fluorescence dual-modal imaging of tumorsFootnote
Peer review under responsibility of The Ceramic Society of Japan and the Korean Ceramic Society.

Koichiro HayashiDivision of Green Materials, EcoTopia Science Institute, Nagoya UniversityFuro-cho, Chikusa-kuNagoya464-8603Japan;Department of Anatomy and Cell Biology, Institute of Health Biosciences, The University of Tokushima Graduate School3-18-15 Kuramoto-choTokushima770-8503JapanCorrespondence[email protected]

Sakamoto WataruDivision of Green Materials, EcoTopia Science Institute, Nagoya UniversityFuro-cho, Chikusa-kuNagoya464-8603Japan

Toshinobu YogoDivision of Green Materials, EcoTopia Science Institute, Nagoya UniversityFuro-cho, Chikusa-kuNagoya464-8603Japan

Abstract

Silica nanoparticles containing covalently linked iodine and a near-infrared (NIR) fluorescence dye, namely porphyrin, have been synthesized through a one-pot sol–gel reaction. These particles are called iodinated silica/porphyrin hybrid nanoparticles (ISP HNPs). The ISP HNPs have both high X-ray absorption coefficient and NIR fluorescence. The ISP HNPs modified with folic acid (FA) and polyethylene glycol (PEG), denoted as FA-PEG-ISP HNPs, enabled the successful visualization of tumors in mice by both X-ray computed tomography (CT) and fluorescence imaging (FI). Thus, the FA-PEG-ISP HNPs are useful as contrast agents or probes for CT/FI dual-modal imaging.

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Peer review under responsibility of The Ceramic Society of Japan and the Korean Ceramic Society.

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Iodinated silica/porphyrin hybrid nanoparticles for X-ray computed tomography/fluorescence dual-modal imaging of tumorsFootnote
Peer review under responsibility of The Ceramic Society of Japan and the Korean Ceramic Society.

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Iodinated silica/porphyrin hybrid nanoparticles for X-ray computed tomography/fluorescence dual-modal imaging of tumorsFootnotePeer review under responsibility of The Ceramic Society of Japan and the Korean Ceramic Society.

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Iodinated silica/porphyrin hybrid nanoparticles for X-ray computed tomography/fluorescence dual-modal imaging of tumorsFootnote
Peer review under responsibility of The Ceramic Society of Japan and the Korean Ceramic Society.