OncoImmunology, Volume 2, Issue 4 (2013)

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OncoImmunology, Volume 2, Issue 4 (2013)

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Editor's Corner

Editorial
Cancer immunotherapy turns viral
Lorenzo Galluzzi & Enrico Lugli
Article: e24802
Published online: 01 Apr 2013
CitationforCancer immunotherapy turns viral | Full Text | References | PDF (116.7 KB)
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Original Research

Article
Collaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors
Paul Spear, Amorette Barber & Charles L. Sentman
Article: e23564
Published online: 01 Apr 2013
AbstractforCollaboration of chimeric antigen receptor (CAR)-expressing T cells and host T cells for optimal elimination of established ovarian tumors | Full Text | References | PDF (576.8 KB)
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Article
TIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
Kaori Sakuishi, Shin Foong Ngiow, Jenna M. Sullivan, Michele W. L. Teng, Vijay K. Kuchroo, Mark J Smyth & Ana C. Anderson
Article: e23849
Published online: 01 Apr 2013
AbstractforTIM3+FOXP3+ regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer | Full Text | References | PDF (520.7 KB) | Supplemental
  • 4113 Views
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Open Access
Article
Functional characterization of a STAT3-dependent dendritic cell-derived CD14+ cell population arising upon IL-10-driven maturation
Jelle J. Lindenberg, Rieneke van de Ven, Sinéad M. Lougheed, Anoek Zomer, Saskia JAM Santegoets, Arjan W. Griffioen, Erik Hooijberg, Alfons J.M. van den Eertwegh, Victor L. Thijssen, Rik J. Scheper, Dinja Oosterhoff & Tanja D. de Gruijl
Article: e23837
Published online: 01 Apr 2013
AbstractforFunctional characterization of a STAT3-dependent dendritic cell-derived CD14+ cell population arising upon IL-10-driven maturation | Full Text | References | PDF (1.4 MB) | Supplemental
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Article
The immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4+ T cells
Shamaila Munir, Gitte Holmen Andersen, Inge Marie Svane & Mads Hald Andersen
Article: e23991
Published online: 01 Apr 2013
AbstractforThe immune checkpoint regulator PD-L1 is a specific target for naturally occurring CD4+ T cells | Full Text | References | PDF (665.8 KB)
  • 1476 Views
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Article
Hepatic metastases of colorectal cancer are rather homogeneous but differ from primary lesions in terms of immune cell infiltration
Niels Halama, Anna Spille, Tina Lerchl, Karsten Brand, Esther Herpel, Stefan Welte, Sophia Keim, Bernd Lahrmann, Fee Klupp, Christoph Kahlert, Jürgen Weitz, Niels Grabe, Dirk Jaeger & Inka Zoernig
Article: e24116
Published online: 01 Apr 2013
AbstractforHepatic metastases of colorectal cancer are rather homogeneous but differ from primary lesions in terms of immune cell infiltration | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1311 Views
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Brief Report

Brief Report
Priming of PRAME- and WT1-specific CD8+ T cells in healthy donors but not in AML patients in complete remission
Implications for immunotherapy
Willemijn van den Ancker, Jurjen M. Ruben, Theresia M. Westers, Dewi Wulandari, Hetty J. Bontkes, Erik Hooijberg, Anita G.M. Stam, Saskia JAM Santegoets, Gert J. Ossenkoppele, Tanja D de Gruijl & Arjan van de Loosdrecht
Article: e23971
Published online: 01 Apr 2013
AbstractforPriming of PRAME- and WT1-specific CD8+ T cells in healthy donors but not in AML patients in complete remission | Full Text | References | PDF (308.4 KB)
  • 1071 Views
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Brief Report
Human perforin mutations and susceptibility to multiple primary cancers
Joseph A. Trapani, Kevin Y.T. Thia, Miles Andrews, Ian D. Davis, Craig Gedye, Philip Parente, Suzanne Svobodova, Jenny Chia, Kylie Browne, Ian G. Campbell, Wayne A. Phillips, Ilia Voskoboinik & Jonathan S. Cebon
Article: e24185
Published online: 01 Apr 2013
AbstractforHuman perforin mutations and susceptibility to multiple primary cancers | Full Text | References | PDF (340.6 KB) | Supplemental
  • 1105 Views
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Review

