Nucleosides, Nucleotides & Nucleic Acids, Volume 30, Issue 12 (2011)

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Nucleosides, Nucleotides & Nucleic Acids, Volume 30, Issue 12 (2011)

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Editorials

Editorial
Proceedings of the 14th International Symposium on Purine and Pyrimidine Metabolism in Man
G. J. Peters & K. Ichida
Pages: 999-1000
Published online: 01 Dec 2011
CitationforProceedings of the 14th International Symposium on Purine and Pyrimidine Metabolism in Man | Full Text | PDF (60.4 KB)
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Original Articles

Article
Gout and Hyperuricemia in Japan: Perspectives for International Research on Purines and Pyrimidines in Man
Tatsuo Hosoya, Iwao Ohno, Kimiyoshi Ichida & Godefridus J. Peters
Pages: 1001-1010
Published online: 01 Dec 2011
AbstractforGout and Hyperuricemia in Japan: Perspectives for International Research on Purines and Pyrimidines in Man | Full Text | References | PDF (182.5 KB)
  • 522 Views
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Article
Treating Hyperuricemia of Gout: Safety and Efficacy of Febuxostat and Allopurinol in Older Versus Younger Subjects
Michael A. Becker, Patricia A. MacDonald, Barbara Hunt & Lhanoo Gunawardhana
Pages: 1011-1017
Published online: 01 Dec 2011
AbstractforTreating Hyperuricemia of Gout: Safety and Efficacy of Febuxostat and Allopurinol in Older Versus Younger Subjects | Full Text | References | PDF (65.2 KB)
  • 1436 Views
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Article
Japanese Guideline for the Management of Hyperuricemia and Gout: Second Edition
Hisashi Yamanaka
Pages: 1018-1029
Published online: 01 Dec 2011
AbstractforJapanese Guideline for the Management of Hyperuricemia and Gout: Second Edition | Full Text | References | PDF (190.4 KB)
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Article
Effects of Losartan/Hydrochlorothiazide on Serum Uric Acid Levels and Blood Pressure in Hypertensive Patients
S. Fujimori, Y. Oka, N. Ogata & K. Eto
Pages: 1030-1034
Published online: 01 Dec 2011
AbstractforEffects of Losartan/Hydrochlorothiazide on Serum Uric Acid Levels and Blood Pressure in Hypertensive Patients | Full Text | References | PDF (82 KB)
  • 457 Views
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Article
Efficacy of Benzbromarone in Hyperuricemic Patients Associated with Chronic Kidney Disease
S. Fujimori, K. Ooyama, H. Ooyama & H. Moromizato
Pages: 1035-1038
Published online: 01 Dec 2011
AbstractforEfficacy of Benzbromarone in Hyperuricemic Patients Associated with Chronic Kidney Disease | Full Text | References | PDF (50.2 KB)
  • 531 Views
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Article
Relationship Between Hyperuricemia and Chronic Kidney Disease
Iwao Ohno
Pages: 1039-1044
Published online: 01 Dec 2011
AbstractforRelationship Between Hyperuricemia and Chronic Kidney Disease | Full Text | References | PDF (175.2 KB)
  • 1784 Views
  • 36 CrossRef citations
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Article
Comorbidities in Patients with Gout
Naomi Ichikawa, Atsuo Taniguchi, Wako Urano, Ayako Nakajima & Hisashi Yamanaka
Pages: 1045-1050
Published online: 01 Dec 2011
AbstractforComorbidities in Patients with Gout | Full Text | References | PDF (61.4 KB)
  • 483 Views
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Article
Investigation on Hyperuricemia in Children with Obesity or Various Pediatric Disorders
Masaru Kubota, Ayako Nagai, Li Tang & Masakuni Tokuda
Pages: 1051-1059
Published online: 01 Dec 2011
