mAbs, Volume 7, Issue 3 (2015)

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mAbs, Volume 7, Issue 3 (2015)

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Perspective

Implementing quality by design for biotech products: Are regulators on track?
Francesca Luciani, Sara Galluzzo, Andrea Gaggioli, Nanna Aaby Kruse, Pascal Venneugues, Christian K Schneider, Carlo Pini & Daniela Melchiorri
Pages: 451-455
Published online: 01 May 2015
AbstractforImplementing quality by design for biotech products: Are regulators on track? | Full Text | References | PDF (159.6 KB)
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Book Review

Book Review
Fusion protein technologies for biopharmaceuticals: Applications and challenges
Editor Stefan R Schmidt
Sven Berger, Peter Lowe & Michael Tesar
Pages: 456-460
Published online: 01 May 2015
AbstractforFusion protein technologies for biopharmaceuticals: Applications and challenges | Full Text | PDF (96.7 KB)
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Reports

Article
Insights into the molecular basis of a bispecific antibody's target selectivity
Yariv Mazor, Anna Hansen, Chunning Yang, Partha S Chowdhury, Jihong Wang, Geoffrey Stephens, Herren Wu & William F Dall’Acqua
Pages: 461-469
Published online: 01 May 2015
AbstractforInsights into the molecular basis of a bispecific antibody's target selectivity | Full Text | References | PDF (581.3 KB) | Supplemental
  • 6234 Views
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Article
Fab-based bispecific antibody formats with robust biophysical properties and biological activity
Xiufeng Wu, Arlene J Sereno, Flora Huang, Steven M Lewis, Ricky L Lieu, Caroline Weldon, Carina Torres, Cody Fine, Micheal A Batt, Jonathan R Fitchett, Andrew L Glasebrook, Brian Kuhlman & Stephen J Demarest
Pages: 470-482
Published online: 01 May 2015
AbstractforFab-based bispecific antibody formats with robust biophysical properties and biological activity | Full Text | References | PDF (1.4 MB) | Supplemental
  • 6104 Views
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Article
Balancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics
Amita Datta-Mannan, Arunkumar Thangaraju, Donmienne Leung, Ying Tang, Derrick R Witcher, Jirong Lu & Victor J Wroblewski
Pages: 483-493
Published online: 01 May 2015
AbstractforBalancing charge in the complementarity-determining regions of humanized mAbs without affecting pI reduces non-specific binding and improves the pharmacokinetics | Full Text | References | PDF (530.2 KB)
  • 5458 Views
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Article
An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions
Michelle Kinder, Allison R Greenplate, William R Strohl, Robert E Jordan & Randall J Brezski
Pages: 494-504
Published online: 01 May 2015
AbstractforAn Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions | Full Text | References | PDF (693.5 KB) | Supplemental
  • 3830 Views
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Article
Boosting antibody developability through rational sequence optimization
Daniel Seeliger, Patrick Schulz, Tobias Litzenburger, Julia Spitz, Stefan Hoerer, Michaela Blech, Barbara Enenkel, Joey M Studts, Patrick Garidel & Anne R Karow
Pages: 505-515
Published online: 01 May 2015
AbstractforBoosting antibody developability through rational sequence optimization | Full Text | References | PDF (706.4 KB) | Supplemental
  • 4774 Views
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Article
Reconstructing and mining the B cell repertoire with ImmunediveRsity
Bernardo Cortina-Ceballos, Elizabeth Ernestina Godoy-Lozano, Hugo Sámano-Sánchez, Andrés Aguilar-Salgado, Martín Del Castillo Velasco-Herrera, Carlos Vargas-Chávez, Daniel Velázquez-Ramírez, Guillermo Romero, José Moreno, Juan Téllez-Sosa & Jesús Martínez-Barnetche
Pages: 516-524
Published online: 01 May 2015
AbstractforReconstructing and mining the B cell repertoire with ImmunediveRsity | Full Text | References | PDF (665.6 KB) | Supplemental
  • 3369 Views
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Article
Hydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody
Jayant Arora, John M Hickey, Ranajoy Majumdar, Reza Esfandiary, Steven M Bishop, Hardeep S Samra, C Russell Middaugh, David D Weis & David B Volkin
Pages: 525-539
Published online: 01 May 2015
AbstractforHydrogen exchange mass spectrometry reveals protein interfaces and distant dynamic coupling effects during the reversible self-association of an IgG1 monoclonal antibody | Full Text | References | PDF (1 MB) | Supplemental
  • 3477 Views
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Article
Characterizing monoclonal antibody structure by carboxyl group footprinting
