mAbs, Volume 6, Issue 2 (2014)

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mAbs, Volume 6, Issue 2 (2014)

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Meeting Report

Meeting Report
9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland
Janice M Reichert, Alain Beck, Alexey A Lugovskoy, Thierry Wurch, Steven Coats & Randall J Brezski
Pages: 309-326
Published online: 17 Jan 2014
Abstractfor9th Annual European Antibody Congress, November 11–13, 2013, Geneva, Switzerland | Full Text | References | PDF (329 KB)
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Report

Article
Assessment of chemical modifications of sites in the CDRs of recombinant antibodies
Susceptibility vs. functionality of critical quality attributes
Markus Haberger, Katrin Bomans, Katharina Diepold, Michaela Hook, Jana Gassner, Tilman Schlothauer, Adrian Zwick, Christian Spick, Jochen Felix Kepert, Brigitte Hienz, Michael Wiedmann, Hermann Beck, Philipp Metzger, Michael Mølhøj, Constanze Knoblich, Ulla Grauschopf, Dietmar Reusch & Patrick Bulau
Pages: 327-339
Published online: 17 Jan 2014
AbstractforAssessment of chemical modifications of sites in the CDRs of recombinant antibodies | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
Engineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells
Jeffrey C Kang, Jayakumar S Poovassery, Pankaj Bansal, Sungyong You, Isabel M Manjarres, Raimund J Ober & E Sally Ward
Pages: 340-353
Published online: 26 Dec 2013
AbstractforEngineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells | Full Text | References | PDF (3.3 MB) | Supplemental
  • 2259 Views
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Article
Sortase-catalyzed in vitro functionalization of a HER2-specific recombinant Fab for tumor targeting of the plant cytotoxin gelonin
Petra Kornberger & Arne Skerra
Pages: 354-366
Published online: 09 Dec 2013
AbstractforSortase-catalyzed in vitro functionalization of a HER2-specific recombinant Fab for tumor targeting of the plant cytotoxin gelonin | Full Text | References | PDF (2.2 MB) | Supplemental
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Article
Evaluation of human pancreatic RNase as effector molecule in a therapeutic antibody platform
Thomas Schirrmann, André Frenzel, Lars Linden, Beatrix Stelte-Ludwig, Jörg Willuda, Axel Harrenga, Stefan Dübel, Beate Müller-Tiemann & Mark Trautwein
Pages: 367-380
Published online: 15 Jan 2014
AbstractforEvaluation of human pancreatic RNase as effector molecule in a therapeutic antibody platform | Full Text | References | PDF (1.8 MB)
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Article
A new class of bispecific antibodies to redirect T cells for cancer immunotherapy
Diane L Rossi, Edmund A Rossi, Thomas M Cardillo, David M Goldenberg & Chien-Hsing Chang
Pages: 381-391
Published online: 02 Dec 2013
AbstractforA new class of bispecific antibodies to redirect T cells for cancer immunotherapy | Full Text | References | PDF (2.2 MB) | Supplemental
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Article
HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design
Bart ECG de Goeij, Matthias Peipp, Simone de Haij, Edward N van den Brink, Christian Kellner, Thilo Riedl, Rob de Jong, Tom Vink, Kristin Strumane, Wim K Bleeker & Paul WHI Parren
Pages: 392-402
Published online: 03 Jan 2014
AbstractforHER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate design | Full Text | References | PDF (1,017.8 KB) | Supplemental
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Article
The ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer
Siqi Han, Yanchun Meng, Qing Tong, Guangchao Li, Xunmin Zhang, Yalin Chen, Shi Hu, Lei Zheng, Wenlong Tan, Hui Li, Yang Chen, Ge Zhang, Bohua Li & Yajun Guo
Pages: 403-408
Published online: 09 Dec 2013
AbstractforThe ErbB2-targeting antibody trastuzumab and the small-molecule SRC inhibitor saracatinib synergistically inhibit ErbB2-overexpressing gastric cancer | Full Text | References | PDF (1.3 MB) | Supplemental
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Article
Increasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity
Stefanie Derer, Pia Glorius, Martin Schlaeth, Stefan Lohse, Katja Klausz, Umesh Muchhal, John R Desjarlais, Andreas Humpe, Thomas Valerius & Matthias Peipp