AbstractforInvestigation on Hyperuricemia in Children with Obesity or Various Pediatric Disorders | Full Text | References | PDF (115.4 KB)
  • 827 Views
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Article
Hyperuricemia in Pediatric Malignancies Before Treatment
Ayako Nagai, Masaru Kubota, Li Tang, Souichi Adachi, Ikuya Usami & Kousaku Matsubara
Pages: 1060-1065
Published online: 01 Dec 2011
AbstractforHyperuricemia in Pediatric Malignancies Before Treatment | Full Text | References | PDF (63.3 KB)
  • 288 Views
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Article
Effect of Urine pH on Uric Acid Excretion by Manipulating Food Materials
A. Kanbara & I. Seyama
Pages: 1066-1071
Published online: 01 Dec 2011
AbstractforEffect of Urine pH on Uric Acid Excretion by Manipulating Food Materials | Full Text | References | PDF (242.5 KB)
  • 606 Views
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Article
Urinary Stone Analysis in a Patient with Hyperuricemia to Determine the Mechanism of Stone Formation
Kiyoko Kaneko, Norifumi Yoshida, Keitaro Okazaki, Tomoyo Yamanobe, Noriko Yamaoka, Makoto Yasuda, Nobuyuki Ogata, Yasukazu Yamada, Shunya Uchida & Shin Fujimori
Pages: 1072-1076
Published online: 01 Dec 2011
AbstractforUrinary Stone Analysis in a Patient with Hyperuricemia to Determine the Mechanism of Stone Formation | Full Text | References | PDF (159.3 KB)
  • 266 Views
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Article
Safety of Intradermal Injection of Monosodium Urate Crystals as a Vaccine Carrier in Volunteers
Ippei Sakamaki, Kunihiro Inai & Hiroshi Tsutani
Pages: 1077-1084
Published online: 01 Dec 2011
AbstractforSafety of Intradermal Injection of Monosodium Urate Crystals as a Vaccine Carrier in Volunteers | Full Text | References | PDF (490 KB)
  • 240 Views
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Article
Allopurinol Enhances the Activity of Hypoxanthine-Guanine Phosphoribosyltransferase in Inflammatory Bowel Disease Patients During Low-Dose Thiopurine Therapy: Preliminary Data of an Ongoing Series
Margien L. Seinen, Nanne K. H. de Boer, Kees Smid, Dirk P. van Asseldonk, Gerd Bouma, Adriaan A. van Bodegraven & Godefridus J. Peters
Pages: 1085-1090
Published online: 01 Dec 2011
AbstractforAllopurinol Enhances the Activity of Hypoxanthine-Guanine Phosphoribosyltransferase in Inflammatory Bowel Disease Patients During Low-Dose Thiopurine Therapy: Preliminary Data of an Ongoing Series | Full Text | References | PDF (134.5 KB)
  • 364 Views
  • 17 CrossRef citations
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Article
ABCG2 is a High-Capacity Urate Transporter and its Genetic Impairment Increases Serum Uric Acid Levels in Humans
Akiyoshi Nakayama, Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Yuki Ikebuchi, Kousei Ito, Tatsuo Hosoya, Yoshikatsu Kanai, Hiroshi Suzuki & Nariyoshi Shinomiya
Pages: 1091-1097
Published online: 01 Dec 2011
AbstractforABCG2 is a High-Capacity Urate Transporter and its Genetic Impairment Increases Serum Uric Acid Levels in Humans | Full Text | References | PDF (173.5 KB)
  • 816 Views
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Article
Identification of ABCG2 Dysfunction as a Major Factor Contributing to Gout
H. Matsuo, T. Takada, K. Ichida, T. Nakamura, A. Nakayama, Y. Takada, C. Okada, Y. Sakurai, T. Hosoya, Y. Kanai, H. Suzuki & N. Shinomiya
Pages: 1098-1104
Published online: 01 Dec 2011
AbstractforIdentification of ABCG2 Dysfunction as a Major Factor Contributing to Gout | Full Text | References | PDF (129.4 KB)
  • 456 Views