Review Article
Trial watch
DNA vaccines for cancer therapy
Laura Senovilla, Erika Vacchelli, Pauline Garcia, Alexander Eggermont, Wolf Hervé Fridman, Jérôme Galon, Laurence Zitvogel, Guido Kroemer & Lorenzo Galluzzi
Article: e23803
Published online: 01 Apr 2013
AbstractforTrial watch | Full Text | References | PDF (242.6 KB)
  • 1532 Views
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Review Article
Role of dendritic cells in the regulation of antitumor immunity
Nathalie Wathelet & Muriel Moser
Article: e23973
Published online: 01 Apr 2013
AbstractforRole of dendritic cells in the regulation of antitumor immunity | Full Text | References | PDF (289.7 KB)
  • 611 Views
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Review Article
Myeloid derived suppressor cells
Targets for therapy
Todd J. Waldron, Jon G. Quatromoni, Tatiana A. Karakasheva, Sunil Singhal & Anil K. Rustgi
Article: e24117
Published online: 01 Apr 2013
AbstractforMyeloid derived suppressor cells | Full Text | References | PDF (262.9 KB)
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Author's View

Exploiting invariant NKT cells to promote T-cell responses to cancer vaccines
Martin K. Hunn & Ian F. Hermans
Article: e23789
Published online: 01 Apr 2013
AbstractforExploiting invariant NKT cells to promote T-cell responses to cancer vaccines | Full Text | References | PDF (344.2 KB)
  • 627 Views
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Open Access
Immunotherapy with artificial adjuvant vector cells
Harnessing both arms of the immune response
Shin-ichiro Fujii & Kanako Shimizu
Article: e23432
Published online: 01 Apr 2013
AbstractforImmunotherapy with artificial adjuvant vector cells | Full Text | References | PDF (262 KB)
  • 729 Views
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Open Access
High-density lipoproteins delivering interleukin-15
Maria C. Ochoa, Ignacio Melero & Pedro Berraondo
Article: e23410
Published online: 01 Apr 2013
AbstractforHigh-density lipoproteins delivering interleukin-15 | Full Text | References | PDF (405 KB)
  • 528 Views
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Open Access
Personalized medicine for cancer therapy
Lessons learned from tumor-associated antigens
Christina Springstead Scanlon & Nisha J. D’Silva
Article: e23433
Published online: 01 Apr 2013
AbstractforPersonalized medicine for cancer therapy | Full Text | References | PDF (270 KB)
  • 479 Views
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Open Access
Distribution, function and predictive value of tumor-infiltrating γδ T lymphocytes
Francesco Dieli, Giorgio Stassi, Matilde Todaro, Serena Meraviglia, Nadia Caccamo & Adriana Cordova
Article: e23434
Published online: 01 Apr 2013
AbstractforDistribution, function and predictive value of tumor-infiltrating γδ T lymphocytes | Full Text | References | PDF (195.4 KB)
  • 532 Views
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Open Access
Co-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines
Haval Shirwan, Rajesh K. Sharma, Abhishek K. Srivastava & Esma S. Yolcu
Article: e23440
Published online: 01 Apr 2013
AbstractforCo-stimulatory tumor necrosis factor ligands as adjuvants for the development of subunit-based anticancer vaccines | Full Text | References | PDF (202.4 KB)
  • 507 Views
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Open Access
Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
Wan Lu Pang, Weng Tong Ho & Herbert Schwarz
Article: e23441
Published online: 01 Apr 2013
AbstractforEctopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance | Full Text | References | PDF (422.7 KB)
  • 556 Views
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Open Access
Targeting cathepsin G in myeloid leukemia
Gheath Alatrash
Article: e23442
Published online: 01 Apr 2013
AbstractforTargeting cathepsin G in myeloid leukemia | Full Text | References | PDF (304.1 KB)
  • 658 Views
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Open Access
Mimotope vaccine efficacy gets a "boost" from native tumor antigens
Jonathan D. Buhrman & Jill E. Slansky
Article: e23492
Published online: 01 Apr 2013
AbstractforMimotope vaccine efficacy gets a "boost" from native tumor antigens | Full Text | References | PDF (311.8 KB)
  • 538 Views
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Immunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands
Valerie Chew & Jean-Pierre Abastado
Article: e23493
Published online: 01 Apr 2013
AbstractforImmunomodulation of the tumor microenvironment by Toll-like receptor-3 (TLR3) ligands | Full Text | References | PDF (195.8 KB)
  • 728 Views
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Delineating the "galectin signature" of the tumor microenvironment
Daniel Compagno, Diego J. Laderach, Lucas Gentilini, Felipe M. Jaworski & Gabriel A. Rabinovich
Article: e23565
Published online: 01 Apr 2013
AbstractforDelineating the "galectin signature" of the tumor microenvironment | Full Text | References | PDF (357.5 KB)
  • 643 Views
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The RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis
Yasufumi Kaneda
Article: e23566
Published online: 01 Apr 2013