Pages: 409-421
Published online: 11 Dec 2013
AbstractforIncreasing FcγRIIa affinity of an FcγRIII-optimized anti-EGFR antibody restores neutrophil-mediated cytotoxicity | Full Text | References | PDF (3.1 MB) | Supplemental
  • 1894 Views
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Article
Combined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody
Céline Monnet, Sylvie Jorieux, Nathalie Souyris, Ouafa Zaki, Alexandra Jacquet, Nathalie Fournier, Fabien Crozet, Christophe de Romeuf, Khalil Bouayadi, Rémi Urbain, Christian K Behrens, Philippe Mondon & Alexandre Fontayne
Pages: 422-436
Published online: 15 Jan 2014
AbstractforCombined glyco- and protein-Fc engineering simultaneously enhance cytotoxicity and half-life of a therapeutic antibody | Full Text | References | PDF (1.4 MB)
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Article
In vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation
Bing Li, Ashley E Fouts, Katharina Stengel, Peng Luan, Michael Dillon, Wei-Ching Liang, Becket Feierbach, Robert F Kelley & Isidro Hötzel
Pages: 437-445
Published online: 16 Jan 2014
AbstractforIn vitro affinity maturation of a natural human antibody overcomes a barrier to in vivo affinity maturation | Full Text | References | PDF (936.2 KB) | Supplemental
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Article
Development of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library
Sebastian Miethe, Christine Rasetti-Escargueil, Yvonne Liu, Siham Chahboun, Thibaut Pelat, Arnaud Avril, Andrè Frenzel, Thomas Schirrmann, Philippe Thullier, Dorothea Sesardic & Michael Hust
Pages: 446-459
Published online: 09 Jan 2014
AbstractforDevelopment of neutralizing scFv-Fc against botulinum neurotoxin A light chain from a macaque immune library | Full Text | References | PDF (2.1 MB)
  • 1281 Views
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Article
Multiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets
Krista M McCutcheon, Julia Gray, Natalie Y Chen, Keyi Liu, Minha Park, Stote Ellsworth, Ralph A Tripp, S Mark Tompkins, Scott K Johnson, Shelly Samet, Lenore Pereira & Lawrence M Kauvar
Pages: 460-473
Published online: 08 Jan 2014
AbstractforMultiplexed screening of natural humoral immunity identifies antibodies at fine specificity for complex and dynamic viral targets | Full Text | References | PDF (8.8 MB) | Supplemental
  • 1913 Views
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Article
Generation of human single-chain variable fragment antibodies specific to dengue virus non-structural protein 1 that interfere with the virus infectious cycle
Ornnuthchar Poungpair, Kunan Bangphoomi, Prapaipit Chaowalit, Nunghathai Sawasdee, Nichapatr Saokaew, Kiattawee Choowongkomon, Wanpen Chaicumpa & Pa-thai Yenchitsomanus
Pages: 474-482
Published online: 15 Jan 2014
AbstractforGeneration of human single-chain variable fragment antibodies specific to dengue virus non-structural protein 1 that interfere with the virus infectious cycle | Full Text | References | PDF (1 MB)
  • 1067 Views
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Article
High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy
Yuqi Liu, Isabelle Caffry, Jiemin Wu, Steven B Geng, Tushar Jain, Tingwan Sun, Felicia Reid, Yuan Cao, Patricia Estep, Yao Yu, Maximiliano Vásquez, Peter M Tessier & Yingda Xu
Pages: 483-492
Published online: 06 Dec 2013
AbstractforHigh-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy | Full Text | References | PDF (1.3 MB)
  • 9551 Views
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Article
Hybridization-based antibody cDNA recovery for the production of recombinant antibodies identified by repertoire sequencing
Javier Valdés-Alemán, Juan Téllez-Sosa, Marbella Ovilla-Muñoz, Elizabeth Godoy-Lozano, Daniel Velázquez-Ramírez, Humberto Valdovinos-Torres, Rosa E Gómez-Barreto & Jesús Martinez-Barnetche
Pages: 493-501
Published online: 11 Dec 2013
AbstractforHybridization-based antibody cDNA recovery for the production of recombinant antibodies identified by repertoire sequencing | Full Text | References | PDF (770.5 KB) | Supplemental
  • 1057 Views
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Article
The effect of the neonatal Fc receptor on human IgG biodistribution in mice