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Article
Pathogenic GLUT9 Mutations Causing Renal Hypouricemia Type 2 (RHUC2)
Y. Kawamura, H. Matsuo, T. Chiba, S. Nagamori, A. Nakayama, H. Inoue, Y. Utsumi, T. Oda, J. Nishiyama, Y. Kanai & N. Shinomiya
Pages: 1105-1111
Published online: 01 Dec 2011
AbstractforPathogenic GLUT9 Mutations Causing Renal Hypouricemia Type 2 (RHUC2) | Full Text | References | PDF (165.7 KB)
  • 563 Views
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Article
Diagnostic Tests for Primary Renal Hypouricemia
Ivan Sebesta, Blanka Stiburkova, Josef Bartl, Kimiyoshi Ichida, Makoto Hosoyamada, Judy Taylor & Anthony Marinaki
Pages: 1112-1116
Published online: 01 Dec 2011
AbstractforDiagnostic Tests for Primary Renal Hypouricemia | Full Text | References | PDF (114.8 KB)
  • 456 Views
  • 32 CrossRef citations
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Article
ABCG2/BCRP Dysfunction as a Major Cause of Gout
Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Akiyoshi Nakayama, Hiroshi Suzuki, Tatsuo Hosoya & Nariyoshi Shinomiya
Pages: 1117-1128
Published online: 01 Dec 2011
AbstractforABCG2/BCRP Dysfunction as a Major Cause of Gout | Full Text | References | PDF (378.9 KB)
  • 818 Views
  • 21 CrossRef citations
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Article
The PRPP Synthetase Spectrum: What Does it Demonstrate About Nucleotide Syndromes?
John A. Duley, John Christodoulou & Arjan P. M. de Brouwer
Pages: 1129-1139
Published online: 01 Dec 2011
AbstractforThe PRPP Synthetase Spectrum: What Does it Demonstrate About Nucleotide Syndromes? | Full Text | References | PDF (172.4 KB)
  • 1068 Views
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Article
Stable Isotope Dilution Mass Spectrometric Assay for PRPP Using Enzymatic Procedures
Y. Shinohara, Y. Suzuki, H. Hasegawa, M. Nakamura, T. Nishiyama, A. Hiratsuka & K. Ichida
Pages: 1140-1146
Published online: 01 Dec 2011
AbstractforStable Isotope Dilution Mass Spectrometric Assay for PRPP Using Enzymatic Procedures | Full Text | References | PDF (110.3 KB)
  • 179 Views
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Article
Gene Expression of Enzymes Required for the De Novo Synthesis and Degradation of Pyrimidines in Rat Peripheral Tissues and Brain
Johannes Gerlach, Monika Löffler & Martin K.-H. Schäfer
Pages: 1147-1154
Published online: 01 Dec 2011
AbstractforGene Expression of Enzymes Required for the De Novo Synthesis and Degradation of Pyrimidines in Rat Peripheral Tissues and Brain | Full Text | References | PDF (302 KB)
  • 172 Views
  • 7 CrossRef citations
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Article
Initial Studies to Define the Physiologic Role of cN-II
Daniela Nicole Filoni, Rossana Pesi, Maria Giovanna Careddu, Marcella Camici, Simone Allegrini, Anita Collavoli, Ilaria Scarfone, Francesca Zucchi, Alvaro Galli & Maria Grazia Tozzi
Pages: 1155-1160
Published online: 01 Dec 2011
AbstractforInitial Studies to Define the Physiologic Role of cN-II | Full Text | References | PDF (107.9 KB)
  • 196 Views
  • 3 CrossRef citations
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Article
Inosine, not Adenosine, Initiates Endothelial Glycocalyx Degradation in Cardiac Ischemia and Hypoxia
B. F. Becker, J. Fischer, H. Hartmann, C. C. Chen, C. P. Sommerhoff, J. Tschoep, P. C. Conzen & T. Annecke
Pages: 1161-1167
Published online: 01 Dec 2011
AbstractforInosine, not Adenosine, Initiates Endothelial Glycocalyx Degradation in Cardiac Ischemia and Hypoxia | Full Text | References | PDF (166.2 KB)
  • 282 Views
  • 17 CrossRef citations
