OncoImmunology, Volume 6, Issue 4 (2017)

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OncoImmunology, Volume 6, Issue 4 (2017)

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Brief Report

Article
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy
Jan Willem Kleinovink, Koen A. Marijt, Mark J. A. Schoonderwoerd, Thorbald van Hall, Ferry Ossendorp & Marieke F. Fransen
Article: e1294299
Published online: 07 Apr 2017
AbstractforPD-L1 expression on malignant cells is no prerequisite for checkpoint therapy | Full Text | References | PDF (1 MB) | Supplemental
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Article
Preclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma
Abhishek D. Garg, Lien Vandenberk, Matthias Van Woensel, Jochen Belmans, Marco Schaaf, Louis Boon, Steven De Vleeschouwer & Patrizia Agostinis
Article: e1295903
Published online: 07 Apr 2017
AbstractforPreclinical efficacy of immune-checkpoint monotherapy does not recapitulate corresponding biomarkers-based clinical predictions in glioblastoma | Full Text | References | PDF (1.4 MB) | Supplemental
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Original Research

Article
Adaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy
Jun Ren, William R. Gwin, Xinna Zhou, Xiaoli Wang, Hongyan Huang, Ni Jiang, Lei Zhou, Pankaj Agarwal, Amy Hobeika, Erika Crosby, Zachary C. Hartman, Michael A. Morse, Kevin H. Eng & H. Kim Lyerly
Article: e1264563
Published online: 05 Apr 2017
AbstractforAdaptive T cell responses induced by oncolytic Herpes Simplex Virus-granulocyte macrophage-colony-stimulating factor therapy expanded by dendritic cell and cytokine-induced killer cell adoptive therapy | Full Text | References | PDF (816.8 KB) | Supplemental
  • 1395 Views
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Article
Calreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia
Xiufen Chen, Dominick Fosco, Douglas E. Kline & Justin Kline
Article: e1278332
Published online: 12 Apr 2017
AbstractforCalreticulin promotes immunity and type I interferon-dependent survival in mice with acute myeloid leukemia | Full Text | References | PDF (972.9 KB) | Supplemental
  • 1961 Views
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Article
CD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes
Sara Labiano, Florinda Meléndez-Rodríguez, Asís Palazón, Álvaro Teijeira, Saray Garasa, Iñaki Etxeberria, M. Ángela Aznar, Alfonso R. Sánchez-Paulete, Arantza Azpilikueta, Elixabet Bolaños, Carmen Molina, Hortensia de la Fuente, Patricia Maiso, Francisco Sánchez-Madrid, Manuel Ortiz de Landázuri, Julián Aragonés & Ignacio Melero
Article: e1283468
Published online: 30 Mar 2017
AbstractforCD69 is a direct HIF-1α target gene in hypoxia as a mechanism enhancing expression on tumor-infiltrating T lymphocytes | Full Text | References | PDF (942.9 KB) | Supplemental
  • 2108 Views
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Article
The mutational status of p53 can influence its recognition by human T-cells
Katerina Shamalov, Shlomo N. Levy, Miryam Horovitz-Fried & Cyrille J. Cohen
Article: e1285990
Published online: 05 Apr 2017
AbstractforThe mutational status of p53 can influence its recognition by human T-cells | Full Text | References | PDF (872 KB) | Supplemental
  • 2008 Views
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Article
Oncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation
Rūta Veinalde, Christian Grossardt, Laura Hartmann, Marie-Claude Bourgeois-Daigneault, John C. Bell, Dirk Jäger, Christof von Kalle, Guy Ungerechts & Christine E. Engeland
Article: e1285992
Published online: 07 Apr 2017
AbstractforOncolytic measles virus encoding interleukin-12 mediates potent antitumor effects through T cell activation | Full Text | References | PDF (815.3 KB) | Supplemental
  • 2375 Views
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Article
Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy
Hélène Roussel, Eléonore De Guillebon, Lucie Biard, Marion Mandavit, Laure Gibault, Elisabeth Fabre, Martine Antoine, Paul Hofman, Michèle Beau-Faller, Hélène Blons, Claire Danel, Françoise Le Pimpec Barthes, Alain Gey, Clémence Granier, Marie Wislez, Pierre Laurent-Puig, Stéphane Oudard, Patrick Bruneval, Cécile Badoual, Jacques Cadranel & Eric Tartour
Article: e1286437
Published online: 24 Mar 2017
AbstractforComposite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy | Full Text | References | PDF (1 MB) | Supplemental
  • 1291 Views
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Article
A novel nanobody-based target module for retargeting of T lymphocytes to EGFR-expressing cancer cells via the modular UniCAR platform
Susann Albert, Claudia Arndt, Anja Feldmann, Ralf Bergmann, Dominik Bachmann, Stefanie Koristka, Florian Ludwig, Pauline Ziller-Walter, Alexandra Kegler, Sebastian Gärtner, Marc Schmitz, Armin Ehninger, Marc Cartellieri, Gerhard Ehninger, Hans-Jürgen Pietzsch, Jens Pietzsch, Jörg Steinbach & Michael Bachmann