Nancy Chen, Weirong Wang, Scott Fauty, Yulin Fang, Lora Hamuro, Azher Hussain & Thomayant Prueksaritanont
Pages: 502-508
Published online: 09 Jan 2014
AbstractforThe effect of the neonatal Fc receptor on human IgG biodistribution in mice | Full Text | References | PDF (1.2 MB)
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Article
Comparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency
Louise Saul, Louise Saul, Debra H Josephs, Debra H Josephs, Keith Cutler, Keith Cutler, Andrew Bradwell, Andrew Bradwell, Panagiotis Karagiannis, Panagiotis Karagiannis, Chris Selkirk, Chris Selkirk, Hannah J Gould, Hannah J Gould, Paul Jones, Paul Jones, James F Spicer, James F Spicer, Sophia N Karagiannis & Sophia N Karagiannis
Pages: 509-522
Published online: 14 Jan 2014
AbstractforComparative reactivity of human IgE to cynomolgus monkey and human effector cells and effects on IgE effector cell potency | Full Text | References | PDF (1.8 MB) | Supplemental
  • 1578 Views
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Article
ARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade
Karen Silence, Torsten Dreier, Mahan Moshir, Peter Ulrichts, Sofie ME Gabriels, Michael Saunders, Harald Wajant, Peter Brouckaert, Leander Huyghe, Tim Van Hauwermeiren, Alain Thibault & Hans J De Haard
Pages: 523-532
Published online: 06 Dec 2013
AbstractforARGX-110, a highly potent antibody targeting CD70, eliminates tumors via both enhanced ADCC and immune checkpoint blockade | Full Text | References | PDF (748.3 KB)
  • 5191 Views
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Article
3D modeling and characterization of the human CD115 monoclonal antibody H27K15 epitope and design of a chimeric CD115 target
Benoît Grellier, Benoît Grellier, Fabrice Le Pogam, Fabrice Le Pogam, Marc Vitorino, Marc Vitorino, Jean-Philippe Starck, Jean-Philippe Starck, Michel Geist, Michel Geist, Vanessa Duong, Vanessa Duong, Hélène Haegel, Hélène Haegel, Thierry Menguy, Thierry Menguy, Jean-Yves Bonnefoy, Jean-Yves Bonnefoy, Jean-Baptiste Marchand, Jean-Baptiste Marchand, Philippe Ancian & Philippe Ancian
Pages: 533-546
Published online: 06 Jan 2014
Abstractfor3D modeling and characterization of the human CD115 monoclonal antibody H27K15 epitope and design of a chimeric CD115 target | Full Text | References | PDF (3.6 MB) | Supplemental
  • 1318 Views
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Article
Preclinical characterization of an anti-methamphetamine monoclonal antibody for human use
Misty W Stevens, Misty W Stevens, Misty W Stevens, Misty W Stevens, Rachel L Tawney, Rachel L Tawney, Rachel L Tawney, Rachel L Tawney, C Michael West, C Michael West, C Michael West, C Michael West, Alicia D Kight, Alicia D Kight, Alicia D Kight, Alicia D Kight, Ralph L Henry, Ralph L Henry, Ralph L Henry, Ralph L Henry, S Michael Owens, S Michael Owens, S Michael Owens, S Michael Owens, W Brooks Gentry, W Brooks Gentry, W Brooks Gentry & W Brooks Gentry
Pages: 547-555
Published online: 23 Dec 2013
AbstractforPreclinical characterization of an anti-methamphetamine monoclonal antibody for human use | Full Text | References | PDF (383.1 KB)
  • 1311 Views
  • 23 CrossRef citations
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Article
Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models
Kathleen R Whiteman, Holly A Johnson, Michele F Mayo, Charlene A Audette, Christina N Carrigan, Alyssa LaBelle, Lawrence Zukerberg, John M Lambert & Robert J Lutz
Pages: 556-566
Published online: 08 Jan 2014
AbstractforLorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models | Full Text | References | PDF (959.1 KB)
  • 2729 Views
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Article
Preclinical evaluation of 89Zr-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys
Prelude to Phase 1 clinical studies
Danielle J Vugts, Derrek A Heuveling, Marijke Stigter-van Walsum, Stefan Weigand, Mats Bergstrom, Guus AMS van Dongen & Tapan K Nayak
Pages: 567-575
Published online: 09 Dec 2013
AbstractforPreclinical evaluation of 89Zr-labeled anti-CD44 monoclonal antibody RG7356 in mice and cynomolgus monkeys | Full Text | References | PDF (2 MB) | Supplemental
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