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Article
Lipophilic Prodrugs and Formulations of Conventional (Deoxy)Nucleoside and Fluoropyrimidine Analogs in Cancer
Godefridus J. Peters, Auke D. Adema, Irene V. Bijnsdorp & Marit L. Sandvold
Pages: 1168-1180
Published online: 01 Dec 2011
AbstractforLipophilic Prodrugs and Formulations of Conventional (Deoxy)Nucleoside and Fluoropyrimidine Analogs in Cancer | Full Text | References | PDF (271.4 KB)
  • 416 Views
  • 8 CrossRef citations
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Article
Fludarabine Nucleoside Modulates Nuclear “Survival and Death” Proteins in Resistant Chronic Lymphocytic Leukemia Cells
Silke Henrich, Swetlana Mactier, Giles Best, Stephen P. Mulligan, Ben Crossett & Richard Ian Christopherson
Pages: 1181-1189
Published online: 01 Dec 2011
AbstractforFludarabine Nucleoside Modulates Nuclear “Survival and Death” Proteins in Resistant Chronic Lymphocytic Leukemia Cells | Full Text | References | PDF (208.2 KB)
  • 248 Views
  • 6 CrossRef citations
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Article
Combination Effects of Digalloylresveratrol With Arabinofuranosylcytosine and Difluorodeoxycytidine in Human Leukemia and Pancreatic Cancer Cells
Philipp Saiko, Geraldine Graser, Sibylle Madlener, Simone Schwarz, Georg Krupitza, Walter Jaeger, Venkateswarlu Somepalli, Trimurtulu Golakoti, Monika Fritzer-Szekeres & Thomas Szekeres
Pages: 1190-1196
Published online: 01 Dec 2011
AbstractforCombination Effects of Digalloylresveratrol With Arabinofuranosylcytosine and Difluorodeoxycytidine in Human Leukemia and Pancreatic Cancer Cells | Full Text | References | PDF (91.6 KB)
  • 196 Views
  • 2 CrossRef citations
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Article
Deoxyribose Protects Against Rapamycin-Induced Cytotoxicity in Colorectal Cancer Cells In Vitro
I. V. Bijnsdorp & G. J. Peters
Pages: 1197-1202
Published online: 01 Dec 2011
AbstractforDeoxyribose Protects Against Rapamycin-Induced Cytotoxicity in Colorectal Cancer Cells In Vitro | Full Text | References | PDF (134.7 KB)
  • 269 Views
  • 4 CrossRef citations
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Article
Determination of the Phosphorylated Metabolites of Gemcitabine and of Difluorodeoxyuridine by LCMSMS
Richard J. Honeywell, Elisa Giovannetti & G. J. Peters
Pages: 1203-1213
Published online: 01 Dec 2011
AbstractforDetermination of the Phosphorylated Metabolites of Gemcitabine and of Difluorodeoxyuridine by LCMSMS | Full Text | References | PDF (331.6 KB)
  • 365 Views
  • 7 CrossRef citations
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Article
Regulation of Deoxycytidine Kinase Expression and Sensitivity to Gemcitabine by Micro-RNA 330 and Promoter Methylation in Cancer Cells
Jasmina Hodzic, Elisa Giovannetti, Begona Diosdado Calvo, A. D. Adema & G. J. Peters
Pages: 1214-1222
Published online: 01 Dec 2011
AbstractforRegulation of Deoxycytidine Kinase Expression and Sensitivity to Gemcitabine by Micro-RNA 330 and Promoter Methylation in Cancer Cells | Full Text | References | PDF (183 KB)
  • 601 Views
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Article
Characterization of Oligomeric and Kinetic Properties of Tomato Thymidine Kinase 1
Zeeshan Mutahir, Nicolai Balle Larsen, Louise Slot Christiansen, Karl-Magnus Andersson, Ricardo Rico, Sofia Mebrahtu Wisen, Anders Ranegaard Clausen, Birgitte Munch-Petersen & Jure Piškur
Pages: 1223-1226
Published online: 01 Dec 2011
AbstractforCharacterization of Oligomeric and Kinetic Properties of Tomato Thymidine Kinase 1 | Full Text | References | PDF (83 KB)