Article: e1287246
Published online: 30 Mar 2017
AbstractforA novel nanobody-based target module for retargeting of T lymphocytes to EGFR-expressing cancer cells via the modular UniCAR platform | Full Text | References | PDF (1.7 MB)
  • 3036 Views
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Article
Digital analysis and epigenetic regulation of the signature of rejection in colorectal cancer
Viktor H. Koelzer, Lena Sokol, Stefan Zahnd, Lucine Christe, Heather Dawson, Martin D. Berger, Daniel Inderbitzin, Inti Zlobec & Alessandro Lugli
Article: e1288330
Published online: 30 Mar 2017
AbstractforDigital analysis and epigenetic regulation of the signature of rejection in colorectal cancer | Full Text | References | PDF (1,015.7 KB) | Supplemental
  • 1177 Views
  • 9 CrossRef citations
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Article
LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4+ T cells
Huihui Liu, Yanfei Zhang, Zhengyang Liu, Pingzhang Wang, Xiaoning Mo, Weiwei Fu, Wanchang Liu, Yingying Cheng & Wenling Han
Article: e1292195
Published online: 07 Apr 2017
AbstractforLYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4+ T cells | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1175 Views
  • 9 CrossRef citations
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Article
IL15 induces a potent antitumor activity in NK cells isolated from malignant pleural effusions and overcomes the inhibitory effect of pleural fluid
D. Croxatto, S. Martini, L. Chiossone, F. Scordamaglia, C. F. Simonassi, L. Moretta, M. C. Mingari & P. Vacca
Article: e1293210
Published online: 07 Apr 2017
AbstractforIL15 induces a potent antitumor activity in NK cells isolated from malignant pleural effusions and overcomes the inhibitory effect of pleural fluid | Full Text | References | PDF (1.1 MB) | Supplemental
  • 981 Views
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Article
Tumor-infiltrating neutrophils predict benefit from adjuvant chemotherapy in patients with muscle invasive bladder cancer
Lin Zhou, Le Xu, Lingli Chen, Qiang Fu, Zheng Liu, Yuan Chang, Zongming Lin & Jiejie Xu
Article: e1293211
Published online: 07 Apr 2017
AbstractforTumor-infiltrating neutrophils predict benefit from adjuvant chemotherapy in patients with muscle invasive bladder cancer | Full Text | References | PDF (1.1 MB) | Supplemental
  • 1539 Views
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Article
Characterization of a human anti-tumoral NK cell population expanded after BCG treatment of leukocytes
Eva M. García-Cuesta, Gloria Esteso, Omodele Ashiru, Sheila López-Cobo, Mario Álvarez-Maestro, Ana Linares, Mei M. Ho, Luis Martínez-Piñeiro, Hugh T. Reyburn & Mar Valés-Gómez
Article: e1293212
Published online: 12 Apr 2017
AbstractforCharacterization of a human anti-tumoral NK cell population expanded after BCG treatment of leukocytes | Full Text | References | PDF (1.2 MB) | Supplemental
  • 1994 Views
  • 17 CrossRef citations
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Article
Formyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways
Nella Prevete, Federica Liotti, Anna Illiano, Angela Amoresano, Piero Pucci, Amato de Paulis & Rosa Marina Melillo
Article: e1293213
Published online: 07 Apr 2017
AbstractforFormyl peptide receptor 1 suppresses gastric cancer angiogenesis and growth by exploiting inflammation resolution pathways | Full Text | References | PDF (1.3 MB) | Supplemental
  • 1686 Views
  • 35 CrossRef citations
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Article
HLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses
Vitaly Kochin, Takayuki Kanaseki, Serina Tokita, Sho Miyamoto, Yosuke Shionoya, Yasuhiro Kikuchi, Daichi Morooka, Yoshihiko Hirohashi, Tomohide Tsukahara, Kazue Watanabe, Shingo Toji, Yasuo Kokai, Noriyuki Sato & Toshihiko Torigoe
Article: e1293214
Published online: 07 Apr 2017
AbstractforHLA-A24 ligandome analysis of colon and lung cancer cells identifies a novel cancer-testis antigen and a neoantigen that elicits specific and strong CTL responses | Full Text | References | PDF (1.5 MB) | Supplemental
  • 2467 Views
  • 20 CrossRef citations
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Article
The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy?
Christine Böger, Hans-Michael Behrens, Sandra Krüger & Christoph Röcken
Article: e1293215
Published online: 07 Apr 2017
AbstractforThe novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy? | Full Text | References | PDF (1.1 MB) | Supplemental
  • 3694 Views
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Article
HLA dependent immune escape mechanisms in B-cell lymphomas: Implications for immune checkpoint inhibitor therapy?
Marcel Nijland, Rianne N. Veenstra, Lydia Visser, Chuanhui Xu, Kushi Kushekhar, Gustaaf W. van Imhoff, Philip M. Kluin, Anke van den Berg & Arjan Diepstra
Article: e1295202
