 2021
AbstractforAgonistic nanobodies and antibodies to human VISTA | Full Text | References | PDF (4.6 MB) | EPUB | Supplemental
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Development of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors
Nicola J. Mason, Nicholas Chester, Ailian Xiong, Antonia Rotolo, Ying Wu, Sho Yoshimoto, Patrick Glassman, Gayathri Gulendran & Don L. Siegel
Article: 2004638
Published online: 02 Dec 2021
AbstractforDevelopment of a fully canine anti-canine CTLA4 monoclonal antibody for comparative translational research in dogs with spontaneous tumors | Full Text | References | PDF (1.1 MB) | EPUB | Supplemental
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