![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Canarium odontophyllum (CO) (Miq.) (Burseraceae) has been traditionally consumed for its antioxidant benefit in maintaining longetivity. However, there is no report concerning its pharmacological activity on blood vessels. This study was aimed to investigate the effects of CO aqueous leaf extract on isolated aortic rings.
Methods Isolated thoracic aortic rings were suspended in a tissue bath and placed between 2 tungsten wires and connected to an isometric force transducer. The tension changes were recorded to a data acquisition system.
Results The leaf aqueous extract (3–15mg/ml) induced relaxation in endothelium-intact and endothelium-denuded aortic rings precontracted with PE. Incubation with nitric oxide enzyme inhibitor L-NAME, however, did not alter the CO-induced vasorelaxant on endothelium-intact aortic ring. The vasorelaxant effect of CO was endothelium-independent as it reduced the contraction induced by extracellular Ca2+ in endothelium-denuded aortic ring precontracted by PE and KCl in Ca2+-free Krebs solution. However, CO did not inhibit the release of intracellular Ca2+ from sarcoplasmic reticulum.
Conclusion This study suggests that the vasorelaxant effect of aqueous extract from CO leaves was endothelium-independent and was possibly mediated through the blockade of voltage-dependent calcium channel and receptor-operated calcium channel.
Acknowledgement
This project was funded by Universiti Kebangsaan Malaysia under the Research University Grant Code Grant GUP-2014-059.