Published online: 07 Apr 2017
AbstractforHLA dependent immune escape mechanisms in B-cell lymphomas: Implications for immune checkpoint inhibitor therapy? | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2828 Views
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Article
Generation and functional characterization of MDSC-like cells
Annkristin Heine, Stefanie Andrea Erika Held, Jonas Schulte-Schrepping, Julia Friederike Andrea Wolff, Kathrin Klee, Thomas Ulas, Niklas Arndt Schmacke, Solveig Nora Daecke, Kati Riethausen, Joachim L. Schultze & Peter Brossart
Article: e1295203
Published online: 07 Apr 2017
AbstractforGeneration and functional characterization of MDSC-like cells | Full Text | References | PDF (1.1 MB) | Supplemental
  • 4031 Views
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Article
Host antitumor resistance improved by the macrophage polarization in a chimera model of patients with HCC
Akira Asai, Yusuke Tsuchimoto, Hideko Ohama, Shinya Fukunishi, Yasuhiro Tsuda, Makiko Kobayashi, Kazuhide Higuchi & Fujio Suzuki
Article: e1299301
Published online: 27 Apr 2017
AbstractforHost antitumor resistance improved by the macrophage polarization in a chimera model of patients with HCC | Full Text | References | PDF (978.2 KB) | Supplemental
  • 1809 Views
  • 23 CrossRef citations
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Article
Pro-necrotic molecules impact local immunosurveillance in human breast cancer
Gautier Stoll, Yuting Ma, Heng Yang, Oliver Kepp, Laurence Zitvogel & Guido Kroemer
Article: e1299302
Published online: 27 Apr 2017
AbstractforPro-necrotic molecules impact local immunosurveillance in human breast cancer | Full Text | References | PDF (1.2 MB) | Supplemental
  • 2473 Views
  • 76 CrossRef citations
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Article
T cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth
Else M. Inderberg, Sébastien Wälchli, Marit R. Myhre, Sissel Trachsel, Hilde Almåsbak, Gunnar Kvalheim & Gustav Gaudernack
Article: e1302631
Published online: 27 Apr 2017
AbstractforT cell therapy targeting a public neoantigen in microsatellite instable colon cancer reduces in vivo tumor growth | Full Text | References | PDF (850 KB) | Supplemental
  • 3853 Views
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Article
Adoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma
Alexander A. Tong, Hasan Hashem, Saada Eid, Frederick Allen, Daniel Kingsley & Alex Y. Huang
Article: e1303586
Published online: 27 Apr 2017
AbstractforAdoptive natural killer cell therapy is effective in reducing pulmonary metastasis of Ewing sarcoma | Full Text | References | PDF (1,005.6 KB) | Supplemental
  • 2229 Views
  • 15 CrossRef citations
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Article
A BARF1-specific mAb as a new immunotherapeutic tool for the management of EBV-related tumors
Riccardo Turrini, Anna Merlo, Debora Martorelli, Damiana Antonia Faè, Roberta Sommaggio, Isabella Monia Montagner, Vito Barbieri, Oriano Marin, Paola Zanovello, Riccardo Dolcetti & Antonio Rosato
Article: e1304338
Published online: 27 Apr 2017
AbstractforA BARF1-specific mAb as a new immunotherapeutic tool for the management of EBV-related tumors | Full Text | References | PDF (1,017.6 KB)
  • 1594 Views
  • 12 CrossRef citations
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Article
Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling
Peter J. Siska, Romany A. N. Johnpulle, Alice Zhou, Jennifer Bordeaux, Ju Young Kim, Bashar Dabbas, Naveen Dakappagari, Jeffrey C. Rathmell, W. Kimryn Rathmell, Alicia K. Morgans, Justin M. Balko & Douglas B. Johnson
Article: e1305535
Published online: 27 Apr 2017
AbstractforDeep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling | Full Text | References | PDF (1.4 MB) | Supplemental
  • 2508 Views
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Review

Article
B cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment
Giulia Chiaruttini, Silvia Mele, James Opzoomer, Silvia Crescioli, Kristina M. Ilieva, Katie E. Lacy & Sophia N. Karagiannis
Article: e1294296
Published online: 07 Apr 2017
AbstractforB cells and the humoral response in melanoma: The overlooked players of the tumor microenvironment | Full Text | References | PDF (764.8 KB)
  • 3464 Views
  • 45 CrossRef citations
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Article
TIE-2 expressing monocytes in human cancers
Riccardo Turrini, Angélique Pabois, Ioannis Xenarios, George Coukos, Jean-François Delaloye & Marie-Agnès Doucey
Article: e1303585
Published online: 27 Apr 2017
AbstractforTIE-2 expressing monocytes in human cancers | Full Text | References | PDF (697.7 KB)
  • 1949 Views
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Erratum

Correction
Erratum
Article: e1311485
Published online: 07 Apr 2017
CitationforErratum | Full Text | PDF (105 KB)
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