Phosphodiesterase type 5 inhibitors as a treatment for erectile dysfunction: Current information and new horizons

Peer review under responsibility of Arab Association of Urology.

Abstract

Introduction:

Over the past 15 years, the discovery and development of oral medications that selectively inhibit the enzyme phosphodiesterase type 5 (PDE5) have revolutionised the treatment of erectile dysfunction (ED). Currently, three PDE5 inhibitors are widely available clinically, i.e., sildenafil, vardenafil and tadalafil. New PDE5 inhibitors, including avanafil and udenafil, are now in clinical use in a few countries, and other compounds are under development.

Methods:

We describe the current use and future direction of PDE5 inhibitors in the treatment of ED.

Results and conclusion:

Each PDE5 inhibitor has an excellent and comparable efficacy and tolerability. These drugs are highly effective for ED of various causes, and are effective in preventing ED after radical prostatectomy. However, whilst being at least 60% effective, PDE5 inhibitors are still ineffective in at least 30% of patients, prompting current research into other pharmacological targets for ED.

Keywords:

• Erectile dysfunction
• Phosphodiesterase type 5 inhibitors
• Penile disorders

Abbreviations:

• ED, erectile dysfunction
• PDE5(i), phosphodiesterase type 5 (inhibitors)
• IIEF, International Index of Erectile Function
• SHIM, Sexual Health Inventory in Men
• NO, nitric oxide
• sGC, soluble guanylyl cyclase
• cGMP, cyclic guanosine monophosphate
• GTP, guanosine triphosphate
• FDA, USA Food and Drug Administration
• Cmax, maximum serum concentration
• Tmax, time to Cmax
• RCT, randomised controlled trial

Notes

Peer review under responsibility of Arab Association of Urology.