![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
A convenient synthesis of a new series of nano steroidal pyrazolones is reported. They were characterized by X-ray diffraction, scanning electron microscopy, UV–vis light, Fourier transform-infrared spectroscopy, 1H and 13C nuclear magnetic resonance, mass spectroscopy and analytical data. The X-ray diffraction patterns at room temperature showed that two nano steroids, 7 and 8, are formed in single phase with hexagonal crystal symmetry, while nano steroid 9 is formed with orthorhombic crystal symmetry. Compounds 1–3 are formed with hexagonal, monoclinic and tetragonal crystal symmetry, respectively. Scanning electron microscopy showed that the crystals of nano steroids 7–9 are brick-shaped agglomerates with less sharp edges and a rough surface with a few microcrystals, while the homogeneous crystal of nano steroid 3 has an approximate spherical morphology of nano particles conjoined to the chains. UV–vis absorption analysis showed that the band gap energy of nano steroids 7 and 8 was 3.70 eV and 4.61 eV, while that of 2 and 3 was 4.38 eV and 4.27 eV, respectively. Nano steroids 2, 3 and 7–9 were screened for antimicrobial activity against various strains; nano compound 7 showed potential antimicrobial activity.
Acknowledgements
The authors are thankful to the Chairman, Department of Chemistry, for providing research facilities, the All India Institute of Medical Sciences, New Delhi, for providing SEM micrographs, Zakir Hussain College of Engineering and Technology, Aligarh Muslim University, for X-ray diffraction analysis, UV–vis spectrometry and particle size analysis. The financial assistance provided by the (UGC) India and SAP (DRS-1) is also acknowledged.
Notes
Peer review under responsibility of Taibah University