  • 220 Views
  • 5 CrossRef citations
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Article
A New Expression Vector for Production of Enzymes in the Yeast Saccharomyces (Lachancea) Kluyveri
A. Rasmussen, Y. Lv, K. D. Schnackerz & J. Piškur
Pages: 1227-1232
Published online: 01 Dec 2011
AbstractforA New Expression Vector for Production of Enzymes in the Yeast Saccharomyces (Lachancea) Kluyveri | Full Text | References | PDF (164.6 KB)
  • 245 Views
  • 1 CrossRef citations
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Article
Inborn Errors of Purine and Pyrimidine Metabolism: How Much We Owe to H. Anne Simmonds
Vanna Micheli & Sylvia Sestini
Pages: 1233-1242
Published online: 01 Dec 2011
AbstractforInborn Errors of Purine and Pyrimidine Metabolism: How Much We Owe to H. Anne Simmonds | Full Text | References | PDF (205.9 KB)
  • 722 Views
  • 6 CrossRef citations
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Article
Purine Nucleoside Phosphorylase Deficiency: A Mutation Update
P. L. C. Walker, Adele Corrigan, Monica Arenas, Emilia Escuredo, Lynette Fairbanks & Anthony Marinaki
Pages: 1243-1247
Published online: 01 Dec 2011
AbstractforPurine Nucleoside Phosphorylase Deficiency: A Mutation Update | Full Text | References | PDF (54.5 KB)
  • 589 Views
  • 33 CrossRef citations
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Article
Hypoxanthine Guanine Phosphoribosyltransferase (HPRT) Mutations in the Asian Population
Y. Yamada, N. Wakamatsu, A. Taniguchi, K. Kaneko & S. Fujimori
Pages: 1248-1255
Published online: 01 Dec 2011
AbstractforHypoxanthine Guanine Phosphoribosyltransferase (HPRT) Mutations in the Asian Population | Full Text | References | PDF (70.8 KB)
  • 330 Views
  • 10 CrossRef citations
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Article
Simultaneous Determination of Purine and Pyrimidine Metabolites in Hprt-Deficient Cell Lines
N. Yamaoka, K. Inazawa, S. Inagawa, M. Yasuda, K. Mawatari, K. Nakagomi, S. Fujimori, Y. Yamada & K. Kaneko
Pages: 1256-1259
Published online: 01 Dec 2011
AbstractforSimultaneous Determination of Purine and Pyrimidine Metabolites in Hprt-Deficient Cell Lines | Full Text | References | PDF (134.7 KB)
  • 316 Views
  • 5 CrossRef citations
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Article
HPRT Deficiency: Identification of Twenty-Four Novel Variants Including an Unusual Deep Intronic Mutation
A. Corrigan, M. Arenas, E. Escuredo, L. Fairbanks & A. Marinaki
Pages: 1260-1265
Published online: 01 Dec 2011
AbstractforHPRT Deficiency: Identification of Twenty-Four Novel Variants Including an Unusual Deep Intronic Mutation | Full Text | References | PDF (269.3 KB)
  • 306 Views
  • 9 CrossRef citations
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Article
Molecular Characterization of a Deletion in the HPRT1 Gene in a Patient with Lesch–Nyhan Syndrome
A. Taniguchi, Y. Yamada, M. Hakoda, C. Sekita, M. Kawamoto, H. Kaneko & H. Yamanaka
Pages: 1266-1271
Published online: 01 Dec 2011
AbstractforMolecular Characterization of a Deletion in the HPRT1 Gene in a Patient with Lesch–Nyhan Syndrome | Full Text | References | PDF (210 KB)
  • 358 Views
  • 3 CrossRef citations
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Article
Molecular Analysis of X-Linked Inborn Errors of Purine Metabolism: HPRT1 and PRPS1 Mutations
Yasukazu Yamada, Kenichiro Yamada, Noriko Nomura, Arisa Yamano, Reiko Kimura, Misako Naiki, Daisuke Fukushi, Nobuaki Wakamatsu, Atsuo Taniguchi, Noriko Yamaoka, Kiyoko Kaneko & Shin Fujimori
Pages: 1272-1275