Parminder Kaur, Sara E Tomechko, Janna Kiselar, Wuxian Shi, Galahad Deperalta, Aaron T Wecksler, Giridharan Gokulrangan, Victor Ling & Mark R Chance
Pages: 540-552
Published online: 01 May 2015
AbstractforCharacterizing monoclonal antibody structure by carboxyl group footprinting | Full Text | References | PDF (517.8 KB) | Supplemental
  • 1953 Views
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Article
An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies
Patricia Estep, Isabelle Caffry, Yao Yu, Tingwan Sun, Yuan Cao, Heather Lynaugh, Tushar Jain, Maximiliano Vásquez, Peter M Tessier & Yingda Xu
Pages: 553-561
Published online: 01 May 2015
AbstractforAn alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies | Full Text | References | PDF (799 KB) | Supplemental
  • 6024 Views
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Article
The criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development
Lowell J Brady, Jyoti Velayudhan, Devi B Visone, Ken C Daugherty, Jeff L Bartron, Michael Coon, Cabot Cornwall, Peter J Hinckley & Lisa Connell-Crowley
Pages: 562-570
Published online: 01 May 2015
AbstractforThe criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development | Full Text | References | PDF (710.4 KB) | Supplemental
  • 1785 Views
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Article
Production of α2,6-sialylated IgG1 in CHO cells
Céline Raymond, Anna Robotham, Maureen Spearman, Michael Butler, John Kelly & Yves Durocher
Pages: 571-583
Published online: 01 May 2015
AbstractforProduction of α2,6-sialylated IgG1 in CHO cells | Full Text | References | PDF (685.6 KB)
  • 5009 Views
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Article
A tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19+ tumor cells
Uwe Reusch, Johannes Duell, Kristina Ellwanger, Carmen Herbrecht, Stefan HJ Knackmuss, Ivica Fucek, Markus Eser, Fionnuala McAleese, Vera Molkenthin, Fabrice Le Gall, Max Topp, Melvyn Little & Eugene A Zhukovsky
Pages: 584-604
Published online: 01 May 2015
AbstractforA tetravalent bispecific TandAb (CD19/CD3), AFM11, efficiently recruits T cells for the potent lysis of CD19+ tumor cells | Full Text | References | PDF (909 KB) | Supplemental
  • 8496 Views
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Article
Generation and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β
Susan E Lacy, Chengbin Wu, Dominic J Ambrosi, Chung-Ming Hsieh, Sahana Bose, Renee Miller, Donna M Conlon, Edit Tarcsa, Ravi Chari, Tariq Ghayur & Rajesh V Kamath
Pages: 605-619
Published online: 01 May 2015
AbstractforGeneration and characterization of ABT-981, a dual variable domain immunoglobulin (DVD-IgTM) molecule that specifically and potently neutralizes both IL-1α and IL-1β | Full Text | References | PDF (526.8 KB) | Supplemental
  • 4033 Views
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Article
Monoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis
Lin Cheng, Xian Tang, Li Liu, Jie Peng, Kenji Nishiura, Allen Ka Loon Cheung, Jia Guo, Xilin Wu, Hang Ying Tang, Minghui An, Jingying Zhou, Ka Wai Cheung, Hui Wang, Xinyuan Guan, Zhiwei Wu & Zhiwei Chen
Pages: 620-629
Published online: 01 May 2015
AbstractforMonoclonal antibodies specific to human Δ42PD1: A novel immunoregulator potentially involved in HIV-1 and tumor pathogenesis | Full Text | References | PDF (789.6 KB)
  • 1793 Views
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Article
Dose – response relationship of bevacizumab in hereditary hemorrhagic telangiectasia
Nicolas Azzopardi, Sophie Dupuis-Girod, David Ternant, Anne-Emmanuelle Fargeton, Isabelle Ginon, Frédéric Faure, Evelyne Decullier, Adeline Roux, Marie-France Carette, Brigitte Gilbert-Dussardier, Pierre-Yves Hatron, Pascal Lacombe, Vanessa Leguy-Seguin, Sophie Rivière, Romain Corre, Sabine Bailly & Gilles Paintaud
Pages: 630-637
Published online: 01 May 2015
AbstractforDose – response relationship of bevacizumab in hereditary hemorrhagic telangiectasia | Full Text | References | PDF (456.7 KB) | Supplemental
  • 1308 Views
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Article
Potent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model
Jonathan Nambiar, Adam W Clarke, Doris Shim, David Mabon, Chen Tian, Karolina Windloch, Chris Buhmann, Beau Corazon, Matilda Lindgren, Matthew Pollard, Teresa Domagala, Lynn Poulton & Anthony G Doyle
Pages: 638-650
Published online: 01 May 2015
AbstractforPotent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model | Full Text | References | PDF (965 KB) | Supplemental
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Retraction

Retraction
Editorial retraction
Page: 651
Published online: 01 May 2015
CitationforEditorial retraction | Full Text | PDF (25.8 KB)
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