AbstractforThe RIG-I/MAVS signaling pathway in cancer cell-selective apoptosis | Full Text | References | PDF (229.8 KB)
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Interferon α may be back on track to treat acute myeloid leukemia
Evelien L.J.M. Smits, Sébastien Anguille & Zwi N. Berneman
Article: e23619
Published online: 01 Apr 2013
AbstractforInterferon α may be back on track to treat acute myeloid leukemia | Full Text | References | PDF (323.3 KB)
  • 710 Views
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Toll-like receptor 5 and the emerging role of bacteria in carcinogenesis
Joonas H. Kauppila, Antti E. Mattila, Tuomo J. Karttunen & Tuula Salo
Article: e23620
Published online: 01 Apr 2013
AbstractforToll-like receptor 5 and the emerging role of bacteria in carcinogenesis | Full Text | References | PDF (469.4 KB)
  • 702 Views
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NK cells from malignant pleural effusions are potent antitumor effectors
A clue for adoptive immunotherapy?
Paola Vacca, Stefania Martini, Maria C. Mingari & Lorenzo Moretta
Article: e23638
Published online: 01 Apr 2013
AbstractforNK cells from malignant pleural effusions are potent antitumor effectors | Full Text | References | PDF (305.3 KB)
  • 499 Views
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Lessons learned from a highly-active CD22-specific chimeric antigen receptor
Adrienne H. Long, Waleed M. Haso & Rimas J. Orentas
Article: e23621
Published online: 01 Apr 2013
AbstractforLessons learned from a highly-active CD22-specific chimeric antigen receptor | Full Text | References | PDF (324 KB)
  • 1794 Views
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A novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system
Bryan D. Choi, Ira Pastan, Darell D Bigner & John H. Sampson
Article: e23639
Published online: 01 Apr 2013
AbstractforA novel bispecific antibody recruits T cells to eradicate tumors in the “immunologically privileged” central nervous system | Full Text | References | PDF (196.7 KB)
  • 949 Views
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Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy
Christopher A. Alvarez-Breckenridge, Jianhua Yu, Michael A. Caligiuri & E Antonio Chiocca
Article: e23658
Published online: 01 Apr 2013
AbstractforUncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy | Full Text | References | PDF (290.8 KB)
  • 715 Views
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Glycan-mediated modification of the immune response
Caroline B. Madsen, Anders E. Pedersen & Hans H. Wandall
Article: e23659
Published online: 01 Apr 2013
AbstractforGlycan-mediated modification of the immune response | Full Text | References | PDF (342.6 KB)
  • 783 Views
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The CCL5/CCR5 axis promotes metastasis in basal breast cancer
Marco Velasco-Velázquez & Richard G. Pestell
Article: e23660
Published online: 01 Apr 2013
AbstractforThe CCL5/CCR5 axis promotes metastasis in basal breast cancer | Full Text | References | PDF (471.3 KB)
  • 1531 Views
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Re-orienting the immune system
Durable tumor regression and successful re-induction therapy using anti-PD1 antibodies
Evan J. Lipson
Article: e23661
Published online: 01 Apr 2013
AbstractforRe-orienting the immune system | Full Text | References | PDF (347.6 KB)
  • 922 Views
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Inhibition of tumor angiogenesis by globotriaosylceramide immunotargeting
Stéphane Birklé, Ariane Desselle, Tanguy Chaumette, Marie-Hélène Gaugler, Denis Cochonneau, Julien Fleurence, Nolwenn Dubois, Philippe Hulin, Jacques Aubry & François Paris
Article: e23700
Published online: 01 Apr 2013
AbstractforInhibition of tumor angiogenesis by globotriaosylceramide immunotargeting | Full Text | References | PDF (132.2 KB)
  • 452 Views
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Dacarbazine mediates antimelanoma effects via NK cells
Alice Hervieu, Grégoire Mignot & François Ghiringhelli
Article: e23714
Published online: 01 Apr 2013
AbstractforDacarbazine mediates antimelanoma effects via NK cells | Full Text | References | PDF (203.8 KB)
  • 585 Views
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Enhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress
Siegfried Hekimi
Article: e23793
Published online: 01 Apr 2013
AbstractforEnhanced immunity in slowly aging mutant mice with high mitochondrial oxidative stress | Full Text | References | PDF (244.5 KB)
  • 519 Views
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The immunological identity of tumor
Self implications
Jason Miska, Priyadharshini Devarajan & Zhibin Chen
Article: e23794
Published online: 01 Apr 2013
AbstractforThe immunological identity of tumor | Full Text | References | PDF (662.2 KB)
  • 457 Views
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Toward the next generation of NK cell-based adoptive cancer immunotherapy
Jing Ni, Matthias Miller, Ana Stojanovic & Adelheid Cerwenka
Article: e23811
Published online: 01 Apr 2013
AbstractforToward the next generation of NK cell-based adoptive cancer immunotherapy | Full Text | References | PDF (298 KB)
  • 789 Views
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