Role of susceptibility weighted imaging and evoked potential studies in early detection of neuropsychiatric manifestations in the patients with systemic lupus erythematosus

Peer review under responsibility of Alexandria University Faculty of Medicine.

Available online 13 January 2014

Abstract

Background

Central nervous system involvement in SLE as a part of neuropsychiatric lupus is a complex diagnostic entity due to its multiple clinical presentations.

Objective

This study aimed to assess the value of susceptibility weighted imaging (SWI) and neurophysiological assessment on 30 patients with SLE in order to determine the value in the early diagnosis and management of neurological manifestation of lupus.

Materials and methods

Thirty patients with ACR criteria for SLE are involved in this study. Antiphospholipid antibodies, SWI, and evoked response studies were used to assess neurological involvement in SLE.

Results

Eighteen patients presented with clinical neurological manifestations attributed to neurological lupus. Abnormal SWI findings were found in 16 patients. 11 SLE patients were positive for antiphospholipid. 17 patients presented with abnormal neurophysiological parameters. No correlation between individual neurophysiological disorders (NPD) and specific neuropsychiatric symptoms was observed. There was no significant correlation between the electro physiologic findings and SLE related auto antibodies.

Conclusions

SWI and neurophysiological studies may provide a useful test in the evaluation and management of early neurological lupus.

Abbreviations:

• SLE
• systemic lupus erythematosus
• CNS
• central nervous system
• SWI
• susceptibility weighted imaging
• PA
• antiphospholipid antibodies
• aCL
• anticardiolipin antibodies
• LA
• lupus anticoagulant

KEYWORDS:

• Systemic lupus erythematosus
• Neurological lupus
• Susceptibility weighted imaging
• Neurophysiological tests

Notes

Peer review under responsibility of Alexandria University Faculty of Medicine.

Available online 13 January 2014