Published online: 01 Dec 2011
AbstractforMolecular Analysis of X-Linked Inborn Errors of Purine Metabolism: HPRT1 and PRPS1 Mutations | Full Text | References | PDF (114.1 KB)
  • 303 Views
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Article
Inborn Errors in Purine Metabolism: Role of 5′-Nucleotidases and Their Involvement in the Etiology of Neurological Impairments
Tozzi Maria Grazia
Pages: 1276-1283
Published online: 01 Dec 2011
AbstractforInborn Errors in Purine Metabolism: Role of 5′-Nucleotidases and Their Involvement in the Etiology of Neurological Impairments | Full Text | References | PDF (165.1 KB)
  • 361 Views
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Article
Detection of Mutant Uromodulin in Transgenic Mouse Harboring a Mutant Human UMOD Gene
Makoto Yasuda, Kiyoka Kaneko, Hiroka Hachisu, Noriko Yamaoka, Ken-ichi Mawatari, Kazuya Nakagomi, Norihiko Minoura & Makoto Hosoyamada
Pages: 1284-1289
Published online: 01 Dec 2011
AbstractforDetection of Mutant Uromodulin in Transgenic Mouse Harboring a Mutant Human UMOD Gene | Full Text | References | PDF (248.3 KB)
  • 169 Views
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Article
The Increased Protein Level of URAT1 was Observed in Obesity/Metabolic Syndrome Model Mice
Masaru Doshi, Yuichi Takiue, Hidetsugu Saito & Makoto Hosoyamada
Pages: 1290-1294
Published online: 01 Dec 2011
AbstractforThe Increased Protein Level of URAT1 was Observed in Obesity/Metabolic Syndrome Model Mice | Full Text | References | PDF (184.2 KB)
  • 591 Views
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Article
Increased Expression of SLC2A9 Decreases Urate Excretion From the Kidney
Toru Kimura, Sirirat Amonpatumrat, Ai Tsukada, Toshiyuki Fukutomi, Promsuk Jutabha, Thanapol Thammapratip, Eun J. Lee, Kimiyoshi Ichida, Naohiko Anzai & Hiroyuki Sakurai
Pages: 1295-1301
Published online: 01 Dec 2011
AbstractforIncreased Expression of SLC2A9 Decreases Urate Excretion From the Kidney | Full Text | References | PDF (204.4 KB)
  • 467 Views
  • 15 CrossRef citations
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Article
Apical Voltage-Driven Urate Efflux Transporter NPT4 in Renal Proximal Tubule
P. Jutabha, N. Anzai, M. F. Wempe, S. Wakui, H. Endou & H. Sakurai
Pages: 1302-1311
Published online: 01 Dec 2011
AbstractforApical Voltage-Driven Urate Efflux Transporter NPT4 in Renal Proximal Tubule | Full Text | References | PDF (154.3 KB)
  • 581 Views
  • 25 CrossRef citations
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Article
Human Uric Acid Transporter 1 (hURAT1): An Inhibitor Structure–Activity Relationship (SAR) Study
M. F. Wempe, B. Quade, P. Jutabha, T. Iwen, M. Frick, P. J. Rice, S. Wakui & H. Endou
Pages: 1312-1323
Published online: 01 Dec 2011
AbstractforHuman Uric Acid Transporter 1 (hURAT1): An Inhibitor Structure–Activity Relationship (SAR) Study | Full Text | References | PDF (290.2 KB)
  • 442 Views
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Article
Translocation of Nucleoside Analogs Across the Plasma Membrane in Hematologic Malignancies
Paula X. Fernández-Calotti, Dolors Colomer & Marçal Pastor-Anglada
Pages: 1324-1340
Published online: 01 Dec 2011
AbstractforTranslocation of Nucleoside Analogs Across the Plasma Membrane in Hematologic Malignancies | Full Text | References | PDF (221.1 KB)
  • 435 Views
  • 13 CrossRef citations
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CORRIGENDUM

Corrigendum
Page: 1341
Published online: 01 Dec 2011
CitationforCorrigendum | Full Text | PDF (22.4 KB)
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